Abstract:
:Hepatitis C Virus (HCV) infection is treated with peg-interferon α2a or α2b and ribavirin. International studies show that drug user adherence to treatment is 40% to 60% and increases if the patient is in addiction treatment. The aim of the Together To Take Care (TTTC) study was to achieve better adherence to HCV therapy in randomly selected drug users, who are considered "difficult to treat." The secondary aim of the TTTC Study Group was to standardize a method for a multidisciplinary management of the liver disease in drug users. The TTTC group data were matched with a control group. Adherence: The 93.7% of patients followed therapy prescribed; of the patients infected by HCV genotype (gt) 3, all completed therapy as scheduled. For the 48-week treatment group, 66.7% of patients completed therapy (2 of 9 patients stopped treatment for breakthrough). Toxicological results: 10 (62.5%) patients were negative in the toxicological tests (opiates, cocaine, and alcohol). Virological results: 8 of 16 patients were infected by HCV gt 1, and 8 were infected by gt 3; 2 of 16 (12.5%) patients were human immunodeficiency virus (HIV) coinfected (1 HCV gt 1a and 1 HCV gt 3). All patients: 11 of 16 (68.75%) patients were HCV ribonucleic acid undetectable 24 weeks after completing therapy (sustained virological response, SVR). Gt 1: 4 of 8 (50.0%) showed SVR. Gt 3: 7 of 8 (87.5%) showed SVR. Overall, the HCV gt 3 patients had 87.5% probability of SVR, whereas gt 1 patients had 50% probability of SVR (gt 3/gt 1 patients odds ratio = 7). The results were analyzed by Fisher exact test. Our results show that good healthcare management plays an important role in increasing patients' adherence to therapy. In the project "TTTC," the patients work with the physicians to take responsibility for their health and acquire self-efficacy and self-awareness, thanks to the special care.
journal_name
J Addict Medjournal_title
Journal of addiction medicineauthors
Curcio F,Di Martino F,Capraro C,Angelucci F,Bulla F,Caprio N,Cascone A,D'ascoli G,Focaccio F,Gaveglia M,Longobardo A,Martini S,Masucci S,Morra A,Pasquale G,Pisapia R,Plenzik M,Veneruso C,Villano G,Russo M,De Rosadoi
10.1097/ADM.0b013e3181cae4d0subject
Has Abstractpub_date
2010-12-01 00:00:00pages
223-32issue
4eissn
1932-0620issn
1935-3227pii
01271255-201012000-00006journal_volume
4pub_type
杂志文章abstract::Standardized patient placement criteria such as those developed by the American Society of Addiction Medicine are increasingly common in substance abuse treatment, but it is unclear what factors are associated with their use or with treatment units' provision of related services. This study examined these issues in th...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e31818ebb6f
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:This study examines sociodemographic and clinical characteristics, as a function of primary substance of abuse, among clients approached, screened, and assessed for eligibility in a 10-site effectiveness trial of a Web-based psychosocial intervention for substance use disorders. Consistent with the design of ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e31829e3971
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Individuals in the criminal justice system engage in behaviors that put them at high risk for HIV. This study sought to identify characteristics of individuals who are under community corrections supervision (eg, probation) and at risk for HIV. METHODS:Approximately 25,000 individuals under community correct...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e3182781806
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Among people living with HIV (PLWH), high levels of adherence to prescribed antiretroviral therapy (ART) is required to achieve optimal treatment outcomes. However, little is known about the effects of daily pill burden on adherence amongst PLWH who use drugs. We sought to investigate the association between...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000403
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Effective and safe pain management interventions in methadone maintenance treatment are needed. METHODS:We examined the feasibility (ie, single-session attendance) and acceptability (ie, patient satisfaction and booster session attendance) of cognitive-behavioral therapy-informed groups for pain management-...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000055
更新日期:2014-09-01 00:00:00
abstract::The purpose of this study was to examine the correlates of recreational gambling in lower-income compared with middle/higher-income groups. We examined, by logistic regression, a nationally representative U.S. adult sample (n = 2417) from the 1998 Gambling Impact and Behavior Study (GIBS) to investigate the influence ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e318125088f
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:The effects of cannabis on clinical outcomes of treatment services for other drug use disorders remains unclear. The primary aim of the current study was to investigate the effects of recent cannabis consumption on the severity of cocaine withdrawal and depressive symptoms during a 3-week inpatient treatment...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000599
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:If employee drug use plays a significant part in the incidence of workplace accidents, one would anticipate the positivity rates of postaccident drug tests to be higher than the positivity rates for random tests. Past studies examined the difference of a dichotomous outcome between 2 groups. Dichotomous (p...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000254
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Although smoking is a major health issue among depressed psychiatric inpatients and interest in quitting is high, successful quit rates remain low among this population. We sought to understand preferences that depressed inpatient smokers may have for cessation treatments. METHODS:Eighty smokers (60% women,...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000027
更新日期:2014-03-01 00:00:00
abstract::: COVID-19 pandemic has resulted in devastating mortality and morbidity consisting of socioeconomic and health effects that have included respiratory/pulmonary, cardiovascular, mental health and neurological consequences such as anxiety, depression, and substance use. Extensive efforts are underway to develop preventi...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000771
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:Iran ranks first per capita in the use of opiates, but we have little information about possible differences regarding the 2 most commonly used illicit drugs, namely opium and its dross (residue). DESIGN:This is a cross-sectional study. SETTING:A cross-sectional study about drug abuse and drug dependence i...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e3181db69ef
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Cocaine is a known risk factor for several vascular ischemic events. The underlying mechanisms leading to the complications are not fully understood, although thrombus formation and accelerated atherosclerosis are prominent findings. Evidence of endothelial dysfunction (ED), a key phenomenon in the pathogene...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000109
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:The present research explored the effect of reward sensitivity bias and metacognitive deficits on substance use disorder (SUD) in the decision-making process. METHODS:The behavioral activation system (BAS) was used as a predictive marker of dysfunctional behavior during the Iowa gambling task (IGT). We also...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000065
更新日期:2014-11-01 00:00:00
abstract::: Acknowledging the needs and challenges of women with opioid use disorder is an essential step to reduce the opioid epidemic in the United States. Efforts that can help women include increasing psychosocial services to address trauma, increasing access to medication treatment for opioid use disorder, reducing barrier...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000622
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Substance use disorders during pregnancy are a concern both to the public and medical community, because the negative consequences can be detrimental to both mother and the fetus. The accurate identification of prenatal drug exposure is necessary to determine appropriate medical and psychosocial intervention...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000521
更新日期:2019-11-01 00:00:00
abstract::Four young ketamine abusers with lower urinary tract symptoms presented to regional hospitals in Shenzhen, China. Investigations demonstrated contracted bladders and other urinary tract abnormalities. There have been few reports of similar findings in ketamine abusers in the Chinese mainland. We followed up each patie...
journal_title:Journal of addiction medicine
pub_type: 杂志文章,评审
doi:10.1097/ADM.0b013e3182312863
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the prospective associations between at-risk/problem/pathological gambling (ARPG) and incident medical conditions among older adults. METHODS:Secondary data analysis of the National Epidemiologic Survey on Alcohol and Related Conditions, waves 1 and 2, collected from 2001 to 2002 and 2004 to 200...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e31829e9b36
更新日期:2013-11-01 00:00:00
abstract::How do addiction treatment programs integrate the expectation of relapse into drug abuse treatment? This article serves as a thought piece to pose questions rather than definitive solutions. It reflects a distillation of discussions that occurred at the National Institute on Drug Abuse meeting titled "Program Response...
journal_title:Journal of addiction medicine
pub_type: 杂志文章,评审
doi:10.1097/ADM.0b013e31820497ae
更新日期:2011-09-01 00:00:00
abstract::Opioid dependent pregnant and post-partum women and their infants are a complex and vulnerable population requiring individualized, comprehensive and multidisciplinary treatment. Though methadone maintenance in the setting of comprehensive service provision during pregnancy significantly improves pregnancy outcomes fo...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e31817e6105
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To identify the incidence, characteristics, and factors associated with against medical advice (AMA) discharge among hospitalized patients with opioid use disorder (OUD) and injection related infections (eg, endocarditis, osteomyelitis, epidural abscesses). METHODS:This retrospective cohort study evaluated ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000725
更新日期:2020-08-14 00:00:00
abstract:PURPOSE:: This study was designed to conduct a needs assessment concerning methadone counselors' experiences working with methadone-maintained patients with chronic pain and measure counselors' interest in receiving specialized training to treat such patients. METHODS:: A survey, developed by the authors, was administ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e31815ec240
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Individuals with psychiatric disease, substance abuse, and/or housing instability have a high prevalence of chronic hepatitis C virus (HCV) infection. However, such individuals are often excluded from treatment for HCV infection because of a perceived inability to adhere to the rigorous medication regimen re...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e31829b1a6c
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Prescription Drug Monitoring Programs (PDMPs) are intended to help reduce prescription drug misuse and opioid overdose, yet little is known about the longitudinal patterns of opioid prescribing that may be associated with mortality. This study investigated longitudinal opioid prescribing patterns among patien...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000458
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Individuals with substance use disorders (SUDs) have unique reproductive health needs. The aim of this study was to evaluate these needs and assess the acceptability of family planning service delivery of SUD treatment clients. METHODS:Reproductive health needs of drug treatment clients were assessed using ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000175
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Publicly funded addiction treatment organizations have been slow to adopt pharmacotherapies. Few studies have examined the organizational factors associated with adoption of different types of medication in this treatment sector. This study identifies organization-level facilitators and barriers to the use o...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0b013e3181b41a32
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:Investigate patterns of methamphetamine use over time, specifically factors associated with remission from dependent and harmful patterns of use; and examine drug treatment and health/support service utilization pathways among people who use methamphetamine. METHODS:People who regularly use methamphetamine ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000469
更新日期:2019-03-01 00:00:00
abstract::This clinical case presentation and discussion illustrates a culturally adapted alcohol and drug use intervention using the Screening, Brief Intervention, and Referral to Treatment (SBIRT) approach, incorporating motivational interviewing skills. This case conference serves to complement the accompanying review articl...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000149
更新日期:2015-09-01 00:00:00
abstract::Buprenorphine/naloxone maintenance therapy is often prescribed in primary care to treat opioid dependence. Previous reports have described concomitant abuse of opioids and clonidine. In this case, a primary care patient on buprenorphine/naloxone maintenance therapy demonstrating altered mental status, hallucinations, ...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000081
更新日期:2014-11-01 00:00:00
abstract::This case study of the development and implementation of an opioid overdose prevention program is based on an actual clinic's experience, but information about the clinic, including details of implementation and outcome measures, has been changed. Four experts reflect on the medical, administrative, peer-support, comm...
journal_title:Journal of addiction medicine
pub_type: 杂志文章
doi:10.1097/ADM.0000000000000032
更新日期:2014-05-01 00:00:00
abstract::Tobacco use is a major threat to public health in the United States, and the number one cause of preventable death. Although most smokers try to quit unaided, robust data indicate that pairing behavioral support to US Food Drug Administration-approved cessation medications significantly increase cessation rates. Those...
journal_title:Journal of addiction medicine
pub_type: 杂志文章,评审
doi:10.1097/ADM.0000000000000239
更新日期:2016-09-01 00:00:00