Abstract:
PURPOSE:To investigate the feasibility and safety of using biocompatible, nanofibrous electrospun polycaprolactone (PCL) and combination of polylactic acid (PLLA) and PCL mats in a canine model. MATERIALS AND METHODS:Plasma-treated electrospun unseeded mats were implanted in three dogs. The first dog was sacrificed after 3 months and the second and third ones after 4 months, and then, the graft was examined macroscopically with subsequent morphological and histochemical evaluation. RESULTS:Both films showed high levels of cell infiltration and tissue formation, but body response to PLLA/PCL mat in comparison to PCL mat was very low. All three implantation models showed the same light microscopic morphology, immunohistochemistry, and scanning electron microscopy results; nevertheless, only the PCL/PLLA model showed favorable clinical results. CONCLUSION:Based on these data, nanofibrous PLLA/PCL scaffolding could be a suitable material for the bladder tissue engineering; however, it deserves further investigations.
journal_name
Urol Jjournal_title
Urology journalauthors
Shakhssalim N,Dehghan MM,Moghadasali R,Soltani MH,Shabani I,Soleimani Msubject
Has Abstractpub_date
2012-01-01 00:00:00pages
410-9issue
1eissn
1735-1308issn
1735-546Xpii
1390/635journal_volume
9pub_type
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