Molecular biologic assessment of cutaneous specimens of ocular rosacea.

Abstract:

PURPOSE:To characterize the molecular biologic environment of pathological skin in ocular rosacea and to differentiate the levels of inflammatory molecules in ocular rosacea from those of normal skin. METHODS:The concentrations of 48 molecules were assayed in cutaneous biopsies taken from patients with ocular rosacea and from normal controls. RESULTS:There were very few molecular differences between the 2 groups, and 43 of the 48 molecules that were measured in this study were not significantly different between the 2 groups. The concentrations of 5 molecules (interleukin-1β, interleukin-16, stem cell factor, monocyte chemotactic protein-1, and monokine induced by γ-interferon) were significantly enriched in ocular rosacea. CONCLUSIONS:Ocular rosacea is a highly ordered molecular process and involves elevations in the concentrations of specific molecules. The particular pattern of enrichment supports the notion that ocular rosacea represents a disorder of innate immunity. Furthermore, these molecules may represent novel therapeutic targets in the future management of this disorder.

authors

Wladis EJ,Iglesias BV,Adam AP,Gosselin EJ

doi

10.1097/IOP.0b013e31824dd9d4

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

246-50

issue

4

eissn

0740-9303

issn

1537-2677

journal_volume

28

pub_type

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