The morphine sparing effects of diclofenac sodium following abdominal surgery.

Abstract:

:A randomised, double-blind placebo controlled study was undertaken to assess the analgesic efficacy of diclofenac. Following major abdominal surgery and 12 hours later, patients received either placebo or diclofenac 75 mg intramuscularly and their cumulative morphine requirements administered by a patient-controlled system over 24 hours were compared. Pain scores were also measured. Arterial blood gases and coagulation studies were assessed pre- and postoperatively. Morphine consumption was significantly greater in the placebo group (59.5 compared to 38.5 mg, p less than 0.01). Pain scores were significantly lower in the diclofenac group at 4 hours, but not thereafter. Arterial carbon dioxide was significantly increased in the control groups. There was no significant change in platelet count within each group, but a significant difference between the groups (p less than 0.05).

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Hodsman NB,Burns J,Blyth A,Kenny GN,McArdle CS,Rotman H

doi

10.1111/j.1365-2044.1987.tb05377.x

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

1005-8

issue

9

eissn

0003-2409

issn

1365-2044

journal_volume

42

pub_type

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