Planning deficit in children with neurofibromatosis type 1: a neurocognitive trait independent from attention-deficit hyperactivity disorder (ADHD)?

Abstract:

:Neurofibromatosis type 1 is associated with executive dysfunctions and comorbidity with attention-deficit hyperactivity disorder (ADHD) in 30% to 50% of children. This study was designed to clarify the neurocognitive phenotype observed in neurofibromatosis type 1 by testing the hypothesis that children with neurofibromatosis type 1 have specific planning deficits independently from intellectual level and ADHD comorbidity. Eighteen children with neurofibromatosis type 1 were pair-matched to 18 children with ADHD and 18 healthy controls. All groups were assessed on the presence of ADHD symptoms (Conners Scales) and planning deficits (Tower of London). Compared with control group, groups with neurofibromatosis type 1 and ADHD demonstrated significant impairment of planning and problem solving. The lack of correlation between Tower of London results and Conners subscale scores in neurofibromatosis type 1 group confirmed that the planning and problem-solving deficit is not directly related to inattention level. These findings suggested that the executive impairment probably represents a peculiar trait of neurofibromatosis type 1 neurocognitive phenotype.

journal_name

J Child Neurol

authors

Galasso C,Lo-Castro A,Di Carlo L,Pitzianti MB,D'Agati E,Curatolo P,Pasini A

doi

10.1177/0883073813517001

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1320-6

issue

10

eissn

0883-0738

issn

1708-8283

pii

0883073813517001

journal_volume

29

pub_type

杂志文章
  • Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia.

    abstract::Detecting silent cerebral infarcts on magnetic resonance images (MRIs) in children with sickle cell anemia is challenging, yet reproducibility of readings has not been examined in this population. We evaluated consensus rating, inter-, and intra-grader agreement associated with detecting silent cerebral infarct on scr...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073813506491

    authors: Liem RI,Liu J,Gordon MO,Vendt BA,McKinstry RC 3rd,Kraut MA,Strouse JJ,Ball WS,DeBaun MR

    更新日期:2014-12-01 00:00:00

  • Long-term oral baclofen treatment in a child with cerebral palsy: electroencephalographic changes and clinical adverse effects.

    abstract::Baclofen is widely used to control spasticity in children with cerebral palsy. Several publications described clinical adverse effects of baclofen oral treatment, but the effect of baclofen on seizure potentiation is still controversial. We describe a 10-year-old female patient with cerebral palsy, epilepsy, and menta...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073809357243

    authors: De Rinaldis M,Losito L,Gennaro L,Trabacca A

    更新日期:2010-10-01 00:00:00

  • Cholesterol ester storage disease with unusual neurological manifestations in two siblings: a report from South India.

    abstract::Cholesterol ester storage disease is a rare autosomal recessive storage disorder resulting from lysosomal acid lipase deficiency. Two siblings manifested with hepatosplenomegaly, ptosis, and bilateral external ophthalmoplegia. Evaluation revealed hyperlipidemia and bilateral adrenal calcifications. Leukocyte acid lipa...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807307104

    authors: Bindu PS,Taly AB,Christopher R,BharatKumar PV,Panda S,Netravathi M,Ravishankar S,Mahadevan A,Yasha TC,Gayathri N

    更新日期:2007-12-01 00:00:00

  • Pediatric anti-N-methyl-D-aspartate (NMDA) receptor encephalitis: experience of a tertiary care teaching center from north India.

    abstract::Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is characterized by acute- or subacute-onset encephalopathy with extrapyramidal, psychiatric, and epileptic manifestations. Diagnosis is confirmed by positive antibodies to NMDA receptor in cerebrospinal fluid and serum. Eleven pediatric cases presented over a 2-y...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073813494474

    authors: Chakrabarty B,Tripathi M,Gulati S,Yoganathan S,Pandit AK,Sinha A,Rathi BS

    更新日期:2014-11-01 00:00:00

  • Athletic participation after acute ischemic childhood stroke: a survey of pediatric stroke experts.

    abstract::Minimal evidence exists about the risk of recurrent childhood acute ischemic stroke in patients subjected to a subsequent head or neck injury. Recurrent or multiple dissections have been demonstrated in select cases. Minor head trauma has also been associated with acute ischemic stroke. The objective of this study was...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807306271

    authors: Bernard TJ,deVeber GA,Benke TA

    更新日期:2007-08-01 00:00:00

  • Hypertensive encephalopathy in childhood.

    abstract::Hypertensive encephalopathy is an uncommon but recognized complication of malignant hypertension in children. We reviewed the clinical course, laboratory studies, and outcomes of 12 patients with hypertensive encephalopathy seen at the University of Iowa Hospitals and Clinics between 1979 and 1994. The most common pre...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389601100305

    authors: Wright RR,Mathews KD

    更新日期:1996-05-01 00:00:00

  • Behavioral and electrophysiologic predictors of treatment response to stimulants in children with attention disorders.

    abstract::Behavioral and quantitative electroencephalography (EEG) techniques were used to evaluate treatment response to stimulant therapy in children with attention disorders. A sample of 130 children with attention disorders were evaluated with Conners and Diagnostic and Statistical Manual of Mental Disorders--III rating sca...

    journal_title:Journal of child neurology

    pub_type: 临床试验,杂志文章

    doi:10.1177/088307389901400601

    authors: Chabot RJ,Orgill AA,Crawford G,Harris MJ,Serfontein G

    更新日期:1999-06-01 00:00:00

  • Acute pseudotumoral hemicerebellitis in a child: a rare and distinct entity?

    abstract::A pseudotumoral presentation of acute hemicerebellitis is rare in pediatric age. The authors report a new single case study of a 7-year-old child with pseudotumoral unilateral cerebellitis mimicking an intracranial tumor, which clinically presented itself with signs of intracranial hypertension and mild contralateral ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814545114

    authors: Alberini E,Vellante V,Zennaro F,Calligaris L,Barbi E,Carrozzi M,Devescovi R

    更新日期:2015-03-01 00:00:00

  • Gingival enlargement in children treated with antiepileptics.

    abstract::This study was conducted to determine the occurrence, severity, and risk factors of gingival enlargement in children treated with valproate and other nonvalproate antiepileptic drugs. A cross-sectional study was carried out in which data obtained from 68 epileptic children under treatment were compared with those from...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738040190120901

    authors: Tan H,Gürbüz T,Dağsuyu IM

    更新日期:2004-12-01 00:00:00

  • Bilateral putaminal necrosis associated with the mitochondrial DNA A8344G myoclonus epilepsy with ragged red fibers (MERRF) mutation: an infantile case.

    abstract::Myoclonus epilepsy with ragged red fibers (MERRF) is one of the major mitochondrial encephalomyopathies. Its main clinical features are myoclonus epilepsy, ataxia, and myopathy with ragged red fibers. Whereas there is a close correlation between MERRF syndrome and the A8344G mutation of mitochondrial DNA, the reverse ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738060210010901

    authors: Orcesi S,Gorni K,Termine C,Uggetti C,Veggiotti P,Carrara F,Zeviani M,Berardinelli A,Lanzi G

    更新日期:2006-01-01 00:00:00

  • Congenital Visual Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic Acid (RNA) Synthetase (KARS) Mutations: The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease.

    abstract::Aminoacyl-transfer ribonucleic acid (RNA) synthetases (ARSs) are a group of enzymes required for the first step of protein translation. Each aminoacyl-transfer RNA synthetase links a specific amino acid to its corresponding transfer RNA component within the cytoplasm, mitochondria, or both. Mutations in ARSs have been...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814553272

    authors: McMillan HJ,Humphreys P,Smith A,Schwartzentruber J,Chakraborty P,Bulman DE,Beaulieu CL,FORGE Canada Consortium.,Majewski J,Boycott KM,Geraghty MT

    更新日期:2015-07-01 00:00:00

  • Cerebrospinal fluid levels of nitric oxide and nitrotyrosine in neonates with mild hypoxic-ischemic encephalopathy.

    abstract::The objective of this study was to determine the role of cerebral nitric oxide and its powerful oxidant peroxynitrite following mild birth asphyxia. The cerebrospinal fluid levels of nitric oxide and 3-nitrotyrosine as a marker for peroxynitrite are measured in neonates with mild hypoxic-ischemic encephalopathy. Based...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738020170111101

    authors: Gücüyener K,Ergenekon E,Demiryürek T,Erbaş D,Oztürk G,Koç E,Atalay Y

    更新日期:2002-11-01 00:00:00

  • A simple method for diagnosis of autosomal recessive spinal muscular atrophy by denaturing high-performance liquid chromatography.

    abstract::Autosomal recessive spinal muscular atrophy is caused by mutations in the survival motoneuron (SMN) gene. There are two nearly identical copies of this gene present on chromosome 5q13; however, only the telomeric copy of this gene is affected in spinal muscular atrophy. In this study, we describe a new method to detec...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738030180041301

    authors: Mazzei R,Conforti FL,Muglia M,Sprovieri T,Patitucci A,Magariello A,Gabriele AL,Quattrone A

    更新日期:2003-04-01 00:00:00

  • Scaled Vibratory Feedback Can Bias Muscle Use in Children With Dystonia During a Redundant, 1-Dimensional Myocontrol Task.

    abstract::Vibratory feedback can be a useful tool for rehabilitation. We examined its use in children with dystonia to understand how it affects muscle activity in a population that does not respond well to standard rehabilitation. We predicted scaled vibration (ie, vibration that was directly or inversely proportional to muscl...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073816671830

    authors: Liyanagamage SA,Bertucco M,Bhanpuri NH,Sanger TD

    更新日期:2017-02-01 00:00:00

  • Insights on chronic-relapsing opsoclonus-myoclonus from a pilot study of mycophenolate mofetil.

    abstract::Opsoclonus-myoclonus syndrome is characterized by abnormal lymphocyte trafficking into brain. The authors hypothesized that mycophenolate mofetil, a lymphocyte proliferation inhibitor, might be therapeutic. The cerebrospinal fluid and blood immunophenotypes of 15 children with predominantly chronic-relapsing opsoclonu...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073808324217

    authors: Pranzatelli MR,Tate ED,Travelstead AL,Baumgardner CA,Gowda NV,Halthore SN,Kerstan P,Kossak BD,Mitchell WG,Taub JW

    更新日期:2009-03-01 00:00:00

  • Ischemic stroke in the young: evaluation and age comparison of patients six months to thirty-nine years.

    abstract::Ischemic stroke in the young is uncommon, but we currently evaluate at least one young stroke patient at our institutions each week. We undertook this chart review of strokes in patients between the ages of 6 months and 39 years to review all conditions associated with, and thus possibly contributory to, the stroke. W...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389300800311

    authors: Kerr LM,Anderson DM,Thompson JA,Lyver SM,Call GK

    更新日期:1993-07-01 00:00:00

  • Guidelines for resuscitation in the delivery room of extremely preterm infants.

    abstract::Ethical problems related to intensive care of extremely preterm newborns of < or = 25 weeks' gestational age and at risk of disability have been extensively debated. The Bioethical Committee of the Department of Paediatrics of the University Hospital of Padua organized and started a multidisciplinary group to release ...

    journal_title:Journal of child neurology

    pub_type: 指南,杂志文章,实务指引

    doi:10.1177/088307380401900106011

    authors: Verlato G,Gobber D,Drago D,Chiandetti L,Drigo P,Working Group of Intensive Care in the Delivery Room of Extremely Premature Newborns.

    更新日期:2004-01-01 00:00:00

  • Accessory brains (extracerebral heterotopias): unusual prenatal intracranial mass lesions.

    abstract::Prenatal ultrasonographic evidence of intracranial mass lesions generally results in a diagnosis of primary glial or primitive neuroectodermal neoplasm. We describe two infants, one who was stillborn at 25 weeks' estimated gestational age and one term infant who was born live and died shortly after birth with large in...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389400900410

    authors: Harris CP,Townsend JJ,Klatt EC

    更新日期:1994-10-01 00:00:00

  • Advancing the medical management of epilepsy: disease modification and pharmacogenetics.

    abstract::Despite the recent development of new antiepilepsy drugs, a significant number of children are still unable to achieve seizure freedom without side effects. Understanding the factors behind individual variability in antiepilepsy drug tolerability and dose response and incorporating these factors into a treatment plan ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/08830738020170011301

    authors: Glauser TA

    更新日期:2002-01-01 00:00:00

  • A neurologic presentation of familial hemophagocytic lymphohistiocytosis which mimicked septic emboli to the brain.

    abstract::Familial hemophagocytic lymphohistiocytosis is an inherited deficiency of natural killer cell function and excessive cytokine activity, which predominantly presents in early childhood. The initial symptoms of familial hemophagocytic lymphohistiocytosis are often nonspecific but may be predominantly neurologic. The cas...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807304203

    authors: Turtzo LC,Lin DD,Hartung H,Barker PB,Arceci R,Yohay K

    更新日期:2007-07-01 00:00:00

  • Impact of recent seizures on cerebral blood flow in patients with sturge-weber syndrome: study of 2 cases.

    abstract::Patients with refractory seizures, including those with Sturge-Weber syndrome, undergo functional studies in preparation for surgery. Perfusion studies in Sturge-Weber syndrome by single photon emission computed tomography and positron emission tomography generally demonstrate hypoperfusion in the diseased tissue. We ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807302597

    authors: Oguz KK,Senturk S,Ozturk A,Anlar B,Topcu M,Cila A

    更新日期:2007-05-01 00:00:00

  • Automated tandem mass spectrometry for mass newborn screening for disorders in fatty acid, organic acid, and amino acid metabolism.

    abstract::Development of acylcarnitine and amino acid profiling using tandem mass spectrometry, and its application for use with dried blood specimens collected on filter-paper cards, has introduced an innovative new technology for detecting inborn errors of fatty acid, organic acid, and amino acid metabolism. From November 1, ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073899014001021

    authors: Naylor EW,Chace DH

    更新日期:1999-11-01 00:00:00

  • Meningismus is a commonly overlooked finding in tension-type headache in children and adolescents.

    abstract::At present, both migraine and tension-type headaches in children are believed to be chronic primary headaches. Meningeal signs in both cases are ignored or not examined, and the neurologic status is considered normal. This is the first study that focuses on meningeal signs in children with chronic headaches. The study...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738060210050601

    authors: Almazov I,Brand N

    更新日期:2006-05-01 00:00:00

  • Meralgia paresthetica in the pediatric population: a propos of 2 cases.

    abstract::Meralgia paresthetica is a mononeuropathy affecting the lateral femoral cutaneous nerve that is extremely rare in children. Two adolescent females, aged 11 and 13 years, presented due to tingling and pain on the side of the thigh of 2 to 3 weeks duration. The general examination revealed mild obesity; the neurological...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073809336130

    authors: Fernández-Mayoralas DM,Fernández-Jaén A,Jareño NM,Pérez BC,Fernández PM,Sola AG

    更新日期:2010-01-01 00:00:00

  • The role of frontal dysfunction in attention deficit hyperactivity disorder.

    abstract::Among diverse populations concerning the etiology of attention deficit hyperactivity disorder (ADHD), frontal dysfunction remains strong. The influences of frontal systems on attention, particularly the elements of higher mental control postulated as prefrontal functions, are illustrated through presentation of a numb...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/0883073891006001s02

    authors: Benson DF

    更新日期:1991-01-01 00:00:00

  • Activating tasks for the study of visual-spatial attention in ADHD children: a cognitive anatomic approach.

    abstract::The clinical label attention deficit hyperactivity disorder (ADHD) suggests that this syndrome is a disorder of attention. However, the presumed attentional deficits have not been linked either to specific cognitive operations or to specific neural systems. To provide this link, theories of the cognitive anatomy of at...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/0883073891006001s12

    authors: Swanson JM,Posner M,Potkin S,Bonforte S,Youpa D,Fiore C,Cantwell D,Crinella F

    更新日期:1991-01-01 00:00:00

  • Epilepsy treatment in Rett syndrome.

    abstract::Rett syndrome is a neurodevelopmental disorder predominately affecting females. The majority of patients have epilepsy in the early stages of the disease. This study evaluates the clinical course of epilepsy and the effect of antiepileptic drug treatment in Rett syndrome using retrospective data analysis. Epilepsy was...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073811408422

    authors: Krajnc N,Župančič N,Oražem J

    更新日期:2011-11-01 00:00:00

  • Neurobiology of Rett syndrome.

    abstract::Girls with Rett syndrome display signs of neuronal dysfunction including mental retardation, seizures, stereotyped movements, and abnormal breathing and autonomic control. Decelerating head growth during infancy might reflect a disorder in production or pruning of neuronal synapses or both. Recent immunocytochemical s...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/08830738030180100501

    authors: Johnston MV,Mullaney B,Blue ME

    更新日期:2003-10-01 00:00:00

  • Neurofibromatosis type 1: magnetic resonance imaging findings.

    abstract::The purpose of this study was to determine the locations and characterize the types of brain abnormalities noted on brain magnetic resonance imaging in patients with probable and definite neurofibromatosis type 1. Patients with definite neurofibromatosis type 1 (n = 17) were studied when clinically indicated, and pati...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389300800105

    authors: DiMario FJ Jr,Ramsby G,Greenstein R,Langshur S,Dunham B

    更新日期:1993-01-01 00:00:00

  • Cerebrospinal Fluid Analysis for Viruses by Metagenomic Next-Generation Sequencing in Pediatric Encephalitis: Not Yet Ready for Prime Time?

    abstract:BACKGROUND:Metagenomic next-generation sequencing offers an unbiased approach to identifying viral pathogens in cerebrospinal fluid of patients with meningoencephalitis of unknown etiology. METHODS:In an 11-month case series, we investigated the use of cerebrospinal fluid metagenomic next-generation sequencing to diag...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073820972232

    authors: Erdem G,Kaptsan I,Sharma H,Kumar A,Aylward SC,Kapoor A,Shimamura M

    更新日期:2020-11-18 00:00:00