In vitro cytotoxicity of metallic ions released from dental alloys.

Abstract:

:The cytotoxicity of a dental alloy depends on, but is not limited to, the extent of its corrosion behavior. Individual ions may have effects on cell viability that are different from metals interacting within the alloy structure. We aimed to investigate the cytotoxicity of individual metal ions in concentrations similar to those reported to be released from Pd-based dental alloys on mouse fibroblast cells. Metal salts were used to prepare seven solutions (concentration range 100 ppm-1 ppb) of the transition metals, such as Ni(II), Pd(II), Cu(II), and Ag(I), and the metals, such as Ga(III), In(III), and Sn(II). Cytotoxicity on mouse fibroblasts L929 was evaluated using the MTT assay. Ni, Cu, and Ag are cytotoxic at 10 ppm, Pd and Ga at 100 ppm. Sn and In were not able to induce cytotoxicity at the tested concentrations. Transition metals were able to induce cytotoxic effects in concentrations similar to those reported to be released from Pd-based dental alloys. Ni, Cu, and Ag were the most cytotoxic followed by Pd and Ga; Sn and In were not cytotoxic. Cytotoxic reactions might be considered in the etiopathogenesis of clinically observed local adverse reactions.

journal_name

Odontology

journal_title

Odontology

authors

Milheiro A,Nozaki K,Kleverlaan CJ,Muris J,Miura H,Feilzer AJ

doi

10.1007/s10266-014-0192-z

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

136-42

issue

2

eissn

1618-1247

issn

1618-1255

pii

10.1007/s10266-014-0192-z

journal_volume

104

pub_type

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