Biochemical investigation of association of arsenic exposure with risk factors of diabetes mellitus in Pakistani population and its validation in animal model.

Abstract:

:Arsenic is one of the naturally occurring heavy metal that has been reported to cause damaging effects on different body organs. This study was aimed to determine the arsenic level in different water sources and investigate the effect of arsenic exposure on risk factors of diabetes mellitus (DM) in human participants and experimental animals. We recruited 150 participants to investigate the arsenic exposure in their urine and from drinking water. We found that males contained significantly higher (P < 0.001) concentrations of urinary arsenic as compared with that of their female counterparts. Similarly, urinary arsenic concentration was high and showed significant association in the age of ≥ 60 years (P < 0.05), illiterate (P < 0.001), smokers (P < 0.0001), and diabetic (P < 0.0001) participants. Moreover, urinary arsenic exposure was also associated with higher levels of fasting (P < 0.001) and random blood glucose (P < 0.001), HbA1c (P < 0.001), AST, ALT, MDA, IL-6, CRP, blood urea nitrogen, and creatinine in arsenic-exposed diabetics as compared with that of unexposed diabetics. Further, we also exposed the white albino rats with arsenic in drinking water for 30 days and their blood glucose was measured at 15th and 30th days of treatment that was significantly higher (P < 0.001) in arsenic-exposed animals as compared with that of unexposed animals. Similarly, arsenic-exposed animals failed to tolerate exogenously administered glucose (P < 0.001) as compared with that of unexposed animals. Likewise, insulin and glutathione concentrations were also significantly decreased (P < 0.001) in arsenic-exposed animals as compared with that of unexposed animals. The alterations in normal values of glucose, insulin, and glutathione exhibited the damaging effects of arsenic exposure in experimental rats. This study showed that arsenic exposed to human beings and animals through drinking water resulted in the disruption of pancreatic β-cell functioning that provoked the risk factor for development of DM. This study also suggested that long-term arsenic exposure induces hyperglycemia, inflammation, and oxidative stress that may lead to the onset of development of DM.

journal_name

Environ Monit Assess

authors

Rehman K,Fatima F,Akash MSH

doi

10.1007/s10661-019-7670-2

subject

Has Abstract

pub_date

2019-07-25 00:00:00

pages

511

issue

8

eissn

0167-6369

issn

1573-2959

pii

10.1007/s10661-019-7670-2

journal_volume

191

pub_type

杂志文章
  • Indoor air quality modeling for PM 10, PM 2.5, and PM 1.0 in naturally ventilated classrooms of an urban Indian school building.

    abstract::Assessment of indoor air quality (IAQ) in classrooms of school buildings is of prime concern due to its potential effects on student's health and performance as they spend a substantial amount of their time (6-7 h per day) in schools. A number of airborne contaminants may be present in urban school environment. Howeve...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-010-1600-7

    authors: Goyal R,Khare M

    更新日期:2011-05-01 00:00:00

  • Air pollution and diseases of the respiratory tracts in pre-school children: A transfer function model.

    abstract::The purpose of the present statistical analysis was the assessment of the relation between time series of environmental factors and of frequencies of diseases of the respiratory system in pre-school children. During about one year, daily measurements of air pollutants and climatic variables were taken. During the same...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/BF00399299

    authors: Helfenstein U,Ackermann-Liebrich U,Braun-Fahrländer C,Wanner HU

    更新日期:1991-01-01 00:00:00

  • Method for evaluating non-economic effects of air pollution.

    abstract::The basic premise underlying the approach presented in the paper is the assumption that humans are unique beings that can evaluate. The environment is described as a system of resources satisfying human needs. The assessment of the effects of environmental pollution derives from the fact that there is, or will be, non...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/BF00418102

    authors: Janikowski R,Starzewska A

    更新日期:1991-02-01 00:00:00

  • The challenges of conducting environmental research on privately owned land.

    abstract::Accessing research sites is an integral part of a research in the world today. Researching sites on privately owned lands creates unique challenges when compared to conducting research on government or publicly owned land. This study explores different methods for obtaining landowner information, permission to sample ...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-013-3432-8

    authors: Hargiss CL,DeKeyser ES

    更新日期:2014-02-01 00:00:00

  • Chiral xenobiotics bioaccumulations and environmental health prospectives.

    abstract::The chiral xenobiotics are very dangerous for all of us due to the different enantioselective toxicities of the enantiomers. Besides, these have different enantioselective bioaccumulations and behaviors in our body and other organisms. It is of urgent need to understand the enantioselective bioaccumulations, toxicitie...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-015-4704-2

    authors: Hussain I,ALOthman ZA,Alwarthan AA,Sanagi MM,Ali I

    更新日期:2015-08-01 00:00:00

  • Multi-level modelling of chlorination by-product presence in drinking water distribution systems for human exposure assessment purposes.

    abstract::During drinking water treatment and distribution, chlorine reacts with organic matter occurring in water to form various chlorination by-products (CBPs) such as trihalomethanes (THMs) and haloacetic acids (HAAs). This paper presents the occurrence of THMs and HAAs in different water distribution systems (DS) of the sa...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-010-1709-8

    authors: Legay C,Rodriguez MJ,Miranda-Moreno L,Sérodes JB,Levallois P

    更新日期:2011-07-01 00:00:00

  • A spatio-temporal index for heat vulnerability assessment.

    abstract::The public health consequences of extreme heat events are felt most intensely in metropolitan areas where population density is high and the presence of the urban heat island phenomenon exacerbates the potential for prolonged exposure. This research develops an approach to map potential heat stress on humans by combin...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-011-2502-z

    authors: Kershaw SE,Millward AA

    更新日期:2012-12-01 00:00:00

  • Estimation of chlorophyll a content in inland turbidity waters using WorldView-2 imagery: a case study of the Guanting Reservoir, Beijing, China.

    abstract::Complex optical properties, such as non-pigment suspension and colored dissolved organic matter (CDOM), make it difficult to achieve accurate estimations of remotely sensed chlorophyll a (Chla) content of inland turbidity. Recent attempts have been made to estimate Chla based on red and near-infrared regions where non...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-018-6978-7

    authors: Wang X,Gong Z,Pu R

    更新日期:2018-09-29 00:00:00

  • Status and future of the forest health indicators program of the USA.

    abstract::For two decades, the US Department of Agriculture, Forest Service, has been charged with implementing a nationwide field-based forest health monitoring effort. Given its extensive nature, the monitoring program has been gradually implemented across forest health indicators and inventoried states. Currently, the Forest...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-010-1644-8

    authors: Woodall CW,Amacher MC,Bechtold WA,Coulston JW,Jovan S,Perry CH,Randolph KC,Schulz BK,Smith GC,Tkacz B,Will-Wolf S

    更新日期:2011-06-01 00:00:00

  • An integrated approach to monitoring ecosystem services and agriculture: implications for sustainable agricultural intensification in Rwanda.

    abstract::Maintaining the long-term sustainability of human and natural systems across agricultural landscapes requires an integrated, systematic monitoring system that can track crop productivity and the impacts of agricultural intensification on natural resources. This study presents the design and practical implementation of...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-016-5607-6

    authors: Rosa MF,Bonham CA,Dempewolf J,Arakwiye B

    更新日期:2017-01-01 00:00:00

  • Nationwide classification of forest types of India using remote sensing and GIS.

    abstract::India, a mega-diverse country, possesses a wide range of climate and vegetation types along with a varied topography. The present study has classified forest types of India based on multi-season IRS Resourcesat-2 Advanced Wide Field Sensor (AWiFS) data. The study has characterized 29 land use/land cover classes includ...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-015-4990-8

    authors: Reddy CS,Jha CS,Diwakar PG,Dadhwal VK

    更新日期:2015-12-01 00:00:00

  • Air quality limit and guide values for sulphur dioxide and suspended particulates - A European community directive.

    abstract::On 15 July, 1980, the Council of Ministers of the European Communities adopted a Council Directive on air quality limit values and guide values for sulphur dioxide and suspended particulates. This directive constitutes the first European legislation on stating air quality standards.The guiding principles underlying th...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/BF00403837

    authors: Smeets J

    更新日期:1982-12-01 00:00:00

  • Kinetic and isotherms studies of phosphorus adsorption onto natural riparian wetland sediments: linear and non-linear methods.

    abstract::Riparian wetlands provide critical functions for the improvement of surface water quality and storage of nutrients. Correspondingly, investigation of the adsorption characteristic and capacity of nutrients onto its sediments is benefit for utilizing and protecting the ecosystem services provided by riparian areas. The...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-015-4621-4

    authors: Zhang L,Du C,Du Y,Xu M,Chen S,Liu H

    更新日期:2015-06-01 00:00:00

  • Problems caused by land-misuse; the sample of Erzurum.

    abstract::In especially urban areas and their proximity, environmental pollution has reached a level which threatens both people and public health. Although environmental problems in Turkey have been studied for many cities, including Erzurum, no study is present combining all the environmental matters of the city with short de...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-007-0017-4

    authors: Demircioğlu Yildiz N,Yilmaz H,Toy S

    更新日期:2008-10-01 00:00:00

  • Water demand forecasting: review of soft computing methods.

    abstract::Demand forecasting plays a vital role in resource management for governments and private companies. Considering the scarcity of water and its inherent constraints, demand management and forecasting in this domain are critically important. Several soft computing techniques have been developed over the last few decades ...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-017-6030-3

    authors: Ghalehkhondabi I,Ardjmand E,Young WA 2nd,Weckman GR

    更新日期:2017-07-01 00:00:00

  • Second derivative spectroscopy for the determination of volatilized ammonia from urea-amended soil.

    abstract::A second derivative spectrometer custom fitted with a 1 m stainless steel White cell and maintained at 105°C is used to make real-time measurements of volatilized NH3 from urea-amended soil. Comparison of the technique to impinger data shows a 5-16% discrepancy between the two techniques; however, other experiments pr...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/BF00398842

    authors: Bigelow DS,Ferguson WS,Woodmansee RG

    更新日期:1983-06-01 00:00:00

  • Linked hydrologic and climate variations in British Columbia and Yukon.

    abstract::Climatic and hydrologic variations between the decades 1976-1985 and 1986-1995 are examined at 34 climate stations and 275 hydrology stations. The variations in climate are distributed across a broad spatial area. Temperatures were generally warmer in the most recent decade, with many stations showing significant incr...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1023/a:1006438723879

    authors: Whitfield PH

    更新日期:2001-02-01 00:00:00

  • Uncertainty assessment of mapping mercury contaminated soils of a rapidly industrializing city in the Yangtze River Delta of China using sequential indicator co-simulation.

    abstract::Accurate characterization of heavy-metal contaminated areas and quantification of the uncertainties inherent in spatial prediction are crucial for risk assessment, soil remediation, and effective management recommendations. Topsoil samples (0-15 cm) (n=547) were collected from the Zhangjiagang suburbs of China. The se...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-007-9802-3

    authors: Zhao Y,Xu X,Sun W,Huang B,Darilek JL,Shi X

    更新日期:2008-03-01 00:00:00

  • Assessment of groundwater vulnerability to contamination: a case study.

    abstract::Groundwater is a globally important, valuable resource for human life and economic development. Despite its importance, it is often misused and rarely well managed. Delineation of polluted zone attains significance especially when the pollution affects the human health. Delineation can be done by many approaches: proc...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-019-7493-1

    authors: R R,G S

    更新日期:2019-05-09 00:00:00

  • Equitable fund allocation, an economical approach for sustainable waste load allocation.

    abstract::This research aims to study a novel approach for waste load allocation (WLA) to meet environmental, economical, and equity objectives, simultaneously. For this purpose, based on a simulation-optimization model developed for Haraz River in north of Iran, the waste loads are allocated according to discharge permit marke...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-015-4739-4

    authors: Ashtiani EF,Niksokhan MH,Jamshidi S

    更新日期:2015-08-01 00:00:00

  • A comparison between index of entropy and catastrophe theory methods for mapping groundwater potential in an arid region.

    abstract::In this study, index of entropy and catastrophe theory methods were used for demarcating groundwater potential in an arid region using weighted linear combination techniques in geographical information system (GIS) environment. A case study from Badra area in the eastern part of central of Iraq was analyzed and discus...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-015-4801-2

    authors: Al-Abadi AM,Shahid S

    更新日期:2015-09-01 00:00:00

  • Organochlorine pesticide residues in Songkla Lake.

    abstract::The water quality of Songkla Lake for organochlorine (OC) pesticide contamination was studied from chosen sampling sites (stations) using the lakes geographic data and pollution sources. The water samples were collected monthly from 13 stations in Songkla Lake during September 1991-November 1992. The OC pesticide resi...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/BF00546660

    authors: Kanatharana P,Bunvunno S,Kaewnarong B

    更新日期:1994-10-01 00:00:00

  • Evaluation of uncertainties in environmental impact assessment of naturally occurring radiation exposure situations on example of undisturbed and legacy NORM sites in the Fen Complex, Norway.

    abstract::The risk from naturally occurring radioactive materials (NORM) has been extensively assessed, and this has led to the integration of specific NORM radiation protection requirements within the latest EU Directive 2013/59. Nevertheless, it has been internationally recognised that remaining NORM knowledge gaps and uncert...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-020-08747-8

    authors: Popic JM,Skipperud L

    更新日期:2020-11-24 00:00:00

  • Heavy metal contamination in soil alongside mountain railway in Sichuan, China.

    abstract::Heavy metal concentration in soil was investigated at three sites with different topography (cut slope, flat and embankment) within the vicinity of Chengdu-Kunming railway in Sichuan, China. Surface soil was sampled at certain distances from the track at each site and was analyzed for Cu, Mn, Pb, Zn, Cd by atomic abso...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-008-0293-7

    authors: Liu H,Chen LP,Ai YW,Yang X,Yu YH,Zuo YB,Fu GY

    更新日期:2009-05-01 00:00:00

  • Measuring the wealth of nations.

    abstract::The sustainability of development is closely linked to changes in total per capita wealth. This paper presents estimates of the wealth of nations for nearly 100 countries, broken down into produced assets, natural resources and human resources. While the latter is the dominant form of wealth in virtually all countries...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1023/a:1024054602002

    authors: Hamilton K,Dixon JA

    更新日期:2003-07-01 00:00:00

  • Identification and quantification of microcystins from a Nostoc muscorum bloom occurring in Oukaïmeden River (High-Atlas mountains of Marrakech, Morocco).

    abstract::Health risks generated by cyanobacterial toxins in drinking and recreational waters are clearly recognised. During the monitoring programme on the distribution of toxic freshwater cyanobacteria in various water bodies including reservoirs, ponds and rivers of Morocco, many toxigenic cyanobacteria bloom-forming species...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-008-0220-y

    authors: Oudra B,Dadi-El Andaloussi M,Vasconcelos VM

    更新日期:2009-02-01 00:00:00

  • Managing dredged material in the coastal zone of the Baltic Sea.

    abstract::This article deals with the legal and practical recommendations for the management of dredged material in the riparian countries of the Baltic Sea. The recommendations are contained in three conventions: LC, 2000. London Convention (1972), Convention on the Protection of the Marine Environment of the Baltic Sea area (...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-016-5734-0

    authors: Staniszewska M,Boniecka H

    更新日期:2017-01-01 00:00:00

  • Geochemistry and mobilization of arsenic in Shuklaganj area of Kanpur-Unnao district, Uttar Pradesh, India.

    abstract::The level of arsenic (As) contamination and the geochemical composition of groundwater in Shuklaganj area located on the banks of the Ganges Delta of Kanpur-Unnao district were elucidated. Samples (n = 59) were collected from both India Mark II hand pumps (depth, 30-33 m) and domestic hand pump tube wells (10-12 m) lo...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-011-2310-5

    authors: Chauhan VS,Yunus M,Sankararamakrishnan N

    更新日期:2012-08-01 00:00:00

  • Feeding preference and daily ration of 12 dominant copepods on mono and mixed diets of phytoplankton, rotifers, and detritus in a tropical coastal water.

    abstract::Results of the experimental studies on the feeding habit and daily ration (DR) of 12 dominant copepods from a tropical coastal water (off Kochi, Southwest coast of India) on different food items (phytoplankton, rotifers, and detritus) are presented. Even though, all species of copepods consumed all types of food items...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-017-6215-9

    authors: Jagadeesan L,Jyothibabu R,Arunpandi N,Anjusha A,Parthasarathi S,Pandiyarajan RS

    更新日期:2017-09-11 00:00:00

  • Assessment of elemental concentrations in the urban air (case study: Tehran city).

    abstract::Tehran is one of the megacities of the world with a population of over eight million. Its air is highly polluted mainly due to the suspended particulate matters, which encompasses a wide spectrum of chemical elements. These elements based on their type, size, and impact on the life cycle have various environmental and...

    journal_title:Environmental monitoring and assessment

    pub_type: 杂志文章

    doi:10.1007/s10661-009-0850-8

    authors: Sekhavatjou MS,Rostami A,Hoseini Alhashemi AS

    更新日期:2010-04-01 00:00:00