Chest wall rigidity in two infants after low-dose fentanyl administration.

Abstract:

:Since its introduction into clinical practice, it has been known that fentanyl and other synthetic opioids may cause skeletal muscle rigidity. Involvement of the respiratory musculature, laryngeal structures, or the chest wall may impair ventilation, resulting in hypercarbia and hypoxemia. Although most common with the rapid administration of large doses, this rare adverse effect may occur with small doses especially in neonates and infants. We present 2 infants who developed chest wall rigidity, requiring the administration of neuromuscular blocking agents and controlled ventilation after analgesic doses of fentanyl. Previous reports regarding chest wall rigidity after the administration of low-dose fentanyl in infants and children are reviewed, the pathogenesis of the disorder is discussed, and treatment options offered.

journal_name

Pediatr Emerg Care

journal_title

Pediatric emergency care

authors

Dewhirst E,Naguib A,Tobias JD

doi

10.1097/PEC.0b013e3182535a2a

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

465-8

issue

5

eissn

0749-5161

issn

1535-1815

pii

00006565-201205000-00015

journal_volume

28

pub_type

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