Abstract:
OBJECTIVE:To evaluate the California Cancer Registry in order to define nonclear cell renal cell cancer (RCC) clinical features and outcomes, identify prognostic variables, and generate hypotheses for further study. METHODS:Patients with invasive RCC tumors in the California Cancer Registry from 1998 to 2009 (n = 38,251) were analyzed, of which 4483 (11.7%) were of the nonclear cell type. Baseline clinical demographics and tumor characteristics were collected. Primary outcome measures were 3-year cause-specific survival (CSS) and overall survival (OS). RESULTS:Of 4483 nonclear cell RCC cases, 3304 (73.7%) were diagnosed between 2004 and 2009. Histologic distribution was as follows: papillary 63.9%, chromophobe 33.6%, and "other" 2.5% (including medullary and collecting duct tumors). Univariate analysis showed that chromophobe histology, female sex, and higher socioeconomic status were associated with significantly better OS and CSS. Patients in the later era (2004-2009) appeared to have better OS. Multivariate analysis showed the following to be independently associated with outcomes (hazard ratios shown for CSS and OS, respectively): chromophobe (0.48, 0.56; P <.001), medullary/collecting duct (2.99, 2.42; P <.001), no nephrectomy (2.84, 3.18; P <.001), regional stage (5.84, 1.98; P <.001), distant stage (25.7, 7.67; P <.001), and non-Hispanic blacks (1.5, P = .006; 1.25, P = .03). CONCLUSION:This large registry analysis demonstrated emerging epidemiologic trends in this uncommon RCC subset. Clinical variables associated with CSS and OS were identified that can potentially inform the design of future clinical trials in nonclear cell RCC.
journal_name
Urologyjournal_title
Urologyauthors
Pai A,Brunson A,Brown M,Pan CX,Lara PN Jrdoi
10.1016/j.urology.2013.07.020subject
Has Abstractpub_date
2013-10-01 00:00:00pages
840-5issue
4eissn
0090-4295issn
1527-9995pii
S0090-4295(13)00861-3journal_volume
82pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVES:To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA). METHODS:Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar techniq...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)80461-0
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVES:To analyze the effect of total radiation dose on the outcome of patients treated with external beam radiotherapy for early-stage prostate cancer. METHODS:The records of a total of 738 patients with localized prostate cancer treated with external beam radiotherapy (RT) and no androgen deprivation at our inst...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)00380-5
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To compare the morbidity and functional results after laparoscopic radical prostatectomy with and without previous transurethral resection of the prostate (TURP). METHODS:From May 1998 to January 2005, 640 patients underwent laparoscopic radical prostatectomy, of whom 46 (7.2%) had previously undergone TURP...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.03.019
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To determine whether the prostate has lymphatic/lymph node drainage that is not sampled by conventional lymphadenectomy and whether the transition and peripheral zones of the prostate have a different lymphatic drainage, because up to one quarter of lymph-node-negative patients who undergo radical prostatect...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00921-3
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To determine the outcomes of pregnancy and cesarean delivery (CD) in women with neuropathic bladder (NB) and pediatric lower urinary tract reconstruction (LUTR) as these women often have normal fertility and may become pregnant. METHODS:We reviewed consecutive patients with NB due to spinal dysraphism who un...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2017.11.052
更新日期:2018-04-01 00:00:00
abstract::Chromaffin cell tumors are derived from neural crest cells and can produce and secrete catecholamines. Classic symptoms include headache, palpitations, diaphoresis, and hypertension. Diagnosis is typically in adulthood, and metastatic disease is rarely found. Genetic testing is suggested with young age, extra-adrenal ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2016.05.028
更新日期:2016-12-01 00:00:00
abstract::A successful percutaneous reanastomosis of a transplanted kidney is reported. The kidney already had been operated on several times. The kidney-ureter anastomosis was occluded. Using a combination of ureteroscopy and the percutaneous technique, the old anastomosis was bypassed, and a new one was made. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(88)90448-7
更新日期:1988-07-01 00:00:00
abstract::Transrectal ultrasound may establish the diagnosis of prostatic abscess in an ambiguous clinical setting. Transurethral resection (deroofing) is the treatment preferred by many clinicians, yet intraoperative complete abscess obliteration may be difficult to confirm endoscopically. We report on a patient with a complex...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(91)80117-p
更新日期:1991-05-01 00:00:00
abstract::Urinary incontinence occurring during orgasm in women is an infrequently volunteered symptom. We studied 3 such patients to understand the mechanism behind such leakage. Urodynamic studies were performed prior to and during orgasm. It was found that during orgasm, there was involuntary bladder contraction with simulta...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(88)90160-4
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVES:To assess the staging accuracy and detection of neurovascular bundle involvement by dynamic subtraction contrast-enhanced endorectal magnetic resonance imaging (MRI) in patients with localized prostate cancer. METHODS:In 38 patients with biopsy-proven prostate cancer, endorectal MRI was performed on a 1.5-T...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)01072-4
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To assess the effect of transrectal radiofrequency hyperthermia (TRFH) in 159 patients with chronic prostatitis (CP) and explore the changes of reactive oxygen species in CP patients pretreatment and posttreatment. METHODS:Patients diagnosed with CP were randomized to 6 weeks of tamsulosin plus clarithromyci...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2011.08.046
更新日期:2012-02-01 00:00:00
abstract::Retrograde pyelography to demonstrate the renal pelvis and ureters is a common urologic procedure. Newer contrast materials and better radiographic techniques have obviated many of the previous indications for retrograde studies were independently reviewed by two urologists and a radiologist to determine if the studie...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90196-1
更新日期:1979-11-01 00:00:00
abstract:OBJECTIVE:To utilize Time-Driven Activity-Based Costing to quantify costs of managing recurrent urinary tract infections (RUTI) in women. METHODS:RUTI was defined as ≥2 UTIs in 6 months or ≥3 UTIs in 12 months. A care-delivery value chain outlined RUTI management (visits, urine studies, and imaging) for acute UTI foll...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.01.031
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the outcomes of hand-assisted laparoscopic nephrectomy in patients with significant complicating clinical factors. METHODS:We performed a retrospective review of 322 hand-assisted laparoscopic nephrectomy cases that were completed at a single institution from 1998 to 2004. Patients with a histor...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.07.043
更新日期:2006-01-01 00:00:00
abstract::A case of Torulopsis glabrata fungemia with persistent funguria and pyelonephritis secondary to colonization of renal calculus is presented. The importance of secondary colonization of renal calculi in persistent infection and septicemia is discussed. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(78)90300-x
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to: (1) determine effects of finasteride on transition zone (TZ) volume, TZ ratio (TZ volume/total prostate volume), and total prostate volume; (2) analyze differences in TZ and total volume reduction among patients who improve peak urinary flow rates following finasteride therapy w...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0090-4295(95)80015-8
更新日期:1995-02-01 00:00:00
abstract::A urologic study of 28 patients (11 males and 17 females, 4 to 14 years old) revealed that 23 patients (83%) had organic disease, 20 of whom had lower urinary tract abnormalities. Of 22 patients who were assessed psychologically, 14 had difficulty in adaptation, 20 had special birth order problems, and in 14 onset of ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90572-3
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:To characterize the use of multiparametric magnetic resonance imaging (mpMRI) in male Medicare beneficiaries electing active surveillance for prostate cancer. mpMRI has emerged as a tool that may improve risk-stratification and decrease repeated biopsies in men electing active surveillance. However, the exten...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.02.037
更新日期:2019-08-01 00:00:00
abstract::Ureteral rejection has been studied in the dog utilizing the isolated transplanted ureter technique. While on adequate immunosuppressive therapy, the allograft ureter remains functionally and histologically normal. When the drugs are discontinued, progressive destructive changes occur within the ureteral wall. As the ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(74)90104-6
更新日期:1974-07-01 00:00:00
abstract:OBJECTIVES:To evaluate CYP3A4 expression in human prostrate cancer (PCa) tissues. Enzymes of the cytochrome P450 (CYP) family are key inactivators of testosterone in the liver and prostate. We previously reported that CYP2B6 is a growth-inhibitory and prognostic factor in human PCa; however, the status of CYP3A4 in PCa...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.02.033
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To evaluate, in a screening population, the impact of tumor volume and prostate volume on prostate-specific antigen (PSA) velocity (PSAV) and to find predictors of biochemical failure after radical prostatectomy. Longitudinal PSA changes in men with prostate cancer have been reported to be significantly diff...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.06.020
更新日期:2006-11-01 00:00:00
abstract::We present an unusual case of recurrent reflux on the right side after bilateral vesicoureteroplasty with modified Hutch I technique. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(81)90266-1
更新日期:1981-04-01 00:00:00
abstract::Hemangiomas of the genitalia are extremely rare. A hemangioma is self-limited and usually resolves spontaneously, therefore conservative treatment is generally recommended. However, genital hemangiomas may require surgical treatment if they become symptomatic. Herein we report a case of hemangioma of the penis and scr...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(93)90649-u
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVES:To investigate the association between parity and exophytic bladder cancer growth in the UPII-SV40T transgenic mouse model of bladder cancer. METHODS:The UPII-SV40T transgenic mice express the simian virus 40 large T antigen specifically in the urothelium (driven by uroplakin II promoter) and reliably devel...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.04.028
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To determine the diagnostic yield of secondary and tertiary transrectal ultrasound (TRUS)-guided biopsies of the prostate in men suspected of having carcinoma of the prostate because of an elevated serum prostate-specific antigen (PSA) level or an abnormal digital rectal examination (DRE). METHODS:The patho...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80451-8
更新日期:1996-03-01 00:00:00
abstract::Urethral strictures secondary to trauma have been a frequent cause of obstruction in the male population residing in Saudi Arabia. This study of 59 patients presenting with urethral strictures covers a two-year period. Patients were asked to return for the initial follow-up one month after treatment and were asked abo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90366-0
更新日期:1980-06-01 00:00:00
abstract::In this study, a model system was designed to investigate the metastatic potential of intramuscularly implanted bladder tumor cells in mice. Of the 4 FANFT-induced murine bladder tumors investigated, MBT-2 and -8 metastasized to the lung. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90235-2
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVES:Numerous studies have shown bacille Calmette-Guérin (BCG) to be an effective prophylactic and therapeutic agent for superficial transitional cell carcinoma of the bladder. The high-grade T1 lesion treated by transurethral resection alone is reported to progress to muscle invasion in 30% to 50% of the patient...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)80115-0
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To report biopsy-related and oncologic outcomes in a large prospective active surveillance cohort that was initiated in the premagnetic resonance imaging era and to additionally identify clinical factors associated with disease reclassification in order to inform future studies designed to improve enrollment ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.11.041
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To evaluate differences in stone measurement using computed tomography (CT) and ultrasound (US). Axial unenhanced helical CT is the reference-standard imaging modality for the assessment of urinary tract calculi; however, US is also commonly used. Differences in stone measurement using these techniques are p...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.12.015
更新日期:2010-08-01 00:00:00