Vascular endothelial growth factor overexpression positively modulates the characteristics of periprosthetic tissue of polyurethane-coated silicone breast implant in rats.


BACKGROUND:Capsular contracture is one of the most common complications associated with silicone breast implants. The surface of the implant is one of the factors often associated with the occurrence of capsular contracture. In this study, the authors evaluated the differences in morphologic and molecular characteristics of the capsule formed around polyurethane-coated versus textured-surface silicone implants in rats, mainly the modifications in angiogenesis and the expression of vascular endothelial growth factor (VEGF). METHODS:A pocket was performed on the animal's back, where the silicone implants were introduced. Two groups of animals received a polyurethane-coated silicone implant and the other groups received a textured-surface silicone implant, and the capsules around the prostheses were submitted to histologic and immunohistochemistry analysis, 30 or 90 days after surgery. RESULTS:The capsules around the polyurethane-coated silicone prostheses were significantly thicker than the textured-surface silicone implants. Furthermore, the layer adjacent to the polyurethane-coated silicone implants was more cellular and irregular than the layer around the textured-surface silicone implants. Textured implant periprosthetic capsules presented fewer inflammatory cells and less vascularization than the polyurethane-coated silicone implants. The collagen layer of periprosthetic tissue of textured implants appears to be more continuous and aligned in parallel fashion than polyurethane-coated implants. Immunohistochemical analysis revealed high levels of transforming growth factor-β and VEGF in the capsules around the polyurethane-coated silicone implants when compared with the textured-surface silicone implants. CONCLUSION:These findings suggest that the intense VEGF expression in capsules around the polyurethane-coated silicone implant is able to improve the tissue vascularization, resulting in a softer capsule compared with the textured-surface silicone implant.


Plast Reconstr Surg


Vieira VJ,d'Acampora AJ,Marcos ABW,Di Giunta G,de Vasconcellos ZAA,Bins-Ely J,d'Eça Neves R,Figueiredo CP




Has Abstract


2010-12-01 00:00:00














  • Free omental tissue transfer for extremity coverage and revascularization.

    abstract::Microvascular transfer of the omentum has several unique advantages for the reconstruction and revascularization of extremity wounds. The omentum provides well-vascularized, malleable tissue for reconstruction of extensive soft-tissue defects and has a long vascular pedicle (35 to 40 cm) with sizable vessels, which re...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Maloney CT Jr,Wages D,Upton J,Lee WP

    更新日期:2003-05-01 00:00:00

  • Anatomical Understanding of Target Subcutaneous Tissue Layer for Thinning Procedures in Thoracodorsal Artery Perforator, Superficial Circumflex Iliac Artery Perforator, and Anterolateral Thigh Perforator Flaps.

    abstract:BACKGROUND:Thinned perforator flaps, reported techniques, and degree of thinning differ by study. This study investigated the anatomy of subcutaneous tissue according to the varying fattiness and identified which component and how much of the subcutaneous tissue layer needed to be excluded to meet target flap thickness...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kim SY,Lee YJ,Mun GH

    更新日期:2018-08-01 00:00:00

  • Does the Use of Incisional Negative-Pressure Wound Therapy Prevent Mastectomy Flap Necrosis in Immediate Expander-Based Breast Reconstruction?

    abstract:BACKGROUND:Mastectomy flap necrosis is one of the most common and significant complications in immediate expander-based breast reconstruction. Negative-pressure wound therapy is widely used for open wounds but is not commonly used for closed incisional wounds. However, the postoperative use of incisional negative-press...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kim DY,Park SJ,Bang SI,Mun GH,Pyon JK

    更新日期:2016-09-01 00:00:00

  • Change in Hand Function and Dexterity with Age after Index Pollicization for Congenital Thumb Hypoplasia.

    abstract:BACKGROUND:Little is known about how performance on strength, range of motion, and dexterity measures changes as children with index finger pollicization mature. The authors reviewed performance in range of motion, strength, and dexterity over a 7-year period and report outcomes over time. METHODS:Data from children t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kollitz KM,Tomhave W,Van Heest AE,Moran SL

    更新日期:2018-03-01 00:00:00

  • Nipple-areola reconstruction: satisfaction and clinical determinants.

    abstract::After performing a chart review, the authors identified 120 patients who underwent breast cancer-related reconstruction. All charts were evaluated with regard to breast mound reconstruction type, nipple-areola reconstruction type, the interval between breast mound and nipple-areola reconstruction, the number of proced...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Jabor MA,Shayani P,Collins DR Jr,Karas T,Cohen BE

    更新日期:2002-08-01 00:00:00

  • Use of Closed-Incision Negative-Pressure Therapy in Obstetrics.

    abstract:BACKGROUND:Cesarean delivery is one of the most commonly performed surgeries in the United States. Compared with other surgical procedures, surgical site infection tends to be a relatively uncommon outcome after cesarean delivery in the general population with an incidence rate between 1.46 and 3.82% in the United Stat...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Feinstein GI

    更新日期:2019-01-01 00:00:00

  • Evaluation of three surgical techniques for advancement of the midface in growing children with syndromic craniosynostosis.

    abstract:BACKGROUND:The purpose of this study was to compare clinical outcomes and 1-year postsurgical stability with three different techniques of Le Fort III midface advancement. METHODS:The records of 212 syndromic craniosynostosis patients were reviewed from the period 1973 to 2006. A total of 60 patients satisfied the inc...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Shetye PR,Davidson EH,Sorkin M,Grayson BH,McCarthy JG

    更新日期:2010-09-01 00:00:00

  • A simple method for the correction of the inverted nipple.

    abstract::A procedure is described in which a direct approach to the underlying pathology of the inverted nipple is undertaken. The inverted nipple is raised as desired by freeing it from the surrounding tissue by vertical and horizontal undermining and then is stabilized by purse-string suture. It can be performed as an office...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Hauben DJ,Mahler D

    更新日期:1983-04-01 00:00:00

  • Variations in Frontonasal Flap Design for Single-Stage Reconstruction of the Nasal Tip.

    abstract:BACKGROUND:Single-stage reconstruction of the nasal tip using frontonasal flaps yields variable results. Variations in flap design were used to optimize outcome. METHODS:Consecutive nasal tip reconstructions using frontonasal flaps performed by the author during a 6-year period were studied retrospectively. Patients w...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Scheufler O

    更新日期:2016-12-01 00:00:00

  • The vascularized pig fibula bone flap model: effects of multiple segmental osteotomies on growth and viability.

    abstract::Previous work by this laboratory introduced the pig fibula bone flap as a model for the study of the pathophysiology of vascularized bone flaps. Anatomic and hemodynamic studies demonstrated a significant (p < 0.05) decrease in vascular perfusion after a series of segmental osteotomies and rigid fixation (lag screws a...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Gur E,Chiodo A,Pang CY,Mendes M,Pritzker KP,Neligan PC,Shpitzer T,Forrest CR

    更新日期:1999-04-01 00:00:00

  • The dorsal thoracic fascia: anatomic significance with clinical applications in reconstructive microsurgery.

    abstract::The anatomic distribution and potential arterial flow patterns of the circumflex scapular artery were investigated by Microfil injection. These studies demonstrated that the circumflex scapular artery lies within the dorsal thoracic fascia, which plays a significant role in the circulation of the overlying skin and su...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kim PS,Gottlieb JR,Harris GD,Nagle DJ,Lewis VL

    更新日期:1987-01-01 00:00:00

  • Congenital midline nasal muscle with associated nasal deformity.

    abstract::A case is presented of a congenital nasal deformity consisting of a midline nasal muscle, alar cartilage defect, and partially obstructed nostril. The embryology of nasal development is reviewed, and an attempt is made to explain this unique anomaly. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bauer BS,Kernahan DA

    更新日期:1981-03-01 00:00:00

  • Analysis of the lengthening effect of the muscle repair in functional cleft lip repair.

    abstract::In 14 patients undergoing functional cleft lip repair, changes in the lengths of the key lip segments were measured preoperatively, after the muscle layer was repaired, and after the skin was repaired using pieces of wire bent to follow the curves of the lip in three dimensions. The cleft side of the lip was shorter t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Dado DV

    更新日期:1988-10-01 00:00:00

  • Wound healing: an overview.

    abstract::Understanding wound healing today involves much more than simply stating that there are three phases: inflammation, proliferation, and maturation. Wound healing is a complex series of reactions and interactions among cells and "mediators." Each year, new mediators are discovered and our understanding of inflammatory m...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Broughton G 2nd,Janis JE,Attinger CE

    更新日期:2006-06-01 00:00:00

  • Method for intraoperative positioning of the nipple-areola complex in vertical scar reduction mammaplasty.

    abstract::The desired shape and position of the nipple-areola complex may be difficult to achieve in vertical scar reduction mammaplasty when using the standard technique of preoperative marking of the so-called mosque-shaped areolar pattern of excision. We describe our modified approach of intraoperative final positioning of t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Vogt PM,Mühlberger T,Torres A,Peter FW,Steinau HU

    更新日期:2000-05-01 00:00:00

  • Rat mandibular distraction osteogenesis: Part I. Histologic and radiographic analysis.

    abstract::The application of distraction osteogenesis to craniofacial surgery has altered the approach and treatment of congenital and acquired craniofacial defects. Although the histologic and ultrastructural changes associated with distraction osteogenesis have been described extensively, relatively little is known about the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Rowe NM,Mehrara BJ,Dudziak ME,Steinbreck DS,Mackool RJ,Gittes GK,McCarthy JG,Longaker MT

    更新日期:1998-11-01 00:00:00

  • Botox therapy for ischemic digits.

    abstract:BACKGROUND:Treating patients with Raynaud's phenomenon who have chronic pain and ulcerations is extremely challenging. Unrelenting pain can lead to dysfunction and disuse, rendering the patient debilitated and/or chronically depressed. Pharmacologic vasodilators and surgical sympathectomies offer variable benefits. Out...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Neumeister MW,Chambers CB,Herron MS,Webb K,Wietfeldt J,Gillespie JN,Bueno RA Jr,Cooney CM

    更新日期:2009-07-01 00:00:00

  • Update on ischemia-reperfusion injury for the plastic surgeon: 2011.

    abstract::Ischemia-reperfusion injury occurs when tissue is reperfused following a prolonged period of ischemia. It is a subject of interest to plastic surgeons involved in replantation, free tissue transfer, and composite tissue allotransplantation, as it can have a significant impact on the overall success of these procedures...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Wang WZ,Baynosa RC,Zamboni WA

    更新日期:2011-12-01 00:00:00

  • Leprosy affects the tibial nerves diffusely from the middle of the thigh to the sole of the foot, including skip lesions.

    abstract::This study investigated where leprosy affects the posterior tibial nerve and whether neurolysis is beneficial. Nine patients with bilateral posterior tibial leprous neuropathy with no sensorimotor recovery were studied. Preoperative sensory-muscle and nerve conduction velocity testing revealed the tarsal tunnel to be ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Richard B,Khatri B,Knolle E,Lucas S,Turkof E

    更新日期:2001-06-01 00:00:00

  • Fat necrosis in deep inferior epigastric perforator flaps: an ultrasound-based review of 202 cases.

    abstract:BACKGROUND:In autologous breast reconstruction after mastectomy, fat necrosis is a rather common complication that may lead to secondary corrective surgery. The understanding of fat necrosis until now has been limited because previous studies were based exclusively on physical examination and used diverse definitions. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Peeters WJ,Nanhekhan L,Van Ongeval C,Fabré G,Vandevoort M

    更新日期:2009-12-01 00:00:00

  • Acetyl-L-Carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome: A Double-Blind, Randomized, Controlled Trial.

    abstract:BACKGROUND:Carpal tunnel syndrome is very common. Although surgery is effective in mild and moderate cases, recovery is often incomplete in severe cases. Therefore, adjuvant therapy to improve nerve regeneration in those patients is much needed. Acetyl-L-carnitine has been shown to be effective in other neuropathies. T...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,随机对照试验


    authors: Curran MWT,Morhart MJ,Olson JL,Hachisuka A,Chan KM

    更新日期:2019-01-01 00:00:00

  • Reconstruction of the nipple: a new technique.

    abstract::We propose a simple one-stage procedure for nipple reconstruction. The fundamental basis, the technique itself, and the results obtained demonstrate that a single-flap reconstruction achieves a nipple that will keep its shape 15 months later. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bosch G,Ramirez M

    更新日期:1984-06-01 00:00:00

  • Repair of thoracoabdominal ectopia cordis with myocutaneous flaps and intraoperative tissue expansion.

    abstract::Thoracoabdominal ectopia cordis is a congenital malposition of the heart and abdominal viscera, which are externally situated, carrying an extremely poor prognosis. We report a case of a complete thoracoabdominal ectopia cordis that had undergone successful coverage over the exposed heart and abdominal contents. A few...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Hochberg J,Ardenghy MF,Gustafson RA,Murray GF

    更新日期:1995-01-01 00:00:00

  • Multiple occurrence of pilomatrixoma.

    abstract::Multiple occurrences of pilomatrixoma are rare. Although it has been known as a benign lesion, there are reports of some tumors that have histopathologic features of malignancy. A case of a 68-year-old Caucasian women with multiple pilomatrixoma is presented. She was operated on to remove three other pilomatrixomas on...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Aslan G,Erdoğan B,Aköz T,Görgü M,Seçkin S,Terzioğlu A

    更新日期:1996-09-01 00:00:00

  • The advantages of free abdominal-based flaps over implants for breast reconstruction in obese patients.

    abstract:BACKGROUND:The authors hypothesized that, for obese patients, delayed abdominal-based free flap (rather than implant-based and immediate) breast reconstruction would result in fewer overall complications and reconstruction losses. METHODS:The authors retrospectively analyzed consecutive implant- and abdominal-based fr...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Garvey PB,Villa MT,Rozanski AT,Liu J,Robb GL,Beahm EK

    更新日期:2012-11-01 00:00:00

  • Cleft palate closure at 3 to 7 months of age: a preliminary report.

    abstract::The evolution and present criteria for early soft palate closure are reviewed. A definitive group of patients (operated on at 3 to 7 months of age) is reviewed at least 2 years following their surgery. They are compared with our general clinic population (operated on at 12 to 18 months of age) and had significantly fe...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Randall P,LaRossa DD,Fakhraee SM,Cohen MA

    更新日期:1983-05-01 00:00:00

  • Surgical treatment of radiation injuries of the hand.

    abstract::This paper describes the wound management and treatment of 12 consecutive patients with severe radiation damage to the hands. Three of these were secondary to therapeutic radiation for squamous cell carcinoma in one and synovial sarcoma in two, and nine were healthy professional people exposed to radiation in the work...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Milanov NO,Shilov BL,Tjulenev AV

    更新日期:1993-08-01 00:00:00

  • A reliable method for monitoring the microvascular patency of free jejunal transfers in reconstructing the pharynx and cervical esophagus.

    abstract::Reconstruction of the pharynx and esophagus with revascularized segments of jejunum remains a time-proven entity. Most thromboses and subsequent flap failures have occurred within the first 24 hours after revascularization of the flap. What would therefore be desirable is a safe, proven monitoring system to assess the...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bafitis H,Stallings JO,Ban J

    更新日期:1989-05-01 00:00:00

  • Using the frontal branch of the superficial temporal artery as a landmark for locating the course of the temporal branch of the facial nerve during rhytidectomy: an anatomical study.

    abstract:BACKGROUND:Previous studies have proposed that the frontal branch of the superficial temporal artery could be used to determine the course of the temporal branch of the facial nerve; however, these studies have not documented this relationship. The objective of this study was to thoroughly examine the courses of the fr...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Lei T,Xu DC,Gao JH,Zhong SZ,Chen B,Yang DY,Cui L,Li ZH,Wang XH,Yang SM

    更新日期:2005-08-01 00:00:00

  • Sapphire tip technology for YAG laser excisions in plastic surgery.

    abstract::Thirty-two patients with a variety of vascular and nonvascular lesions have been resected over a 3-year period with the neodymium:YAG laser utilizing sapphire peripheral scalpel devices. These innovative peripheral devices concentrate the YAG laser energy to a small area at the end of the scalpel, providing precise in...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Apfelberg DB,Maser MR,Lash H,White DN

    更新日期:1989-08-01 00:00:00