Tumor-induced osteomalacia - Current imaging modalities and a systematic approach for tumor localization.

Abstract:

:Paraneoplastic syndromes are symptom complexes that cannot be readily explained by local or distant spread of the tumor. They can occur due to hormone production, autoimmunity or other biologically active products produced by the tumor, etc. Tumor induced osteomalacia is a rare paraneoplastic syndrome in which the manifestation is mainly musculoskeletal such as bone pain, fractures and muscle weakness as a consequence of elaboration of fibroblast growth factor 23 (FGF23) by the tumor. Most of these tumors are solitary and small and hence localization of these tumors is often challenging. This review summarizes the various anatomic imaging modalities such as plain radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) and nuclear medicine imaging techniques in the evaluation of these tumors.

journal_name

Clin Imaging

journal_title

Clinical imaging

authors

Rayamajhi SJ,Yeh R,Wong T,Dumeer S,Mittal BR,Remotti F,Chikeka I,Reddy AK

doi

10.1016/j.clinimag.2019.04.007

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

114-123

eissn

0899-7071

issn

1873-4499

pii

S0899-7071(19)30073-7

journal_volume

56

pub_type

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