Genomic prediction in an admixed population of Atlantic salmon (Salmo salar).

abstract：:In the last 40 years, the Asian tiger mosquito Aedes albopictus, indigenous to East Asia, has colonized every continent except Antarctica. Its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile, and the...

journal_title：Frontiers in genetics

authors： Battaglia V,Gabrieli P,Brandini S,Capodiferro MR,Javier PA,Chen XG,Achilli A,Semino O,Gomulski LM,Malacrida AR,Gasperi G,Torroni A,Olivieri A

更新日期：2016-11-23 00:00:00

abstract：:The principles and function of chromatin and nuclear architecture have been extensively studied in model organisms, such as Drosophila melanogaster. However, little is known about the role of these epigenetic processes in transcriptional regulation in other insects including mosquitoes, which are major disease vectors...

journal_title：Frontiers in genetics

authors： Lezcano ÓM,Sánchez-Polo M,Ruiz JL,Gómez-Díaz E

更新日期：2020-12-07 00:00:00

abstract：:The formation mechanism underlying the blue eggshell characteristic has been discovered in birds, and SLCO1B3 is the key gene that regulates the blue eggshell color. Insertion of an endogenous retrovirus, EAV-HP, in the SLCO1B3 5' flanking region promotes SLCO1B3 expression in the chicken shell gland, and this express...

journal_title：Frontiers in genetics

authors： Li Z,Ren T,Li W,Zhou Y,Han R,Li H,Jiang R,Yan F,Sun G,Liu X,Tian Y,Kang X

更新日期：2019-02-26 00:00:00

abstract：:Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological p...

journal_title：Frontiers in genetics

authors： Cirillo E,Parnell LD,Evelo CT

更新日期：2017-11-07 00:00:00

abstract：:Osteogenesis Imperfecta (OI) is a rare inherited bone dysplasia, which is mainly caused by mutations in genes encoding type I collagen including COL1A1 and COL1A2. It has been well established to identify the classical variants as well as consensus splicing-site-variants in these genes in our previous studies. However...

journal_title：Frontiers in genetics

authors： Li L,Cao Y,Zhao F,Mao B,Ren X,Wang Y,Guan Y,You Y,Li S,Yang T,Zhao X

更新日期：2019-10-18 00:00:00

abstract：:In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies. We selected, by reviewing MS Genome Wide Association Studies (GWAS), 107 candidate loci marked...

journal_title：Frontiers in genetics

authors： Ziliotto N,Marchetti G,Scapoli C,Bovolenta M,Meneghetti S,Benazzo A,Lunghi B,Balestra D,Laino LA,Bozzini N,Guidi I,Salvi F,Straudi S,Gemmati D,Menegatti E,Zamboni P,Bernardi F

更新日期：2019-06-26 00:00:00

abstract：:Aptamers are single-stranded nucleic acids that specifically recognize and bind tightly to their cognate targets due to their stable three-dimensional structure. Nucleic acid aptamers have been developed for various applications, including diagnostics, molecular imaging, biomarker discovery, target validation, therape...

journal_title：Frontiers in genetics

authors： Zhou J,Bobbin ML,Burnett JC,Rossi JJ

更新日期：2012-11-02 00:00:00

abstract：:Periconceptional folic acid use can often prevent neural tube defects (NTDs). Variants of genes involved in folate metabolism in mothers and children have been associated with occurrence of NTDs. We identified Irish families with individuals affected by neural tube defects. In these families, we observed that neural t...

journal_title：Frontiers in genetics

authors： Fisk Green R,Byrne J,Crider KS,Gallagher M,Koontz D,Berry RJ

更新日期：2013-11-06 00:00:00

abstract：:Comparative phylogeography has its roots in classical biogeography and, historically, relies on a pattern-based approach. Here, we present a model-based framework for comparative phylogeography. Our framework was initially developed for statistical phylogeography based on a multi-model inference approach, by coupling ...

journal_title：Frontiers in genetics

authors： Collevatti RG,Terribile LC,Diniz-Filho JA,Lima-Ribeiro MS

更新日期：2015-02-17 00:00:00

abstract：:Plant basic helix-loop-helix (bHLH) transcription factors are involved in the regulation of various biological processes in plant growth, development, and stress response. However, members of this important transcription factor family have not been systematically identified and analyzed in pepper (Capsicum annuum L.)....

journal_title：Frontiers in genetics

authors： Zhang Z,Chen J,Liang C,Liu F,Hou X,Zou X

更新日期：2020-09-25 00:00:00

abstract：:MicroRNAs are a class of noncoding RNAs that can be involved in the regulation of gene expression in cancers, including lung cancer. Our previous research has shown that miR-486-5p is one of the most downregulated microRNAs in tissue and serum samples of lung cancer as a good diagnostic biomarker. The objective of thi...

journal_title：Frontiers in genetics

authors： Tian F,Wang J,Ouyang T,Lu N,Lu J,Shen Y,Bai Y,Xie X,Ge Q

更新日期：2019-07-26 00:00:00

abstract：:Abundant genomic heterozygosity can be found in wild strains of the budding yeast Saccharomyces cerevisiae isolated from industrial and clinical environments. The extent to which heterozygosity influences the phenotypes of these isolates is not fully understood. One such case is the PE-2/JAY270 strain, a natural hybri...

journal_title：Frontiers in genetics

authors： Sampaio NMV,Watson RA,Argueso JL

更新日期：2019-09-11 00:00:00

abstract：:In Colchester, Britain's oldest recorded town, during the Roman period there were areas which were clearly used solely as cemeteries. One of the most significant is at Butt Road, which includes a late Roman probable Christian cemetery with an associated building, apparently a church, that overlies and developed from a...

journal_title：Frontiers in genetics

authors： Voong CP,Spencer PS,Navarrete CV,Turner D,Hayrabedyan SB,Crummy P,Holloway E,Wilson MT,Smith PR,Fernández N

更新日期：2017-12-05 00:00:00

abstract：:Advances in technology have made it convenient to obtain a large amount of single cell RNA sequencing (scRNA-seq) data. Since that clustering is a very important step in identifying or defining cellular phenotypes, many clustering approaches have been developed recently for these applications. The general methods can ...

journal_title：Frontiers in genetics

authors： Zhu Y,Zhang DX,Zhang XF,Yi M,Ou-Yang L,Wu M

更新日期：2020-11-04 00:00:00

abstract：Objective:This study reports a Chinese patient with a Congenital Disorder of Glycosylation (CDG) caused by compound-heterozygous mutations in the Conserved Oligomeric Golgi 5 (COG5) gene and thereby offers concrete evidence for early diagnosis. Methods:The clinical manifestations, the results of laboratory examination...

journal_title：Frontiers in genetics

authors： Wang X,Han L,Wang XY,Wang JH,Li XM,Jin CH,Wang L

更新日期：2020-02-27 00:00:00

abstract：:Liver is the main organ of lipid metabolism in chicken, especially for laying hens. To explore the molecular mechanism of lipid metabolism in chicken, five novel genes discovered in chicken liver tissue were systematically studied. Bioinformatic analysis was used to analyze the gene characteristics. The expression pat...

journal_title：Frontiers in genetics

authors： Li H,Li Y,Yang L,Zhang D,Liu Z,Wang Y,Han R,Li G,Li Z,Tian Y,Kang X,Liu X

更新日期：2020-03-31 00:00:00

abstract：:Ionizing radiation (IR) is a high-energy radiation whose biological effects depend on the irradiation doses. Low-dose radiation (LDR) is delivered during medical diagnoses or by an exposure to radioactive elements and has been linked to the occurrence of chronic diseases, such as leukemia and cardiovascular diseases. ...

journal_title：Frontiers in genetics

authors： Shin E,Lee S,Kang H,Kim J,Kim K,Youn H,Jin YW,Seo S,Youn B

更新日期：2020-10-02 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These ...

journal_title：Frontiers in genetics

authors： Fejes AP,Jones MJ,Kobor MS

更新日期：2014-09-18 00:00:00

abstract：:The emergence of eusociality ("true sociality") in several insect lineages represents one of the most successful evolutionary adaptations in the animal kingdom in terms of species richness and global biomass. In contrast to solitary insects, eusocial insects evolved a set of unique behavioral and physiological traits ...

journal_title：Frontiers in genetics

authors： Søvik E,Bloch G,Ben-Shahar Y

更新日期：2015-05-27 00:00:00

abstract：:The often-used A(C)E model that decomposes phenotypic variance into parts due to additive genetic and environmental influences can be extended to a longitudinal model when the trait has been assessed at multiple occasions. This enables inference about the nature (e.g., genetic or environmental) of the covariance among...

journal_title：Frontiers in genetics

authors： Schwabe I,Gu Z,Tijmstra J,Hatemi P,Pohl S

更新日期：2019-10-16 00:00:00

abstract：:Expanded newborn screening for inborn errors of metabolism (IEMs) by tandem mass spectrometry (MS/MS) could simultaneously analyze more than 40 metabolites and identify about 50 kinds of IEMs. Next generation sequencing (NGS) targeting hundreds of IMEs-associated genes as a follow-up test in expanded newborn screening...

journal_title：Frontiers in genetics

authors： Wang T,Ma J,Zhang Q,Gao A,Wang Q,Li H,Xiang J,Wang B

更新日期：2019-10-29 00:00:00

abstract：:mRNA-Seq is a precise and highly reproducible technique for measurement of transcripts levels and yields sequence information of a transcriptome at a single nucleotide base-level thus enabling us to determine splice junctions and alternative splicing events with high confidence. Often analysis of mRNA-Seq data does no...

journal_title：Frontiers in genetics

authors： Bhattacharjee M,Gupta R,Davuluri RV

更新日期：2012-11-27 00:00:00

abstract：:The ability to sense and respond to stressful conditions is essential to maintain organismal homeostasis. It has long been recognized that stress response factors that improve survival in changing conditions can also influence longevity. In this review, we discuss different strategies used by animals in response to de...

journal_title：Frontiers in genetics

authors： Iranon NN,Miller DL

更新日期：2012-11-27 00:00:00

abstract：:Understanding the processes that cause speciation is a key aim of evolutionary biology. Lineages or biomes that exhibit recent and rapid diversification are ideal model systems for determining these processes. Species rich biomes reported to be of relatively recent origin, i.e., since the beginning of the Miocene, inc...

journal_title：Frontiers in genetics

authors： Madriñán S,Cortés AJ,Richardson JE

更新日期：2013-10-09 00:00:00

abstract：:I present here an in-depth, although non-exhaustive, review of two topics in molecular dating. Clock models, which describe the evolution of the rate of evolution, are considered first. Some of the shortcomings of popular approaches-uncorrelated clock models in particular-are presented and discussed. Autocorrelated mo...

journal_title：Frontiers in genetics

authors： Guindon S

更新日期：2020-05-27 00:00:00

abstract：:Decreased expression of the fly and worm Indy genes extends longevity. The fly Indy gene and its mammalian homolog are transporters of Krebs cycle intermediates, with the highest rate of uptake for citrate. Cytosolic citrate has a role in energy regulation by affecting fatty acid synthesis and glycolysis. Fly, worm, a...

journal_title：Frontiers in genetics

authors： Rogina B,Helfand SL

更新日期：2013-04-08 00:00:00

abstract：:There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Toward that, mitochondri...

journal_title：Frontiers in genetics

authors： Machado TS,Macabelli CH,Collado MD,Meirelles FV,Guimarães FEG,Chiaratti MR

更新日期：2020-07-15 00:00:00

abstract：:Ethylmalonic encephalopathy (EE) is a very rare autosomal recessive metabolic disorder that primarily affects children. Less than one hundred EE patients have been diagnosed worldwide. The clinical manifestations include chronic diarrhea, petechiae, orthostatic acrocyanosis, psychomotor delay and regression, seizures,...

journal_title：Frontiers in genetics

authors： Chen X,Han L,Yao H

更新日期：2020-04-17 00:00:00

abstract：:Background: Milroy disease (MD) is rare and autosomal dominant resulting from mutations of the vascular endothelial growth factor receptor-3 (VEGFR-3 or FLT4), which leads to dysgenesis of the lymphatic system. Methods: Here we report a Chinese MD family with 2 affected members of two generations. We identified the mu...

journal_title：Frontiers in genetics

authors： Zhang S,Chen X,Yuan L,Wang S,Moli D,Liu S,Wu Y

更新日期：2019-03-19 00:00:00