Abstract：
:Somatostatin receptors (SSTR) are upregulated in the cells of origin that define numerous neuroendocrine neoplasms. PET imaging with 68Ga-DOTATATE allows specific targeting of SSTR2A, a single species of SSTR receptor, which is commonly overexpressed in a variety of gastroenteropancreatic neuroendocrine tumors, as well as pulmonary carcinoid and head and neck tumors. Due to more specific targeting of SSTR2 as well as lower radiation dose, shorter study length, ability to quantify uptake, and lower cost, 68Ga-DOTATATE has demonstrated superior imaging attributes when compared to 111In-pentetreotide. As with any novel imaging modality, dedicated training, increasing experience and staying up-to-date with scientific publications are required to provide optimal patient care. The purpose of this review is to summarize the current state of the art in SSTR-targeted molecular imaging and discuss ongoing and future potential diagnostic and therapeutic applications.
journal_name
Clin Imagingjournal_title
Clinical imagingauthors
Ivanidze J,Roytman M,Sasson A,Skafida M,Fahey TJ 3rd,Osborne JR,Dutruel SPdoi
10.1016/j.clinimag.2019.04.006subject
Has Abstractpub_date
2019-01-01 00:00:00pages
146-154eissn
0899-7071issn
1873-4499pii
S0899-7071(19)30072-5journal_volume
56pub_type
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