Abstract：
OBJECTIVE:To determine (1) the frequency of testosterone (T) use in 2 academic male infertility practices, (2) the effect on semen parameters, and (3) the potential for reversibility. METHODS:We performed a retrospective review. Inclusion criteria were supplemental T usage at the time of initial visit, T cessation, and semen analyses before and after T cessation. RESULTS:From January 2005 to March 2011, 110 of 1540 patients evaluated for infertility (7.1%) were on supplemental T. Thirty-nine patients met the inclusion criteria. Twenty-two of 39 patients (56%) were started on medical recovery by medical treatment. Median sperm concentration increased from 0 to 6.3 million/mL (P <.0001) after T cessation, with median follow-up of 4.5 months. Eight men (21%) remained azoospermic, and 3 men had sperm concentrations of ≤ 0.1 million/mL. Fifteen of 22 men given medical treatment and 16 of 17 men given no treatment had sperm return to the semen, respectively (P = .1061). Final sperm concentration did not differ between those who received medical treatment and those who did not. CONCLUSION:Exogenous T treatment causes infertility and is common among reproductive-aged men. These effects are transient for some, but not all men had return of sperm to the semen during the study interval, suggesting a possible underlying primary testicular dysfunction or ongoing hypothalamic-pituitary-testicular axis suppression. Education about exogenous T's negative reproductive effects is necessary to avoid this preventable form of infertility. Men with low T levels should have sufficient evaluation to evaluate for underlying pathology before starting T.
journal_name
Urologyjournal_title
Urologyauthors
Kolettis PN,Purcell ML,Parker W,Poston T,Nangia AKdoi
10.1016/j.urology.2014.12.052subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1068-1073issue
5eissn
0090-4295issn
1527-9995pii
S0090-4295(15)00105-3journal_volume
85pub_type
杂志文章,多中心研究相关文献
UROLOGY文献大全abstract：:Smooth muscle tone in the enlarged prostate is directly related to stimulation of the alpha-adrenergic receptors present in prostatic tissue. Variations in tone produce corresponding alterations in the degree of prostatic obstruction. Such variations can explain the spontaneous symptomatic variations seen clinically i...
journal_title：Urology
pub_type： 杂志文章,评审
doi：
更新日期：1988-12-01 00:00:00
abstract：:In men with hormone refractory metastatic prostate cancer, single agents have demonstrated an objective response when using a response rate greater than standard treatment in prior National Prostate Cancer Project (NPCP) trials. Among these agents are methotrexate, cisplatin, 5-fluorouracil, cyclophosphamide, doxorubi...
journal_title：Urology
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1016/s0090-4295(99)00450-1
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between obesity and febrile urinary tract infection (UTI) in young children. METHODS:We reviewed all medical records of children aged <3 years who visited our institution for febrile UTIs and infant national health checkups (controls) between January 2008 and February 2012. All ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.03.032
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:To evaluate differences in stone measurement using computed tomography (CT) and ultrasound (US). Axial unenhanced helical CT is the reference-standard imaging modality for the assessment of urinary tract calculi; however, US is also commonly used. Differences in stone measurement using these techniques are p...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.12.015
更新日期：2010-08-01 00:00:00
abstract：:We present an unusual case of recurrent reflux on the right side after bilateral vesicoureteroplasty with modified Hutch I technique. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(81)90266-1
更新日期：1981-04-01 00:00:00
abstract：OBJECTIVE:To accurately measure the correction obtained by the release of the skin and dartos fascia and that obtained by mobilization of the urethral plate and resection of the underlying fibrous tissue (according to Koyanagi and Mollard), in the release of chordee. METHODS:From February 1996 to February 2011, 234 pa...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.06.050
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:To determine the effect of phospholipase A(2) (PLA(2)) inhibitors on urothelial cell platelet-activating factor (PAF) production in response to tryptase stimulation. METHODS:Urothelial cells isolated from normal human ureters were immortalized with the human papillomavirus type 16E6E7 cell line (TEU-2 cells...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.08.032
更新日期：2011-01-01 00:00:00
abstract：:Divided, or so-called kissing nevi of the penis, which are separated during embryogenesis, are very rare, with only seven studies reported to date. We present a case of a 30-year-old patient with a divided nevus located at the penis that rapidly changed in size and color within 4 months. These clinical features and th...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.11.015
更新日期：2007-02-01 00:00:00
abstract：:A case in which sonography demonstrated that calculi may arise in female urethral diverticula is presented. The diagnosis of female urethral diverticula is reviewed. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(93)90549-p
更新日期：1993-12-01 00:00:00
abstract：OBJECTIVE:To compare our initial robotic-assisted nephroureterectomy (RAN) experience with a well-established practice of performing laparoscopic nephroureterectomy (LN) to treat upper tract urothelial carcinoma (UTUC). METHODS:We reviewed our prospectively maintained minimally invasive surgery database. Patients who ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.079
更新日期：2014-02-01 00:00:00
abstract：:A giant seminoma of undescended testis in a forty-one-year-old Japanese male with Down syndrome is reported as is a review of the literature. The relationship between Down syndrome and testicular cancer are discussed. To our knowledge this is the largest seminoma of undescended testis (weight 3,500 Gm) so far recorded...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(85)90301-2
更新日期：1985-06-01 00:00:00
abstract：OBJECTIVES:Six random systematic core biopsies (SRSCB) of the prostate (biopsies from apex, middle, and base of each lobe) have been commonly used in detection of prostate carcinoma. The objective of this study was to verify the validity of the SRSCB technique in detecting cancer in prostates with low-volume tumor (les...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/S0090-4295(99)80051-X
更新日期：1995-04-01 00:00:00
abstract：:Urodynamics, although not diagnostic of IC, are useful in the differential diagnosis of painful voiding disorders and provide a convenient way to quantitate response to therapy. They may prove useful as prognostic indicators of response to treatment and are of value in those patients in whom surgery is considered. Our...
journal_title：Urology
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：OBJECTIVES:To identify the pretreatment variables that are predictive of response and the duration of response to deferred antiandrogen therapy in men with androgen-independent prostate cancer (AIPC). METHODS:A total of 375 patients receiving androgen deprivation therapy for advanced prostate cancer between 1977 and 2...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2003.11.016
更新日期：2004-04-01 00:00:00
abstract：:Bone fixation of the suprapubic suspension sutures has been used in conjunction with transvaginal needle suspension in 115 women with genuine stress urinary incontinence over the last two years with excellent results being obtained. Utilizing the pubic tubercle as the fixation point for the suspension sutures (rather ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90731-5
更新日期：1988-05-01 00:00:00
abstract：OBJECTIVE:To identify patient and component specific factors that predispose patients to device-related complications when undergoing pressure-regulating balloon (PRB) exchange in men with an artificial urinary sphincter (AUS). METHOD:From 2009 to 2018, 55 patients underwent AUS revision with placement of a higher pre...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.09.026
更新日期：2020-01-01 00:00:00
abstract：:Urethral adenocarcinoma of males is a rare disease with limited prospective data to define optimal treatment. Surgical excision remains the primary treatment for early-stage disease. Multimodality therapy with a combination of chemotherapy, radiation, or surgery has been explored in patients with locally advanced dise...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.11.033
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:To standardize the TUNEL assay by establishing inter- and intraobserver variability, interassay variability, cutoff values, sensitivity and specificity of the assay, and studying the distribution of the DNA damage in a population of infertile men referred to a clinical andrology laboratory. METHODS:Seminal ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.04.036
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:To measure past active surveillance (AS) adoption rates, institute the best practice, and measure the AS adoption rates following implementation. We report our findings over a 3-year period. METHODS:Patient prostate needle biopsy and treatment data from the period August 2011 to August 2014 were retrieved fr...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.11.053
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVES:To determine patient satisfaction with testicular prostheses (TP) for testicular cancer. Reconstruction represents an important part of surgical oncology, yet placement of TP following orchiectomy is infrequently performed. Improved data on patient satisfaction with TP would help in counseling patients with ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.12.006
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:To examine the usefulness of pretreatment testicular sperm extraction because some patients have tumor-induced azoospermia. In view of the high cure rates for testicular germ cell tumors and malignant lymphomas, increasing clinical importance is attached to protecting fertility. High-dose cytostatic therapy ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)02264-1
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVES:To evaluate the correlation between race and lymph node metastasis for prostate cancer by analyzing which preoperative parameters may predict lymph node status in both races. METHODS:We analyzed a group of patients (552 American white men [AWM] and 423 African-American men [AAM]) who underwent radical prost...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(98)00441-5
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the long-term outcomes of penile prosthesis surgery at a teaching institution. METHODS:Patients who had penile prosthesis surgery from 1988 to 1999 at a private teaching hospital and the Dallas Veterans Affairs Medical Center were identified and charts abstracted for age at first prosthesis, eth...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(03)00665-4
更新日期：2003-11-01 00:00:00
abstract：:The role of human papillomavirus (HPV) infection and other reported cofactors in the genesis, evolution, and clinical manifestations of precancerous and cancerous squamous cell lesions of the penis were studied in 34 men. Clinically, all lesions demonstrated aceto-whitening. Histologic changes of HPV infection formed ...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/0090-4295(93)90640-v
更新日期：1993-08-01 00:00:00
abstract：OBJECTIVES:To investigate the clinical utility of fluorescence in situ hybridization (FISH) of voided urine in the detection of bladder cancer and the prediction of its recurrence. METHODS:FISH with centromere-specific probes for chromosomes 9 and 17 was performed to evaluate the chromosomal alterations of exfoliated ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)01074-8
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To describe the different ultrasound (US) findings of mature testicular hamartomas in children. MATERIALS AND METHODS:This is a retrospective study from January 2000 to July 2012 that reviewed the clinical, laboratory, and US findings of 7 children with a pathologic diagnosis of mature teratoma of the testis...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.046
更新日期：2014-01-01 00:00:00
abstract：:The newest development in the treatment of female stress incontinence is the tension-free vaginal tape (TVT) procedure. This procedure was first described by Ulmsten et al. in 1996 and involves recreating suburethral support with a polypropylene mesh, without repositioning the bladder or urethra. In their initial stud...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00707-x
更新日期：2000-12-04 00:00:00
abstract：OBJECTIVES:Xanthogranulomatous pyelonephritis (XGP) is an atypical form of chronic renal infection. The treatment of choice is open nephrectomy, which is challenging, given the extent of the disease and the not uncommon involvement of the renal hilum and contiguous structures. We compared our experience with laparoscop...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)00261-7
更新日期：1999-09-01 00:00:00
abstract：:Nocturnal polyuria (NP), characterized by overproduction of urine at night (greater than 20%-33% of total 24-hour urine volume depending on age), is a major contributing factor in most nocturia cases. Nocturia can be caused by intake, urological, nephrological, hormonal, sleep, and cardiovascular factors. It is theref...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2019.09.022
更新日期：2019-11-01 00:00:00
abstract：:During a ten-year period, 35 children presenting with vesicoureteral reflux, ureteropelvic junction obstruction, or a "small kidney" were found to be hypertensive. Of these, 15 subsequently underwent surgical procedures for relief of hypertension. Seven were "cured," six were "improved," and two were "unchanged." The ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90390-1
更新日期：1988-09-01 00:00:00
