Abstract:
:Patients with metastatic squamous cell cancer of the head and neck (SCCHN) have a poor prognosis, with most patients surviving less than a year. Immunotherapy (IO) is changing the natural history of the disease and programmed death-ligand 1 (PD-L1) inhibitors are showing notable improvements in survival with a more favourable toxicity profile than chemotherapy. To our knowledge, there are no data regarding how checkpoint blockade inhibitors may behave at rechallenge in SCCHN. We present the case of a metastatic hypopharyngeal cancer patient who after progressing clinically and radiologically to PD-L1-based IO and then to second-line cetuximab-based chemotherapy, achieved a partial response to third-line nivolumab. Our case shows that PD(L)1 rechallenge after interval chemotherapy may be worth considering in SCCHN. Studies should try to address which is the optimal treatment sequence in the era of IO in SCCHN.
journal_name
Anticancer Drugsjournal_title
Anti-cancer drugsauthors
Cabezas-Camarero S,Cabrera-Martín MN,Pérez-Segura Pdoi
10.1097/CAD.0000000000000706subject
Has Abstractpub_date
2019-02-01 00:00:00pages
149-152issue
2eissn
0959-4973issn
1473-5741journal_volume
30pub_type
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