Stress hyperglycemia is predictive of worse outcome in patients with acute ischemic stroke undergoing intravenous thrombolysis.

abstract：INTRODUCTION:While the CURE trial demonstrated the benefits of clopidogrel in acute coronary syndromes, patients receiving glycoprotein IIb/IIIa antagonists were excluded. Given the frequent coadministration of these two medications, we sought to examine their interaction and their combined effect on platelet inhibitio...

journal_title：Journal of thrombosis and thrombolysis

authors： Talreja D,Lubbe D,Orford JL,Lennon R,DiBattiste PM,Berger PB

更新日期：2004-08-01 00:00:00

abstract：:Rivaroxaban is a direct factor Xa inhibitor, which is rapidly absorbed in the upper gastrointestinal (GI) tract. In large trials, it has been shown to be effective and safe in VTE treatment. However, in these trials patients with morbid obesity were not reported and it is unknown if the standard dosage of 20 mg rivaro...

journal_title：Journal of thrombosis and thrombolysis

authors： Mahlmann A,Gehrisch S,Beyer-Westendorf J

更新日期：2013-11-01 00:00:00

abstract：:The benefits of thrombolytic therapy in the treatment of acute myocardial infarction are incontrovertible. Large-scale studies combining angiographic and clinical end-points have demonstrated a perfusion-mortality relationship, with the highest survival rate among patients with early restoration of TIMI grade 3 corona...

journal_title：Journal of thrombosis and thrombolysis

authors： Moliterno DJ,Harrington RA,Califf RM,Rapold HJ,Topol EJ

更新日期：1995-01-01 00:00:00

abstract：:The CHADS(2) score is widely used to assess the risk of stroke in patients with atrial fibrillation (AF). Patients with score of 0 and 1 are considered 'low risk' and are often treated with aspirin. In a Danish Study, the CHA(2)DS(2)--VASc score was shown to identify low and high-risk subgroups among patients with CHA...

journal_title：Journal of thrombosis and thrombolysis

authors： Piyaskulkaew C,Singh T,Szpunar S,Saravolatz L 2nd,Rosman H

更新日期：2014-05-01 00:00:00

abstract：:Continuous flow left ventricular assist devices (CF-LVAD) require therapeutic anticoagulation which is often interrupted for procedures or bleeding. Prior to the availability of four factor prothrombin complex concentrate (4F-PCC) in the United States, warfarin was held and its effects reversed by vitamin K or fresh f...

journal_title：Journal of thrombosis and thrombolysis

authors： Rimsans J,Levesque A,Lyons E,Sylvester K,Givertz MM,Mehra MR,Stewart GC,Connors JM

更新日期：2018-08-01 00:00:00

abstract：:The postthrombotic syndrome (PTS) is the most common complication of deep venous thrombosis (DVT) yet has received little attention from clinicians and researchers. Clinically, PTS is characterized by chronic pain, swelling, heaviness and other signs in the affected limb. In severe cases, venous ulcers may develop. PT...

journal_title：Journal of thrombosis and thrombolysis

authors： Kahn SR

更新日期：2006-02-01 00:00:00

abstract：:Point-of-care whole blood coagulation tests are critical in the management of patients who undergo percutaneous coronary intervention. The Hemochron and HemoTec devices have been traditionally used to measure the activated clotting time (ACT) in the cardiac catheterization laboratory. The heparin management test (HMT)...

journal_title：Journal of thrombosis and thrombolysis

authors： Tsimikas S,Beyer R,Hassankhani A

更新日期：2001-05-01 00:00:00

abstract：:We included acute ischemic stroke (AIS) patients who received recombinant tissue plasminogen activator (rt-PA) at three stroke centers via either interhospital transfer or direct presentation and compared the clinical outcomes and time metrics to analyze the impact of interhospital transfer on intravenous thrombolysis...

journal_title：Journal of thrombosis and thrombolysis

authors： Ding Y,Ji Z,Ma L,Zhai T,Gu Z,Niu J,Liu Y

更新日期：2019-11-01 00:00:00

abstract：:The dosage of warfarin is restricted due to its narrow therapeutic index, so, the required dose must be adapted individually to each patient. Variations in warfarin dosage are influenced by genetic factors, the changes in patient diet, anthropometric and clinical parameters. To determine whether VKORC1 G3730A and CYP4...

journal_title：Journal of thrombosis and thrombolysis

authors： Tatarunas V,Lesauskaite V,Veikutiene A,Grybauskas P,Jakuska P,Jankauskiene L,Bartuseviciute R,Benetis R

更新日期：2014-01-01 00:00:00

abstract：:Direct oral anticoagulant (DOAC) starter packs are designed for unique treatment dosing for acute venous thromboembolism (VTE). Inappropriate use of 30-day DOAC starter packs in patients with atrial fibrillation (AF) may increase the risk for bleeding events given higher dosing in the first 1-3 weeks of treatment. A r...

journal_title：Journal of thrombosis and thrombolysis

authors： Feng Y,Pai CW,Seiler K,Barnes GD

更新日期：2021-01-03 00:00:00

abstract：:D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adve...

journal_title：Journal of thrombosis and thrombolysis

authors： Halaby R,Popma CJ,Cohen A,Chi G,Zacarkim MR,Romero G,Goldhaber SZ,Hull R,Hernandez A,Mentz R,Harrington R,Lip G,Peacock F,Welker J,Martin-Loeches I,Daaboul Y,Korjian S,Gibson CM

更新日期：2015-01-01 00:00:00

abstract：:Pregnancy due to its physiological changes is a procoagulant state. The rate of cardiac valve prosthesis thrombosis, deep venous thrombosis and pulmonary embolism are all increased. Thrombolytic therapy with tissue plasminogen activator (rt-PA) is an approved therapy for ischemic stroke, myocardial infarction, pulmona...

journal_title：Journal of thrombosis and thrombolysis

authors： Leonhardt G,Gaul C,Nietsch HH,Buerke M,Schleussner E

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:We investigated the safety and efficacy of several dosing regimens of catheter-directed staphylokinase (SY162) bolus administration for the treatment of long-term venous access catheter occlusion. METHODS:This open-label, ascending dose study enrolled 24 subjects. Three doses of SY162 were evaluated in thre...

journal_title：Journal of thrombosis and thrombolysis

authors： Verhamme P,Goossens G,Maleux G,Collen D,Stas M

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS:Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) ...

journal_title：Journal of thrombosis and thrombolysis

authors： Farrehi PM,Zhu Y,Fay WP

更新日期：2001-12-01 00:00:00

abstract：:Infective endocarditis (IE) remains a severe illness with high mortality rate, despite advances in antibiotic therapy and cardiac surgery. If infectious bacteria and platelets are two key players of human IE vegetation developmental process, their interactions and respective roles in fully developed late-stage IE vege...

journal_title：Journal of thrombosis and thrombolysis

authors： Baudoin JP,Camoin-Jau L,Prasanth A,Habib G,Lepidi H,Hannachi N

更新日期：2020-08-04 00:00:00

abstract：:The risk benefit decision in providing anticoagulation for patients with brain metastases is amongst the most difficult decisions faced by clinicians. The purpose of our study was to evaluate both the risk of intracerebral hemorrhage (ICH) associated with anticoagulation therapy and the effect of anticoagulation on su...

journal_title：Journal of thrombosis and thrombolysis

authors： Hunter BD,Minichiello T,Bent S

更新日期：2017-10-01 00:00:00

abstract：:Anticoagulation is often used in superior vena cava syndrome (SVCS) associated with cancer (i.e malignant SVCS), even without thrombosis, but its effect on outcomes has not been reported. We aimed to determine factors and outcomes associated with thrombosis and anticoagulation in malignant SVCS. Patients with malignan...

journal_title：Journal of thrombosis and thrombolysis

authors： Ratzon R,Tamir S,Friehmann T,Livneh N,Dudnik E,Rozental A,Hamburger-Avnery O,Pereg D,Derazne E,Brenner B,Raanani P,Ten Cate H,Spectre G,Leader A

更新日期：2019-01-01 00:00:00

abstract：:The predictive value of and the influencing factors associated with early neurological improvement (ENI) among patients with acute basilar artery occlusion (BAO) have not been well studied. The present study aimed to evaluate whether ENI predicted a better functional outcome and to identify the influencing factors of ...

journal_title：Journal of thrombosis and thrombolysis

authors： Sun X,Zhang H,Tong X,Gao F,Deng Y,Ma G,Ma N,Mo D,Song L,Liu L,Huo X,Miao Z

更新日期：2021-01-01 00:00:00

abstract：:Drug-eluting stents (DES) reduce the incidence of in-stent restenosis (ISR) after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Whether the use of biomarkers might be of utility to identify patients who remain at risk for DES ISR after primary PCI has never been exami...

journal_title：Journal of thrombosis and thrombolysis

authors： Claessen BE,Stone GW,Mehran R,Witzenbichler B,Brodie BR,Wöhrle J,Witkowski A,Guagliumi G,Zmudka K,Henriques JP,Tijssen JG,Sanidas EA,Chantziara V,Hakim D,Leon S,Xu K,Dangas GD

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The available evidence suggests strongly that intravascular thrombosis is mediated predominantly by tissue-factor and its activation of factor X, which in the presence of factor Va, calcium, and phospholipid (prothrombinase complex) effectively converts prothrombin to thrombin. In vitro experiments have show...

journal_title：Journal of thrombosis and thrombolysis

authors： Spencer FA,Ball SP,Zhang Q,Liu L,Benoit S,Becker RC

更新日期：2000-04-01 00:00:00

abstract：:Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF), collectively known as Philadelphia-negative (Ph-negative) chronic myeloproliferative neoplasms (MPNs), MPNs represent the most common causes of splanchnic vein thrombosis (SVT), including Budd-Chiari syndrome (BCS) and portal ve...

journal_title：Journal of thrombosis and thrombolysis

authors： Yonal I,Pinarbası B,Hindilerden F,Hancer VS,Nalcaci M,Kaymakoglu S,Diz-Kucukkaya R

更新日期：2012-10-01 00:00:00

abstract：:The direct oral anticoagulant dabigatran does not require therapeutic drug monitoring, however emergency measurements are gaining importance. Current assays feature good performance at intermediate and high dabigatran concentrations but show limited accuracy at low concentrations. This area requires more attention as ...

journal_title：Journal of thrombosis and thrombolysis

authors： Härtig F,Poli S,Ebner M,Birschmann I,Kuhn J,Ziemann U,Häring HU,Lehmann R,Peter A,Hörber S

更新日期：2020-04-01 00:00:00

abstract：:The Porthidium genus is represented by the P. lansbergii rozei and P. lansbergii hutmanni (Plh) subspecies in Venezuela. The venom components of these have been little studied, probably due to the low incidence of reported accidents, although acute and serious local effects such as invasive edema and disseminated ecch...

journal_title：Journal of thrombosis and thrombolysis

authors： López-Johnston JC,de Bosch N,Scannone H,Rodríguez-Acosta A

更新日期：2007-12-01 00:00:00

abstract：:We assessed the contribution of serum homocysteine levels, an independent risk factor for vascular disease, and of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation to the variability of carotid intimal-medial thickness (IMT) in patients with non-insulin-dependent diabetes mellitus (NIDDM). Ninety-five pa...

journal_title：Journal of thrombosis and thrombolysis

authors： Mazza A,Motti C,Nulli A,Pastore A,Andreotti F,Ammaturo V,Bianco P,Santoro E,Federici G,Cortese C

更新日期：1999-10-01 00:00:00

abstract：:In a previous study, we observed that one injection of 500 microg of DNA for the plasmid encoding for vascular endothelial growth factor (ph VEGF(165)) into one site in a rat myocardial infarction model resulted in neovascularization confined to angiomatous structures that did not contribute to regional myocardial blo...

journal_title：Journal of thrombosis and thrombolysis

authors： Kloner RA,Dow J,Chung G,Kedes LH

更新日期：2000-12-01 00:00:00

abstract：:Since the reports by Weismann and Tobin in 1958 and Roberts et al. in 1964 called attention to paradoxical thrombosis in patients treated with heparin, the thrombotic aspect of the heparin-induced thrombocytopenia syndrome (HIT) has been emphasized. Yet to this day, the mechanism of thrombosis associated with HIT (HIT...

journal_title：Journal of thrombosis and thrombolysis

authors： Walenga JM,Jeske WP,Messmore HL

更新日期：2000-11-01 00:00:00

abstract：:Based on their mode of action, it is reasonable to expect that the combination therapy of aspirin and a vitamin K antagonist (VKA) may be more beneficial in preventing (athero) thrombotic complications in high-risk patients for cardiovascular events. However, there is no consensus about additional aspirin use in the m...

journal_title：Journal of thrombosis and thrombolysis

authors： Loualidi A,Bredie SH,Janssen MC

更新日期：2009-05-01 00:00:00

abstract：:A definitive diagnosis of heparin-induced thrombocytopenia (HIT) is difficult to make, especially in patients undergoing cardiac surgery. In this retrospective cohort study, we assessed the platelet count trends and the response to fondaparinux in a population of patients of suspected HIT after pulmonary endarterectom...

journal_title：Journal of thrombosis and thrombolysis

authors： Li JF,Wu LJ,Wen GY,Zhou RR,Liu F,Wang W,Yang SQ,Gong JN,Miao R,Gu S,Liu Y,Yang YH

更新日期：2020-09-07 00:00:00

abstract：:Specific therapy of acute spinal ischemia is not established. We report the first case of an MRI-verified cervical spinal ischemia treated by thrombolysis and review the literature. A 72-year old woman with right-sided motor hemiparesis and trunk ataxia was treated by intravenous thrombolysis with full recovery. Three...

journal_title：Journal of thrombosis and thrombolysis

authors： Etgen T,Höcherl C

更新日期：2016-07-01 00:00:00

abstract：:It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes. However, the origin of soluble P-selectin remains unknown. We sought to determine whether platelet expression of P-selectin correlates with plasma levels in the popul...

journal_title：Journal of thrombosis and thrombolysis

authors： Gurbel PA,Kereiakes DJ,Serebruany VL

更新日期：2000-08-01 00:00:00