Abstract：
PURPOSE:Ultrasound can be used to release a therapeutic payload encapsulated within a perfluorocarbon (PFC) emulsion via acoustic droplet vaporization (ADV), a process whereby the PFC phase is vaporized and the agent is released. ADV-generated microbubbles have been previously used to selectively occlude blood vessels in vivo. The coupling of ADV-generated drug delivery and occlusion has therapeutically synergistic potentials. METHODS:Micron-sized, water-in-PFC-in-water (W(1)/PFC/W(2)) emulsions were prepared in a two-step process using perfluoropentane (PFP) or perfluorohexane (PFH) as the PFC phase. Fluorescein or thrombin was contained in the W(1) phase. RESULTS:Double emulsions containing fluorescein in the W(1) phase displayed a 5.7±1.4-fold and 8.2±1.3-fold increase in fluorescein mass flux, as measured using a Franz diffusion cell, after ADV for the PFP and PFH emulsions, respectively. Thrombin was stably retained in four out of five double emulsions. For three out of five formulations tested, the clotting time of whole blood decreased, in a statistically significant manner (p < 0.01), when incubated with thrombin-loaded emulsions exposed to ultrasound compared to emulsions not exposed to ultrasound. CONCLUSIONS:ADV can be used to spatially and temporally control the delivery of water-soluble compounds formulated in PFC double emulsions. Thrombin release could extend the duration of ADV-generated, microbubble occlusions.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Fabiilli ML,Lee JA,Kripfgans OD,Carson PL,Fowlkes JBdoi
10.1007/s11095-010-0277-5subject
Has Abstractpub_date
2010-12-01 00:00:00pages
2753-65issue
12eissn
0724-8741issn
1573-904Xjournal_volume
27pub_type
杂志文章abstract：:New generation vaccines, particularly those based on recombinant proteins and DNA, are likely to be less reactogenic than traditional vaccines but are also less immunogenic. Therefore, there is an urgent need for the development of new and improved vaccine adjuvants. Adjuvants can be broadly separated into two classes...
journal_title：Pharmaceutical research
pub_type： 杂志文章,评审
doi：10.1023/a:1016104910582
更新日期：2002-06-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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journal_title：Pharmaceutical research
pub_type： 杂志文章,评审
doi：10.1007/s11095-013-1196-z
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:Indocyanine green (ICG), an FDA-approved near infrared (NIR) dye, has potential application as a contrast agent for tumor detection. Because ICG binds strongly to plasma proteins and exhibits aqueous, photo, and thermal instability, its current applications are largely limited to monitoring blood flow. To addre...
journal_title：Pharmaceutical research
pub_type： 杂志文章
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1011900527021
更新日期：1998-11-01 00:00:00
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journal_title：Pharmaceutical research
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abstract：:Defined size fractions of polyethyleneglycol powder (MW = 10,000) were mixed with defined size fractions of alpha-lactose monohydrate in order to study the effect of compaction as a function of the weight ratios of the two excipients. For a precise control of the compression cycle, tablets were compressed on a Univers...
journal_title：Pharmaceutical research
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doi：10.1023/a:1015864415693
更新日期：1990-02-01 00:00:00
abstract：:Enoximone and piroximone are cardiotonic agents for use in patients with congestive heart failure. Electroanalytical studies revealed that the dihydroimidazolone functionality was oxidizable and that this property can be analytically useful. The compounds undergo a two-electron, irreversible oxidation in neutral to ac...
journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1015811830830
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journal_title：Pharmaceutical research
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doi：10.1023/a:1011018525121
更新日期：2001-01-01 00:00:00
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journal_title：Pharmaceutical research
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doi：10.1007/s11095-007-9236-1
更新日期：2007-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-10-01 00:00:00
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doi：10.1007/s11095-013-1273-3
更新日期：2014-07-01 00:00:00
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doi：10.1023/a:1011014629551
更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-06-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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更新日期：1995-08-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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更新日期：1994-12-01 00:00:00
abstract：PURPOSE:To dynamically analyze the processes of oral absorption and hepatobiliary distribution of telmisartan using positron emission tomography (PET). METHODS:(11)C-labeled telmisartan ([(11)C]TEL) was orally administered to rats with or without non-radiolabeled telmisartan (0.5, and 10 mg/kg). PET scanning of abdomi...
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pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1026412107574
更新日期：2000-10-01 00:00:00
