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Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age.

Abstract：

:Long synthetic peptides (LSPs) have a variety of important clinical uses as synthetic vaccines and drugs. Techniques for peptide synthesis were revolutionized in the 1960s and 1980s, after which efficient techniques for purification and characterization of the product were developed. These improved techniques allowed the stepwise synthesis of increasingly longer products at a faster rate, greater purity, and lower cost for clinical use. A synthetic peptide approach, coupled with bioinformatics analysis of genomes, can tremendously expand the search for clinically relevant products. In this Review, we discuss efforts to develop a malaria vaccine from LSPs, among other clinically directed work.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Corradin G,Kajava AV,Verdini A

doi

10.1126/scitranslmed.3001387

subject

Has Abstract

pub_date

2010-09-22 00:00:00

pages

50rv3

issue

50

eissn

1946-6234

issn

1946-6242

pii

2/50/50rv3

journal_volume

2

pub_type

杂志文章,评审

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