Abstract:
PURPOSE:To define a threshold radiation dose to non-tumoral liver from 90Y radioembolization that results in hepatic toxicity using pair-production PET. MATERIALS AND METHODS:This prospective single-arm study enrolled 35 patients undergoing radioembolization. A total of 34 patients (27 with HCC and 7 with liver metastases) were included in the final analysis. Of 27 patients with underlying cirrhosis, 22 and 5 patients were Child-Pugh A and B, respectively. Glass and resin microspheres were used in 32 (94%) and 2 (6%) patients, respectively. Lobar and segmental treatment was done in 26 (76%) and 8 (24%) patients, respectively. Volumetric analysis was performed on post-radioembolization time-of-flight PET imaging to determine non-tumoral parenchymal dose. Hepatic toxicity was evaluated up to 120 days post-treatment, with CTCAE grade ≤ 1 compared to grade ≥ 2. RESULTS:The median dose delivered to the non-tumoral liver in the treated lobe was 49 Gy (range 0-133). A total of 15 patients had grade ≤ 1 hepatic toxicity, and 19 patients had grade ≥ 2 toxicity. Patients with a grade ≥ 2 change in composite toxicity (70.7 vs. 43.8 Gy), bilirubin (74.1 vs. 43.3 Gy), albumin (84.2 vs. 43.8 Gy), and AST (94.5 vs. 47.1 Gy) have significantly higher non-tumoral parenchymal doses than those with grade ≤ 1. Liver parenchymal dose and Child-Pugh status predicted grade ≥ 2 toxicity, observed above a dose threshold of 54 Gy. CONCLUSION:Increasing delivered 90Y dose to non-tumoral liver measured by internal pair-production PET correlates with post-treatment hepatic toxicity. The likelihood of toxicity exceeds 50% at a dose threshold of 54 Gy. ClinicalTrials.gov identifier: NCT02848638.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Chan KT,Alessio AM,Johnson GE,Vaidya S,Kwan SW,Monsky W,Wilson AE,Lewis DH,Padia SAdoi
10.1007/s00270-018-1949-5subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1363-1372issue
9eissn
0174-1551issn
1432-086Xpii
10.1007/s00270-018-1949-5journal_volume
41pub_type
杂志文章abstract:INTRODUCTION:Dysfunctional or infected hemodialysis polyester-cuffed catheters often require removal and are dissected out. The DermaPort™, percutaneous vascular access system (PVAS) permanently integrates a titanium mesh with the skin forming a stable, sterile barrier that allows for catheter placement, adjustment, or...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-018-2031-z
更新日期:2018-10-01 00:00:00
abstract::The "arterial plug" is a resistant thrombus that frequently persists at the arterial anastomosis of clotted hemodialysis grafts following thrombolytic therapy. We studied the physical and morphological characteristics of the plug and determined the feasibility of transcatheter removal in vitro using the tulip compress...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900126
更新日期:1997-03-01 00:00:00
abstract::The objective of this study was to explore the role of three-dimensional (3-D) rotational angiography (RA) of the inferior vena cava (IVC; 3-D CV) before filter retrieval and its impact on treatment planning compared with standard anteroposterior cavography (sCV). Thirty patients underwent sCV and 3-D CV before IVC fi...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-008-9405-6
更新日期:2009-01-01 00:00:00
abstract::We performed percutaneously radiofrequency (RF) ablation of 5 renal cell carcinomas (mean diameter 26 +/- 15 mm) with computed-tomography (CT) fluoroscopic guidance using the transhepatic route. The RF electrode was successfully advanced into all tumors. RF ablation caused one minor complication (small asymptomatic pe...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9037-2
更新日期:2007-07-01 00:00:00
abstract::The purpose of this study was to evaluate the fibroid morphology in a cohort of women achieving pregnancy following treatment with uterine artery embolization (UAE) for symptomatic uterine fibroids. A retrospective review of magnetic resonance imaging (MRI) of the uterus was performed to assess pre-embolization fibroi...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9118-2
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:The Zilver PTX drug-eluting stent (Cook Ireland Ltd., Limerick, Ireland) represents an advance in endovascular treatments for atherosclerotic superficial femoral artery (SFA) disease. Clinical data demonstrate improved clinical outcomes compared to bare-metal stents (BMS). This analysis assessed the likely impa...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-012-0494-x
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To determine the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation in patients with liver cirrhosis complicated by thrombosed portal vein. METHODS:This study reviewed 15 cases of TIPS creation in 15 cirrhotic patients with portal vein thrombosis at our institution over an 8-y...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-005-0090-4
更新日期:2006-09-01 00:00:00
abstract::We describe a technique for gaining access to the central collecting system via a chosen calyx, utilizing an alternative entry point to that calyx. An Amplatz nitinol loop snare is then used to convert this access to a traditional approach. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::A 32-year-old woman presented with a pulsatile, painful mass in her left upper arm, originating several days after removal of an Ilizarov external fixation. The diagnosis of a pseudoaneurysm was made by medical history and by physical and ultrasonographic examination of the mass. Angiography confirmed the presence of ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709910028
更新日期:2000-03-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of percutaneous balloon dilatation and temporary internal stenting in the treatment of transplant ureteral strictures. METHODS:Nine patients presenting with obstructed renal transplants were treated by antegrade nephrostomy insertion, ureteroplasty, and temporary internal stenting. Fol...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900412
更新日期:1999-09-01 00:00:00
abstract::Pulmonary parenchymal endometriosis is extremely rare and usually manifests itself with a recurrent hemoptysis associated with the menstrual cycle. The therapies proposed for women with endometriosis consist of medical treatments and surgery. Bronchial artery embolization has become a well-established and minimally in...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9284-2
更新日期:2008-07-01 00:00:00
abstract::Among 3,307 consecutive patients (3,556 legs) with deep venous thrombosis, 54 (1.5%) showed an isolated thrombus of the popliteal vein on phlebography. The majority of those had a history of "effort" or long lasting flexion during air or bus travel. Forty-four percent suffered from pulmonary embolism as the first sign...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02733929
更新日期:1992-07-01 00:00:00
abstract:AIM:The aim of this study is to compare the improvements in irritative versus obstructive symptoms of the International Prostate Symptom Score (IPSS) after prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:Between 2010 and 2018, 186 patients underwent PAE in...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-019-02398-0
更新日期:2020-04-01 00:00:00
abstract::We report a case of an intrahepatic arterioportal fistula in a 61-year-old female liver transplant recipient. The patient presented with massive ascites 7 months after a percutaneous liver biopsy. A large fistula between the right hepatic artery and the right portal vein was diagnosed on color Doppler ultrasound and c...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0193-3
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility of percutaneous hydrodynamic thrombectomy in restoring patency of acutely thrombosed stent-shunts after transjugular intrahepatic portosystemic shunt (TIPS). METHODS:Percutaneous hydrodynamic thrombectomy was performed in five consecutive patients with angiographically documented co...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900133
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:Compare the success of three coaxial fine-needle biopsy techniques in obtaining multiple cytologic specimens of high quality. METHODS:For each of three different biopsy needle and technique combinations (aspiration: 22-gauge Chiba; capillary: 22-gauge Chiba; 22-gauge Autovac aspiration biopsy gun), 30 sites (1...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF00203681
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:To retrospectively compare the postprocedure pain of hepatocellular carcinoma treated with irreversible electroporation (IRE) with radiofrequency ablation (RFA). METHODS:This Health Insurance Portability and Accountability Act-compliant, institutional review board-approved study compared postprocedure pain in ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-012-0426-9
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:The drop-off risk for patients awaiting liver transplantation for hepatocellular carcinoma (HCC) is 22%. Transplant liver availability is expected to worsen, resulting in longer waiting times and increased drop-off rates. Our aim was to determine whether chemoembolization can decrease this risk. PATIENTS ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-0077-7
更新日期:2011-12-01 00:00:00
abstract::The purpose of the study was to evaluate the feasibility and effectiveness of direct porto-caval shunts in patients with Budd-Chiari syndrome (BCS) in whom there is no access to the hepatic veins during transjugular intrahepatic portosystemic shunt (TIPSS). We included six consecutive patients with fulminant/acute Bud...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-005-0103-3
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:In vertebrobasilar occlusion, rapid recanalization is the only substantial means to improve the prognosis. We introduced a standard operating procedure (SOP) for interventional therapy to analyze the effects on interdisciplinary time management. METHODS:Intrahospital time periods between hospital admission a...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0222-y
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:The purpose of this investigation was to evaluate human Thiel-embalmed cadavers with the addition of extracorporeal driven ante-grade pulsatile flow in the aorta as a model for simulation training in interventional techniques and endovascular device testing. MATERIALS AND METHODS:Three human cadavers embalmed ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1643-z
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To assess the efficacy and safety of microcatheter embolization in the treatment of intractable idiopathic epistaxis. METHODS:Thirty-seven patients underwent microcatheter embolization in 1991-1998. We evaluated retrospectively the technical and clinical outcome, the number of complications, the duration of em...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900439
更新日期:1999-11-01 00:00:00
abstract::Entrapment of a central venous catheter (CVC) guide wire in an inferior vena cava (IVC) filter is a rare, but reported complication during CVC placement. With the increasing use of vena cava filters (VCFs), this number will most likely continue to grow. The consequences of this complication can be serious, as continue...
journal_title:Cardiovascular and interventional radiology
pub_type: 信件
doi:10.1007/s00270-012-0374-4
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To experimentally investigate a new homogenously paclitaxel/resveratrol-coated balloon catheter in terms of transport of the coating to the treated tissue and local effects including histology and functional tests. METHODS:Adherence of the coating to the balloon was explored by in vitro simulation of its passa...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-018-2018-9
更新日期:2018-10-01 00:00:00
abstract::Ergotism may cause isolated lower-extremity arterial stenoses that appear amenable to angioplasty but that will recur if the causative agent is not withdrawn. A case of femoral-popliteal stenosis caused by surreptitious ergot ingestion is presented. The lesion initially responded to angioplasty but quickly recurred, w...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02583301
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate the efficacy of the blunt-tipped curved injection needle (BCN) AVAflex (Care Fusion) for vertebral augmentation in cases of Kummel's disease. METHODS:We performed 25 vertebral augmentation procedures on 25 consecutive patients (11 men/14 women; mean age, 67 years) with Kumme...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9985-9
更新日期:2011-10-01 00:00:00
abstract::When compared in a uterine artery embolization (UAE) animal model, Embospheres (ES) (Biosphere Medical, Rockland, MA) were found to induce less uterine ischemia than polyvinyl alcohol (PVA) particles. Given this finding, we aimed to test the hypothesis that ES is associated with less pain after UAE than PVA in human p...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-003-0045-6
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:Congenital hemophilia is a hereditary bleeding disorder that affects 1 in 5,000 males and is characterized by repetitive musculoskeletal bleeding episodes. Selective embolization of the knee and elbow arteries can prevent bleeding episodes. To evaluate the long-term efficacy of these procedures, we assessed the...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-012-0480-3
更新日期:2013-08-01 00:00:00
abstract::A Palmaz stent had dislodged into the left pulmonary artery after TIPS. After transfemoral catheterization of the left pulmonary artery, the stent was retrieved into the right femoral vein employing an angioplastic balloon catheter and finally extracted after surgical venotomy. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02807232
更新日期:1995-03-01 00:00:00
abstract::The authors describe a case in which a biliary-hepatic artery fistula was created by a glidewire perforation during percutaneous transhepatic biliary drainage and was successfully treated by embolization via the transbiliary tract. Great caution should be exercised to avoid perforation when a Terumo hydrophilic glidew...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF00192455
更新日期:1994-09-01 00:00:00