Abstract:
PURPOSE:To experimentally investigate a new homogenously paclitaxel/resveratrol-coated balloon catheter in terms of transport of the coating to the treated tissue and local effects including histology and functional tests. METHODS:Adherence of the coating to the balloon was explored by in vitro simulation of its passage to the lesion. Paclitaxel and resveratrol transfer to the vessel wall was investigated in porcine coronary and peripheral arteries. Matrix-assisted laser desorption/ionization (MALDI) was used for direct microscopic visualization of paclitaxel in arterial tissue. Inhibition of neointimal proliferation and tolerance of complete coating and resveratrol-only coating was investigated in pigs 4 weeks after treatment, and the effect of resveratrol on inflammation and healing after 3 and 7 days. RESULTS:Drug loss on the way to the lesion was < 10% of dose, while 65 ± 13% was detected at the site of balloon inflation. After treatment similar proportions of drug were detected in coronary and peripheral arteries, i.e., 7.4 ± 4.6% of dose or 125 ± 74 ng/mg tissue. MALDI showed circumferential deposition. Inhibition of neointimal proliferation by paclitaxel/resveratrol coating was significant (p = 0.001) whereas resveratrol-only coating did not inhibit neointimal proliferation. During the first week after treatment of peripheral arteries with resveratrol-only balloons, we observed nominally less inflammation and fibrin deposition along with a significant macrophage reduction and more pronounced re-endothelialization. No safety issues emerged including left ventricular ejection fraction for detection of potential distal embolization after high-dose treatment of coronary arteries. CONCLUSIONS:Paclitaxel/resveratrol-coated balloons were effective and safe in animal studies. Beyond acting as excipient resveratrol may contribute to vascular healing.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Speck U,Häckel A,Schellenberger E,Kamann S,Löchel M,Clever YP,Peters D,Scheller B,Trog S,Bettink Sdoi
10.1007/s00270-018-2018-9subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1599-1610issue
10eissn
0174-1551issn
1432-086Xpii
10.1007/s00270-018-2018-9journal_volume
41pub_type
杂志文章abstract::This study evaluated the safety, feasibility, and clinical utility of hyaluronic acid gel injection to separate the gastrointestinal tract from the tumor during liver radiofrequency ablation (RFA). Eleven patients with liver tumors measuring 0.9-3.5 cm (mean ± standard deviation, 2.1 ± 0.8 cm) that were adjacent to th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0546-x
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To describe the technique and feasibility of renal artery angioplasty and stenting from the radial artery. METHODS:A series of 19 patients were evaluated for transradial renal artery intervention. Procedures were performed using carbon dioxide gas (CO2) as the preferred angiographic contrast agent. Interventio...
journal_title:Cardiovascular and interventional radiology
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doi:10.1007/s00270-001-0114-7
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abstract::Deep vein thrombosis (DVT) and pulmonary embolism (PE) are both characterized by unreliable clinical diagnosis and significant long-term sequelae. In patients with DVT, popliteal valvular insufficiency is associated with increased risk for postphlebitic syndrome. Current data show thrombolytic therapy to be more effec...
journal_title:Cardiovascular and interventional radiology
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doi:10.1007/BF02577090
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abstract::The solitary kidney, either after nephrectomy or on a congenital basis, may be impaired by infection, stones, obstruction, and trauma. Because of the possibility of further renal compromise by damage of the remaining nephron units, there is reluctance to utilize percutaneous techniques in cases of solitary kidney, and...
journal_title:Cardiovascular and interventional radiology
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abstract:PURPOSE:To report the chest radiograph measurement technique for placing bedside peripherally inserted central catheters (PICCs). MATERIALS AND METHODS:Two hundred and thirty-two consecutive pediatric patients, mean age of 56.3 months (range: 0-203 months), underwent PICC placement from January 2015 to May 2017 (28 mo...
journal_title:Cardiovascular and interventional radiology
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doi:10.1007/s00270-017-1857-0
更新日期:2018-03-01 00:00:00
abstract::We report a case of an intrahepatic arterioportal fistula in a 61-year-old female liver transplant recipient. The patient presented with massive ascites 7 months after a percutaneous liver biopsy. A large fistula between the right hepatic artery and the right portal vein was diagnosed on color Doppler ultrasound and c...
journal_title:Cardiovascular and interventional radiology
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doi:10.1007/s00270-004-0193-3
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abstract:PURPOSE:The treatment of ruptured vertebral artery dissecting aneurysms (VADAs) continues to be controversial. Our goal was to evaluate the safety, efficacy, and long-term outcomes of internal trapping and stent-assisted coiling (SAC) for ruptured VADAs distal to the posterior inferior cerebellar artery (supra-PICA VAD...
journal_title:Cardiovascular and interventional radiology
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doi:10.1007/s00270-014-0981-3
更新日期:2015-06-01 00:00:00
abstract::The Bard prostate biopsy gun under ultrasonic guidance provides consistent, high quality prostatic core samples for histopathologic diagnosis. This device can be adapted for biopsy of abdominal organs using computed tomographic guidance. We demonstrate how these technical modifications can be made. Having used this mo...
journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::The purpose of this study was to evaluate the feasibility of multislice computed tomographic (MSCT) angiography as a noninvasive method for detecting ostial, proximal, and middle segment coronary stenosis or occlusion and anatomy in patients with transposition of the great arteries who had undergone arterial switch op...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-008-9432-3
更新日期:2009-03-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0617-z
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Two stent types (a new Wallstent and a Z-stent) were investigated in 30 patients with recurrent malignant superior vena caval syndrome (SVCS). METHODS:Eligibility requirements were that the patient had recurrent symptoms after appropriate radiation therapy, chemotherapy, or both; >/= 75% of the vessel was occl...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02577610
更新日期:1996-05-01 00:00:00
abstract::A type II endoleak (T2EL) is the most common endoleak after endovascular aneurysm repair (EVAR), and a persistent T2EL has been occasionally associated with aneurysmal enlargement. Typical findings of a T2EL consist of an endoleak cavity with inflow and outflow arteries of aortic branch vessels. However, an atypical T...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1778-y
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00270-020-02684-2
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To investigate the incidence and clinical significance of platelet responsiveness in patients receiving clopidogrel after peripheral angioplasty procedures. MATERIALS AND METHODS:This prospective study included patients receiving antiplatelet therapy with clopidogrel 75 mg after infrainguinal angioplasty or st...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0577-3
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:The purpose of this study is to accentuate the efficacy of direct stenting (stent placement without predilatation of the lesion) in patients with acute lower limb arterial ischemia (ALLI). MATERIALS AND METHODS:Between January 2010 and September 2015, 16 patients (11 men and 5 women) underwent direct stenting ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-016-1500-5
更新日期:2017-02-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900116
更新日期:1997-03-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-007-9284-2
更新日期:2008-07-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02807227
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doi:10.1007/s00270-016-1297-2
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-005-0063-7
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:To develop an effective prognostic nomogram for patients with hepatocellular carcinoma (HCC) after thermal ablation. METHODS:A total of 772 patients with intrahepatic primary or recurrent HCC who underwent radiofrequency ablation or microwave ablation between March 2011 and October 2016 were included. 602 pati...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02617-z
更新日期:2020-11-01 00:00:00
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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abstract::Placement of a balloon-expandable metallic stent (Strecker-Stent) for biliary drainage has been attempted in 30 patients. The stent was successfully implanted in 22 patients; in the remaining 8 patients, dilatation of the biliary stricture prior to stent placement was inadequate and delivery of the Strecker-Stent was,...
journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
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journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0584-4
更新日期:2013-12-01 00:00:00
abstract::The authors describe a case in which a biliary-hepatic artery fistula was created by a glidewire perforation during percutaneous transhepatic biliary drainage and was successfully treated by embolization via the transbiliary tract. Great caution should be exercised to avoid perforation when a Terumo hydrophilic glidew...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00