Reduced Transcriptomic Approach for Screening and Prediction of Chemical Toxicity.

abstract：:Strong evidence supports the idea that specific metabolites of estrogens, mainly catechol estrogen-3,4-quinones, can react with DNA to become endogenous initiators of breast, prostate, and other human cancers. Oxidation of the catechol estrogen metabolites 4-hydroxyestradiol (4-OHE2) and 2-OHE2 leads to the quinones, ...

journal_title：Chemical research in toxicology

authors： Zahid M,Kohli E,Saeed M,Rogan E,Cavalieri E

更新日期：2006-01-01 00:00:00

abstract：:The mechanism of formation of etheno (epsilon) adducts of nucleic acid bases from 2-haloacetaldehydes is generally assumed to occur via initial Schiff base formation resulting from reaction of the aldehyde with an exocyclic amine. We recently revised the 1H NMR assignments of the epsilon protons of 1,N2-epsilon-Guo (G...

journal_title：Chemical research in toxicology

authors： Guengerich FP,Persmark M

更新日期：1994-03-01 00:00:00

abstract：:Metabolic pathways of the mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) remain incompletely characterized in humans. In this study, the metabolism of MeIQx was investigated in primary human hepatocytes. Six metabolites were characterized by UV and mass spectroscopy. Novel metabolites were additionally ...

journal_title：Chemical research in toxicology

authors： Langouët S,Welti DH,Kerriguy N,Fay LB,Huynh-Ba T,Markovic J,Guengerich FP,Guillouzo A,Turesky RJ

更新日期：2001-02-01 00:00:00

abstract：:Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how metabolic capacity is influenced among patients. Cytochrome P450s (P450 or CYP for a specific isoform) catalyze the first m...

journal_title：Chemical research in toxicology

authors： Jones DR,Kim SY,Guderyon M,Yun CH,Moran JH,Miller GP

更新日期：2010-05-17 00:00:00

abstract：:Among the cellular components that can react directly with peroxynitrite in the presence of physiological CO(2) concentrations are sulfur-, selenium-, and metal-containing proteins, in particular hemoproteins. We have previously shown that the reactions of peroxynitrite with oxymyoglobin (MbFeO(2)) and oxyhemoglobin p...

journal_title：Chemical research in toxicology

authors： Herold S,Exner M,Boccini F

更新日期：2003-03-01 00:00:00

abstract：:Mitomycin C (MC), a cytotoxic anticancer drug and bifunctional DNA DNA alkylating agent, induces cross-linking of the complementary strands of DNA. The DNA interstrand cross-links (ICLs) are thought to be the critical cytotoxic lesions produced by MC. Decarbamoyl mitomycin C (DMC) has been regarded as a monofunctional...

journal_title：Chemical research in toxicology

authors： Palom Y,Suresh Kumar G,Tang LQ,Paz MM,Musser SM,Rockwell S,Tomasz M

更新日期：2002-11-01 00:00:00

abstract：:The importance of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis is expected to grow substantially due to recent failures in detecting severe toxicity issues of new chemical entities during preclinical/clinical development. Traditionally, safety risk assessment studies for humans have b...

journal_title：Chemical research in toxicology

authors： Goracci L,Valeri A,Sciabola S,Aleo MD,Moritz W,Lichtenberg J,Cruciani G

更新日期：2020-01-21 00:00:00

abstract：:Alcohol consumption is associated with an increased risk of several types of malignancy by mechanisms that remain to be elucidated. Most of the ingested ethanol is converted to acetaldehyde but the formation of free radical metabolites such as the 1-hydroxyethyl radical has been also demonstrated to occur in vitro and...

journal_title：Chemical research in toxicology

authors： Nakao LS,Augusto O

更新日期：1998-08-01 00:00:00

abstract：:Complex formation between nitrosoglutathione (GSNO) and Zn(II), Cd(II), and Ni(II) ions was studied by potentiometry and spectroscopic techniques. GSNO forms simple ML and ML2 type complexes (L = GSNO) with these ions. The stability of GSNO in HEPES buffer solution, pH 7.4, increased in the presence of both Zn(II) and...

journal_title：Chemical research in toxicology

authors： Krezel A,Bal W

更新日期：2004-03-01 00:00:00

abstract：:Although many phenols and catechols found as polyphenol natural products are antioxidants and have putative disease-preventive properties, others have deleterious health effects. One possible route to toxicity is the bioactivation of the phenolic function to quinones that are electrophilic, redox-agents capable of mod...

journal_title：Chemical research in toxicology

authors： Tu T,Giblin D,Gross ML

更新日期：2011-09-19 00:00:00

abstract：:The recent guidance on "Safety Testing of Drug Metabolites" issued by the U.S. Food and Drug Administration, Center for Drug Evaluation and Research (CDER) has highlighted the importance of identifying and characterizing drug metabolites as early as possible in drug discovery and development. Furthermore, upon identif...

journal_title：Chemical research in toxicology

authors： Vishwanathan K,Babalola K,Wang J,Espina R,Yu L,Adedoyin A,Talaat R,Mutlib A,Scatina J

更新日期：2009-02-01 00:00:00

abstract：:The measurement of metabolites constitutes a useful tool for detection of exposure and in pharmacokinetic studies. Epoxidation with subsequent glutathione conjugation and mercapturic acid formation is an important deactivation pathway for naphthalene, a toxin which presumably causes lung disease. The mercapturic acid ...

journal_title：Chemical research in toxicology

authors： Marco MP,Nasiri M,Kurth MJ,Hammock BD

更新日期：1993-05-01 00:00:00

abstract：:Flucloxacillin, an isoxazolyl-penicillin, causes cholestasis and biliary epithelium injury. The aim of the study was to determine whether flucloxacillin, either directly or through metabolite formation, may induce cytotoxicity in hepatic or biliary cells. Cytotoxicity was assessed by lactate dehydrogenase release in p...

journal_title：Chemical research in toxicology

authors： Lakehal F,Dansette PM,Becquemont L,Lasnier E,Delelo R,Balladur P,Poupon R,Beaune PH,Housset C

更新日期：2001-06-01 00:00:00

abstract：:A new procedure has been developed for the extraction of 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) and other heterocyclic aromatic amines from human breast milk samples. Extracts were analyzed by high-performance liquid chromatography/electrospray ionization/tandem mass spectrometry (HPLC/ESI-MS/MS) with...

journal_title：Chemical research in toxicology

authors： Scott KA,Turesky RJ,Wainman BC,Josephy PD

更新日期：2007-01-01 00:00:00

abstract：:The hydroperoxide of linoleic acid (13-HPODE) degrades to 9,12-dioxo-10(E)-dodecenoic acid (DODE), which readily modifies proteins. This study identified the major proteins in MCF7 cells modified by DODE. To reduce false positives, three methods were used to identify DODE-modified proteins. First, cells were treated w...

journal_title：Chemical research in toxicology

authors： Slade PG,Williams MV,Brahmbhatt V,Dash A,Wishnok JS,Tannenbaum SR

更新日期：2010-03-15 00:00:00

abstract：:To prevent the accumulation of reactive oxygen species and limit associated damage to biological macromolecules, cells express a variety of oxidant-detoxifying enzymes, including peroxiredoxins. In Saccharomyces cerevisiae, the peroxiredoxin Tsa1 plays a key role in peroxide clearance and maintenance of genome stabili...

journal_title：Chemical research in toxicology

authors： Loberg MA,Hurtig JE,Graff AH,Allan KM,Buchan JA,Spencer MK,Kelly JE,Clodfelter JE,Morano KA,Lowther WT,West JD

更新日期：2019-03-18 00:00:00

abstract：:3'-Hydroxyacetanilide (AMAP) is a nonhepatotoxic regioisomer of acetaminophen (APAP) that nonetheless does form reactive metabolites which bind to hepatic proteins. Because differences in the nature of reactive metabolites formed from AMAP and APAP may explain differences in their propensity to cause hepatotoxicity, c...

journal_title：Chemical research in toxicology

authors： Rashed MS,Nelson SD

更新日期：1989-01-01 00:00:00

abstract：:The neurotrophic factor pleiotrophin (PTN) is upregulated in different brain areas after the administration of different drugs of abuse, including psychostimulants. PTN has been shown to prevent cocaine-induced cytotoxicity in NG108-15 and PC12 cells. We previously demonstrated that specific phosphoproteins related to...

journal_title：Chemical research in toxicology

authors： Vicente-Rodríguez M,Herradón G,Ferrer-Alcón M,Uribarri M,Pérez-García C

更新日期：2015-07-20 00:00:00

abstract：:The reactions of aqueous ClO2 with tyrosine, N-acetyltyrosine, and dopa (3,4-dihydroxyphenylalanine) are investigated from pH 4 to 7. The reaction rates increase greatly with pH to give a series of oxidized products. Tyrosine and N-acetyltyrosine have similar reactivities with second-order rate constants (25.0 degrees...

journal_title：Chemical research in toxicology

authors： Napolitano MJ,Green BJ,Nicoson JS,Margerum DW

更新日期：2005-03-01 00:00:00

abstract：:Estrogens, including the natural hormones estrone (E(1)) and estradiol (E(2)), are thought to be involved in tumor induction. Specifically, catechol estrogen quinones (CEQs) derived from the catechol estrogens 4-hydroxyestrone (4-OHE(1)) and 4-hydroxyestradiol (4-OHE(2)) react with DNA and form DNA adducts (Cavalieri,...

journal_title：Chemical research in toxicology

authors： Jankowiak R,Markushin Y,Cavalieri EL,Small GJ

更新日期：2003-03-01 00:00:00

abstract：:3,N4-Etheno-2'-deoxycytidine, 3-(hydroxyethyl)-2'-deoxyuridine, and 3,N4-ethano-2'-deoxy-cytidine are found in DNA of cells treated with either vinyl chloride or 1,3-bis(2-chloroethyl)-nitrosourea. These exocyclic and related DNA adducts were incorporated into oligodeoxynucleotides, which were then used as templates f...

journal_title：Chemical research in toxicology

authors： Zhang W,Johnson F,Grollman AP,Shibutani S

更新日期：1995-01-01 00:00:00

abstract：:Metabolically formed dihydrodiol epoxides in the bay-region of polycyclic aromatic hydrocarbons are thought to be responsible for the genotoxic properties of these environmental pollutants. The hexacyclic aromatic hydrocarbon dibenzo[def,mno]chrysene (anthanthrene), although lacking this structural feature, was found ...

journal_title：Chemical research in toxicology

authors： Platt KL,Degenhardt C,Grupe S,Frank H,Seidel A

更新日期：2002-03-01 00:00:00

abstract：:The risk of potential human exposure to mixed nanomaterials in consumer, occupational, and medicinal settings is increasing as nanomaterials enter both the workplace and the marketplace. In this study, we investigated the toxicity of mixed engineered carbon black (ECB) and maghemite iron oxide (Fe(2)O(3)) nanoparticle...

journal_title：Chemical research in toxicology

authors： Berg JM,Ho S,Hwang W,Zebda R,Cummins K,Soriaga MP,Taylor R,Guo B,Sayes CM

更新日期：2010-12-20 00:00:00

abstract：:For decades, many studies have linked maternal smoking to an increased risk of preterm birth. As a result, the scientific community has long hypothesized that exposure to environmental tobacco smoke (ETS), commonly referred to as second-hand smoke, is also associated with an increased risk of preterm birth. Multiple s...

journal_title：Chemical research in toxicology

authors： Elkin ER,O'Neill MS

更新日期：2017-07-17 00:00:00

abstract：:Exposure of individual histone proteins (H1, H2A, H2B, H3, or H4) and histone octamers (consisting of two molecules each of H2A, H2B, H3, and H4) to hydroxyl radicals, generated by gamma-irradiation, in the presence of O(2) generates protein-bound hydroperoxides in a dose-dependent fashion; this is in accord with prev...

journal_title：Chemical research in toxicology

authors： Luxford C,Dean RT,Davies MJ

更新日期：2000-07-01 00:00:00

abstract：:The first method for generating (*)NO and O(2)(*)(-) at any known, constant ratio has been developed. Spermine NONOate and di(4-carboxybenzyl)hyponitrite decay with first-order kinetics and exactly equal rate constants (half-lives of 80 min) at 37 degrees C and pH 7.5 to give 200 and 40 mol % (*)NO and O(2)(*)(-), res...

journal_title：Chemical research in toxicology

authors： Hodges GR,Marwaha J,Paul T,Ingold KU

更新日期：2000-12-01 00:00:00

abstract：:A series of alpha-(X-substituted-methyl)-gamma,gamma-dimethyl-gamma-butyrolactones (series 1), a series of alpha-(2-X-substituted-ethyl)-gamma,gamma-dimethyl-gamma-butyrolactones (series 2), where X is a leaving group, and the compound alpha-(3-bromopropyl)-gamma,gamma-butyrolactone (3) were synthesized. Their reactio...

journal_title：Chemical research in toxicology

authors： Franot C,Roberts DW,Smith RG,Basketter DA,Benezra C,Lepoittevin JP

更新日期：1994-05-01 00:00:00

abstract：:There are discrepancies about whether chlorpyrifos is able to induce neurodevelopmental toxicity or not. We previously reported alterations in the pattern of expression of biomarker genes of differentiation in D3 mouse embryonic stem cells caused by chlorpyrifos and its metabolites chlorpyrifos-oxon and 3,5,6-trichlor...

journal_title：Chemical research in toxicology

authors： Estevan C,Fuster E,Del Río E,Pamies D,Vilanova E,Sogorb MA

更新日期：2014-09-15 00:00:00

abstract：:Oxidative stress is a commonly cited mechanism of toxicity of environmental agents. Ubiquitous environmental chemicals such as the diesel exhaust component 1,2-naphthoquinone (1,2-NQ) induce oxidative stress by redox cycling, which generates hydrogen peroxide (H2O2). Cysteinyl thiolate residues on regulatory proteins ...

journal_title：Chemical research in toxicology

authors： Wages PA,Lavrich KS,Zhang Z,Cheng WY,Corteselli E,Gold A,Bromberg P,Simmons SO,Samet JM

更新日期：2015-12-21 00:00:00

abstract：:Deoxynivalenol (DON) is a trichothecene mycotoxin that is produced by several species of Fusarium, which may infect grain crops. DON, as well as other type-B trichothecenes, contain an α,β-unsaturated carbonyl group that may react with sulfhydryl groups in, for example, amino acids and peptides. Such conjugates have b...

journal_title：Chemical research in toxicology

authors： Uhlig S,Ivanova L,Miles CO

更新日期：2020-02-17 00:00:00