Abstract:
: Background: Multi-drug resistance is considered a serious health threat particularly in the intensive care unit (ICU) setting. Studies evaluating multi-drug-resistant (MDR) pathogens in critically ill trauma patients are limited. The objectives were to describe the incidence of MDR, extensive-drug-resistant (XDR), and pan-drug-resistant (PDR) organism growth in ICU patients admitted with traumatic injuries and to identify any risk factors associated with MDR growth. Patients and Methods: This was a retrospective single-center cohort study of all ICU adult patients identified via the institution's trauma registry from January 1, 2016 to August 31, 2017. Patients were included if they had positive culture growth with susceptibility data taken during the index hospitalization. Patients were excluded if their cultures were drawn within 48 hours of emergency department triage. Study groups were defined based on the presence of at least one MDR pathogen during the index hospitalization. Results: A total of 2,578 charts were reviewed and 95 patients (mean age, 60 years; 66 males [69%]) with 201 total cultures were included. The majority of positive cultures were from respiratory (69%) and urinary (16%) sources. Of the 201 positive cultures, the majority of species identified was Enterobacteriaceae (47%), Staphylococcus (32%), Enterococcus (7%), Acinetobacter (5%), and Pseudomonas (3%). Of the 95 patients with positive cultures, the incidence of MDR, XDR, and PDR organisms was found to be 31%, 17%, and 0%, respectively. Augmented renal clearance (ARC) was the only risk factor associated with an increased risk for MDR organism growth (adjusted odds ratio 9.78, 95% confidence interval [CI] 2.56-37.41; p = 0.001). Conclusions: In this cohort of critically ill trauma patients, the incidence of an MDR pathogen occurred in 31% of patients. This is the first study to find an association of ARC and multi-drug resistance, which should be further validated as a potential cause for MDR organisms.
journal_name
Surg Infect (Larchmt)journal_title
Surgical infectionsauthors
Cucci M,Wooten C,Fowler M,Mallat A,Hieb N,Mullen Cdoi
10.1089/sur.2019.031subject
Has Abstractpub_date
2020-02-01 00:00:00pages
15-22issue
1eissn
1096-2964issn
1557-8674journal_volume
21pub_type
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journal_title:Surgical infections
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journal_title:Surgical infections
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journal_title:Surgical infections
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pub_type: 杂志文章,评审
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journal_title:Surgical infections
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Surgical infections
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journal_title:Surgical infections
pub_type: 杂志文章,评审
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journal_title:Surgical infections
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journal_title:Surgical infections
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