Abstract:
OBJECTIVES:We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA). METHODS:In a multicentre trial of 254 patients, CTA and invasive coronary angiography were performed, with FFR in 484 vessels. CTA data sets were analysed by semi-automated software to quantify stenosis and non-calcified (NCP), low-density NCP (LD-NCP, < 30 HU), calcified and total plaque volumes, contrast density difference (CDD, maximum difference in luminal attenuation per unit area) and plaque length. ML integration included automated feature selection and model building from quantitative CTA with a boosted ensemble algorithm, and tenfold stratified cross-validation. RESULTS:Eighty patients had ischaemia by FFR (FFR ≤ 0.80) in 100 vessels. Information gain for predicting ischaemia was highest for CDD (0.172), followed by LD-NCP (0.125), NCP (0.097), and total plaque volumes (0.092). ML exhibited higher area-under-the-curve (0.84) than individual CTA measures, including stenosis (0.76), LD-NCP volume (0.77), total plaque volume (0.74) and pre-test likelihood of coronary artery disease (CAD) (0.63); p < 0.006. CONCLUSIONS:Integrated ML ischaemia risk score improved the prediction of lesion-specific ischaemia by invasive FFR, over stenosis, plaque measures and pre-test likelihood of CAD. KEY POINTS:• Integrated ischaemia risk score improved prediction of ischaemia over quantitative plaque measures • Integrated ischaemia risk score showed higher prediction of ischaemia than standard approach • Contrast density difference had the highest information gain to identify lesion-specific ischaemia.
journal_name
Eur Radioljournal_title
European radiologyauthors
Dey D,Gaur S,Ovrehus KA,Slomka PJ,Betancur J,Goeller M,Hell MM,Gransar H,Berman DS,Achenbach S,Botker HE,Jensen JM,Lassen JF,Norgaard BLdoi
10.1007/s00330-017-5223-zsubject
Has Abstractpub_date
2018-06-01 00:00:00pages
2655-2664issue
6eissn
0938-7994issn
1432-1084pii
10.1007/s00330-017-5223-zjournal_volume
28pub_type
临床试验,杂志文章,多中心研究abstract::Multidetector computed tomography (CT) plays an important role in the detection, risk stratification and prognosis evaluation of acute pulmonary embolism. This review will discuss the technical improvements for imaging peripheral pulmonary arteries, the methods of assessing pulmonary embolism severity based on CT find...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-015-3679-2
更新日期:2015-09-01 00:00:00
abstract::An aberrant channel was identified on CT in the petrous bone in four patients presenting with unrelated otological symptoms. These channels occurred unilaterally in each case. In two patients, the channel was seen to run between the sigmoid sinus sulcus and the superior petrosal sinus sulcus; in one of these patients,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1492-5
更新日期:2009-12-01 00:00:00
abstract::We report a rare case of dysplasia epiphysealis hemimelica (DEH) in the wrist of a 7-year-old boy. Clinical, radiological and histopathological manifestations are discussed. The correct diagnosis of DEH, however, was made by the confrontation of the radiological and pathological data. The radiologist should inform the...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050766
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To determine the sensitivity and positive predictive value (PPV) of gadobenate-enhanced MR imaging for the detection of liver metastases. METHODS:This systematic review and meta-analysis was conducted according to PRISMA guidelines. A comprehensive search (EMBASE, PubMed) was performed to identify relevant ...
journal_title:European radiology
pub_type: 杂志文章,meta分析
doi:10.1007/s00330-019-06110-1
更新日期:2019-10-01 00:00:00
abstract::The purpose of this study was to report the CT findings of renal cell carcinoma of clear type (RCCCT) and to determine if there are characteristic morphologic features in RCCCT with respect to tumor size, architectural patterns, and pathologic stage. The CT scans of 35 patients with RCCCT were reviewed retrospectively...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050140
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To compare single-energy (SECT) and dual-energy (DECT) abdominal CT examinations in matched patient cohorts regarding differences in radiation dose and image quality performed with second- and third-generation dual-source CT (DSCT). METHODS:We retrospectively analysed 200 patients (100 male, 100 female; mea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4383-6
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:To compare the three-dimensional (3D)-fast spin-echo (FSE)-Cube with a conventional imaging protocol in evaluation of dacryostenosis. METHODS:Thirty-three patients with epiphora underwent examinations using Cube magnetic resonance dacryocystography (MRD) and a conventional protocol, which included 3D fast-r...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3462-9
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To investigate the detection rate of pulmonary nodules in ultralow-dose CT acquisitions. MATERIALS AND METHODS:In this lung phantom study, 232 nodules (115 solid, 117 ground-glass) of different sizes were randomly distributed in a lung phantom in 60 different arrangements. Every arrangement was acquired once...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4192-3
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:Detection and pattern analysis of fascicular nerve hyperintensities in the T2-weighted image are the backbone of magnetic resonance neurography (MRN) as they may represent lesions of various etiologies. The aim of this study was to assess the prevalence of fascicular nerve hyperintensities in healthy individu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06145-4
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate a pumping emulsification device that can improve the physiochemical properties and stability of lipiodol emulsion for conventional transarterial chemoembolization. MATERIALS AND METHODS:A pumping emulsification device constructed of a glass membrane with a hydrophobic surface with pore size of 50 μ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5197-x
更新日期:2018-05-01 00:00:00
abstract::The aim of this study was to describe the MRI findings and clinical observations in a fatigue stress fracture of the sacrum. In this retrospective study, 380 conscripts (53 women, 327 men; age range 18-29 years, mean age 20.7 years) who suffered from stress-related hip pain were studied with MRI of the pelvis. The fin...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1989-2
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To determine the diagnostic performance of a deep learning (DL) model in evaluating myometrial invasion (MI) depth on T2-weighted imaging (T2WI)-based endometrial cancer (EC) MR imaging (ECM). METHODS:We retrospectively enrolled 530 patients with pathologically proven EC at our institution between January 1,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06870-1
更新日期:2020-09-01 00:00:00
abstract::To assess the effect of the osmolarity for small bowel distension in MRI, ten volunteers ingested at two separate occasions negative oral contrast agents with different quantity and osmolarity: (1) a water solution combined with 2.0% sorbitol and 0.2% locus bean gum (LBG) with a quantity of 1500 ml and an osmolarity o...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2711-3
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:To evaluate visualization of the right adrenal vein (RAV) with multidetector CT and non-contrast-enhanced MR imaging in patients with primary aldosteronism. METHODS:A total of 125 patients (67 men) scheduled for adrenal venous sampling (AVS) were included. Dynamic 64-detector-row CT and balanced steady-stat...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3872-3
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To assess reduced volumes of contrast agent on image quality for coronary computed tomography angiography (CCTA) by using single-beat cardiac imaging with 320-slice CT.
MATERIALS AND METHODS:Forty consecutive male patients (mean age: 55.8 years) undergoing CCTA with body weight journal_title:European radiology pub_type: 杂志文章 doi:10.1007/s00330-009-1692-z 更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:To investigate the diagnostic accuracy, through quantitative analysis, of contrast-enhanced ultrasound (CEUS), using a microbubble contrast agent, in the differentiation of thyroid nodules. METHODS:This prospective study enrolled 46 patients with solitary, scintigraphically non-functional thyroid nodules. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2385-6
更新日期:2012-06-01 00:00:00
abstract::The authors described a very rare case of the cystic lymphangioma (CL) of the left upper extremity in a 12-year-old patient. The diagnosis was made by US and MRI and confirmed by histological examination of the resected specimen. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2347-8
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:Duchenne muscular dystrophy (DMD) is the most common and severe dystrophinopathy. DMD carriers rarely present with clinical symptoms, but may suffer from cardiac involvement. Because echocardiographic findings are inconsistent and cardiac magnetic resonance imaging (CMRI) data are limited, this study sought ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3694-3
更新日期:2015-10-01 00:00:00
abstract::Fragmentation by pigtail rotation catheter may be a therapeutic option in acute massive pulmonary embolism, especially in patients with high risk of right ventricular failure. We report a patient with an occlusion of the right intermediate pulmonary artery by a large embolus, slightly protruding into the perfused righ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300100905
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. METHODS:Thirty-two consecutive patients with a total of 166 liver lesions wer...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2658-0
更新日期:2013-03-01 00:00:00
abstract::The peritoneum is the largest and most complexly arranged serous membrane in the body. The potential peritoneal spaces, the peritoneal reflections forming peritoneal ligaments, mesenteries, omenta and the natural flow of peritoneal fluid determine the route of spread of intraperitoneal fluid and, consequently, disease...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050485
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the safety and efficacy of balloon-occluded transcatheter arterial chemoembolization (B-TACE) for the treatment of HCC refractory to conventional TACE (C-TACE). METHODS:This single-center retrospective analysis included 60 consecutive patients who underwent B-TACE (mean age, 61.4 years; male:fem...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06911-9
更新日期:2020-10-01 00:00:00
abstract::Our objective was to assess the clinical value of an early arterial scan for assessing the hepatic and mesenteric vasculature in patients with suspected primary or metastatic hypervascular liver disease undergoing multislice computed tomography. In 42 patients a very early arteriographic scan was performed before stan...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1566-0
更新日期:2003-05-01 00:00:00
abstract::The original version of this article, published on 01 August 2018, unfortunately contained two mistakes. ...
journal_title:European radiology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00330-018-5713-7
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the agreement between automated breast volume scanner (ABVS) and conventional ultrasound (US) as a second-look (SL) tool for assessing additional findings found on MRI. METHODS:Over a 7-month period, we prospectively assigned to SL-US and SL-ABVS all patients undergoing 1.5 T breast MRI in whom ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4749-4
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). METHODS:In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4245-2
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:This study evaluated the performance of a novel automated software tool for epicardial fat volume (EFV) quantification compared to a standard manual technique at coronary CT angiography (cCTA). METHODS:cCTA data sets of 70 patients (58.6 ± 12.9 years, 33 men) were retrospectively analysed using two differen...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-3052-2
更新日期:2014-02-01 00:00:00
abstract:PROPOSE:To establish evidence-based recommendations for musculoskeletal kinematic 4D-CT on wide area-detector CT. MATERIALS AND METHODS:In order to assess factors influencing image quality in kinematic CT studies, a phantom consisting of a polymethylmethacrylate rotating disk with round wells of different sizes was im...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4362-y
更新日期:2017-02-01 00:00:00
abstract::Arteriovenous malformations of the scrotum are extremely rare. A case of scrotal arteriovenous malformation and its preoperative embolization in a child is presented. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050686
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To assess feasibility and image quality (IQ) of a new post-processing algorithm for retrospective extraction of an optimised multi-phase CT (time-resolved CT) of the liver from volumetric perfusion imaging. METHODS:Sixteen patients underwent clinically indicated perfusion CT using 4D spiral mode of dual-sour...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2992-x
更新日期:2014-01-01 00:00:00