Effects of chronic polybrominated diphenyl ether exposure on gonadal development in the northern leopard frog, Rana pipiens.

Abstract:

:Polybrominated diphenyl ethers (PBDEs) are bioaccumulative, persistent organic pollutants used as flame retardants in consumer goods. Concentrations of PBDEs in North American wildlife have been increasing for decades and been shown to have estrogenic effects on sexual development. No studies, however, have examined the effects of PBDEs on the sexual development of North American frogs at ecologically relevant concentrations. This study examined the effects of five dietary concentrations of DE-71 (0, 1.1, 6.1, 71.4, and 634 ng ΣPBDEs/g diet), a technical PBDE mixture, on the gonadal development of the northern leopard frog, Rana pipiens. Tadpoles were exposed chronically from the time they became free-swimming until metamorphosis. Frogs were killed either at metamorphic climax or 10 weeks after completing metamorphosis, processed for histology, and examined for alterations in sexual development. The experimental group exposed to PBDEs at 1.1 ng/g had a significantly larger proportion of females compared with the expected 50:50 sex ratio. At 10 weeks post-metamorphosis, male frogs exposed to 6.1 and 71.4 ng/g had significantly smaller testes, but all other measure of gonadal development tested showed no effects. No intersex or increased incidence of gonadal abnormality were detected. These findings indicate that PBDEs may disrupt sexual differentiation in frogs at low, environmentally relevant concentrations.

journal_name

Environ Toxicol Chem

authors

Van Schmidt ND,Cary TL,Ortiz-Santaliestra ME,Karasov WH

doi

10.1002/etc.1702

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

347-54

issue

2

eissn

0730-7268

issn

1552-8618

journal_volume

31

pub_type

杂志文章
  • Kraft mill effluent survey: progress toward best management practices for reducing effects on fish reproduction.

    abstract::Pulp and paper mill effluents have been linked to effects on fish reproduction for more than 25 years. To date, the causes of these effects and remedial strategies have eluded investigators. Recent work has shown that the degree of reproductive effect caused by a mill effluent is related to the overall organic content...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.526

    authors: Kovacs TG,Martel PH,O'Connor BI,Parrott JL,McMaster ME,Van Der Kraak GJ,MacLatchy DL,van den Heuvel MR,Hewitt LM

    更新日期:2011-06-01 00:00:00

  • Chemical analysis of fish bile extracts for monitoring endocrine disrupting chemical exposure in water: Bisphenol A, alkylphenols, and norethindrone.

    abstract::The present study determined concentrations of estrogenic bisphenol A (BPA), nonylphenol, octylphenol (4-tert-octylphenol), butylphenol (4-tert-butylphenol), and progestogenic norethindrone by liquid chromatography-tandem mass spectrometry in bile extracts from field fish from the Xin'an River and market fish in Shang...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3176

    authors: Wu M,Pan C,Yang M,Xu B,Lei X,Ma J,Cai L,Chen J

    更新日期:2016-01-01 00:00:00

  • An evaluation of the influence of substrate on the response of juvenile freshwater mussels (fatmucket, Lampsilis siliquoidea) in acute water exposures to ammonia.

    abstract::Acute 96-h ammonia toxicity to three-month-old juvenile mussels (Lampsilis siliquoidea) was evaluated in four treatments (water-only, water-only with feeding, water and soil, and water and sand) using an exposure unit designed to maintain consistent pH and ammonia concentrations in overlying water and in pore water su...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.259

    authors: Miao J,Barnhart MC,Brunson EL,Hardesty DK,Ingersoll CG,Wang N

    更新日期:2010-09-01 00:00:00

  • Identifying the causes of sediment-associated toxicity in urban waterways in South China: incorporating bioavailabillity-based measurements into whole-sediment toxicity identification evaluation.

    abstract::Sediments in urban waterways of Guangzhou, China, were contaminated by a variety of chemicals and showed prevalent toxicity to benthic organisms. A combination of whole-sediment toxicity identification evaluation (TIE) and bioavailability-based extraction was used to identify the causes of sediment toxicity. Of the 6 ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2970

    authors: Yi X,Li H,Ma P,You J

    更新日期:2015-08-01 00:00:00

  • Biomagnification and tissue distribution of perfluoroalkyl substances (PFASs) in market-size rainbow trout (Oncorhynchus mykiss).

    abstract::The present study investigated the biomagnification potential as well as the substance and tissue-specific distribution of perfluoroalkyl substances (PFASs) in market-size rainbow trout (Oncorhynchus mykiss). Rainbow trout with an average body weight of 314 ± 21 g were exposed to perfluorobutane sulfonate (PFBS), perf...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2279

    authors: Goeritz I,Falk S,Stahl T,Schäfers C,Schlechtriem C

    更新日期:2013-09-01 00:00:00

  • Stage-dependent susceptibility to copper in Rhinella arenarum embryos and larvae.

    abstract::Copper toxicity in different embryonic and larval stages of the common South American toad Rhinella arenarum was evaluated by means of continuous and 24-h pulse treatments in 12 different developmental stages. Lethal concentrations (LC) of 10, 50, and 90% of continuous treatment with Cu from early blastula (S.4), comp...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.674

    authors: Aronzon CM,Sandoval MT,Herkovits J,Pérezcoll CS

    更新日期:2011-12-01 00:00:00

  • Effects of atrazine on fathead minnow in a short-term reproduction assay.

    abstract::Atrazine is the most extensively used herbicide in the United States. Part-per-million concentrations of atrazine have been reported in agricultural runoff. It is detectable in surface waters and precipitation throughout the year, and it has been found in groundwater sources of drinking water. Recent studies indicate ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/03-180

    authors: Bringolf RB,Belden JB,Summerfelt RC

    更新日期:2004-04-01 00:00:00

  • Accumulation and DNA damage in fathead minnows (Pimephales promelas) exposed to 2 brominated flame-retardant mixtures, Firemaster 550 and Firemaster BZ-54.

    abstract::Firemaster 550 and Firemaster BZ-54 are two brominated formulations that are in use as replacements for polybrominated diphenyl ether (PBDE) flame retardants. Two major components of these mixtures are 2,3,4,5-tetrabromo-ethylhexylbenzoate (TBB) and 2,3,4,5-tetrabromo-bis(2-ethylhexyl) phthalate (TBPH). Both have been...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.94

    authors: Bearr JS,Stapleton HM,Mitchelmore CL

    更新日期:2010-03-01 00:00:00

  • Methylmercury uptake and distribution kinetics in sheepshead minnows, Cyprinodon variegatus, after exposure to Ch3Hg-spiked food.

    abstract::The distribution kinetics of methylmercury (CH3Hg[II]) was determined in sheepshead minnows (Cyprinodon variegatus) after a single dose of different CH3Hg(II)-spiked food to determine what factors influence the bioavailability, uptake, and redistribution of CH3Hg(II) to various organs of C. variegatus. The kinetics of...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/03-258

    authors: Leaner JJ,Mason RP

    更新日期:2004-09-01 00:00:00

  • Subcellular distribution of zinc in Daphnia magna and implication for toxicity.

    abstract::We examined the subcellular partitioning of zinc (Zn) in Daphnia magna both under acute and chronic exposures. In the acute Zn toxicity tests, the daphnids were exposed to different Zn concentrations for 48 h or to one lethal concentration (1,000 microg/L) for different durations (time to death for up to 47 h). Signif...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.229

    authors: Wang WX,Guan R

    更新日期:2010-08-01 00:00:00

  • Accumulation and elimination of lanthanum by duckweed (Lemna minor L.) as influenced by organism growth and lanthanum sorption to glass.

    abstract::Lanthanide emissions to the environment increase as a result of the growing industrial applications of these elements. However, robust data to evaluate the environmental fate of lanthanides are scarce. This article describes the accumulation and elimination of lanthanum (La) by common duckweed (Lemna minor L.). Specia...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Weltje L,Brouwer AH,Verburg TG,Wolterbeek HT,de Goeij JJ

    更新日期:2002-07-01 00:00:00

  • Creation of a Curated Aquatic Toxicology Database: EnviroTox.

    abstract::Flexible, rapid, and predictive approaches that do not require the use of large numbers of vertebrate test animals are needed because the chemical universe remains largely untested for potential hazards. Development of robust new approach methodologies and nontesting approaches requires the use of existing information...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4382

    authors: Connors KA,Beasley A,Barron MG,Belanger SE,Bonnell M,Brill JL,de Zwart D,Kienzler A,Krailler J,Otter R,Phillips JL,Embry MR

    更新日期:2019-05-01 00:00:00

  • Effects of using synthetic sea salts when measuring and modeling copper toxicity in saltwater toxicity tests.

    abstract::Synthetic sea salts are often used to adjust the salinity of effluent, ambient, and laboratory water samples to perform toxicity tests with marine and estuarine species. The U.S. Environmental Protection Agency (U.S. EPA) provides guidance on salinity adjustment in its saltwater test guidelines. The U.S. EPA suggests ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/06-215r1.1

    authors: Arnold WR,Cotsifas JS,Winter AR,Klinck JS,Smith DS,Playle RC

    更新日期:2007-05-01 00:00:00

  • Global change and mercury cycling: challenges for implementing a global mercury treaty.

    abstract::The Minamata Convention aims to protect human health and the environment from anthropogenic emissions and releases of mercury. In the present study, the provisions of the Minamata Convention are examined to assess their influence on global biogeochemical cycling of Hg. Although the convention's scope covers all major ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2374

    authors: Selin NE

    更新日期:2014-06-01 00:00:00

  • An assessment of biodegradability of quaternary carbon-containing fragrance compounds: comparison of experimental OECD screening test results and in silico prediction data.

    abstract::An assessment of biodegradability was carried out for fragrance substances containing quaternary carbons by using data obtained from Organisation for Economic Co-operation and Development (OECD) 301F screening tests for ready biodegradation and from Biowin and Catalogic prediction models. Despite an expected challengi...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2523

    authors: Seyfried M,Boschung A

    更新日期:2014-05-01 00:00:00

  • The derivation of effects threshold concentrations of lead for European freshwater ecosystems.

    abstract::The main objective of the present study was to derive ecologically relevant effect threshold concentrations of (dissolved) Pb for selected European Union (EU) freshwater rivers, using the 2008 EU Voluntary Risk Assessment Report as a starting point and more advanced methodologies than those used in the Voluntary Risk ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3262

    authors: Van Sprang PA,Nys C,Blust RJ,Chowdhury J,Gustafsson JP,Janssen CJ,De Schamphelaere KA

    更新日期:2016-05-01 00:00:00

  • Effect of maternal exposure to tributyltin on reproduction of the pearl oyster (Pinctada fucata martensii).

    abstract::We examined the effect of tributyltin (TBT) on reproduction of the pearl oyster (Pinctada fucata martensii). In a maternal exposure test, five female pearl oysters were exposed to TBT at measured concentrations of 0 (control), 0.092, or 0.191 microg/L at 25 degreesC for one week, and the embryo developmental success (...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/03-265

    authors: Inoue S,Oshima Y,Nagai K,Yamamoto T,Go J,Kai N,Honjo T

    更新日期:2004-05-01 00:00:00

  • On the impact of sample size on median lethal concentration estimation in acute fish toxicity testing: Is n = 7/group enough?

    abstract::The fish acute toxicity test method is foundational to aquatic toxicity testing strategies, yet the literature lacks a concise sample size assessment. Although various sources address sample size, historical precedent seems to play a larger role than objective measures. We present a novel and comprehensive quantificat...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4098

    authors: Carr GJ,Bailer AJ,Rawlings JM,Belanger SE

    更新日期:2018-06-01 00:00:00

  • Ecotoxicity of Nitrogen, Sulfur, or Oxygen Heterocycles and Short-Chained Alkyl Phenols Commonly Detected in Contaminated Groundwater.

    abstract::Nitrogen, sulfur, or oxygen heterocyclic aromatic hydrocarbons (NSO-HETs) and short-chained alkyl phenols (SCAPs) are commonly detected in groundwater at contaminated sites and in the surrounding environment. It is now scientific consensus that these chemicals pose a risk to human and ecosystem health. However, toxici...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4423

    authors: Brinkmann M,Schneider AL,Bluhm K,Schiwy S,Lehmann G,Deutschmann B,Müller A,Tiehm A,Hollert H

    更新日期:2019-06-01 00:00:00

  • Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller's sea eagles and white-tailed sea eagles, threatened species, in Hokkaido, Japan.

    abstract::Polychlorinated biphenyls (PCBs), including coplanar congeners, hexachlorocyclohexane isomers, chlordane-related compounds, and hexachlorobenzene, were found in the breast muscle of Steller's sea eagles (SSE) and white-tailed sea eagles (WSE) threatened species, collected in Hokkaido, Japan, during the two years from ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/1551-5028(2002)021<0842:apopbc>2.0.co;2

    authors: Sakamoto KQ,Kunisue T,Watanabe M,Masuda Y,Iwata H,Tanabe S,Akahori F,Ishizuka M,Kazusaka A,Fujita S

    更新日期:2002-04-01 00:00:00

  • The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio).

    abstract::The authors performed a toxicity test with ciprofloxacin in fertilized eggs of common carp according to guideline 210 of the Organisation for Economic Co-operation and Development. The tested concentrations were 1 μg L(-1) , 100 μg L(-1) , 500 μg L(-1) , 1000 μg L(-1) , and 3000 μg L(-1) . Accelerated hatching was fou...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3317

    authors: Zivna D,Plhalova L,Chromcova L,Blahova J,Prokes M,Skoric M,Marsalek P,Praskova E,Stepanova S,Svobodova Z

    更新日期:2016-07-01 00:00:00

  • A survey of neonicotinoid use and potential exposure to northern bobwhite (Colinus virginianus) and scaled quail (Callipepla squamata) in the Rolling Plains of Texas and Oklahoma.

    abstract::Northern bobwhite (quail) (Colinus virginianus) and scaled quail (Callipepla squamata) populations have declined dramatically in the Rolling Plains ecoregion of Texas and Oklahoma (USA). There is rising concern about potential toxicity of neonicotinoids to birds. To investigate this concern, the authors examined crops...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3305

    authors: Turaga U,Peper ST,Dunham NR,Kumar N,Kistler W,Almas S,Presley SM,Kendall RJ

    更新日期:2016-06-01 00:00:00

  • Evaluation of statistical methods for left-censored environmental data with nonuniform detection limits.

    abstract::Monte Carlo simulations were used to evaluate statistical methods for estimating 95% upper confidence limits of mean constituent concentrations for left-censored data with nonuniform detection limits. Two primary scenarios were evaluated: data sets with 15 to 50% nondetected samples and data sets with 51 to 80% nondet...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/05-548r.1

    authors: Sinha P,Lambert MB,Trumbull VL

    更新日期:2006-09-01 00:00:00

  • Distribution, characterization, and exposure of MC252 oil in the supratidal beach environment.

    abstract::The distribution and characteristics of MC252 oil:sand aggregates, termed surface residue balls (SRBs), were measured on the supratidal beach environment of oil-impacted Fourchon Beach in Louisiana (USA). Probability distributions of 4 variables, surface coverage (%), size of SRBs (mm(2) of projected area), mass of SR...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2599

    authors: Lemelle KR,Elango V,Pardue JH

    更新日期:2014-07-01 00:00:00

  • Toxicity of aqueous fullerene in adult and larval Fundulus heteroclitus.

    abstract::Aqueous suspensions of fullerene aggregates (aqua-nC60) were used to investigate the movement of carbon-based nanomaterials in a marine water column and to determine their effects on different life stages of a marine teleost. Fullerene aggregates formed precipitates as a result of mixing in natural seawater, and level...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/07-632.1

    authors: Blickley TM,McClellan-Green P

    更新日期:2008-09-01 00:00:00

  • Use of Postregistration Monitoring Data to Evaluate the Ecotoxicological Risks of Pesticides to Surface Waters: A Case Study with Chlorpyrifos in the Iberian Peninsula.

    abstract::Chemical monitoring data sets such as those provided by the implementation of the Water Framework Directive (WFD) offer opportunities to evaluate the ecological risks of pesticides under large spatiotemporal scales and to evaluate the protectiveness of the current prospective risk-assessment framework. As a case study...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4927

    authors: Rico A,Dafouz R,Vighi M,Rodríguez-Gil JL,Daam MA

    更新日期:2021-02-01 00:00:00

  • Validation of a new standardized test method for the freshwater amphipod Hyalella azteca: Determining the chronic effects of silver in sediment.

    abstract::Environment Canada has developed a new 42-d sediment toxicity test method that includes a reproduction test endpoint with the freshwater amphipod Hyalella azteca. Because of concerns that existing standard methodologies, whereby adults are transferred to a water-only exposure before release of their first brood at day...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3453

    authors: Taylor LN,Novak L,Rendas M,Antunes PM,Scroggins RP

    更新日期:2016-10-01 00:00:00

  • The Impact of Pesticides on Flower-Visiting Insects: A Review with Regard to European Risk Assessment.

    abstract::Flower-visiting insects (FVIs) are an ecologically diverse group of mobile, flying species that should be protected from pesticide effects according to European policy. However, there is an ongoing decline of FVI species, partly caused by agricultural pesticide applications. Therefore, the risk assessment framework ne...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章,评审

    doi:10.1002/etc.4572

    authors: Uhl P,Brühl CA

    更新日期:2019-11-01 00:00:00

  • Does subcellular distribution in plants dictate the trophic bioavailability of cadmium to Porcellio dilatatus (Crustacea, Isopoda)?

    abstract::The present study examined how subcellular partitioning of Cd in plants with different strategies to store and detoxify Cd may affect trophic transfer of Cd to the isopod Porcellio dilatatus. The plant species used were Lactuca sativa, a horticultural metal accumulator species; Thlaspi caerulescens, a herbaceous hyper...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/08-154.1

    authors: Monteiro MS,Santos C,Soares AM,Mann RM

    更新日期:2008-12-01 00:00:00

  • Comparison of synthetic surfactants and biosurfactants in enhancing biodegradation of polycyclic aromatic hydrocarbons.

    abstract::Polycyclic aromatic hydrocarbon (PAH) contamination of the environment represents a serious threat to the health of humans and ecosystems. Given the human health effects of PAHs, effective and cost-competitive remediation technologies are required. Bioremediation has shown promise as a potentially effective and low-co...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/02-472

    authors: Makkar RS,Rockne KJ

    更新日期:2003-10-01 00:00:00