A functional magnetic resonance imaging paradigm to identify distinct cortical areas of facial function: a reliable localizer.

Abstract:

BACKGROUND:Irreversible facial paralysis can be surgically treated by importing both a new neural and a new motor muscle supply. Various donor nerves can be used. If a nerve supply other than the facial nerve is used, the patient has to adapt to generate a smile. If branches of the fifth cranial nerve are used, the patient has to learn to clench teeth and smile. Currently, controversy exists regarding whether a patient develops a spontaneous smile if a nerve other than the facial nerve is used. The authors postulate that brain adaptation in facial palsy patients can occur because of neural plasticity. The authors aimed to determine whether functional magnetic resonance imaging could topographically differentiate activity between the facial nerve- and the trigeminal nerve-related cortical areas. METHODS:A new paradigm of study using functional magnetic resonance imaging based on blood oxygen level-dependent signal activation was tested on 15 voluntary healthy subjects to find a sensitive localizer for teeth clenching and smiling. Subjects smiled to stimulate the facial nerve-related cortex, clenched their jaws to stimulate the trigeminal nerve-related cortex, and tapped their finger as a control condition. RESULTS:Smiling and teeth clenching showed distinct and consistent areas of cortical activation. Trigeminal and facial motor cortex areas were found to be distinct areas with minimal overlapping. CONCLUSIONS:The authors successfully devised a functional magnetic resonance imaging paradigm effective for activating specific areas corresponding to teeth clenching and smiling. This will allow accurate mapping of cortical plasticity in facial reanimation patients.

journal_name

Plast Reconstr Surg

authors

Romeo M,Vizioli L,Breukink M,Aganloo K,Lao J,Cotrufo S,Caldara R,Morley S

doi

10.1097/PRS.0b013e3182818b68

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

527e-533e

issue

4

eissn

0032-1052

issn

1529-4242

pii

00006534-201304000-00017

journal_volume

131

pub_type

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