Abstract:
:Cervical cancer is the fourth most common cancer among women worldwide and its development is mainly associated with human papillomavirus infection, a highly sexually transmissible virus. The expression of E6 and E7 viral oncoproteins deregulates cell repairing mechanisms through impairment of tumor suppressor protein functions, such as p53 or retinoblastoma protein. Although the implementation of new preventive vaccines has decreased the infection rate and cervical cancer progression, there are still many women who are affected by this pathology. Nowadays, the main treatment often requires the use of invasive techniques. From well-established strategies, like DNA vaccines and gene therapy, to innovative gene silencing technologies; different methodologies are currently under scrutiny that target the E6 and E7 oncoproteins and/or their modes of action.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Almeida AM,Queiroz JA,Sousa F,Sousa Âdoi
10.1016/j.drudis.2019.07.011subject
Has Abstractpub_date
2019-10-01 00:00:00pages
2044-2057issue
10eissn
1359-6446issn
1878-5832pii
S1359-6446(19)30310-1journal_volume
24pub_type
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