Fibrosclerotic lymphedema: pathophysiology and therapy.

Abstract:

:We describe our experience with 12 patients with severe fibrotic lymphedema treated between 1979 and 1987. Each patient initially underwent nonoperative treatment (postural drainage and pneumatic compression) and in 10 patients who required operation, these measures were continued postoperatively. Operation included excision of subcutaneous tissue (debulking), which was extensive in 8 and limited in 2 patients. Only 2 patients were satisfactorily managed by nonoperative treatment alone. Based on the extensive pathophysiologic changes that occur in the tissue microenvironment with lymph stasis, it is unlikely that at this advanced stage of lymphedema that nonoperative treatment alone or "physiologic" operations such as lymphatic-venous shunt or lymphatic collector reconstruction is satisfactory. Rather, nearly all such patients require limited or extensive excision of the fibrotic-edematous subcutaneous tissue.

journal_name

Lymphology

journal_title

Lymphology

authors

Talarico F,Brunetto D,Scialabba M,Pernice I,Valenti G,Benvegna S,Mastrandrea G,Rusignuolo F

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

11-5

issue

1

eissn

0024-7766

issn

2522-7963

journal_volume

24

pub_type

杂志文章
  • Diagnostic protocol for lymphoscintigraphy in newborns.

    abstract::The purpose of this methods paper is to offer pediatricians and nuclear medicine physicians a diagnostic protocol for performing lymphoscintigraphy in newborns that may be useful for enhancing diagnosis and management of newborns with congenital lymphatic abnormalities. Indications for lymphoscintigraphy, choice of tr...

    journal_title:Lymphology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Bellini C,Boccardo F,Taddei G,Mazzella M,Arioni C,Villa G,Hennekam RC,Serra G,Campisi C

    更新日期:2005-03-01 00:00:00

  • Antigen-induced changes on high endothelial venules in rat cervical lymph nodes.

    abstract::The effect of antigenic stimulation (paratyphoid vaccine) on high endothelial venules (HEVs) of rat cervical lymph nodes was studied using conventional histological and histometrical techniques. The sequential changes of some morphometric parameters (lymph node weight, HEV diameters) after the antigenic stimulation we...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Dabak DO,Ozturk G

    更新日期:2003-06-01 00:00:00

  • Benign supraclavicular tumorous lymphangiectasia--a new disease?

    abstract::We describe an isolated recurrent non-inflammatory tumorous swelling of the supraclavicular fossa in four premenopausal women. Ultrasonography, magnetic resonance imaging and computer tomography of the neck each suggested an inhomogeneous mass consistent with "lymphangioma." In each patient the clinical course and his...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Preyer S,Kaiserling E,Heinle H,Földi E,Zenner HP,Földi M

    更新日期:1995-09-01 00:00:00

  • Effect of diaphragmatic lymphatic contamination on caudal mediastinal node lymph flow in unanesthetized sheep.

    abstract::Our purpose was to determine the effect of diaphragmatic lymphatics on steady state caudal mediastinal node (CMN) or lung lymph flow in the unanesthetized sheep. After standard lung lymph fistula preparation, in which the CMN efferent was cannulated, nine sheep had an additional extensive cautery procedure in the righ...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Demling RH,Gunther R

    更新日期:1982-12-01 00:00:00

  • Immunodeficiency due to chylous dysplasia: diagnostic and therapeutic considerations.

    abstract::Among primary immunodeficiencies, common variable immunodeficiency (CVID) is defined by an impaired production of immunoglobulins characterized by low levels of plasma immunoglobulins and an altered antibody response. The case reported here was initially interpreted as a CVID. A 20 year old male suffered from diarrhea...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Campisi CC,Spinaci S,Lavagno R,Larcher L,Boccardo F,Santi P,Campisi C

    更新日期:2012-06-01 00:00:00

  • Tumor necrosis factor-alpha and troponin I release in porcine cardiac lymph and coronary sinus blood before and after cardiopulmonary bypass.

    abstract::To assess the concentrations of cardiac troponin I (cTnI) and tumor necrosis factor-alpha (TNFalpha) in cardiac lymph compared with coronary sinus (CS) blood and to measure cardiac lymph flow before and after cardiopulmonary bypass (CPB). In 21 pigs, the main cardiac lymph trunk was cannulated before institution of st...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Vazquez-Jimenez JF,Liakopoulos OJ,Qing M,Messmer BJ,Seghaye MC

    更新日期:2002-09-01 00:00:00

  • Adventitial lymphatics and atherosclerosis.

    abstract::Lymphatic vessels are important in reverse cholesterol transport and play a crucial role in regression of atherosclerotic plaque in experimental animal models. Therefore, we attempted to analyze adventitial microcirculation including lymphatic vessels and adventitial macrophages in large human arteries in various stag...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Drozdz K,Janczak D,Dziegiel P,Podhorska M,Piotrowska A,Patrzalek D,Andrzejak R,Szuba A

    更新日期:2012-03-01 00:00:00

  • Ductus thoracicus lymph in mice. 2. Enzyme activities and protein content.

    abstract::Lymph was collected in anaesthetized mice by a newly developed cervical approach (see preceding paper). Short term drainage, which should not alter the colloid-osmotic forces, meets the physiological requirements for determination of protein content and enzyme activities in lymph and plasma. For cellular enzymes such ...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Lindena J,Trautschold I

    更新日期:1983-12-01 00:00:00

  • Enzyme-histochemical staining of dermal lymphatic capillaries by guanylate cyclase.

    abstract::Human foreskins were examined for enzyme-histochemical staining of microvessels using guanylate cyclase, an enzyme similar to adenylate cyclase. Like 5'-nucleotidase (which hydrolyzes 5'-adenosine monophosphate to adenosine), and adenylate cyclase (which converts adenosine triphosphate to cyclic AMP), guanylate cyclas...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Nishida S,Ohkuma M

    更新日期:1993-12-01 00:00:00

  • Reliability of diagnostic imaging after orchiectomy alone in follow-up of clinical stage I testicular carcinoma: excessive cost with potential risk.

    abstract::From 1981 to 1984, 86 consecutive patients with previously untreated nonseminomatous testicular carcinoma were classified as clinical radiological stage I and treated with orchiectomy alone. The follow-up program included chest x-ray and lymphangiography (LAG) every month and abdominal computed tomography (CT) bimonth...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Tesoro-Tess JD,Pizzocaro G,Zanoni F,Balzarini L,Ceglia E,Petrillo R,Musumeci R

    更新日期:1987-09-01 00:00:00

  • Severe lymphedema caused by repeated self-injury.

    abstract::Lymphedema is divided into primary and secondary forms. Primary lymphedema often develops in young people and may be caused by lymphvascular aplasia, hypoplasia, and hyperplasia. The most frequent cause of secondary lymphedema after lymphatic filariasis is regional lymph node dissection for treatment of a malignant tu...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Mihara M,Hara H,Murai N,Todokoro T,Iida T,Narushima M,Koshima I

    更新日期:2011-12-01 00:00:00

  • The lymphatic vessels of the uterus during the sexual cycles of the mice.

    abstract::Orthograde delineation and characterization of the lymph vascular system in the uterus of the mouse during the sexual cycle was achieved by absorption of Patent Blue Violet and Japan ink. The lymph vessels in the endometrium are dilated by about 8-10 times and of varying calibre during oestrus. A reticular arrangement...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Fabian G

    更新日期:1976-06-01 00:00:00

  • Characterization of congenital lymphatic and blood vascular malformations in the head and neck using blood pool scintigraphy and spect.

    abstract::The purpose of this study was to investigate the usefulness and diagnostic efficacy of blood pool (BP) scintigraphy and SPECT for characterizing congenital vascular malformations (CVMs) in the head and neck area. A total of 154 patients suspected of having head and neck CVMs underwent whole-body BP scintigraphy and he...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Lee JY,Choi JY,Kim YH,Kim DI,Kim YW,Kim KH,Hyun SH,Lee KH,Kim BT

    更新日期:2010-12-01 00:00:00

  • Multi-modal imaging features and lympho-venous shunt for vaginal chylous fistula in lymphangioleiomyomatosis: Case report and review.

    abstract::Vaginal chylous fistula is a very rare lymphatic disorder and lymphangioleiomyomatosis (LAM) is also a rare multisystemic disease. LAM with the development of a vaginal chylous fistula has rarely been reported. Here we report a case of vaginal chylous fistula accompanied with LAM. A 61-year-old woman occasionally expe...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Huo M,Wang Z,Yue Y,Dong J,Wen Z,Xin J

    更新日期:2017-01-01 00:00:00

  • Non-invasive assessment of the lymphedematous limb.

    abstract::Accurate assessment of the swollen limb is crucial to effective management, and usually consists of measurement of volume and assessment of skin condition. Here, we review the different methods available to measure volume, and their accuracy, together with other non-invasive methods available to assess the characteris...

    journal_title:Lymphology

    pub_type: 杂志文章,评审

    doi:

    authors: Stanton AW,Badger C,Sitzia J

    更新日期:2000-09-01 00:00:00

  • Retroperitoneal nodal aplasia, asplenia, chylous effusion and lymphatic dysplasia: an acquired immunodeficiency syndrome?

    abstract::Two adult patients (one in Italy and the other in the USA) are described with similar findings of paraaortic nodal aplasia, asplenism, multiple serous and chylous effusions, and retroperitoneal lymphatic dysplasia. Although the clinical courses are incomplete, this unusual constellation of signs in the setting of norm...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Carini L,Meregaglia LD,Galli C,Segalini G,Strada M,Jones J,Witte MH,Witte CL

    更新日期:1985-03-01 00:00:00

  • Thoracic duct lymph flow and its driving pressure in anesthetized sheep.

    abstract::We examined the relationship between thoracic duct lymph flow (TDF) and its driving pressure (DP) in six anesthetized sheep. DP was determined as the thoracic duct pressure (TDP) minus the innominate vein pressure (VP). TDF was measured using an ultrasound transit-time flow meter, placing a flow probe beside the cauda...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Inagaki M,Onizuka M,Ishikawa S,Yamamoto T,Mitsui T

    更新日期:2000-03-01 00:00:00

  • Lymphatic aneurysm of the heart.

    abstract::The Annular Subvalvular Left Ventricular Aneurysm (ASLVA) is a rare entity, which occurs usually in young ethnic groups from Sub-Saharan Africa and South India. These aneurysms are situated immediately beneath the mitral and aortic valves and extend around in the substance of fibrous ring, from which valves arise. The...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Lupinski RW

    更新日期:2004-09-01 00:00:00

  • Impeded interstitial fluid movement: a factor in pancreatic oedema.

    abstract::Pancreatic oedema was induced by physiological saline infused into the superior pancreatico-duodenal artery of 34, chloralose anaesthetized dogs. Both lymph flow from cannulated pancreatico-duodenal lymphatics and intralymphatic pressure in the non-transected ones increased significantly. The increase in pressure may ...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Papp M,Makara GB,Folly G

    更新日期:1975-12-01 00:00:00

  • Effect of tumor necrosis factor-alpha and interleukin-2 on spleen lymphocyte migration in mouse skin.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) are reported to enhance lymphocyte binding to endothelial cells in vitro. We examined these two agents on lymphocyte migration in vivo. Spleen lymphocytes were radiolabeled with tritiated uridine (3H-UR) and then injected i.v. into mice. Each cytokine (T...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Sun J,Liu Z,Bi Y,Guo Z,Hua T,Ding Z

    更新日期:1999-12-01 00:00:00

  • Functional impact of lymphangiogenesis on fluid transport after lymph node excision.

    abstract::When a lymph node is excised, lymphangiogenesis occurs to maintain flow in the affected area. However, a complex network of small vessels replaces the node and these newly formed vessels might increase resistance to lymph transport. To test this in sheep, the popliteal lymph node from one hind limb was removed surgica...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Kim C,Li B,Papaiconomou C,Zakharov A,Johnston M

    更新日期:2003-09-01 00:00:00

  • Next generation sequencing is here now.

    abstract::The availability of massively parallel DNA sequencers has brought the cost of sequencing genes to affordable levels but the cost of analyzing the huge amount of data has not decreased to the same extent. Thus, only analyzing the sequences of the genes relevant to the patient's condition makes the cost manageable. A pa...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Erickson RP

    更新日期:2014-12-01 00:00:00

  • Culture of smooth muscle cells from guinea pig mesenteric lymphatic vessels.

    abstract::The in vitro culture of lymphatic smooth muscle cells (SMCs) is a crucial step in studying their function and involvement in disease. Yet there is no efficient approach available so far because of the difficulties posed by the small size of most lymphatic vessels. We present a simple yet efficient method for isolating...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Wang DG,Liu ZY,Bi YS,Sun SZ,Shi L,Wang X,Zhang XH

    更新日期:2007-03-01 00:00:00

  • Anterior diaphragmatic lymph nodes.

    abstract::In evaluating patients for malignant disease, involved or uninvolved anterior diaphragmatic lymph nodes (ADLNs) may be observed at computed tomography (CT) evaluation of either the chest or abdomen. While ADLNs have been described on both chest radiography and CT, lymph nodes lateral to the cardiophrenic angles have n...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Libshitz I,Holbert JM

    更新日期:1988-06-01 00:00:00

  • Lymphography in malignant histiocytosis: case report.

    abstract::Malignant histiocytosis is an uncommon, progressive disease with a poor prognosis which is characterized by malaise, fever, lymphadenopathy, and splenomegaly. Lymphadenopathy is commonly present at presentation as well as during the course of the disease. The lymphographic findings in this case report were very simila...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Musumeci R,Castellino RA

    更新日期:1976-06-01 00:00:00

  • The energetics of lymph formation.

    abstract::A very important unanswered problem is the source of the energy required for formation of lymph. The most widely held theory has been that fluid filters from the capillaries, flows through the tissues, and then enters the lymphatic as a result of a continuous positive pressure gradient from the blood capillary to the ...

    journal_title:Lymphology

    pub_type: 杂志文章,评审

    doi:

    authors: Guyton AC,Barber BJ

    更新日期:1980-12-01 00:00:00

  • A meta-analysis of the relationship between lymphatic microvessel density and the survival of patient with colorectal cancer.

    abstract::Colorectal cancer (CRC) is a frequently observed malignant neoplasm that is a leading cause of cancer death despite recent advances in treatment and research. The role of lymphangiogenesis in CRC development is a source of controversy in current research. We undertook this study to examine the relationship between lym...

    journal_title:Lymphology

    pub_type: 杂志文章,meta分析

    doi:

    authors: Chen Y,Yan J,Wang Z,Yu S,Yuan Z,Yang C,Zheng Q

    更新日期:2013-03-01 00:00:00

  • Lymphology, medical ignorance/ignoramics and the Nobel connection: Howard Florey, Joshua Lederberg, and Françoise Barre-Sinoussi.

    abstract::Intriguing interludes with Nobel laureates have marked the history of Lymphology. Bounded (or rather unbounded) by a mutual fascination with ignorance and the unknown, their curiosity converged around microbes, infections, and host responses mediated by the lymphatic system. These studies transcended a simple "molecul...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Witte MH

    更新日期:2008-12-01 00:00:00

  • The distribution of an oil-based corticosteroid following intralymphatic infusion.

    abstract::Following infusion of tritium labeled clobetasol propionate in Ultrafluid Lipidol (UFL) into a right hind limb lymphatic of rabbits, the radioactivity levels in various tissues at intervals up to 28 days were determined by liquid scintillation counting. There was a rapid decline in activity in the right popliteal node...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Fyfe NC,Webb WA,Kinmonth JB

    更新日期:1984-12-01 00:00:00

  • The value of lymphangiography in chyluria: a report of three cases.

    abstract::The lymphographic findings in three patients suffering from idiopathic chyluria are described. These findings included lymphangiectases and retrograde filling of kidney lymphatics;bilaterally in two and unilaterally in one patient. In the latter patient, the contrast was also seen entering the renal calyces and pelvis...

    journal_title:Lymphology

    pub_type: 杂志文章

    doi:

    authors: Morag B,Hertz M,Rubinstein ZJ

    更新日期:1977-03-01 00:00:00