Abstract：
OBJECTIVE:To evaluate our own experience with primary Ewing sarcoma family tumors (ESFTs) of the kidney and to review cases of this in published reports. MATERIALS AND METHODS:Institutional cases of renal ESFT were identified in our pathology database. The retrieved records were reviewed for relevant data. Published cases of renal ESFTs were identified from the National Library of Medicine Medline database and restricted to English language studies. The factors associated with initial surgical management (diagnostic biopsy vs surgical resection) were analyzed using chi-square analysis. RESULTS:We diagnosed and treated 10 cases of renal ESFT from 2002 to 2011 and identified an additional 97 published cases describing this tumor. A review of these 107 cases revealed that renal ESFTs more often presented with distant metastases than did ESFTs of the bone or soft tissue. Moreover, patients rarely received preoperative (neoadjuvant) chemotherapy, the current standard of care for ESFT, often because of early total tumor resection without diagnostic biopsy. Younger patients and patients with distant metastases were more likely to undergo diagnostic biopsy as initial management (P <.0001), allowing for use of neoadjuvant chemotherapy. CONCLUSION:ESFTs of the kidney should be considered in the differential diagnosis of renal masses. Preoperative biopsy should be considered to identify these tumors to allow for delivery of neoadjuvant chemotherapy.
journal_name
Urologyjournal_title
Urologyauthors
Rowe RG,Thomas DG,Schuetze SM,Hafez KS,Lawlor ER,Chugh Rdoi
10.1016/j.urology.2012.10.016subject
Has Abstractpub_date
2013-02-01 00:00:00pages
347-53issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(12)01264-2journal_volume
81pub_type
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