Abstract:
INTRODUCTION:For the evaluation of the congestive heart failure (CHF) in rat models, the use of special equipment for echocardiography for dynamic evaluation is suggested. The optimal doxorubicin dose for CHF induction has still not been established. AIMS:The aims of our study was to find a reliable doxorubicin CHF rat model using a general ultrasound (US) equipment for in vivo ultrasound examination of the systemic circulation, to establish the optimal doxorubicin dose, and to assess the feasibility of US guided administration of the drug. MATERIAL AND METHODS:Sixty Wistar rats, weighing 180-200 g were assigned to 3 groups (n=20 in each): group A - 4 time intraperitoneal doxorubicin "Sigma"administration, cumulative dose 2.49 mg/animal or 12.45 mg/kg; group B and 5 time doxorubicin administration, cumulative dose 3.03 mg/animal or 15.15 mg/kg; and group C- controls (injected same volume of saline). Dynamic US using linear 12 MHz transducer was used to establish the CHF modifications. Two rats with CHF were injected under US guidance in the pleural cavity with 0.06 ml cardiotropic drug levosimendan and two rats in the pericardial cavity. RESULTS:We established the optimal cumulative doxorubicin dose for CHF induction at 12.45 mg/kg. At a higher dose, more than 40% of animals died. A lower dose did not induce significant clinical and US CHF criteria. Congestion (followed by weight gain) led to lower animal mortality. Preliminary results indicate a similar positive cardioprotective effect of drug injection into pericardial and pleural cavities under US guidance, demonstrating that this technique is useful for drug administration. CONCLUSIONS:US is an effective modality for in vivo monitoring of the rat organs for the study of cardiovascular function or for drug administration under US guidance. Suggested model (optimal dose of doxorubicin for simulation of CHF of 2.5 mg/animal, a cumulative dose of 12.45 mg/kg in 4 injections every 3 days) can be used for research purposes.
journal_name
Med Ultrasonjournal_title
Medical ultrasonographyauthors
Spivak M,Bubnov R,Yemets I,Lazarenko L,Timoshok N,Vorobieva A,Mohnatyy S,Ulberg Z,Reznichenko L,Grusina T,Zhovnir V,Zholobak Ndoi
10.11152/mu.2013.2066.151.ms1ddc2subject
Has Abstractpub_date
2013-03-01 00:00:00pages
23-8issue
1eissn
1844-4172issn
2066-8643journal_volume
15pub_type
杂志文章abstract::. ...
journal_title:Medical ultrasonography
pub_type: 社论
doi:10.11152/mu-1441
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journal_title:Medical ultrasonography
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journal_title:Medical ultrasonography
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doi:
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journal_title:Medical ultrasonography
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journal_title:Medical ultrasonography
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journal_title:Medical ultrasonography
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
doi:10.11152/mu.2013.2066.163.hb1
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journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:10.11152/mu.2013.2066.152.is1ir2
更新日期:2013-06-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:10.11152/mu.2014.2066.161.sbs1bk2
更新日期:2014-03-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:10.11152/mu.2013.2066.162.ya1fhb2
更新日期:2014-06-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
doi:10.11152/mu.2013.2066.173.khu
更新日期:2015-09-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
abstract::. ...
journal_title:Medical ultrasonography
pub_type: 社论
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更新日期:2020-03-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章
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更新日期:2017-01-31 00:00:00
abstract:AIM:Holoprosencephaly (HPE) is the most common brain malformation. A wide spectrum of anatomical variants are characterized by a lack of midline separation of the cerebral hemispheres. The aim of this study was to assess the ultrasound diagnostic criteria for HPE. MATERIAL AND METHOD:A database of 175 fetuses with cen...
journal_title:Medical ultrasonography
pub_type: 杂志文章,多中心研究
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更新日期:2019-05-02 00:00:00
abstract::. ...
journal_title:Medical ultrasonography
pub_type: 社论
doi:10.11152/mu-2928
更新日期:2020-11-18 00:00:00
abstract:AIMS:To evaluate the agreement between a visual and an automatic counting system of lung B-lines by ultrasound (US) as well as to test the inter- and intra-observer reliability of both systems in patients with lung diseases. MATERIAL AND METHODS:We included four patients with different lung conditions. Four ultrasonog...
journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:10.11152/mu-1885
更新日期:2019-02-17 00:00:00
abstract:AIM:To identify the mean values of Shear Wave Elastography (SWE) in pancreatic neoplasms. MATERIAL AND METHOD:This pilot case-control study was conducted in a tertiary care setting and data were collected in a prospective manner. Thirty-three subjects were included and divided into two groups: 18 healthy subjects and ...
journal_title:Medical ultrasonography
pub_type: 杂志文章
doi:10.11152/mu-1492
更新日期:2018-08-30 00:00:00
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journal_title:Medical ultrasonography
pub_type: 杂志文章,评审
doi:10.11152/mu.2013.2066.174.evp
更新日期:2015-12-01 00:00:00