Abstract:
PURPOSE:To characterize the molecular biologic environment of pathological skin in ocular rosacea and to differentiate the levels of inflammatory molecules in ocular rosacea from those of normal skin. METHODS:The concentrations of 48 molecules were assayed in cutaneous biopsies taken from patients with ocular rosacea and from normal controls. RESULTS:There were very few molecular differences between the 2 groups, and 43 of the 48 molecules that were measured in this study were not significantly different between the 2 groups. The concentrations of 5 molecules (interleukin-1β, interleukin-16, stem cell factor, monocyte chemotactic protein-1, and monokine induced by γ-interferon) were significantly enriched in ocular rosacea. CONCLUSIONS:Ocular rosacea is a highly ordered molecular process and involves elevations in the concentrations of specific molecules. The particular pattern of enrichment supports the notion that ocular rosacea represents a disorder of innate immunity. Furthermore, these molecules may represent novel therapeutic targets in the future management of this disorder.
journal_name
Ophthalmic Plast Reconstr Surgjournal_title
Ophthalmic plastic and reconstructive surgeryauthors
Wladis EJ,Iglesias BV,Adam AP,Gosselin EJdoi
10.1097/IOP.0b013e31824dd9d4subject
Has Abstractpub_date
2012-07-01 00:00:00pages
246-50issue
4eissn
0740-9303issn
1537-2677journal_volume
28pub_type
杂志文章abstract::A 26-year-old woman with congenital lamellar ichthyosis presented with bilateral cicatricial ectropion of the upper and lower eyelids. There was severe exposure keratopathy with corneal perforation in the left eye. The generalized skin involvement necessitated the use of an alternative to correct the cicatricial ectro...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3182082f4e
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To study the canalicular anatomy in patients with an enlarged sac secondary to nasolacrimal duct obstruction. METHODS:This study included 76 lacrimal drainage systems (LDS) of 41 adult patients with a palpable sac, which were visualized using posteroanterior digital subtraction macrodacryocystography. In 42 LD...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181647d01
更新日期:2008-03-01 00:00:00
abstract::Kocuria rosea is usually a nonpathogenic commensal colonizing the skin and oropharynx but can become an opportunistic pathogen in immunocompromised states. Documented cases of any infections with K. rosea are exceedingly rare. This study reports the first case of canaliculitis with K. rosea, its clinicomicrobiological...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3182a650dd
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To examine the positional relationship between the ethmoidal foramina and the frontoethmoidal suture. METHODS:Eighty-four orbits of 42 Japanese cadavers (24 male and 18 female cadavers; average age at death, 81.0 years; range, 61-101 years), fixed in 10% buffered formalin, were used for investigation. The most...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e318222eb82
更新日期:2011-11-01 00:00:00
abstract::The implantation of an orbital hydroxyapatite implant was complicated by conjunctival dehiscence, cutaneous fistula formation, and infection with Staphylococcus aureus. Pathologic examination of the sphere 2 years after its implantation revealed reduction in the size of the implant, peripheral lamellar bone formation ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199606000-00008
更新日期:1996-06-01 00:00:00
abstract::A 47-year-old women presented with a mass on the right medial canthal area for 10 years. On examination, an 18 × 12-mm sized, hard, unmovable subcutaneous mass was palpated. The tear meniscus was high, but the lacrimal outflow system was patent when irrigated. The mass was surgically excised. It was well-demarcated wi...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181e173c4
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To report the novel use of the osteotome as an adjunctive instrument in Endoscopic Dacryocystorhinostomy (DCR). MATERIALS AND METHODS:A retrospective interventional case series of 15 patients, underwent endoscopic DCR at the Singapore National Eye Centre, by a single ophthalmologist and rhinologist between Apr...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3182622375
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:The pathogenesis, natural history, histopathology, and recommended treatment for orbital angiosarcoma are illustrated and reviewed. METHODS:Case report. RESULTS:A 71-year-old white male presented with bluish discoloration and swelling of the left medial canthal area. A fine needle aspiration and excisional bi...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199911000-00019
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:Acquired nasolacrimal duct obstruction (NLDO) is a common problem leading to epiphora, the pathophysiology of which remains unclear. Culture-based studies have found Staphylococcal species to be the most prevalent organisms, reported in 47% to 73% of patients with NLDO. Recently, culture-independent molecular m...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001473
更新日期:2020-01-01 00:00:00
abstract::Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan may result in hemorrhagic tumor necrosis with acute orbital and intracranial inflammation. ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181b9ffed
更新日期:2010-05-01 00:00:00
abstract::A mass that recurred after dacryocystectomy for benign squamous papilloma of the lacrimal sac was diagnosed as a high-grade mucoepidermoid carcinoma in a 53-year-old man on histopathology. Local excision to the orbital periosteum was performed and gave a margin free of invasion. Neither local recurrence nor systemic m...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181eea4e4
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:The goal of this study is to determine the functional and dynamic effects of hyaluronic acid (HA) gel injection into the levator plane for improving upper eyelid retraction in patients with thyroid eye disease (TED). METHODS:This is a prospective, non-randomized study of consecutive patients with symptomatic u...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000130
更新日期:2014-09-01 00:00:00
abstract::An 81-year-old man with ocular irritation associated with lower eyelid retraction, horizontal laxity of the lower eyelids, and hypoplastic inferior orbital rims underwent bilateral placement of porous polyethylene orbital rim onlay implants. Two weeks after surgery, he developed vertical binocular diplopia on downgaze...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-200301000-00014
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Soft tissue dermal fillers, both temporary and permanent, are used frequently in facial rejuvenation. As the use of fillers increases, ischemic complications including skin necrosis are becoming more prevalent. In the literature, topical nitroglycerin paste has been recommended in the early treatment of patient...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000446
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To describe 9 cases of chronic cutaneous lupus of the eyelid, its potential similarities with squamous epithelial malignancies, and clinical and histopathologic features that assist in distinguishing lupus from epidermal neoplasia. METHODS:The authors identified and reviewed 9 cases of cutaneous lupus involvin...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181f29d4d
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To describe the technique of anterior approach white-line advancement for correction of ptosis. METHODS:Retrospective review of consecutive cases that underwent anterior approach white-line advancement for correction of aponeurotic ptosis. In this technique, the posterior surface of the levator aponeurosis (wh...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000543
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:Pilomatrixoma is a benign tumor of the hair follicle, occurring more frequently in the head and neck. There are relatively few published large case series in the ophthalmic literature. The purpose of this study was to evaluate additional case series of patients with periocular pilomatrixoma, treated in the inst...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000164
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Mucoepidermoid carcinoma involving the eye or its adnexa generally arises from the conjunctiva. We describe a nodular lesion of the lower eyelid skin with histologic features consistent with low-grade mucoepidermoid carcinoma. METHOD:Case report. RESULTS:By histology, the tumor demonstrated areas of squamous ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199909000-00013
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:Myopathic blepharoptoses (ptoses) is a complex group of disorders. To date, no formal categorization scheme has been developed based on associated ocular and systemic findings, genetic fingerprint, treatment, and prognosis for each ptosis in this group. We report a new classification scheme for myopathic ptoses...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章,评审
doi:10.1097/IOP.0000000000001405
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:We describe the first reported cases of cerebral vasospasm, ischemia, and infarct after orbital decompression surgery for Graves disease-related ophthalmopathy. METHODS:We present two patients who had inadvertent penetration of the dura mater during orbital decompression surgery. One case was recognized at sur...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/01.iop.0000134248.64325.c7
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To evaluate current physician patterns for diagnostic lacrimal imaging in patients with epiphora related to lacrimal obstruction. METHODS:An invitation was sent to members of the American Society of Ophthalmic Plastic and Reconstruction Surgeons in September 2008 to participate in a short web-based questionnai...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0b013e3181b8c747
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:The purpose of the present study is to report authors' experience of primary powered endoscopic dacryocystorhinostomy in the setting of acute dacryocystitis and lacrimal sac abscess. METHODS:A prospective interventional case series of 20 primary powered endoscopic dacryocystorhinostomies were performed in 20 p...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000309
更新日期:2015-07-01 00:00:00
abstract::Primary adenocarcinomas of the lacrimal gland rarely display sebaceous differentiation. An anaplastic lacrimal gland neoplasm manifesting this feature was excised from a 64-year-old man who initially appeared with recurrent painless subconjunctival hemorrhages. Globe displacement and tumor-induced hyperopia were later...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-199112000-00001
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:To report three patients with sinonasal undifferentiated carcinoma (SNUC) that invaded the orbit. METHODS:Retrospective small case series. The clinical, radiographic, and pathologic features of three patients with SNUC were reviewed. RESULTS:Three patients with SNUC that invaded the orbit were evaluated. A bi...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-200107000-00009
更新日期:2001-07-01 00:00:00
abstract::Thirty-nine cases of orbital exenteration performed at the Orbital Unit of the University of Naples during a 10-year period are reviewed. The incidence of dural exposure and CSF leaks is evaluated and related to the different pathologies. The appropriate treatments of these complications are discussed. ...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/00002341-198703020-00001
更新日期:1987-01-01 00:00:00
abstract::Progressive hemifacial atrophy or Parry Romberg syndrome may present with variable ocular features, the commonest being enophthalmos. We report a mild case in a 62-year-old man who presented with upper eyelid retraction, nocturnal lagophthalmos, and symptoms of corneal exposure. Recession of the levator muscle correct...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between time to surgical intervention and extraocular motility outcomes in children following repair of an orbital floor fracture with inferior rectus entrapment. METHODS:After institution review board's approval, a retrospective, consecutive case series of 28 children with unilate...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000993
更新日期:2018-07-01 00:00:00
abstract::The authors describe a 9-year-old female who presented with swelling, proptosis, and tenderness of the right upper eyelid and MRI imaging demonstrating right lacrimal gland enlargement. After failing treatment with corticosteroids, the patient underwent a biopsy that was consistent with IgG4-related orbital disease. S...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000959
更新日期:2018-01-01 00:00:00
abstract::Ocular tick infestation is a rare occurrence. The authors report a case that is unique for being the first published example from New England, for its chronic presentation, and for the inclusion of histopathologic analysis in its diagnostic workup. A 75-year-old man was evaluated for a persistent eyelid growth seconda...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000000231
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:The authors present a new series of our experience using posterior approach levatorpexy for congenital ptosis with poorer levator function (LF) in comparison with our first published report. This technique avoids a skin incision or any resection in addition to no excision of tissue. METHODS:A consecutive serie...
journal_title:Ophthalmic plastic and reconstructive surgery
pub_type: 杂志文章
doi:10.1097/IOP.0000000000001056
更新日期:2018-09-01 00:00:00