Abstract:
OBJECTIVE:Angiogenesis is a crucial event for pancreatic carcinogenesis, and it also plays an important role in chronic pancreatitis. The aim of our study was to evaluate the mRNA expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in chronic inflammatory or malignant pancreatic pathology in order to elucidate the differences in expression patterns and potential clinical implications. METHODS:Thirty-five patients who had undergone endoscopic ultrasonography followed by endoscipic ultrasound-guided fine needle aspiration (EUS-FNA) of focal pancreatic masses were included in the study. VEGF and EGFR mRNA expression levels in the samples collected by EUS-FNA were analyzed using quantitative real-time polymerase chain reaction (PCR). RESULTS:VEGF expression was detected in all chronic pancreatitis and adenocarcinoma samples and in only 62.5% of pancreatic neuroendocrine tumors. EGFR expression was detected in only 40% of the chronic pancreatitis cases, 76.9% of adenocarcinomas and in 50% of pancreatic neuroendocrine tumors. Both VEGF and EGFR mRNA levels were significantly higher in pancreatic ductal adenocarcinoma than those in normal tissue. VEGF expression inversely correlated with pancreatic ductal adenocarcinoma size, while EGFR expression was related to local invasiveness of adenocarcinoma. CONCLUSION:Both VEGF and EGFR mRNA expression in EUS-FNA samples may be used as a diagnostic marker associated with invasiveness in patients with pancreatic adenocarcinoma.
journal_name
Endosc Ultrasoundjournal_title
Endoscopic ultrasoundauthors
Angelescu R,Burada F,Angelescu C,Gheonea DI,Iordache S,Mixich F,Ioana M,Săftoiu Adoi
10.4103/2303-9027.117692subject
Has Abstractpub_date
2013-04-01 00:00:00pages
86-91issue
2eissn
2303-9027issn
2226-7190pii
EUS-2-86journal_volume
2pub_type
杂志文章abstract::Double layered peritoneal folds or ligaments act as conduits for the passage of blood vessels in intraperitoneal organs and also provide a pathway for the spread of disease. It is difficult to identify these normal peritoneal folds at imaging. Computed tomography is the most common imaging modality used to detect dise...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/2303-9027.151317
更新日期:2015-01-01 00:00:00
abstract:Backgrounds and Objectives:No study on the use of lumen-apposing fully covered self-expanding metal stent (LAMS) to drain pancreatic fluid collections (PFCs) has evaluated outcomes of patients in the outpatient setting. The objective of this multicenter study was to evaluate the clinical outcomes, success rate, and adv...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_30_17
更新日期:2019-01-01 00:00:00
abstract::Submucosal tumors (SMTs) are usually discovered fortuitously during routine endoscopy, including various non-neoplastic and neoplastic conditions. Endoscopic ultrasound (EUS) is considered to be the best imaging procedure to characterize SMTs and to determine the need for further treatment. In this review, the followi...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.7178/eus.06.003
更新日期:2013-07-01 00:00:00
abstract:Background and Objectives:We investigated the relationship between the interruption of the muscularis propria of the lower esophageal sphincter (LES) measured by EUS and the relief of dysphagia in patients with esophageal achalasia treated by per-oral endoscopic myotomy (POEM). Patients and Methods:Patients with achal...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_30_20
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:The secure closure of the wall defect is a critical stage of endoscopic full-thickness resection (EFTR). The aim of this study was to compare the closure of post-EFTR defects using an endoscopic ultrasound-guided puncture suture device (PSD) with the metal clip (MC) technique in a randomized, comparative, por...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/2303-9027.187891
更新日期:2016-07-01 00:00:00
abstract::The European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) introduced guidelines on the use of contrast-enhanced ultrasound (CEUS) in 2004. This EFSUMB-document focused mainly on liver applications. However, new applications extending beyond the liver were developed thereafter. Increased inte...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.7178/eus.03.003
更新日期:2012-10-01 00:00:00
abstract::Endobronchial ultrasound (EBUS) has gained importance for mediastinal lymph node staging. Contrast-enhanced EBUS is so far not a discussed technique including contrast-enhanced high mechanical index (MI)-EBUS and potentially contrast-enhanced low MI-EBUS. Possible use could include characterization of mediastinal lymp...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.4103/2303-9027.200215
更新日期:2017-01-01 00:00:00
abstract::Endobronchial ultrasound (EBUS) has emerged as a routinely performed procedure in diagnostic bronchoscopy. Extending the view beyond the airway wall, EBUS provides evaluation of tumor involvement of tracheobronchial wall and mediastinum and plays an essential role as a guidance technique for peripheral pulmonary disea...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.7178/eus.02.003
更新日期:2012-07-01 00:00:00
abstract::Metastatic cancer to the pancreas is rare and accounts for less than 2% of all pancreatic malignancies. Renal cell cancer, malignant melanoma, lung, colon and breast carcinoma are among the few tumors known to metastasize to the pancreas. The pancreas is a rare site of solitary metastasis, but it is often involved in ...
journal_title:Endoscopic ultrasound
pub_type:
doi:10.4103/2303-9027.121248
更新日期:2013-10-01 00:00:00
abstract:Background and Objectives:Procurement of tissue core biopsy samples may overcome some of the limitations of endoscopic ultrasound (EUS)-guided fine-needle aspiration. We aimed at assessing the safety, histological sample procurement yield, and diagnostic accuracy of a newly available histology needle. Materials and Me...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_33_17
更新日期:2018-09-01 00:00:00
abstract::Endobronchial ultrasound (EBUS) is a useful technique for the diagnosis and staging of the lung and mediastinal lesions, which is crucial for selecting treatment protocol. Under EBUS guidance, transbronchial needle aspiration (TBNA) is widely applied for obtaining specimens for histological, cytological, and molecular...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.4103/eus.eus_40_18
更新日期:2018-11-01 00:00:00
abstract::Pancreatic pseudocysts are fluid collections in the peripancreatic tissues associated with acute or chronic pancreatitis. Endoscopic ultrasound (EUS)-guided drainage has become an established indication, having better results as compared to percutaneous drainage, nonguided endoscopic drainage, or surgical drainage. Th...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/2303-9027.170424
更新日期:2015-10-01 00:00:00
abstract:Objectives:The project is aimed to compare the tissue sampling rate and the diagnostic accuracy rate of EUS-FNA using 22G nitinol and reverse bevel-tipped needles. Subjects and Methods:This was a prospective, randomized, crossover study in a tertiary academic hospital. All consecutive adult patients undergoing EUS-gui...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_113_17
更新日期:2018-01-01 00:00:00
abstract:Background and Objectives:EUS-guided biliary drainage (EUS-BD) is increasingly reported as a salvage technique after failed endoscopic retrograde cholangiopancreatography, but it is still controversial whether EUS-BD can replace transpapillary biliary stenting. Therefore, we conducted this multicenter, prospective stud...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_17_18
更新日期:2019-03-01 00:00:00
abstract::[This corrects the article DOI: 10.4103/eus.eus_9_19]. ...
journal_title:Endoscopic ultrasound
pub_type: 已发布勘误
doi:10.4103/2303-9027.282542
更新日期:2020-05-01 00:00:00
abstract:Background and Objectives:EUS-guided tissue acquisition with rapid on-site cytologic evaluation (ROSE) has been used to increase the diagnostic yield. However, ROSE is not available in many centers. To date, only a few studies have assessed the adequacy of histologic cores in macroscopic on-site evaluation (MOSE) durin...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_34_19
更新日期:2019-09-01 00:00:00
abstract:Background and Objectives:The radial echoendoscope is still widely used for the investigation of abnormalities in the gastrointestinal wall and for stone detection in the extrahepatic biliary tree. Due to aging patient population, EUS is frequently performed in fragile and elderly individuals. We aimed to compare the m...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_3_19
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Endoscopic ultrasonography (EUS)-guided fine-needle aspiration (FNA) have a better accuracy for the detection of pancreatic tumors compared with others images modalities. We assessed if the image criteria of elastography and contrast harmonic echo-endoscopic ultrasound could help in choosing the appropriat...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:
更新日期:2014-04-01 00:00:00
abstract::Numerous clinical pathways exist for patients presenting with a suspicious pancreatic mass. These range from direct surgical intervention following staging, with preoperative cross-sectional imaging, EUS with or without fine-needle aspiration or fine-needle core biopsy; neoadjuvant chemotherapy and/or radiation therap...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_28_20
更新日期:2020-05-01 00:00:00
abstract::Endoscopic ultrasound (EUS) is a reference technique for diagnosing and staging several different diseases. EUS-guided biopsies and fine needle aspirations are used to improve diagnostic performance of cases where a definitive diagnosis cannot be obtained through conventional EUS. However, EUS-guided tissue sampling r...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.7178/eus.01.003
更新日期:2012-04-01 00:00:00
abstract:Background and Objective:Robust data in favor of clear superiority of 22G fine-needle biopsy (FNB) over 22G FNA for an echoendoscopic-guided sampling of pancreatic masses are lacking. The objective of this study is to compare the diagnostic outcomes and sample adequacy of these two needles. Materials and Methods:Compu...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.4103/eus.eus_4_19
更新日期:2020-05-01 00:00:00
abstract::Direct referral of patients for EUS - instead of preprocedural consultation with the endosonographer - has become standard practice (like for other endoscopic procedures) as it is time- and cost-effective. To ensure appropriate indications and safe examinations, the endosonographer should carefully consider what infor...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.4103/eus.eus_54_18
更新日期:2019-01-01 00:00:00
abstract:Background and Objectives:EUS guided core biopsy was once rarely performed but is now entering mainstream practice. Neuroendocrine tumors often warrant core biopsy as sufficient tissue must be obtained to allow for special staining to ensure a correct diagnosis. Traditionally these lesions were sampled with FNA needles...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_51_17
更新日期:2018-09-01 00:00:00
abstract::Endoscopic ultrasound (EUS) is one of the best diagnostic methods for diseases of the digestive tract and surrounding organs. Whereas EUS-guided fine needle aspiration (FNA) has been very useful for providing histological confirmation for previously hard to reach lesions, elastography is aiming to obtain a "virtual bi...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.4103/2303-9027.123009
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic value of endoscopic ultrasonography (EUS) and contrast-enhanced harmonic (CEH) EUS in patients with gastrointestinal stromal tumors (GISTs). PATIENTS AND METHODS:About 19 patients with suspected GISTs underwent EUS and CEH-EUS before tumor resection. The malignant potential was ass...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/2303-9027.180475
更新日期:2016-03-01 00:00:00
abstract:Background and Objectives:EUS-FNA is applied widely in clinical practice, but there remains a lack of authentic training models. The present study aimed to develop a novel swine training model and to perform a preliminary assessment of its feasibility and efficacy. Materials and Methods:To create an internal lesion-li...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_13_20
更新日期:2020-07-01 00:00:00
abstract::Insulinoma is the most common functioning islet cell tumor of the pancreas, with an annual incidence of 4 cases/1 million individuals. It is treated by surgical methods. Open surgery was once considered the standard approach for the treatment of insulinoma. However, the procedure is traumatic and requires a large inci...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章,评审
doi:10.4103/2303-9027.194703
更新日期:2017-05-01 00:00:00
abstract::For a definitive diagnosis of fine-needle aspiration (FNA)/biopsy, one of the reliable techniques to determine the adequacy and accuracy rapid on-site evaluation (ROSE) of cytological samples is preferable. Because of the lack of trained pathologists, alternatives have to be explored. This study is primarily conducted...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/eus.eus_27_20
更新日期:2020-11-01 00:00:00
abstract::Lung cancer is one of the major causes of death in the world. Small cell carcinoma is the most aggressive type and can spread rapidly. The association of a small cell carcinoma with hepatic hilar metastasis and biliary obstruction is rare. Endoscopic ultrasound allows the aspiration of a cytology sample from adenopath...
journal_title:Endoscopic ultrasound
pub_type:
doi:10.4103/2303-9027.193570
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Laparoscopic and natural orifice transluminal endoscopic surgery techniques can diagnose peritoneal findings that suggest tumor cell dissemination. However, they have not been incorporated into routine practice, mainly owing to their complexity. To develop a minimally invasive endoscopic technique for the di...
journal_title:Endoscopic ultrasound
pub_type: 杂志文章
doi:10.4103/2303-9027.144535
更新日期:2014-10-01 00:00:00