Remnant Gastric Cancer After Roux-en-Y Gastric Bypass: Narrative Review of the Literature.

Abstract:

BACKGROUND:The Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed procedures for surgical weight loss. It has been shown that overweight may be associated with an increased risk of gastric cancer. However, the risk of remnant gastric cancer after RYGB has not been defined yet and the development of neoplasm in the excluded stomach remains a matter of concern. METHODS:PubMed, EMBASE, and Web of Science databases were consulted. Articles that described the diagnosis and management of remnant gastric cancer after RYGB were considered. RESULTS:Seventeen patients were included. The age of the patient population ranged from 38 to 71 years. The most commonly reported symptoms were abdominal pain, nausea/vomiting, and anemia. Abdominal computed tomography was used for diagnosis in the majority of patients. The neoplasm was located in the antrum/pre-pyloric region in 70% of cases and adenocarcinoma was the most common tumor histology (80%). An advanced tumor stage (III-IV) was diagnosed in almost 70% of patients and 40% were considered unresectable. Gastrectomy with lymphadenectomy was performed in 9 cases (53%). Post-operative morbidity was 12%. The follow-up ranged from 3 to 26 months and the overall disease-related mortality rate was 33.3%. CONCLUSION:The development of remnant gastric cancer after RYGB is rare. Surgeons should be aware of this potential event and the new onset of epigastric pain, nausea, and anemia should raise clinical suspicion. Further epidemiologic studies are warranted to deeply investigate the post-RYGB-related risk of remnant gastric cancer development in high-risk populations.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Tornese S,Aiolfi A,Bonitta G,Rausa E,Guerrazzi G,Bruni PG,Micheletto G,Bona D

doi

10.1007/s11695-019-03892-7

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

2609-2613

issue

8

eissn

0960-8923

issn

1708-0428

pii

10.1007/s11695-019-03892-7

journal_volume

29

pub_type

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