A plausible anti-apoptotic role of up-regulated OCT4B1 in bladder tumors.

Abstract:

PURPOSE:To investigate and compare the expression of OCT4B1 between tumor and non-tumor bladder tissues. MATERIALS AND METHODS:We investigated the expression of OCT4B1 in 30 tumor and non-tumor surgical specimens of the bladder, using the TaqMan real-time polymerase chain reaction approach and by carefully designing primers and probes specific for the amplification of the variant. RESULTS:Most tumor and non-tumor samples of the bladder showed OCT4B1 expression, but its expression level was significantly higher in the tumors (P < .002). Moreover, the up-regulation of OCT4B1 was more significant in high-grade tumors compared to the low-grade ones (P < .05). We have also employed the RNA interference strategy to evaluate the functional role of OCT4B1 in a bladder cancer cell line, 5637. Suppression of OCT4B1 caused some changes in cell cycle distribution, and significantly elevated the rate of apoptosis in the cells. CONCLUSION:Our findings suggest that OCT4B1 plays a potential role in tumor initiation and/or progression of the bladder cancer. Additionally, OCT4B1 can be regarded as a new tumor marker for detection, classification, and treatment of the bladder cancer. However, more experimental studies are needed to replicate our findings.

journal_name

Urol J

journal_title

Urology journal

authors

Asadzadeh J,Asadi MH,Shakhssalim N,Rafiee MR,Kalhor HR,Tavallaei M,Mowla SJ

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

574-80

issue

3

eissn

1735-1308

issn

1735-546X

pii

1595/668

journal_volume

9

pub_type

杂志文章
  • Prediction of prostatic involvement by transitional cell carcinoma of the bladder using pathologic characteristics of the bladder tumor.

    abstract:INTRODUCTION:The aim of this prospective study is to determine the relationship between the pathologic characteristics of the transitional cell carcinoma (TCC) of the bladder and prostatic involvement. MATERIALS AND METHODS:Sixty men with bladder TCC underwent standard radical cystoprostatectomy and were enrolled in t...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Tabibi A,Simforoosh N,Parvin M,Abadpour B,Abdi H,Khafri S

    更新日期:2006-07-01 00:00:00

  • Effect of smoking on prognostic factors of transitional cell carcinoma of the bladder.

    abstract:PURPOSE:This study was conducted to evaluate the effects of smoking on the clinical characteristics and growth trend of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS:In a retrospective case-control study from February 2000 to March 2003, patients with TCC of bladder, referred to our clinic, w...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Mohseni MG,Zand S,Aghamir SM

    更新日期:2004-10-01 00:00:00

  • Urinary Tract Endometriosis.

    abstract::Recently, occurrence of urinary tract endometriosis (UTE) is more frequently diagnosed. According to literature, it refers to approximately 0.3 to even 12% of all women with endometriosis. The pathogenesis of UTE has not been clearly explained so far. The actually proposed hypotheses include embryonic, migration, tran...

    journal_title:Urology journal

    pub_type: 杂志文章,评审

    doi:

    authors: Kołodziej A,Krajewski W,Dołowy Ł,Hirnle L

    更新日期:2015-09-04 00:00:00

  • Comparison of safety and efficacy of laparoscopic pyelolithotomy versus percutaneous nephrolithotomy in patients with renal pelvic stones: a randomized clinical trial.

    abstract:PURPOSE:A randomized clinical trial was designed to compare the efficacy, success rate and surgical complications of percutaneous nephrolithotomy (PCNL) and laparoscopic pyelolithotomy (LP). MATERIALS AND METHODS:Sixty patients with renal pelvic stones larger than 2 cm were randomly divided into two groups of LP and P...

    journal_title:Urology journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Basiri A,Tabibi A,Nouralizadeh A,Arab D,Rezaeetalab GH,Hosseini Sharifi SH,Soltani MH

    更新日期:2014-11-30 00:00:00

  • Modified Hinderer's Technique for Serious Proximal Hypospadias with Ventral Curvature: Outcomes and Our Experience.

    abstract:PURPOSE:Hypospadias is a congenital anomaly that includes defi¬cient ventral structure of the penis. Proximal hypospadias cases make up 20% of all hypospadias cases. The choice of operative technique for hypospadias repair depends on the severity, and it is influenced by the surgeon's experience and perception of where...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.4376

    authors: Ciftci I,Gunduz M,Sekmenli T

    更新日期:2019-10-21 00:00:00

  • Retained Surgical Gauze Presenting With Gross Hematuria: A Case Report.

    abstract::Gossipyboma is a mass which is made around a cotton sponge or abdominal compress retained in a patient during surgery accidentally. Patients manifest with either acute or chronic symptoms due to complications. Here in wereported an 89-year-old man case of transvesical migration of gossipyboma who presented with gross ...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Javanmard B,Yousefi MR,Fadavi B,Fallah Karkan M

    更新日期:2017-08-29 00:00:00

  • Does Preoperative Use of Dutasteride Decrease Bleeding During Open Prostatectomy?

    abstract:PURPOSE:To investigate whether use of dutasteride, a 5-alpha reductase inhibitor, for at least four weeks preoperatively affected the blood loss during open prostatectomy (OP). MATERIALS AND METHODS:Retrospective analysis was made of the data of 110 patients who had undergone OP. Group I comprised 50 patients that use...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.3693

    authors: Demirbas A,Resorlu B,Gulpinar MT,Kardas S,Doluoglu OG,Tepeler A,Kilinc MF,Karakan T,Ozcan S

    更新日期:2018-01-23 00:00:00

  • Capsulotomy for treatment of compartment syndrome in patients with post extracorporeal shock wave lithotripsy renal hematomas: safe and effective, but also advisable?

    abstract:PURPOSE:To examine whether surgical decompression of hematomas by capsulotomy can help to improve long-term renal function following extracorporeal shock wave lithotripsy (SWL). MATERIALS AND METHODS:This study retrospectively identified 7 patients who underwent capsulotomy for post SWL renal hematomas between 2008 an...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Al Ghazal A,Schnoeller TJ,Baechle C,Steinestel J,Jentzmik F,Steffens S,Hirning C,Schrader M,Schrader AJ

    更新日期:2014-07-08 00:00:00

  • Laparoscopic Pyelolithotomy for the Management of Large Renal Stones with Intrarenal Pelvis Anatomy.

    abstract:PURPOSE:The role of laparoscopic pyelolithotomy in the management of renal stones is evolving. One of the challenges in LPL for renal stones are patients with intrarenal pelvis. Here we present our experience with laparoscopic pyelolithotomy for the management of renal stones with intrarenal pelvis anatomy. MATERIALS ...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.5576

    authors: Simforoosh N,Radfar MH,Valipour R,Dadpour M,Kashi AH

    更新日期:2020-04-13 00:00:00

  • Orchidopexy for retractile testes in infertile men: a prospective clinical study.

    abstract:INTRODUCTION:Retractile testis may affect testicular parenchyma and spermatogenesis, and surgical treatment has been recommended for infertile men with retractile testes. We evaluated outcomes of orchidopexy in men with idiopathic infertility who suffered from bilateral retractile testes. MATERIALS AND METHODS:We perf...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Dadfar MR

    更新日期:2007-07-01 00:00:00

  • Does Systemic Disease Aggravate the Severity of Dry Mouth by Anticholinergics in Overactive Bladder Patients?

    abstract:PURPOSE:In overactive bladder (OAB) patients with systemic diseases, dry mouth tends to be more prominent owing to the effects of systemic diseases or related medications. We evaluated how systemic diseases affect dry mouth before and after anticholinergic treatment. MATERIALS AND METHODS:OAB patients were enrolled in...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Lee KC,Seong BM

    更新日期:2017-03-16 00:00:00

  • Comparison of the Effects of Clofibrate and Silafibrate on Sperm Parameters Quality and Sex Hormones in Male Rats.

    abstract:PURPOSE:Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of clofibrate, called silafibrate, have shown good lipid lowering effects. This study was designed to assess the role of silafibrate as a peroxisome proliferator-activated receptors (PPARs) agonist...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.3954

    authors: Delashoub M,Ziaee M,Khorrami A,Banan-Khojasteh SM

    更新日期:2018-03-18 00:00:00

  • Diuresis renography for differentiation of upper urinary tract dilatation from obstruction: F+20 and F-15 methods.

    abstract:INTRODUCTION:The aim of this study was to evaluate diuresis renography with an intravenous injection of furosemide 20 minutes after administering the radiopharmaceutical (F+20 protocol) or 15 minutes before (F-15 protocol) in patients with upper urinary tract dilatation. MATERIALS AND METHODS:Twenty-one patients with ...

    journal_title:Urology journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Taghavi R,Ariana K,Arab D

    更新日期:2007-01-01 00:00:00

  • Postoperative Progress after Stone Removal Following Treatment for Obstructive Acute Pyelonephritis Associated with Urinary Tract Calculi: A Retrospective Study.

    abstract:PURPOSE:We aimed to identify the prevalence and risk factors of three outcomes after stone removal following treatment for obstructive acute pyelonephritis (APN) associated with urinary tract calculi: immediate postoperative febrile urinary tract infection (UTI), stone recurrence, and APN recurrence during the follow-u...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.4847

    authors: Yamashita S,Kohjimoto Y,Higuchi M,Ueda Y,Iguchi T,Hara I

    更新日期:2020-03-16 00:00:00

  • Is modified retroperitoneal lymph node dissection alive for clinical stage I non-seminomatous germ cell testicular tumor?

    abstract:PURPOSE:To evaluate efficacy of modified retroperitoneal lymph node dissection (RPLND) in the management of patients with pathological stage (PS) I non-seminomatous germ cell testicular tumor (NSGCT) in a retrospective study. MATERIALS AND METHODS:Between April 2002 and April 2012, 55 patients with clinical stage (CS)...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Basiri A,Ghaed MA,Simforoosh N,Tabibi A,Danesh A,Nouralizadeh A,Parizi MK

    更新日期:2013-04-01 00:00:00

  • Evaluation of the Results and Complications of Transabdominal Preperitoneal Laparoscopic Inguinal Hernia Repair in Patients with a History of Radical Prostatectomy.

    abstract:PURPOSE:Radical prostatectomy is one of the most common urological surgeries. Inguinal hernia is a well-known complication of radical prostatectomy. There are many controversies about selection of surgical techniques for repair of inguinal hernia. Traditionally laparoscopic approach was contraindicated for patients wit...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.4751

    authors: Izadpanahi MH,Milasi R

    更新日期:2020-01-26 00:00:00

  • The α1 adrenoceptor antagonist tamsulosin for the treatment of voiding symptoms improves nocturia and sleep quality in women.

    abstract:PURPOSE:Nocturia is the main cause of disturbance of sleep maintenance and negatively impacts quality of life (QoL). We assessed the effects of the α1-adrenoceptor antagonist, tamsulosin, on nocturia and quality of sleep, for the treatment of lower urinary tract symptoms (LUTS) in women with a maximal flow rate (Qmax) ...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Kim SO,Choi HS,Kwon D

    更新日期:2014-07-08 00:00:00

  • Ratios of free to total prostate-specific antigen and total prostate specific antigen to protein concentrations in saliva and serum of healthy men.

    abstract:INTRODUCTION:We evaluated the ratio of free to total prostate-specific antigen (PSA) and PSA to protein concentrations in saliva and serum of healthy men. MATERIALS AND METHODS:Concentrations of protein, free PSA, and total PSA in serum and saliva were measured in 30 healthy men aged 42 to 73 years, and their ratios w...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Ayatollahi H,Darabi Mahboub MR,Mohammadian N,Parizadeh MR,Kianoosh T,Khabbaz Khoob M,Kamalian F

    更新日期:2007-10-01 00:00:00

  • Pre-operative imaging may overestimate the kidney tumor size.

    abstract:PURPOSE:To compare the kidney tumor size on radical nephrectomy pathology specimen with size estimated by computed tomography (CT) scan and ultrasonography. MATERIALS AND METHODS:The tumor size on pathology specimen of 40 patients who had undergone radical nephrectomy at our center from March 2003 until March 2009 was...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Nasseh HR,Falahatkar S,Ghanbari A,Bagheri Chenari H

    更新日期:2012-10-01 00:00:00

  • Trans-Obturator Approach and the Native Tissue in the treatment of High Stage Prolapse of the Anterior Vaginal Wall: Midterm Results of a New Surgical Technique.

    abstract:PURPOSE:Pelvic organ prolapse is a common condition  as a consequence of the pelvic floor support weakness. This study evaluated the clinical results of treating the high stage prolapse of the anterior vaginal wall using a trans-obturator approach and the native vaginal wall tissue. METHODS:This was a prospective anal...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.5619

    authors: Sharifiaghdas F

    更新日期:2020-06-18 00:00:00

  • Does age affect outcomes of percutaneous nephrolithotomy?

    abstract:INTRODUCTION:The present study aimed to assess the efficacy and safety of percutaneous nephrolithotomy (PCNL) in elderly patients. MATERIALS AND METHODS:We retrospectively reviewed 50 PCNLs performed in the elderly patients (age > 65 years) carried out in our clinic from 2001 through 2007 and compared those with 248 P...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Karami H,Mazloomfard MM,Golshan A,Rahjoo T,Javanmard B

    更新日期:2010-01-01 00:00:00

  • Risk Factors Associated with Chronic Kidney Disease In Infants With Posterior Urethral Valve: A Single Center Study of 110 Patients Managed By Valve Ablation And Bladder Neck Incision.

    abstract:PURPOSE:Concurrent valve ablation and bladder neck incision is suggested as an effective and safe treatment approach in posterior urethral valve children with prominent bladder neck. We evaluated chronic kidney disease risk factors in these children. MATERIALS AND METHODS:We retrospectively reviewed medical records of...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v16i7.6038

    authors: Amirzargar H,Shahab E,Ghahestani S,Hekmati P,Arshadi H

    更新日期:2020-09-23 00:00:00

  • Is RIRS Safe and Efficient In Patients With Kidney Stones Who Had Previous Open, Endoscopic, or Percutaneous Kidney Stone Surgery? One Center Retrospective Study.

    abstract:PURPOSE:In our study, we assessed the efficiency and reliability of retrograde intrarenal surgery secondary to open surgery for kidney stone treatment. Moreover, we compared the efficiency and safety of retrograde intrarenal surgery for the patients with previous history of open surgery, percutaneous nephrolithotomy, s...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.4950

    authors: Baylan B,Sari S,Cakici MC,Selmi V,Özdemir H,Ozok HU,Karakoyunlu AN,Topaloglu H,Sagnak AL,Ersoy H

    更新日期:2020-05-16 00:00:00

  • Appendiceal conduit: A novel technique to be applied after radical cystectomy: A case study report.

    abstract::This paper introduces a novel technique, known as appendiceal conduit. It could be used as an alternative for ileal conduit and cutaneous ureterostomy, ultimately applied after radical cystectomy. The six-month follow-up indicated that the patient had appendix-stoma as nipple without any stenosis, nor did he have any ...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v0i0.5513

    authors: Moudi E,Ghasemi Shektaie SH,Rostami G

    更新日期:2020-06-18 00:00:00

  • Effect of hydroalcoholic extract of Hypericum perforatum L. leaves on ethylene glycol-induced kidney calculi in rats.

    abstract:PURPOSE:To investigate the effects of the hydroalcoholic extract of Hypericum perforatum (H. perforatum) leaves on the kidney calculi in rats. MATERIALS AND METHODS:Fifty-two Wistar male rats were randomly divided into 4 groups: Groups 2, 3, and 4 received ethylene glycol (EG) 1% + ammonium chloride (0.5%)-added drink...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Khalili M,Jalali MR,Mirzaei-Azandaryani M

    更新日期:2012-04-01 00:00:00

  • Comparing absorbable and nonabsorbable sutures in corporeal plication for treatment of congenital penile curvature.

    abstract:PURPOSE:To compare the outcome of corporeal plication using absorbable versus nonabsorbable sutures for the treatment of congenital penile curvature. MATERIALS AND METHODS:Thirty-eight men older than 15 years old with congenital penile curvature were enrolled in the study. Patients were randomly divided into two equal...

    journal_title:Urology journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Basiri A,Sarhangnejad R,Ghahestani SM,Radfar MH

    更新日期:2011-10-01 00:00:00

  • Sexual Dysfunction in Premenopausal Women With Obstructive Sleep Apnea.

    abstract:PURPOSE:Sexual functions in the males with obstructive sleep apnea syndrome (OSAS) have been well investigated in the literature; however sexual functions in the premenopausal women with OSAS have been studied to a lesser extent. MATERIALS AND METHODS:The study included 22 premenopausal women diagnosed as OSAS by the ...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:10.22037/uj.v14i6.3891

    authors: Yilmaz Z,Sirinocak PB,Voyvoda B,Ozcan L

    更新日期:2017-11-04 00:00:00

  • Transcutaneous ultrasound guided nephrolithotomy: the first report from Iran.

    abstract:PURPOSE:To evaluate the safety and efficacy of transcutaneous ultrasound guided nephrolithotomy. MATERIALS AND METHODS:From December 1999 to December 2000, 12 patients with renal stone were selected for PCNL. Six patients had failed ESWL and the remainder had multiple and large stones in pelvis and lower calyx. Ultras...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Etemadian M,Amjadi M,Simforoosh N

    更新日期:2004-04-01 00:00:00

  • Asymptomatic bacteriuria in users of intrauterine devices.

    abstract:INTRODUCTION:The aim of this study was to compare the frequency of asymptomatic bacteriuria in women who use intrauterine devices (IUDs) as a contraceptive method with subjects who use tubal ligation (TL). MATERIALS AND METHODS:A cohort study was conducted on women who were candidates for IUD insertion or TL (control)...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Fallahian M,Mashhady E,Amiri Z

    更新日期:2005-07-01 00:00:00

  • Does the use of smaller Amplatz sheath size reduce complication rates in percutaneous nephrolithotomy?

    abstract:PURPOSE:To evaluate the effect of Amplatz sheath size used in percutaneous nephrolithotomy (PCNL) on postoperative outcomes, bleeding and renal impairment rates. MATERIALS AND METHODS:We retrospectively evaluated the records of 91 patients who had undergone PCNL. We divided the patients into 2 groups according to Ampl...

    journal_title:Urology journal

    pub_type: 杂志文章

    doi:

    authors: Karakose A,Aydogdu O,Atesci YZ

    更新日期:2014-09-02 00:00:00