Mitochondrial respiratory efficiency is positively correlated with human sperm motility.

Abstract:

OBJECTIVE:To correlate sperm mitochondrial respiratory efficiency with variations in sperm motility and with sperm morphologic anomalies. METHODS:Sperm mitochondrial respiratory activity was evaluated with a polarographic assay of oxygen consumption carried out in hypotonically-treated sperm cells. A possible relationship among sperm mitochondrial respiratory efficiency, sperm motility, and morphologic anomalies was investigated. RESULTS:Mitochondrial respiratory efficiency was positively correlated with sperm motility and negatively correlated with the percentage of immotile spermatozoa. Moreover, midpiece defects impaired mitochondrial functionality. CONCLUSION:Our data indicate that an increase in sperm motility requires a parallel increase in mitochondrial respiratory capacity, thereby supporting the fundamental role played by mitochondrial oxidative phosphorylation in sperm motility of normozoospermic subjects. These results are of physiopathological relevance because they suggest that disturbances of sperm mitochondrial function and of energy production could be responsible for asthenozoospermia.

journal_name

Urology

journal_title

Urology

authors

Ferramosca A,Provenzano SP,Coppola L,Zara V

doi

10.1016/j.urology.2011.12.042

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

809-14

issue

4

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(12)00002-7

journal_volume

79

pub_type

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