Altered body composition in male long-term survivors of paediatric allogeneic haematopoietic stem cell transplantation: impact of conditioning regimen, chronic graft-versus-host disease and hypogonadism.

abstract：:SCT from an HLA-compatible sibling donor is an adoptive immunotherapy for cytokine-refractory, metastatic clear-cell renal cell cancer (RCC). However, the recent introduction of targeted therapy compounds has reduced the interest in this therapeutic strategy. We have reanalyzed our series with the aim to assess long-t...

journal_title：Bone marrow transplantation

authors： Bregni M,Bernardi M,Servida P,Pescarollo A,Crocchiolo R,Treppiedi E,Corradini P,Ciceri F,Peccatori J

更新日期：2009-08-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) was performed in 95 patients with chronic myelogenous leukemia (CML) in chronic phase and their data were reported to the European Bone Marrow Transplant Registry. Most patients presented bad prognostic factors. The results were analysed by September 1, 1993. The actuarial p...

journal_title：Bone marrow transplantation

authors： Reiffers J,Goldman J,Meloni G,Cahn JY,Faberes C,Apperley J

更新日期：1994-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) is a frequent and major complication after allogeneic stem cell transplantation. For many years psoralen and ultraviolet (UV)-A light have been used in the treatment of chronic cutaneous graft-versus-host disease, but few patients have received PUVA therapy for aGVHD. We assesse...

journal_title：Bone marrow transplantation

authors： Wiesmann A,Weller A,Lischka G,Klingebiel T,Kanz L,Einsele H

更新日期：1999-01-01 00:00:00

abstract：:Collection of peripheral blood stem cells (PBSC) does not require anesthesia or multiple marrow aspirations, and hence, is far less invasive than bone marrow collection. Most importantly, PBSC can be collected from the body's entire pool of HSC to provide more stem cells than marrow aspiration performed at localized i...

journal_title：Bone marrow transplantation

authors： Takaue Y,Kawano Y,Watanabe T,Watanabe A

更新日期：1998-12-01 00:00:00

abstract：:Paecilomyces varioti, a fungus resembling penicillium spp, has been described in conjunction with impaired host defence or foreign body implants. We report a case of Paecilomyces varioti catheter-related fungemia that occurred during neutropenia in an allogeneic BMT patient receiving antifungal prophylaxis with flucon...

journal_title：Bone marrow transplantation

authors： Shing MM,Ip M,Li CK,Chik KW,Yuen PM

更新日期：1996-02-01 00:00:00

abstract：:Urine cytology was studied prospectively for the presence of human polyomavirus (HPV) in 17 consecutive patients undergoing marrow transplantation and correlated with hematuria and hemorrhagic cystitis. Of the 15 evaluable patients, nine had cytologic findings consistent with HPV infection during the first month after...

journal_title：Bone marrow transplantation

authors： Cottler-Fox M,Lynch M,Deeg HJ,Koss LG

更新日期：1989-05-01 00:00:00

abstract：:Post-BMT subjects have an increased bone fracture risk. Additionally, several factors were associated with osteopenia and osteoporosis in these individuals. We aimed to identify other factors associated with osteopenia and osteoporosis in allogeneic post-BMT subjects. We conducted a cross-sectional study with 47 allog...

journal_title：Bone marrow transplantation

authors： Faulhaber GA,Premaor MO,Moser Filho HL,Silla LM,Furlanetto TW

更新日期：2009-06-01 00:00:00

abstract：:Up to now there are no data on long-term effects of allogeneic peripheral blood cell transplantation (AlloPBPCT). In particular, long term effects on healthy donors by the mobilization procedure which includes the exposition to G-CSF over several days are unknown. Recently the possibility of an increase in risk for ac...

journal_title：Bone marrow transplantation

authors： Hasenclever D,Sextro M

更新日期：1996-03-01 00:00:00

abstract：:Intrabone marrow cord blood transplantation (IB-CBT) was proposed as a promising treatment modality to improve hematological recovery. However, clinical advantages of IB-CBT over conventional IV CBT have been unclear. We conducted a prospective single-center trial of IB-CBT to evaluate its safety and superiority in te...

journal_title：Bone marrow transplantation

authors： Kurita N,Gosho M,Yokoyama Y,Kato T,Obara N,Sakata-Yanagimoto M,Hasegawa Y,Uchida N,Takahashi S,Kouzai Y,Atsuta Y,Kurata M,Ichinohe T,Chiba S

更新日期：2017-04-01 00:00:00

abstract：:To augment graft cell dose, we evaluated the safety of the combined transplantation of two partially HLA-matched umbilical cord blood (UCB) units. Five patients with transfusion-dependent thalassemia, median age 11.1 years (range 10-13.1), received 2 UCB units after myeloablative conditioning. Cord blood units were a ...

journal_title：Bone marrow transplantation

authors： Jaing TH,Yang CP,Hung IJ,Chen SH,Sun CF,Chow R

更新日期：2007-08-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) was given to 23 patients with steroid-refractory acute GVHD (aGVHD, grade II (n=10), III (n=7) or IV (n=6)). The median duration of ECP was 7 months (1-33) and the median number of ECP cycles in each patient was 10. Twelve patients (52%) had complete responses. Eleven patients (48%) ...

journal_title：Bone marrow transplantation

authors： Perfetti P,Carlier P,Strada P,Gualandi F,Occhini D,Van Lint MT,Ibatici A,Lamparelli T,Bruno B,Raiola AM,Dominietto A,Di Grazia C,Bregante S,Zia S,Ferrari GM,Stura P,Pogliani E,Bacigalupo A

更新日期：2008-11-01 00:00:00

abstract：:Despite antibiotics, antifungals and haematopoietic growth factors, infections remain a major threat to neutropenic patients. To determine the role of granulocyte transfusions (GTs) in anti-infective therapy during neutropenia, GT administration was randomized in 74 adults with haematological or malignant diseases, fe...

journal_title：Bone marrow transplantation

authors： Seidel MG,Peters C,Wacker A,Northoff H,Moog R,Boehme A,Silling G,Grimminger W,Einsele H

更新日期：2008-11-01 00:00:00

abstract：:While PBSC collection has become a safe procedure for adults, only a few reports exist about its efficacy, safety and feasibility in paediatric patients, especially extremely low-weight infants. We describe successful PBSC collection in three infants of less than 10 kg body weight (BW; range: 6.92-9.4 kg) suffering fr...

journal_title：Bone marrow transplantation

authors： Nussbaumer W,Schönitzer D,Trieb T,Fink FM,Maurer-Dengg K,Höcker P,Wagner A,Schwaighofer H,Nachbaur D,Niederwieser D

更新日期：1996-07-01 00:00:00

abstract：:PBSCs are usually mobilized using G-CSF with or without chemotherapy. With the emergence of newer mobilizing agents, predicting poor mobilization may allow early intervention and prevent the costs and complications associated with remobilization. We retrospectively evaluated a cohort of 1556 patients seen between Janu...

journal_title：Bone marrow transplantation

authors： Sinha S,Gastineau D,Micallef I,Hogan W,Ansell S,Buadi F,Dingli D,Dispenzieri A,Gertz M,Greiner C,Hayman S,Inwards D,Johnston P,Lacy M,Litzow M,Porrata L,Winters JL,Kumar S

更新日期：2011-07-01 00:00:00

abstract：:The protection of hematopoietic stem and progenitor cells and their environment is required for recovery from radiation-induced (RI) myelosuppression. To achieve this goal, we propose a new gene therapy strategy based on local and short-term synthesis and expression of Sonic hedgehog morphogene (Shh) at the niche leve...

journal_title：Bone marrow transplantation

authors： Drouet M,Garrigou P,Peinnequin A,Hérodin F

更新日期：2014-02-01 00:00:00

abstract：:Data on long-term follow-up of donors for hematopoietic stem cell transplantation (HSCT) are limited. Donors of 612 adult allogeneic HSCT were studied, at a median of 81 (14-181) months post-HSC donation. Nine donors had severe health problems. Five donors died from aggressive malignancies or terminal illness, at a me...

journal_title：Bone marrow transplantation

authors： Au WY,Lie AK,Cheng JW,Liang R,Kwong YL

更新日期：2006-03-01 00:00:00

abstract：:A patient with chronic myeloid leukemia (CML) who developed a disseminated infection by mycobacterium avium complex (MAC) was successfully treated with rifampin, ethambutol, isoniazid, cycloserin and ciprofloxacin. Diagnosis was proven by histologic examination of hepatic biopsy and culture of the liver biopsy materia...

journal_title：Bone marrow transplantation

authors： Hermida G,Richard C,Baro J,Garcia-Ruiz JC,Barreiro G,Fariñas C,Zubizarreta A

更新日期：1995-07-01 00:00:00

abstract：:The management of acute leukaemia which relapses following an allogeneic stem cell transplant remains a major challenge. In this review we summarize the outcomes of the currently available treatment modalities and discuss emerging novel approaches. ...

journal_title：Bone marrow transplantation

authors： Shaw BE,Russell NH

更新日期：2008-03-01 00:00:00

abstract：:We designed a phase I clinical trial of escalating doses of topotecan with CY and carboplatin in combination with autologous hematopoietic SCT (AHSCT) for the treatment of relapsed or persistent platinum sensitive ovarian or primary peritoneal carcinoma. After stem cell collection, 16 patients received topotecan at 1....

journal_title：Bone marrow transplantation

authors： Litzow MR,Peethambaram PP,Safgren SL,Keeney GL,Ansell SM,Dispenzieri A,Elliott MA,Gastineau DA,Gertz MA,Inwards DJ,Lacy MQ,Micallef IN,Porrata LF,Lingle WL,Hartmann LC,Frost MH,Barrette BA,Long HJ,Suman VJ,Reid JM,

更新日期：2010-03-01 00:00:00

abstract：:The best donors for hematopoietic SCT (HSCT) are fully-matched siblings. In patients without fully-matched siblings, HLA registries or cord blood banks are alternative strategies with some restrictions. Owing to the high rate of consanguineous marriage in our country, between 2006 and 2013, extended family searches we...

journal_title：Bone marrow transplantation

authors： Hamidieh AA,Dehaghi MO,Paragomi P,Navaei S,Jalali A,Eslami GG,Behfar M,Ghavamzadeh A

更新日期：2015-04-01 00:00:00

abstract：:We have evaluated the efficacy of administering recombinant human erythropoietin (rh-Epo) to 11 healthy bone marrow donors weighing less than 30 kg. Three weeks before harvesting, the donors received 100 units/kg/day rh-Epo subcutaneously and oral iron supplementation (2.5 mg/kg twice daily). Six children with hematoc...

journal_title：Bone marrow transplantation

authors： Martínez AM,Sastre A,Muñoz A,Badell I,Maldonado MS,Cubells J

更新日期：1998-07-01 00:00:00

abstract：:Allogeneic SCT for older patients remains challenging at least in part due to graft-versus-host disease (GVHD) and higher non-relapse mortality (NRM). We conducted a prospective pilot study primarily for older patients undergoing matched unrelated donor (MUD) SCT using a reduced-intensity (RIC) melphalan-based conditi...

journal_title：Bone marrow transplantation

authors： Shah MV,Saliba RM,Rondon G,Chen J,Soebbing D,Rus I,Alousi A,Oran B,Kebriaei P,Qazilbash M,Parmar S,Hosing C,Khouri IF,Popat UR,Champlin RE,Ciurea SO

更新日期：2019-04-01 00:00:00

abstract：:A 51-year-old patient with refractory CLL elected to participate in a trial of nonmyeloablative trans- plantation from an HLA-matched unrelated donor. He received low-dose fludarabine/TBI, with infusion of donor PBPC and cyclosporin (CsA)/MMF. Early post transplant he experienced explosive tumor growth with respirator...

journal_title：Bone marrow transplantation

authors： Nieto Y,Bearman SI,Shpall EJ,Jones RB,Cagnoni PJ,Rabinovitch RA,McSweeney PA

更新日期：2001-12-01 00:00:00

abstract：:Data on 65 sibling bone marrow transplantations (BMT) for various hematological disorders are reported. 51 patients had leukemia, 8 severe aplastic anemia, 4 myelodysplastic syndrome, one suffered from non-Hodgkin lymphoma and one from myeloid metaplasia. All but two patients have engrafted. Overall, 43 (66%) of 65 pa...

journal_title：Bone marrow transplantation

authors： Mistrík M,Bojtárová E,Demecková E,Hrubisko M,Holománová D,Buc M,Fehérvízyová E,Bátorová A,Kusiková M,Sakalová A

更新日期：1998-12-01 00:00:00

abstract：:Bone marrow aspirates are composed of two cellular compartments, an abundant buffy coat suspension and a minor particulate fraction. The particulate fraction is routinely removed by filtration prior to transplantation in order to reduce the risk of embolism. This study shows that the filter-retained fraction includes ...

journal_title：Bone marrow transplantation

authors： Blazsek I,Delmas Marsalet B,Legras S,Marion S,Machover D,Misset JL

更新日期：1999-04-01 00:00:00

abstract：:The incidence of secondary malignancy following autologous stem cell transplantation (ASCT) is increasing. We describe a patient with stage IVB Hodgkin's disease who developed primary amelanotic malignant melanoma of the tongue 18 months following autologous stem cell transplantation. She was treated by partial glosse...

journal_title：Bone marrow transplantation

authors： Ben-Yosef R,Braverman I,Saah D,Nagler R,Shohat S,Or R,Nagler A

更新日期：1996-11-01 00:00:00

abstract：:We have tested the immunologic status and hematologic parameters of mice 2 months (short-term survivors) or 18 months (long-term survivors) after lethal total body irradiation and syngeneic bone marrow transplantation (SBMT), and of normal mice of corresponding age. Long-term SBMT survivors showed significantly lowere...

journal_title：Bone marrow transplantation

authors： Skórski T,Kawalec M,Ratajczak M,Szczylik C,Kawiak J

更新日期：1990-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is an immune-susceptible malignancy, as demonstrated by its responsiveness to allogeneic stem cell transplantation (alloSCT). However, by employing inhibitory signaling pathways, including PD-1/PD-L1, leukemia cells suppress T cell-mediated immune attack. Notably, impressive clinical effic...

journal_title：Bone marrow transplantation

authors： van Ens D,Mousset CM,Hutten TJA,van der Waart AB,Campillo-Davo D,van der Heijden S,Vodegel D,Fredrix H,Woestenenk R,Parga-Vidal L,Jansen JH,Schaap NPM,Lion E,Dolstra H,Hobo W

更新日期：2020-12-01 00:00:00

abstract：:Auto-SCT and Allo-SCT are procedures conventionally associated with intensive transfusion support. This dependence has historically prevented SCT in individuals with religious or personal objections to transfusion. More recently, a growing body of literature supports the feasibility of 'bloodless transplants': SCT wit...

journal_title：Bone marrow transplantation

authors： Sloan JM,Ballen K

更新日期：2008-05-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Bone marrow transplantation

authors： Moffet JR,Mahadeo KM,McArthur J,Hsing DD,Gertz SJ,Smith LS,Loomis A,Fitzgerald JC,Nitu ME,Duncan CN,Hall MW,Pinos EL,Tamburro RF,Simmons RA,Troy J,Cheifetz IM,Rowan CM,Investigators of the Pediatric Acute Lung Injury an

更新日期：2020-02-01 00:00:00