Impact of Oral-Cecal Transit Time on the Interpretation of Lactulose Breath Tests After RYGB: a Personalized Approach to the Diagnosis of SIBO.

Abstract:

BACKGROUND:Traditionally, small intestinal bacterial overgrowth (SIBO) is diagnosed when there is an early peak in breath hydrogen or methane. Given unclear intestinal transit time in Roux-en-Y gastric bypass (RYGB) patients, it is unknown if the traditional approach at diagnosing SIBO is adequate in this patient population. AIM:To assess oral-cecal transit time (OCTT) and its impact on the interpretation of breath tests in the diagnosis of SIBO in patients with RYGB. METHODS:This study was a retrospective review of prospectively collected data on RYGB patients who underwent testing for SIBO using lactulose breath test (LBT) with or without small bowel follow-through (SBFT) to assess OCTT. Outcomes of SIBO test based on LBT alone versus LBT with OCTT were compared using a chi-squared test. RESULTS:Sixty-two of the 151 RYGB patients who underwent LBT underwent an additional SBFT to assess OCTT. Median OCTT was 60 min. Of these, 59.7% had OCTT shorter than 90 min. Based on LBT alone, 36/62 patients (58.1%) were classified as positive SIBO. When LBT results were combined with OCTT, 26/36 patients (72.2%) had hydrogen or methane rise within OCTT, suggesting 27.8% false positive rate. Patients with true positive SIBO based on LBT and OCTT had a higher response rate to antibiotics compared to those with false positive SIBO (78.3% vs. 33.3%, p = 0.03). CONCLUSION:A personalized approach of combining LBT with SBFT to assess OCTT may improve the accuracy of SIBO testing and enhance clinical outcomes in patients with RYGB.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Jirapinyo P,Makuvire TT,Dong WY,Chan WW,Thompson CC

doi

10.1007/s11695-018-3575-3

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

771-775

issue

3

eissn

0960-8923

issn

1708-0428

pii

10.1007/s11695-018-3575-3

journal_volume

29

pub_type

杂志文章
  • Prediction of whole-body and segmental body composition by bioelectrical impedance in morbidly obese subjects.

    abstract:BACKGROUND:Validated equations for body composition analysis using bioelectrical impedance (BIA) in morbidly obese (MO) subjects are scarce. Thus, our aim was todevelop new equations from physical and BIA parameters to estimate whole-body and segmental body composition inMO subjects, with dual-energy X-ray absorptiomet...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-011-0570-3

    authors: Jiménez A,Omaña W,Flores L,Coves MJ,Bellido D,Perea V,Vidal J

    更新日期:2012-04-01 00:00:00

  • Surgical treatment of morbid obesity: mid-term outcomes of the laparoscopic ileal interposition associated to a sleeve gastrectomy in 120 patients.

    abstract::The aim of this study was to evaluate the mid-term outcomes of the laparoscopic ileal interposition associated to a sleeve gastrectomy (LII-SG) for the treatment of morbid obesity. The procedure was performed in 120 patients: 71 women and 49 men with mean age of 41.4 years. Mean body mass index (BMI) was 43.4 ± 4.2 kg...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-010-0232-x

    authors: DePaula AL,Stival AR,Halpern A,Vencio S

    更新日期:2011-05-01 00:00:00

  • Laparoscopic adjustable gastric banding versus open vertical banded gastroplasty: a prospective randomized trial.

    abstract:BACKGROUND:Laparoscopic adjustable gastric banding (LAGB) and open vertical banded gastroplasty (VBG) are treatment modalities for morbid obesity. However, few prospective randomized clinical trials (RCT) have been performed to compare both operations. METHODS:100 patients (50 per group) were included in the study. Po...

    journal_title:Obesity surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1381/096089205774512456

    authors: van Dielen FM,Soeters PB,de Brauw LM,Greve JW

    更新日期:2005-10-01 00:00:00

  • The effect of Roux-en-Y gastric bypass on prescription drug costs.

    abstract:BACKGROUND:This study examines the effect of weight loss following laparoscopic Roux-en-Y gastric bypass (RYGBP) for morbid obesity on prescription drug costs in patients over the age of 54. METHODS:78 patients aged 55 to 75 who met the inclusion criteria were identified in a database of 1,060 morbidly obese patients ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892041975677

    authors: Snow LL,Weinstein LS,Hannon JK,Lane DR,Ringold FG,Hansen PA,Pointer MD

    更新日期:2004-09-01 00:00:00

  • The Impact of Bariatric Surgery on Cardiopulmonary Function: Analyzing VO2 Recovery Kinetics.

    abstract:PURPOSE:To assess cardiopulmonary capacity, autonomic heart function, and oxygen recovery kinetics during exercise testing before and after bariatric surgery. METHODS:This is a prospective cohort study. Symptom-limited cardiopulmonary exercise testing was performed with 24 patients, 1 week before and 4 months after ba...

    journal_title:Obesity surgery

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11695-018-3469-4

    authors: Remígio MI,Santa Cruz F,Ferraz Á,Remígio MC,Parente G,Nascimento I,Brandão D,Dornelas de Andrade AF,de Moraes Neto F,Campos J

    更新日期:2018-12-01 00:00:00

  • Type 1 Diabetes Mellitus and Bariatric Surgery: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Type 1 diabetes mellitus (T1DM) has a rising global prevalence. Although it is vastly outnumbered by type 2 diabetes mellitus rates, it remains a persistent worldwide source of morbidity and mortality. Increasingly, its sufferers are afflicted by obesity and its complications. The objective of the study is t...

    journal_title:Obesity surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11695-015-1999-6

    authors: Ashrafian H,Harling L,Toma T,Athanasiou C,Nikiteas N,Efthimiou E,Darzi A,Athanasiou T

    更新日期:2016-08-01 00:00:00

  • The effects of pneumoperitoneum on respiratory mechanics during general anesthesia for bariatric surgery.

    abstract:BACKGROUND:The effects of pneumoperitoneum (PPM) on respiratory mechanics during bariatric surgery were investigated. PATIENTS AND METHODS:10 patients with BMI 50.5+/-8 kg/m(2) (range 40.9- 66.8) who underwent laparoscopic adjustable gastric banding with the Swedish band under general anesthesia were studied. Besides ...

    journal_title:Obesity surgery

    pub_type: 临床试验,杂志文章

    doi:10.1381/096089204322857582

    authors: El-Dawlatly AA,Al-Dohayan A,Abdel-Meguid ME,El-Bakry A,Manaa EM

    更新日期:2004-02-01 00:00:00

  • Large Bariatric-Specific Stents and Over-the-Scope Clips in the Management of Post-Bariatric Surgery Leaks.

    abstract:BACKGROUND:Endoscopic stents are successful in the management of surgical leaks; however, stent migration remains a significant problem. In this study, we present our approach depending on a large bariatrics-specific stent (Mega stent) and over-the-scope clips in the management of post-bariatric surgery leaks. METHODS...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-017-2808-1

    authors: Shehab H,Abdallah E,Gawdat K,Elattar I

    更新日期:2018-01-01 00:00:00

  • Assessing Motivational Stages and Processes of Change for Weight Management Around Bariatric Surgery: a Multicenter Study.

    abstract:INTRODUCTION/PURPOSE:The assessment of the patients' motivation as a predictor of behavioral change via five stages (pre-contemplation, contemplation, preparation, action, and maintenance) and four processes (emotional re-evaluation, weight management actions, environmental restructuring, and weight consequences evalua...

    journal_title:Obesity surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11695-019-04001-4

    authors: Lecube A,Sánchez E,Andrés A,Saldaña C,Morales MJ,Calañas A,Miñambres I,Pellitero S,Cordido F,Bueno M,Caixàs A,Vilarrasa N,Obesity Group of the Spanish Society of Endocrinology and Nutrition (GOSEEN).

    更新日期:2019-10-01 00:00:00

  • A Comprehensive Approach for the Prevention of Nausea and Vomiting Following Sleeve Gastrectomy: a Randomized Controlled Trial.

    abstract:BACKGROUND:Postoperative nausea and vomiting (PONV) following sleeve gastrectomy (SG) is a common occurrence. The effect of specific interventions in PONV prevention within enhanced recovery pathways remains unclear. The aim of this study was to evaluate the impact of a comprehensive approach for the prevention of PONV...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04795-8

    authors: Spaniolas K,Nie L,Moller D,Tatarian T,Hesketh A,Yang J,Docimo S,Bates A,Gan TJ,Pryor A

    更新日期:2020-11-01 00:00:00

  • Laparoscopic conversion of laparoscopic gastric banding to Roux-en-Y gastric bypass: a review of 70 patients.

    abstract:BACKGROUND:The feasibility and outcomes of conversion of laparoscopic adjustable gastric banding (LAGB) to laparoscopic Roux-en-Y gastric bypass (LRYGBP) was evaluated. METHODS:From November 2000 to March 2004, all patients who underwent laparoscopic conversion of LAGB to LRYGBP were retrospectively analyzed. The proc...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审

    doi:10.1381/0960892042584003

    authors: Mognol P,Chosidow D,Marmuse JP

    更新日期:2004-11-01 00:00:00

  • Gastric Bypass-Related Effects on Glucose Control, β Cell Function and Morphology in the Obese Zucker Rat.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGB) may improve beta cell function by mechanisms other than caloric restriction and body weight loss. We aimed to assess the impact of anatomical and hormonal alterations specific to RYGB on glucose homeostasis, β cell function and morphology. METHODS:Male Zucker(fa/fa) rats unde...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-015-1882-5

    authors: Seyfried F,Miras AD,Rotzinger L,Nordbeck A,Corteville C,Li JV,Schlegel N,Hankir M,Fenske W,Otto C,Jurowich C

    更新日期:2016-06-01 00:00:00

  • BAROS: an effective system to evaluate the results of patients after bariatric surgery.

    abstract:BACKGROUND:Success in bariatric surgery is most often evaluated by a sufficient loss of excess weight and an improvement in the medical conditions. The expected increase in quality of life (QoL) after weight loss, however, has not often been systematically analyzed. BAROS (Bariatric Analysis and Reporting Outcome Syste...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089200321593940

    authors: Wolf AM,Falcone AR,Kortner B,Kuhlmann HW

    更新日期:2000-10-01 00:00:00

  • Laparoscopic closure of the Petersen mesenteric defect.

    abstract::Small-bowel obstruction secondary to internal hernia is a known postoperative complication of laparoscopic Roux-en-Y gastric bypass (RYGBP). Petersen's defect is the most common site of postoperative internal herniation. The authors describe their technique of closure of the infracolic component of the Petersen's defe...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089206777346727

    authors: Coleman MH,Awad ZT,Pomp A,Gagner M

    更新日期:2006-06-01 00:00:00

  • Timing of pregnancy after gastric bypass-a national register-based cohort study.

    abstract:BACKGROUND:Current recommendations suggest postponing pregnancy by at least 1 year after gastric bypass. During the first postoperative year, women are in a catabolic phase with a rapid weight loss which may increase the risk of adverse pregnancy and neonatal outcomes. This study tested the hypothesis that the risk of ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-013-0903-5

    authors: Kjær MM,Nilas L

    更新日期:2013-08-01 00:00:00

  • Biliopancreatic diversion with transitory gastric restriction and duodenal bulb preservation: 88 patients since 1992.

    abstract:BACKGROUND:Over 10 years, 88 patients underwent biliopancreatic diversion with transitory gastric restriction (BPD-TGR) as a first choice operation or after gastric restrictive procedures. METHODS:From 1992 to 1999, BPD-TGR was performed on 71 patients as a first choice operation (Group 1 - BMI 41.9 +/- 6.5). The TGR ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892041590836

    authors: Vassallo C,Negri L,Rovati P,Della Valle A,Tata S,Berbiglia G,Pessina A,Ramaioli F,Dono C,Fariseo M

    更新日期:2004-06-01 00:00:00

  • The impact of various anthropometric measurements of obesity on pulmonary function in candidates for surgery.

    abstract:BACKGROUND:Obesity has proven to be associated with respiratory symptoms and impaired pulmonary function, which could increase the incidence of postoperative complications after bariatric surgery. However, the component of obesity that has the most influence on pulmonary function has not been identified, especially in ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-009-9961-0

    authors: Wei YF,Wu HD,Chang CY,Huang CK,Tai CM,Hung CM,Tseng WK,Wu CC

    更新日期:2010-05-01 00:00:00

  • Endoscopic findings of asymptomatic patients one year after Roux-en-Y gastric bypass for treatment of obesity.

    abstract:BACKGROUND:In the late post-operative period, the necessity of performing an upper gastrointestinal endoscopy (GIE) to check for complications is controversial. Some authors suggest it should be routine for all patients, others selectively, but not all patients with endoscopic abnormalities are symptomatic and some abn...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-013-0936-9

    authors: Spinosa SR,Valezi AC

    更新日期:2013-09-01 00:00:00

  • The effect of Roux-en-Y gastric bypass on zinc nutritional status.

    abstract:BACKGROUND:Researchers have found that zinc nutritional status in obese and diabetic subjects is altered: low zinc concentrations in plasma and erythrocytes, with high urinary zinc excretion, were observed. This study evaluated the effect of Roux-en-Y gastric bypass (RYGBP) on plasma, erythrocyte and urinary zinc conce...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-007-9105-3

    authors: Pires LV,Martins LM,Geloneze B,Tambascia MA,Hadad do Monte SJ,do Nascimento Nogueira N,Santos de Sousa G,Marreiro DN

    更新日期:2007-05-01 00:00:00

  • Early postoperative insulin-resistance changes after sleeve gastrectomy.

    abstract:INTRODUCTION:Biliopancreatic diversion and gastric bypass are associated with a rapid improvement in insulin resistance few days after surgery. The purpose of this study was to evaluate the short-term effects in insulin resistance following sleeve gastrectomy (SG). MATERIALS AND METHODS:Between December 2007 and Septe...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-009-0017-2

    authors: Rizzello M,Abbatini F,Casella G,Alessandri G,Fantini A,Leonetti F,Basso N

    更新日期:2010-01-01 00:00:00

  • Impact on Dyslipidemia After Laparoscopic Sleeve Gastrectomy.

    abstract:BACKGROUND:Improvement of dyslipidemia is an important benefit of bariatric surgery. The benefits of laparoscopic sleeve gastrectomy (LSG) among dyslipidemia are still a matter of debate. METHODS:We conducted a retrospective descriptive study between 2010 and 2013. Obese patients undergoing LSG, with recorded dyslipid...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-018-3343-4

    authors: Vigilante A,Signorini F,Marani M,Paganini V,Viscido G,Navarro L,Obeide L,Moser F

    更新日期:2018-10-01 00:00:00

  • Comparison of nutritional deficiencies after Roux-en-Y gastric bypass and after biliopancreatic diversion with Roux-en-Y gastric bypass.

    abstract:BACKGROUND:Patients undergoing either Roux-en-Y gastric bypass (RYGBP) or biliopancreatic diversion (BPD) with RYGBP are at risk of developing metabolic sequelae secondary to malabsorption. We compared the differences in nutritional complications between these two bariatric operations. METHODS:A retrospective analysis...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089202762252334

    authors: Skroubis G,Sakellaropoulos G,Pouggouras K,Mead N,Nikiforidis G,Kalfarentzos F

    更新日期:2002-08-01 00:00:00

  • A study of discrimination within the medical community as viewed by obese patients.

    abstract:BACKGROUND:Although prejudice may not be verbal in nature, the lack of response from professional and non-professional medical personnel regarding the obese patients' needs (medical equipment, comfortable surroundings, properly fitting attire, etc.), leads one to assume that obese patients continue to be a target of un...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089202321144513

    authors: Kaminsky J,Gadaleta D

    更新日期:2002-02-01 00:00:00

  • Emergency sleeve gastrectomy as rescue treatment for acute gastric necrosis due to type II paraesophageal hernia in an obese woman with gastric banding.

    abstract::A morbidly obese 42-year-old woman presented with a 1-week history of left chest pain. She had undergone laparoscopic adjustable gastric banding 16 months earlier with a body mass index (BMI) of 49.2 kg/m2. Diagnostic workup revealed a large left pleural empyema and ruled out band slippage. At left thoracotomy, a misd...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-007-9374-x

    authors: Bernante P,Breda C,Zangrandi F,Pomerri F,Pelizzo MR,Foletto M

    更新日期:2008-06-01 00:00:00

  • Delayed Intra Splenic Abscess: a Specific Complication Following Laparoscopic Sleeve Gastrectomy.

    abstract:BACKGROUND:Delayed intra splenic abscess after laparoscopic sleeve gastrectomy (LSG) is a very rare complication with poor manifestations. METHODS:We present three cases of delayed intrasplenic abscess which were managed in our departmentof minimal invasive surgery. DISCUSSION:Splenic abscess may occur in the early p...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-017-3069-8

    authors: Nassour F,Schoucair NM,Tranchart H,Maitre S,Dagher I

    更新日期:2018-02-01 00:00:00

  • Management of Type 2 Late Sleeve Leak by Laparoscopic Suturing and Conversion to Roux-en-Y Gastric Bypass: Video Report.

    abstract:BACKGROUND:Laparoscopic sleeve forming gastrectomy (SFG) is a commonly performed bariatric procedure for the surgical management of morbid obesity. Staple line gastric leaks occur infrequently but are the most feared complication causing prolonged morbidity (Burgos et al., Obes Surg 19(12):1672-7, 2009; Márquez et al.,...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-015-1813-5

    authors: Praveenraj P,Gomes RM,Kumar S,Senthilnathan P,Parthasarathi R,Rajapandian S,Palanivelu C

    更新日期:2015-10-01 00:00:00

  • The utility of routine postoperative upper gastrointestinal swallow studies following laparoscopic sleeve gastrectomy.

    abstract::Laparoscopic sleeve gastrectomy (LSG) has grown in popularity in recent years for the treatment of morbid obesity. Controversy exists regarding the usefulness of upper gastrointestinal (UGI) swallow studies on the first postoperative day in detecting possible complications. The aim of our study was to determine the ef...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-014-1243-9

    authors: Mizrahi I,Tabak A,Grinbaum R,Beglaibter N,Eid A,Simanovsky N,Hiller N

    更新日期:2014-09-01 00:00:00

  • Decreased Levels of Circulating Cancer-Associated Protein Biomarkers Following Bariatric Surgery.

    abstract:BACKGROUND:Epidemiological studies have identified obesity as a major risk factor for cancer in humans, and trials have demonstrated a significant reduction in the incidence of cancer after bariatric surgery. The rapidity of weight loss after bariatric surgery provides an opportunity to identify the molecular changes a...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-016-2321-y

    authors: Farey JE,Fisher OM,Levert-Mignon AJ,Forner PM,Lord RV

    更新日期:2017-03-01 00:00:00

  • Duodenal-Jejunal Bypass Liner (DJBL) Improves Cardiovascular Risk Biomarkers and Predicted 4-Year Risk of Major CV Events in Patients with Type 2 Diabetes and Metabolic Syndrome.

    abstract:BACKGROUND:The duodenal-jejunal bypass liner (DJBL) represents a novel endoscopic minimally invasive treatment option for obesity-associated type 2 diabetes (T2D), affecting body weight and metabolic control. Until now, the effects of DJBL on cardiovascular risk have never been investigated. METHODS:Between 2012 and 2...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-019-04324-2

    authors: Roehlen N,Laubner K,Bettinger D,Schwacha H,Hilger H,Koenig C,Grueninger D,Krebs A,Seufert J

    更新日期:2020-04-01 00:00:00

  • Serum vaspin concentrations in relation to insulin sensitivity following RYGB-induced weight loss.

    abstract:BACKGROUND:Recently, vaspin was identified as a novel adipokine with insulin-sensitizing effects that might be implicated in endogenous glucose regulation. Our objective was to evaluate the impact of acute weight loss and metabolic changes on serum vaspin concentrations in morbidly obese subjects following laparoscopic...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-009-9882-y

    authors: Handisurya A,Riedl M,Vila G,Maier C,Clodi M,Prikoszovich T,Ludvik B,Prager G,Luger A,Kautzky-Willer A

    更新日期:2010-02-01 00:00:00