Abstract:
:The purpose of this study was to determine the locations and characterize the types of brain abnormalities noted on brain magnetic resonance imaging in patients with probable and definite neurofibromatosis type 1. Patients with definite neurofibromatosis type 1 (n = 17) were studied when clinically indicated, and patients with probable neurofibromatosis type 1 (n = 9) were studied to evaluate for asymptomatic optic pathway glioma. Of the 26 patients evaluated, 14 (53%) had high-intensity signal abnormalities and 11 (42%) had significant structural abnormalities. Subsequent clinical follow-up has confirmed conversion to a definite neurofibromatosis type 1 diagnosis in three of the four cases of probable neurofibromatosis type 1 who had high-intensity signal abnormalities. The most common locations of high-intensity signal lesions were in the globus pallidus of the basal ganglia and cerebellar white matter. Tortuous or thickened optic nerves and/or optic chiasm were seen in eight cases. Brain magnetic resonance imaging scans frequently reveal high-intensity signal lesions and structural abnormalities in selected patients with both probable and definite neurofibromatosis type 1. These findings may allow for a definitive diagnosis in clinically probable cases.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
DiMario FJ Jr,Ramsby G,Greenstein R,Langshur S,Dunham Bdoi
10.1177/088307389300800105subject
Has Abstractpub_date
1993-01-01 00:00:00pages
32-9issue
1eissn
0883-0738issn
1708-8283journal_volume
8pub_type
杂志文章abstract::The objective of this study was to determine the impact of migraine headaches on health-related quality of life among Canadian adolescents. The Canadian Community Health Survey (CCHS) collects information related to health status, health care utilization, and health determinants for the Canadian population. Analysis w...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807307987
更新日期:2008-01-01 00:00:00
abstract::We report the unique case of late-onset pancraniosynostosis presenting with rapid visual deterioration, without other symptoms of increased intracranial pressure. A 10-year-old girl had episodes of blurry vision for 1 month. Magnetic resonance imaging (MRI) demonstrated a borderline Chiari I malformation. Ophthalmolog...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813495307
更新日期:2014-08-01 00:00:00
abstract::There are scarce reports of childhood stroke from China. Our objective was to describe the clinical spectrum, risk factors, and imaging characteristics of childhood stroke in China. Using a hospital discharge database, children with stroke who were first admitted from 2002 to 2011 were retrospectively enrolled. We ide...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814538667
更新日期:2015-03-01 00:00:00
abstract::Two siblings with familial encephalopathy, calcification of the basal ganglia, and cerebrospinal fluid lymphocytosis, constituting the triad of Aicardi-Goutieres syndrome, are reported. This syndrome resembles congenital intrauterine infections, which must be meticulously excluded. Aicardi-Goutieres syndrome is extrem...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101601009
更新日期:2001-10-01 00:00:00
abstract::Transient neonatal myasthenia gravis is a postsynaptic neuromuscular transmission defect occurring in 21% of infants born to women with active (and, less commonly, in remission) acquired myasthenia gravis. Although passive-transfer acetylcholine receptor (AChR) antibodies are found in the majority of these newborns, t...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307389200700202
更新日期:1992-04-01 00:00:00
abstract::In general, people with learning disabilities are a heterogeneous population that require a multidisciplinary evaluation and careful, well-planned intervention. Despite this heterogeneity, patterns of problems often co-occur. Therefore, diagnosticians and educators should look beyond single areas of achievement such a...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738950100S102
更新日期:1995-01-01 00:00:00
abstract::The sphenoid sinus is often referred to as the "neglected sinus." Isolated sphenoid sinusitis is a rare disease with potentially devastating complications. It occurs at an incidence of about 2.7% of all sinus infections. Although headache is the most common presenting symptom, there is no typical headache pattern. Thr...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101601203
更新日期:2001-12-01 00:00:00
abstract::A 12-year-old boy with perinatally acquired human immunodeficiency virus infection an d Centers for Disease Control and Prevention class C3 disease presented with acute onset of confusion and a right-sided movement disorder 5 months after beginning a new antiretroviral regimen. His CD4 count had been below 50 cells/mi...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307380201700613
更新日期:2002-06-01 00:00:00
abstract::This investigation correlated incidence and degree of autonomic dysfunction with the degree of motor impairment in children hospitalized with Guillain-Barré syndrome. Motor weakness varies, as does the effect on autonomic function including heart rate, vasomotor stability, sweating, continence, and blood pressure. Aft...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811420872
更新日期:2012-05-01 00:00:00
abstract::Recently, a new disease entity has been defined: the disease of vanishing white matter. This leukoencephalopathy has an autosomal-recessive mode of inheritance. No cause or biochemical marker is known. We studied cerebrospinal fluid amino acids in five patients with the disease and found a consistent, moderate elevati...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389901401108
更新日期:1999-11-01 00:00:00
abstract::Despite being a treatable and preventable zoonosis, brucellosis is still endemic in certain areas of the world. Nervous system involvement is a rare but an important complication of brucellosis in childhood. Neurobrucellosis should be taken into consideration in the differential diagnosis of any kind of neurological s...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811402205
更新日期:2011-10-01 00:00:00
abstract::Direct perfusion of specific regions of the central nervous system by convection-enhanced delivery is becoming more widely used for the delivery of compounds in the research and treatment of various neural disorders. In contrast to other currently available central nervous system delivery techniques, convection-enhanc...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073808321064
更新日期:2008-10-01 00:00:00
abstract::The objective of this study was to investigate the incidence of acute flaccid paralysis in the pediatric population of Honduras over an 11-year period, determine what percentage of acute flaccid paralysis was Guillain-Barré syndrome, and identify the epidemiologic features of Guillain-Barré syndrome. There were 546 ch...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738030180110801
更新日期:2003-11-01 00:00:00
abstract::Reversible posterior leukoencephalopathy syndrome is an increasingly recognized disorder with typical radiologic findings of bilateral gray- and white-matter abnormalities in the posterior regions of the cerebral hemispheres. The majority of patients with reversible posterior leukoencephalopathy syndrome are adults, a...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738060210060901
更新日期:2006-06-01 00:00:00
abstract::We reviewed the data from 215 consecutively imaged children who were referred because of neurologic disease. We specifically looked for evidence of cerebral arterial infarction in the form of focal brain damage in an arterial vascular distribution. Twenty-eight showed an arterial infarction pattern. All the major cere...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388700200413
更新日期:1987-10-01 00:00:00
abstract::Paroxysmal tonic upgaze of childhood is an eye movement abnormality characterized by periodic episodes of conjugate upward eye deviation. Although the spectrum of paroxysmal tonic upgaze has broadened considerably, a specific pathophysiology has not been elucidated. We report an infant with paroxysmal tonic upgaze who...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200021601
更新日期:2005-02-01 00:00:00
abstract::We report a case of a neonate with sectional narrowing of the spinal cord on the level of T12 to L2 and a deformed vertebral body on a different level, L4. In previously described cases of sectional spinal dysgenesis, the vertebral and spinal cord malformations are usually found on the same level. Our case may represe...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101600819
更新日期:2001-08-01 00:00:00
abstract::High-functioning adolescents and young adults with mitochondrial disease are now attempting transitions to postsecondary environments. This pilot and case study explores factors that interfere with their successful transition through behavior-rating scales addressing academic skills and behavior. In the Behavior Asses...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812442589
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Acute flaccid myelitis has emerged as the leading cause of acute flaccid paralysis in children. Acute flaccid myelitis leads to significant physical disability; hence, objective outcome measures to study disease severity and progression are desirable. In addition, nerve transfer to improve motor function in ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820939392
更新日期:2020-11-01 00:00:00
abstract::Computerized neurocognitive testing has become a growing practice across medical populations, but particularly within sports medicine and the management of sports-related concussion. Although traditional neuropsychological measures are solely administered and interpreted by neuropsychologists, computerized cognitive t...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073814559645
更新日期:2016-01-01 00:00:00
abstract::Neuromotor function was assessed in 94 children of normal intelligence with Tourette syndrome, Tourette syndrome and attention-deficit hyperactivity disorder (ADHD), or ADHD only, using the Physical and Neurological Examination of Subtle Signs (PANESS). Time to complete six motor movements was analyzed separately by s...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389701200705
更新日期:1997-10-01 00:00:00
abstract::We report our experience in a cohort of patients with hyperphenylalaninemia in a tertiary care referral center in Lebanon. Forty-one sequential patients were studied: 34 classical phenylketonuria (PKU), 3 hyperphenylalaninemia (non-PKU), and 4 biopterin metabolism defects. The majority of cases were clinically diagnos...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073810375116
更新日期:2011-02-01 00:00:00
abstract::On April 19, 1995, Oklahoma City (and the United States) lost its innocence. Almost all Oklahomans can relate exactly what they were doing either at 9:02 AM that day or when they first learned of the bombing. Of course, the whole world watched the events unfold through around-the-clock television coverage. One of the ...
journal_title:Journal of child neurology
pub_type: 传,历史文章,杂志文章
doi:10.1177/088307389501000510
更新日期:1995-09-01 00:00:00
abstract::We present 12 cases of males with myalgia and cramps and a normal muscle strength examination. All the patients had muscle dystrophin values consistent with Becker muscular dystrophy. Five of the patients had a normal electromyogram, and five had normal light microscopic muscle biopsy results. Of particular note, four...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389601100105
更新日期:1996-01-01 00:00:00
abstract::In this article, we describe a 14-year-old boy with a confirmed diagnosis of Friedreich ataxia who underwent cardiac transplantation for left ventricular failure secondary to dilated cardiomyopathy with restrictive physiology. His neurological status prior to transplantation reflected early signs of neurological disea...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073812448229
更新日期:2012-09-01 00:00:00
abstract::We assessed 10 youth football players (13.4 ± 0.7 y) immediately before and after their season to explore the effects of football participation on selected clinical measures of neurologic function. Postseason postural stability in a closed-eye condition was improved compared to preseason (P = .017). Neurocognitive tes...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813509887
更新日期:2014-12-01 00:00:00
abstract::Erythromelalgia is a rare condition characterized by episodic painful erythema and warmth often affecting, but not limited to, the distal extremities. This condition is notoriously difficult to treat. We report a young female patient with seronegative polyarthritis who presented with a 6-year history of recurrent bout...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811427784
更新日期:2012-07-01 00:00:00
abstract::There is increased necessity to focus research on school-aged athletes with sports-related concussion (SRC). This study assessed differences in symptom reporting and neurocognitive performance in youth athletes who sustained a sports-related concussion. A total of 1345 concussed and 3529 nonconcussed athletes (ages 8-...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818766815
更新日期:2018-06-01 00:00:00
abstract::We describe the clinical utility of echo-planar diffusion-weighted imaging in neonatal cerebral infarction. Eight full-term neonates aged 1 to 8 days referred for neonatal seizures were studied. Patients were followed for a mean of 17 months with detailed neurologic examinations at regular intervals. Head computed tom...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380001500905
更新日期:2000-09-01 00:00:00
abstract::A nondescribed behavioral disorder was observed during wake-sleep transitions in 2 young children. Two boys had episodes of abnormal behavior in hypnagogic-and occasionally hypnopompic-periods for 1 year from the time they were 1 year and several months old. The episodes consisted of irregular body movements, which co...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808314964
更新日期:2008-08-01 00:00:00