Bladder tissue engineering using biocompatible nanofibrous electrospun constructs: feasibility and safety investigation.

Abstract:

PURPOSE:To investigate the feasibility and safety of using biocompatible, nanofibrous electrospun polycaprolactone (PCL) and combination of polylactic acid (PLLA) and PCL mats in a canine model. MATERIALS AND METHODS:Plasma-treated electrospun unseeded mats were implanted in three dogs. The first dog was sacrificed after 3 months and the second and third ones after 4 months, and then, the graft was examined macroscopically with subsequent morphological and histochemical evaluation. RESULTS:Both films showed high levels of cell infiltration and tissue formation, but body response to PLLA/PCL mat in comparison to PCL mat was very low. All three implantation models showed the same light microscopic morphology, immunohistochemistry, and scanning electron microscopy results; nevertheless, only the PCL/PLLA model showed favorable clinical results. CONCLUSION:Based on these data, nanofibrous PLLA/PCL scaffolding could be a suitable material for the bladder tissue engineering; however, it deserves further investigations.

journal_name

Urol J

journal_title

Urology journal

authors

Shakhssalim N,Dehghan MM,Moghadasali R,Soltani MH,Shabani I,Soleimani M

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

410-9

issue

1

eissn

1735-1308

issn

1735-546X

pii

1390/635

journal_volume

9

pub_type

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