当前位置： SCI文献检索 > BRITISH JOURNAL OF PHARMACOLOGY期刊下所有文献 > Age and the antihypertensive effect of aspirin in rats.

Age and the antihypertensive effect of aspirin in rats.

Abstract：

:1. We previously showed that chronic exposure to aspirin (100 mg kg-1 daily, by mouth) is effective in preventing the onset of hypertension in young (28-84 day old) spontaneously hypertensive rats (SHRs). This is contrary to what others have reported using older SHRs. 2. Renal prostaglandin F2 alpha was also reduced in young SHRs and Wistar-Okamoto strain rats (WKYs) exposed to aspirin. 3. In the present study we extended the period of aspirin treatment in young rats to beyond 84 days of age. We found that aspirin lost its antihypertensive effect in SHR and WKY rats at 110 +/- 7 days of age regardless of whether the exposure to aspirin had begun at age 28, 49 or 87 days. 4. We conclude that the loss of antihypertensive effect of aspirin in the SHR and in older WKY rats, is determined by some factor(s) probably not related to prostaglandin F2 alpha, which reaches full expression in the 110 +/- 7 day old rat, or is fully dissipated at this age. 5. The anti-PGF2 alpha activity of aspirin in the SHR and WKY rat was short-lived and apparently unrelated in time to the antihypertensive effect of aspirin.

journal_name

Br J Pharmacol

journal_title

British journal of pharmacology

authors

Tuttle RS,Yager J,Northrup N

doi

10.1111/j.1476-5381.1988.tb11585.x

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

755-8

issue

3

eissn

0007-1188

issn

1476-5381

journal_volume

94

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF PHARMACOLOGY文献大全
  • Study of the effector mechanism involved in the production of haemorrhagic necrosis of the small intestine in rat passive anaphylaxis.

    abstract：:1. The effector mechanism of intestinal necrosis in rat anaphylaxis was studied following several complementary approaches: (i) the use of monoclonal antibodies (mAb) belonging to different classes (IgG1, IgG2b and IgE anti-DNP), (ii) the assay of mediators, and (iii) the use of pharmacological tools. 2. Lethality and...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1994.tb13197.x

    authors： Pellón MI,Steil AA,Furió V,Sánchez Crespo M

    更新日期：1994-08-01 00:00:00

  • Enhancement by neuropeptide Y (NPY) of the dihydropyridine-sensitive component of the response to alpha 1-adrenoceptor stimulation in rat isolated mesenteric arterioles.

    abstract：:1. The mechanism by which neuropeptide Y (NPY) potentiates the vasoconstriction induced by alpha 1-adrenoceptor agonists was investigated in 3rd generation mesenteric arterioles of the rat. 2. At a maximally active concentration, nitrendipine (10(-6) M) displaced to the right the concentration-response curves to norad...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1990.tb14714.x

    authors： Andriantsitohaina R,Stoclet JC

    更新日期：1990-02-01 00:00:00

  • Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig.

    abstract：:1. The GABA-B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPi) have antitussive activity in the cat and guinea pig. The purpose of this study was to investigate the sites of action of these GABA-B receptor agonists to inhibit the cough reflex. 2. Single intracerebroventricular (i.c.v.) cannulas wer...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1994.tb17145.x

    authors： Bolser DC,DeGennaro FC,O'Reilly S,Chapman RW,Kreutner W,Egan RW,Hey JA

    更新日期：1994-12-01 00:00:00

  • Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves in the isolated guinea-pig ileum.

    abstract：:1. The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli. 2. NPY inhibited or suppressed the cholinergic contractile response...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1991.tb09809.x

    authors： Takaki M,Nakayama S

    更新日期：1991-06-01 00:00:00

  • Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve.

    abstract：BACKGROUND AND PURPOSE:Amitriptyline is often prescribed as a first-line treatment for neuropathic pain but its precise mode of analgesic action remains uncertain. Amitriptyline is known to inhibit voltage-dependent ion channels and also to act as an antagonist at ligand-gated ion channels, such as nicotinic acetylchol...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.2009.00347.x

    authors： Freysoldt A,Fleckenstein J,Lang PM,Irnich D,Grafe P,Carr RW

    更新日期：2009-10-01 00:00:00

  • Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels.

    abstract：:1. We examined the effect of the sulphonylurea glimepiride on three types of recombinant ATP-sensitive potassium (K(ATP)) channels. 2. K(ATP) channels share a common pore-forming subunit, Kir6.2, which associates with different sulphonylurea receptor isoforms (SUR1 in beta-cells, SUR2A in heart and SUR2B in smooth mus...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704062

    authors： Song DK,Ashcroft FM

    更新日期：2001-05-01 00:00:00

  • Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat.

    abstract：BACKGROUND AND PURPOSE:A putative novel cannabinoid receptor mediates vasorelaxation to anandamide and abnormal-cannabidiol and is blocked by O-1918 and by high concentrations of rimonabant. This study investigates VSN16, a novel water-soluble agonist, as a vasorelaxant potentially acting at non-CB1, non-CB2 cannabinoi...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0707470

    authors： Hoi PM,Visintin C,Okuyama M,Gardiner SM,Kaup SS,Bennett T,Baker D,Selwood DL,Hiley CR

    更新日期：2007-11-01 00:00:00

  • S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice.

    abstract：BACKGROUND AND PURPOSE:Small molecule glucokinase activators (GKAs) have been associated with potent antidiabetic efficacy and hepatic steatosis in rodents. This study reports the discovery of S 50131 and S 51434, two novel GKAs with an original scaffold and an atypical pharmacological profile. EXPERIMENTAL APPROACH:A...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12172

    authors： De Ceuninck F,Kargar C,Charton Y,Goldstein S,Perron-Sierra F,Ilic C,Caliez A,Rolin JO,Sadlo M,Harley E,Vinson C,Ktorza A

    更新日期：2013-07-01 00:00:00

  • Effect of 781094, a new selective alpha-adrenoceptor antagonist, on the aggregatory responses of human blood platelets and on binding of [3H]-dihydroergocryptine to these cells.

    abstract：:781094 (2-(2(1, 4-benzodioxanyl))-2-imidazoline hydrochloride) is a potent competitive inhibitor of the aggregatory responses of human platelets induced by adrenaline (pA2 = 7.3) and UK-14304. 781094 is a more potent inhibitor of the pro-aggregatory response to clonidine than of that to methoxamine. The alpha 2/alpha ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1983.tb11012.x

    authors： Kerry R,Scrutton MC

    更新日期：1983-06-01 00:00:00

  • Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock.

    abstract：:1 Poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme activated by strand breaks in DNA, which are caused by reactive oxygen species (ROS). Here we investigate the effects of the PARS inhibitors 3-aminobenzamide (3-AB), nicotinamide and 1,5-dihydroxyisoquinoline (ISO) on the circulatory failure and the organ injur...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0702928

    authors： McDonald MC,Filipe HM,Thiemermann C

    更新日期：1999-11-01 00:00:00

  • The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.

    abstract：:1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible m...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1978.tb08460.x

    authors： Davies JA,Williams J

    更新日期：1978-02-01 00:00:00

  • Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors, types A and B, in the cat.

    abstract：:The selective monoamine oxidase (MAO) inhibitors clorgyline, selegiline and AGN 1135 did not cause a change in responses of the cat nictitating membrane to preganglionic sympathetic nerve stimulation at 5 Hz. Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response t...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1985.tb08891.x

    authors： Finberg JP,Youdim MB

    更新日期：1985-06-01 00:00:00

  • Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.

    abstract：:1. Adenosine A(1), A(2A), and A(3) receptors (ARs) and extracellular signal-regulated kinase 1/2 (ERK1/2) play a major role in myocardium protection from ischaemic injury. In this study, we have characterized the adenosine receptor subtypes involved in ERK1/2 activation in newborn rat cardiomyocytes. 2. Adenosine (non...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0705614

    authors： Germack R,Dickenson JM

    更新日期：2004-01-01 00:00:00

  • Factors underlying the increased sensitivity to field stimulation of urinary bladder strips from streptozotocin-induced diabetic rats.

    abstract：:1. The responses of bladder strips from control, streptozotocin-diabetic, and sucrose-drinking rats to electrical field stimulation were investigated. Sucrose-drinking rats were included as additional controls because they have enlarged bladders as a result of non-diabetic diuresis. 2. Bladder strips from diabetic rat...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1994.tb16193.x

    authors： Tammela TL,Briscoe JA,Levin RM,Longhurst PA

    更新日期：1994-09-01 00:00:00

  • Effect of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats.

    abstract：:1. Chronic treatment with a combined ETA/ETB endothelin receptor antagonist has been shown to reduce blood pressure in experimental rat models of hypertension in which endothelin-1 gene overexpression occurs in the walls of blood vessels, particularly small, resistance-sized arteries, but not in those genetic or exper...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0701224

    authors： Schiffrin EL,Turgeon A,Deng LY

    更新日期：1997-07-01 00:00:00

  • Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats.

    abstract：BACKGROUND AND PURPOSE:mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigated the mechanisms asso...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.2011.01716.x

    authors： Deblon N,Bourgoin L,Veyrat-Durebex C,Peyrou M,Vinciguerra M,Caillon A,Maeder C,Fournier M,Montet X,Rohner-Jeanrenaud F,Foti M

    更新日期：2012-04-01 00:00:00

  • Prevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat.

    abstract：:1. The effect of ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, was studied in morphine-addicted rats. Morphine-dependence and tolerance, induced by drinking increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks, were demonstrated by the naloxone-precipitated wit...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1996.tb15504.x

    authors： Hui SC,Sevilla EL,Ogle CW

    更新日期：1996-06-01 00:00:00

  • The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs.

    abstract：BACKGROUND AND PURPOSE:The electromechanical window (EMW), the interval between the end of the T-wave and the end of the left ventricular pressure (LVP) curve, has recently been proposed as a predictor of risk of Torsade de Pointes (TdP) in healthy animals, whereby a negative EMW (mechanical relaxation earlier than rep...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12483

    authors： Stams TR,Bourgonje VJ,Beekman HD,Schoenmakers M,van der Nagel R,Oosterhoff P,van Opstal JM,Vos MA

    更新日期：2014-02-01 00:00:00

  • Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice.

    abstract：:1. The role of smooth muscle-derived lipoprotein lipase (LPL) that translocates to the endothelium surface on vascular dysfunction during atherogenesis is unclear. Thus, the role of vascular LPL on blood vessel reactivity was assessed in transgenic mice that specifically express human LPL in the circulatory system. 2....

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704440

    authors： Esenabhalu VE,Cerimagic M,Malli R,Osibow K,Levak-Frank S,Frieden M,Sattler W,Kostner GM,Zechner R,Graier WF

    更新日期：2002-01-01 00:00:00

  • Multiple actions of glaucine on cyclic nucleotide phosphodiesterases, alpha 1-adrenoceptor and benzothiazepine binding site at the calcium channel.

    abstract：:1. In the present study, the properties of glaucine (an aporphine structurally related to papaverine) were compared with those of papaverine, diltiazem, nifedipine and prazosin. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination of the affinit...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1992.tb14345.x

    authors： Ivorra MD,Lugnier C,Schott C,Catret M,Noguera MA,Anselmi E,D'Ocon P

    更新日期：1992-06-01 00:00:00

  • Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions.

    abstract：:1. Primary porcine hepatocytes and enterocytes were isolated and cultured in Williams' E medium for up to 10 days to investigate potential organ differences in the metabolism of the immunosuppressive compound tacrolimus (FK 506) and of two investigational drugs (KC11346 and KC12291). Using LC-MS (FK506) and HPLC-FL (K...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0703062

    authors： Bader A,Hansen T,Kirchner G,Allmeling C,Haverich A,Borlak JT

    更新日期：2000-01-01 00:00:00

  • The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol (M320), a potent agonist at kappa- and mu-opiate receptors, on urine excretion of rats.

    abstract：:The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride (M320) on urine excretion by rats were investigated. Further studies, using rabbit isolated vas deferens, investigated its interactions with kappa-opiate receptors. The output of urine for a 2 h period after M320, administered subcutaneously to ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1986.tb11180.x

    authors： Abrahams JM,Boura AL,Evans RG,Johnston CI,Olley JE

    更新日期：1986-12-01 00:00:00

  • Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin-1 in the pithed rat.

    abstract：:1. Pithed rats were respired at a fixed rate of 54 cycles min-1 and with a ventilation volume of either 20 (control) or 10 ml kg-1. In these two preparations, the dose-response relationships for the systemic blood pressure responses to endothelin-1, administered i.v., were examined. Also, cardiac output, its distribut...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1989.tb14638.x

    authors： MacLean MR,Randall MD,Hiley CR

    更新日期：1989-11-01 00:00:00

  • A GPR18-based signalling system regulates IOP in murine eye.

    abstract：BACKGROUND AND PURPOSE:GPR18 is a recently deorphaned lipid receptor that is activated by the endogenous lipid N-arachidonoyl glycine (NAGly) as well the behaviourally inactive atypical cannabinoid, abnormal cannabidiol (Abn-CBD). The presence and/or function of any GPR18-based ocular signalling system remain essential...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12136

    authors： Caldwell MD,Hu SS,Viswanathan S,Bradshaw H,Kelly ME,Straiker A

    更新日期：2013-06-01 00:00:00

  • Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase.

    abstract：BACKGROUND AND PURPOSE:Nitric oxide (NO) is known to activate NO-sensitive guanylyl cyclase (NO-GC) and to elicit cGMP production. However, NO has also been proposed to induce cGMP-independent effects. It is accepted practice to use specific NO-GC inhibitors, such as ODQ or NS2028, to assess cGMP-dependent NO effects. ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12275

    authors： Lies B,Groneberg D,Gambaryan S,Friebe A

    更新日期：2013-09-01 00:00:00

  • Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils.

    abstract：:1. The possible mechanisms of action of the inhibitory effect of gomisin C on the respiratory burst of rat neutrophils in vitro was investigated. 2. The peptide formyl-Met-Leu-Phe (FMLP) induced superoxide anion (O2-) formation and O2 consumption, which was inhibited by gomisin C in a concentration-dependent manner (I...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1994.tb17084.x

    authors： Wang JP,Raung SL,Hsu MF,Chen CC

    更新日期：1994-11-01 00:00:00

  • Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.

    abstract：:1. To investigate the role of nitric oxide in epilepsy we have studied the effects of agents which affect nitric oxide synthesis in sound-induced seizures in DBA/2 mice and in genetically epilepsy-prone (GEP) rats. 2. The neuronal selective nitric oxide synthase inhibitor, 7-nitroindazole (7-NI) is anticonvulsant in t...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1996.tb15690.x

    authors： Smith SE,Man CM,Yip PK,Tang E,Chapman AG,Meldrum BS

    更新日期：1996-09-01 00:00:00

  • Bradykinin increases Na(+)-K(+) pump activity in cultured guinea-pig tracheal smooth muscle cells.

    abstract：:1. The effect of bradykinin on the Na+-K+ pump of airway smooth muscle was investigated by measuring ouabain-sensitive (86)Rb(+) uptake in cultured guinea-pig tracheal smooth muscle cells. 2. Bradykinin induced a concentration-dependent increase in ouabain-sensitive (86)Rb(+) uptake, with an EC(50) of 3 nM (pD(2) = 8....

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704198

    authors： Dodson AM,Rhoden KJ

    更新日期：2001-08-01 00:00:00

  • Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase.

    abstract：:1. FPL 67156 (6-N,N-diethyl-beta, gamma-dibromomethylene-D-ATP), is a newly synthesized analogue of ATP. 2. In a rabbit isolated tracheal epithelium preparation, measuring P2U-purinoceptor-dependent chloride secretion, FPL 67156 was discovered to potentiate the responses to UTP but not those to ATP-gamma-S. UTP agonis...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1995.tb13251.x

    authors： Crack BE,Pollard CE,Beukers MW,Roberts SM,Hunt SF,Ingall AH,McKechnie KC,IJzerman AP,Leff P

    更新日期：1995-01-01 00:00:00

  • Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors.

    abstract：:1. The sinus node inhibitors UL FS 49 and DK-AH 269 reduce heart rate by slowing diastolic depolarization rate in the sino-atrial (SA) node, which might originate from the use-dependent blockade of a hyperpolarization-activated current If. A hyperpolarization-activated current Ih, which is present in many types of neu...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0702153

    authors： Raes A,Van de Vijver G,Goethals M,van Bogaert PP

    更新日期：1998-10-01 00:00:00