Rhabdomyolysis associated with olanzapine treatment in a child with Autism.

Abstract:

:Children with autism often display difficult behaviors including tantrums, extreme irritability, and physical aggression. There is emerging evidence that olanzapine is useful in decreasing these disruptive behaviors. The most common adverse effects are weight gain and short-term sedation. On the other hand, olanzapine rarely causes rhabdomyolysis. We report a case with rhabdomyolysis in an autistic child just after 2 doses of olanzapine treatment. Initial creatine kinase value was 30,690 IU/L (range, 5-130 U/L), and rhabdomyolysis resolved with hydration and alkalinization over 7 days. Monitoring serum creatine kinase levels may be useful in pediatric cases after initiation of olanzapine treatment.

journal_name

Pediatr Emerg Care

journal_title

Pediatric emergency care

authors

Karakaya P,Yiş U,Kurul SH,Türkmen MA

doi

10.1097/PEC.0b013e3181c39a22

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

41-2

issue

1

eissn

0749-5161

issn

1535-1815

pii

00006565-201001000-00010

journal_volume

26

pub_type

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