Abstract：
:Heme oxygenase-1 (HO-1), an inducible enzyme, degrades heme to carbon monoxide (CO), iron, and bilirubin. We have investigated the relationship among HO-1 protein expression, HO activity, and CO concentrations in the hippocampus of CO-exposed rats. Western blotting and immunohistochemistry revealed that the enzyme is predominantly localized in hippocampal CA1 and CA3 pyramidal cells and in granule cells of the dentate gyrus. HO enzyme activity was reduced immediately following CO exposure, while expression of HO-1 protein was consistently upregulated in a time-dependent manner. Local CO concentrations in hippocampus rose immediately following exposure, but the elevation was maintained for ~20 h despite the decline in blood carboxyhemoglobin levels toward baseline. We suggest that CO initially inhibits HO enzyme activity, whereas at later time points the inhibition is released and local CO generation is maintained by the activity of the endogenous HO enzyme. And the noninducible form of heme oxygenase, HO-2, was not altered following CO administration. Together these results indicate that the HO/CO pathway in the rat hippocampus is induced by acute CO exposure; local CO production may play a regulatory role in brain injury following CO poisoning.
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Guan L,Zhang YL,Wen T,Wang XF,Zhu MX,Zhao JYdoi
10.1007/s00244-010-9524-3subject
Has Abstractpub_date
2011-01-01 00:00:00pages
165-72issue
1eissn
0090-4341issn
1432-0703journal_volume
60pub_type
杂志文章abstract：:Neonates from CD-1 mice, which were treated during gestation with 100 mg/kg of 2,4,5-T, were studied from day 1 to 30 postpartum (pp) for effects on cardiac development by determining total cardiac activities and isozyme profiles of LDH and CK. On day 1pp, the total activities and isozyme profiles of LDH of the neonat...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01054881
更新日期：1981-09-01 00:00:00
abstract：:Concentrations of heavy metals and cyanide in water and sediments were determined from December 1974 to February 1976 in Yellowknife Bay situated in northern Canada. The bay receives a continuous discharge of liquid waste effluents from an operating gold mine. Arsenic reached a maximum concentration of 3100 mg kg(-1) ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01054855
更新日期：1981-11-01 00:00:00
abstract：:Cerium has been demonstrated to damage liver of mice, but very little is known about the molecular mechanisms underlying the mouse liver apoptosis. In order to understand the liver injury induced by intragastric administration of cerium chloride (CeCl3) for 60 consecutive days, the hepatocyte ultrasrtucture, various o...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-011-9672-0
更新日期：2012-01-01 00:00:00
abstract：:Sediment and water samples collected from 8 sites of the Yangtze River in Nanjing section were characterized with 31 congeners of polychlorodibenzothiophenes (PCDTs). Concentrations and percentage compositions of these PCDTs in water and sediments were analyzed by gas chromatography-mass spectrometry. Results showed t...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-015-0159-2
更新日期：2015-11-01 00:00:00
abstract：:Demographic characteristics of a white-footed mouse (Peromyscus leucopus) population inhabiting a woodland containing a low level of PCBs contamination were compared to an uncontaminated reference site. Although population density was higher on the PCBs-contaminated grid, the population exhibited greater temporal vari...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00214844
更新日期：1994-11-01 00:00:00
abstract：:To identify the best material (soil or dust) to be selected for health-risk assessment studies, road dust and urban soil from three cities with different population densities were collected, and size fractions were analysed for metal content (Pb, Zn, Cu, Cd, Cr, Co, and Ni). Results showed similar distribution of the ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0413-x
更新日期：2017-10-01 00:00:00
abstract：:Children living in Coatzacoalcos, Veracruz, and in nearby surrounding areas are exposed to a mixture of pollutants from different sources. Previous studies in the area have reported genotoxic and haematotoxic compounds, such as lead (Pb), benzene, toluene, and polycyclic aromatic hydrocarbons (PAHs), in environmental ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-014-9999-4
更新日期：2014-07-01 00:00:00
abstract：:Seed germination and early stage seedling growth tests were conducted to determine the ecotoxicological threshold of 2,4, 6-trinitrotoluene (TNT) in two soils of different properties. Soils were amended up to 1,600 mg TNT kg-1 soil and four representative species of higher plants, two dicotyledons (Lepidium sativum L....
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900455
更新日期：1999-02-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00212084
更新日期：1992-04-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-010-9563-9
更新日期：2011-04-01 00:00:00
abstract：:The calculated, acute oral LD50 of acephate and methamidophos to dark-eyed juncos (Junco hyemalis) was 106 mg/kg and 8 mg/kg, respectively. Brain cholinesterase (ChE) activity in birds that died after acephate poisoning was depressed 80% below that of control birds. Birds that died of acute methamidophos poisoning had...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01055620
更新日期：1981-01-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0370-4
更新日期：2017-04-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-015-0237-5
更新日期：2016-02-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9273-8
更新日期：2009-08-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449910043
更新日期：2000-04-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00224804
更新日期：1994-02-01 00:00:00
abstract：:The Tinto and Odiel river basins (SW Spain) are known worldwide for their unique water characteristics. Such uniqueness is a consequence of their flow through the Iberian Pyrite Belt (an area rich in metal sulphides) and the mining activities in the basins. A process of sulphide oxidation occurs in this region, which ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0409-6
更新日期：2018-01-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9203-9
更新日期：2009-05-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0437-2
更新日期：2018-01-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00203555
更新日期：1994-04-01 00:00:00
abstract：:Fish from western Lake Superior (1972-73) contained DDT and PCB residues at concentrations greater than o.1 ppm. The most predominant PCB's were those containing 3 to 6 chlorine atoms per molecule, and GLC data indicated that the mixtures were most like the commercial product Aroclor 1254(2). Other chlorinated contimi...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF02220927
更新日期：1977-01-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-020-00730-1
更新日期：2020-07-01 00:00:00
abstract：:This study was implemented to determine if western mosquitofish (Gambusia affinis) populations in the Grassland Water District suffer from impaired reproduction because of seleniferous inflows of agricultural drainwater from the Grassland Bypass Project. During June to July 2001, laboratory trials with pregnant female...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-2051-3
更新日期：2004-10-01 00:00:00
abstract：:Although Antarctica is considered one of the most pristine areas on Earth, an accelerating human presence in this remote continent, such as scientific operations and functioning of numerous scientific stations, logistics, and tourism activities, has increased the risks of environmental impacts in recent decades. Durin...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-021-00808-4
更新日期：2021-01-21 00:00:00
abstract：:Endosulfan sulfate is a persistent environmental metabolite of endosulfan, an organochlorine insecticide-acaricide presently registered by the United States Environmental Protection Agency. There is, however, limited acute fish toxicity data for endosulfan sulfate. This study determines the acute toxicity (LC₅₀s and L...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-010-9623-1
更新日期：2011-02-01 00:00:00
abstract：:Numerous state and federal agencies are increasingly concerned with the rapid expansion of invasive, noxious weeds across the United States. Herbicides are frequently applied as weed control measures in forest and rangeland ecosystems that frequently overlap with critical habitats of threatened and endangered fish spe...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9281-8
更新日期：2009-05-01 00:00:00
abstract：:Anticoagulant rodenticides are widely used to control rodent infestations. Previous studies have shown that nontarget organisms, such as birds, are at risk for both primary and secondary poisoning. This paper presents rodenticide residue information on the livers from 164 strigiformes which included barn owls (Tyto al...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-009-9402-z
更新日期：2010-02-01 00:00:00
abstract：:Scientists interested in contamination normally deal only with pollution itself, not with people's perceptions of pollution or the relationship between pollution and land use. The overall objective of this article was to examine the relationship between people's perceptions of pollution and their views on future land ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9141-6
更新日期：2008-10-01 00:00:00
abstract：:Residues of organic contaminants--including toxaphene, DDT, trifluralin, hexachlorocyclohexanes, polychlorinated biphenyls, polycyclic aromatic hydrocarbons (PAHs) and nonylphenol--were measured in 32 cotton field soils collected from South Carolina and Georgia in 1999. Toxaphene, trifluralin, DDT and PAHs were the ma...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-002-0267-7
更新日期：2003-07-01 00:00:00
abstract：:Twenty-seven pesticide workers with elevated blood levels of dieldrin (greater than or equal to 15 ppb) were involved in a case-control study which included history and physical examination, comprehensive neurological evaluation, laboratory tests, and psychological and psychomotor testing. No clinically important diff...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01057573
更新日期：1981-01-01 00:00:00
