Computer simulation of the probability of detecting low volume carcinoma of the prostate with six random systematic core biopsies.

Abstract:

OBJECTIVES:Six random systematic core biopsies (SRSCB) of the prostate (biopsies from apex, middle, and base of each lobe) have been commonly used in detection of prostate carcinoma. The objective of this study was to verify the validity of the SRSCB technique in detecting cancer in prostates with low-volume tumor (less than 6 cc). METHODS:We developed a computer model of the prostate to simulate the SRSCB technique. The data for development of this model were taken from 159 radical prostatectomy specimens in which 112 patients had tumor volumes measured and in which 91 prostates had tumors with volumes less than 6 cc (by whole-mount sectioning). RESULTS:The simulation shows that only 20.3% of the simulated prostates, with total aggregate tumor volume between 0.034 and 5.1 cc, had a tumor distribution for which the SRSCB technique has a 95% probability of detecting the tumor. In fact, 26.8% had a tumor distribution that was completely disjointed from the six recommended biopsy regions. To compare these results with other possible occurrence, various biases for the angle of biopsy and the distribution of cancer foci were incorporated into the model. Study results should be viewed with the understanding that any simulated model has its limitations. In our simulated model, the shape of the simulated tumor foci (spherical) does not represent all the possible shapes of prostate cancer. However, these results indicate that detection of cancer with biopsies taken from the apex, middle, and base of each lobe of a prostate with tumor volumes of less than 6 cc may not be as effective as it is in prostates with larger tumor volumes or patients with an abnormal digital rectal examination. The study of bias models suggests that the distributional pattern of cancerous foci can have a significant impact on the effectiveness of a given biopsy strategy. CONCLUSIONS:We concluded that future attempts to improve systematic biopsy strategies for detection of low-volume cancer should include biomechanical characteristics of prostate cancer, including gland volume and tumor distribution. Driven by the conclusions from this idealized model, we have developed a three-dimensional model of the prostate gland from its whole-mount histologic maps. It is anticipated that this continuing investigation will lead to realistic guidelines for improving biopsy techniques.

journal_name

Urology

journal_title

Urology

authors

Daneshgari F,Taylor GD,Miller GJ,Crawford ED

doi

10.1016/S0090-4295(99)80051-X

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

604-9

issue

4

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(99)80051-X

journal_volume

45

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • The Feasibility and Impact of a Presurgical Exercise Intervention Program (Prehabilitation) for Patients Undergoing Cystectomy for Bladder Cancer.

    abstract:OBJECTIVE:To assess the feasibility of a prehabilitation program for cystectomy patients and to determine the effectiveness of the program in improving strength and functional capacity in the peri-operative period. MATERIALS AND METHODS:This phase I/II study accrued patients ≥60 years old from January 2013 to October ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.05.104

    authors: Kaye DR,Schafer C,Thelen-Perry S,Parker C,Iglay-Reger H,Daignault-Newton S,Qin Y,Morgan TM,Weizer AZ,Kaffenberger SD,Herrel LA,Hafez KS,Lee CT,Skolarus TA,Englesbe MJ,Montgomery JS

    更新日期:2020-11-01 00:00:00

  • Sacral Neuromodulation in Urological Practice.

    abstract::Sacral neuromodulation (SNM) is a minimally invasive, restorative treatment to improve voiding and elimination functions. We give a historical perspective of SNM and explore the evidence for the use of this therapy for Food and Drug Administration-approved pathologies as well as disease processes that are being treate...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2016.06.004

    authors: Liberman D,Ehlert MJ,Siegel SW

    更新日期:2017-01-01 00:00:00

  • "Changing the Status Quo: The 100 Most Disruptive Papers in Urology?"

    abstract:OBJECTIVES:To identify key papers in urology using a novel bibliometric index called the disruption score. METHODS:A PubMed search was conducted to identify papers published in Journal of Urology, European Urology, Urology, Urologic Oncology, Journal of Endourology, and BJU International, Nature Reviews Urology. Selec...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.10.073

    authors: Khusid JA,Gupta M,Sadiq AS,Atallah WM,Becerra AZ

    更新日期:2021-01-04 00:00:00

  • Plasma renin activity revealed renal artery stenosis concealed by aneurysms.

    abstract::We describe a case of renovascular hypertension with renal artery stenosis concealed by aneurysms. Arteriography demonstrated no apparent renal artery stenosis, but did reveal aneurysms on the left renal artery. Captopril-loaded renoscintigraphy could not detect disturbed renal perfusion. High basal and exaggerated pl...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.09.045

    authors: Tanemoto M,Abe T,Satoh F,Ito S

    更新日期:2005-03-01 00:00:00

  • Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivo.

    abstract:OBJECTIVES:To evaluate the effect of the fibrin sealant, Evicel, on the neuroregulatory control of penile erections in an experimental rat model. METHODS:Two groups of rats were used: sham-operated rats with exposure of the bilateral cavernous nerves (CNs) and application of saline vehicle (500 microL), and rats treat...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.03.046

    authors: Bivalacqua TJ,Guzzo TJ,Schaeffer EM,Gebska MA,Champion HC,Burnett AL,Gonzalgo ML

    更新日期:2008-11-01 00:00:00

  • Amplatz sheath for cystolithotripsy using Ho: YAG laser in female patients.

    abstract:OBJECTIVE:To evaluate the effectiveness of cystoscopic lithotripsy, we performed Amplatz sheath technique using Ho: YAG laser. Maheshwari first reported the use of an Amplatz sheath in the female urethra in 1998, and Okeke et al reported the use of an Amplatz sheath for male patients during cystolithotripsy in 2004. Th...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.07.046

    authors: Kawahara T,Ito H,Terao H,Kato Y,Ogawa T,Uemura H,Kubota Y,Matsuzaki J

    更新日期:2012-11-01 00:00:00

  • Posterior urethral valves: functional classification.

    abstract::Among 37 boys with posterior urethral valves (PUV), the clinical courses could be divided into three functional levels of severity which did not always correspond to the traditional anatomic classification of valves. Children with PUV presented at all ages, had varying degrees of renal impairment, and manifested a var...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(80)90534-8

    authors: Uehling DT

    更新日期:1980-01-01 00:00:00

  • Cystic mesoblastic nephroma.

    abstract::Mesoblastic nephroma is the most common solid renal neoplasm in the first few months of life. It has been recognized only recently as a distinct entity, having been classified previously as Wilms tumor. There are relatively few ultrasonic descriptions of this entity in the literature. We present an additional case fea...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(82)90590-8

    authors: Slasky BS,Penkrot RJ,Bron KM

    更新日期:1982-02-01 00:00:00

  • Acute renal failure in sickle cell trait.

    abstract::Acute renal failure and a syndrome characteristic of acute renal vein thrombosis developed in a patient with sickle trait and gram-negative bacteremia. It is suggested that intrarenal vaso-occlusion by sickled erythrocytes produced signs and symptoms typical of renal vein thrombosis and contributed to the severity of ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(75)90716-5

    authors: Frascino JA,Grabstald H

    更新日期:1975-08-01 00:00:00

  • Isolated glans insufficiency due to venous leakage.

    abstract::Lack of tumescence of the glans penis during normal penile erection may represent a handicap to sexual intercourse. The pharmacodynamic spongiosography for the evaluation of venous drainage of the corpus spongiosum is described, demonstrating a pathologic venous outflow. The patient was successfully treated by resecti...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(90)80151-c

    authors: Schramek P,Waldhauser M

    更新日期:1990-04-01 00:00:00

  • Bilateral Ureterovaginal Fistulas and Vesicovaginal Fistula in Setting of Retained Pessary.

    abstract::Urogenital fistulas in the setting of foreign body are rare. Isolated vesicovaginal fistula is the most common and has been reported in the setting of retained intraureterine device,1,2 neglected pessary3,4 and atypical insertions related mostly to sexual activity or underlying psychiatric disorders.5-7 Combined vesic...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.04.049

    authors: Rapp DE,Congleton JY,Boatman K,Karp N,Krupski T

    更新日期:2020-07-01 00:00:00

  • Development and Validation of a Deep-learning Model to Assist With Renal Cell Carcinoma Histopathologic Interpretation.

    abstract:OBJECTIVE:To develop and test the ability of a convolutional neural network (CNN) to accurately identify the presence of renal cell carcinoma (RCC) on histopathology specimens, as well as differentiate RCC histologic subtype and grade. MATERIALS AND METHODS:Digital hematoxylin and eosin stained biopsy images were down...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.05.094

    authors: Fenstermaker M,Tomlins SA,Singh K,Wiens J,Morgan TM

    更新日期:2020-10-01 00:00:00

  • Safety of everolimus by treatment duration in patients with advanced renal cell cancer in an expanded access program.

    abstract:OBJECTIVE:To retrospectively analyze the effects of treatment duration on outcomes of everolimus treatment of patients in the RAD001 Expanded-Access Clinical Trial in RCC (REACT) program. METHODS:Patients with metastatic renal cell carcinoma refractory to vascular endothelial growth factor receptor-tyrosine kinase inh...

    journal_title:Urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.urology.2012.09.019

    authors: van den Eertwegh AJ,Karakiewicz P,Bavbek S,Rha SY,Bracarda S,Bahl A,Ou YC,Kim D,Panneerselvam A,Anak O,Grünwald V

    更新日期:2013-01-01 00:00:00

  • Interobserver variability limits exact preoperative staging by computed tomography in bladder cancer.

    abstract:OBJECTIVE:To evaluate the agreement between radiologic staging of bladder cancer using multidetector row computed tomography (CT) and histopathologic staging and estimate the influence of interobserver variability of the CT findings as a potential limitation of this imaging modality. The available data on the value of ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.01.040

    authors: Tritschler S,Mosler C,Tilki D,Buchner A,Stief C,Graser A

    更新日期:2012-06-01 00:00:00

  • Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats.

    abstract:OBJECTIVE:To investigate the potential protective effects of selenium and lycopene, either alone or in combination, for cisplatin-induced oxidative stress and testicular dysfunction in male rats. METHODS:A total of 50 adult male Wistar rats were divided into 5 groups of 10 animals each, as follows: control group (trea...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2011.12.006

    authors: Salem EA,Salem NA,Maarouf AM,Serefoglu EC,Hellstrom WJ

    更新日期:2012-05-01 00:00:00

  • Reduction of prostate-specific antigen after tamsulosin treatment in patients with elevated prostate-specific antigen and lower urinary tract symptoms associated with low incidence of prostate cancer at biopsy.

    abstract:OBJECTIVES:To evaluate the effect of tamsulosin on reducing the serum levels of prostate-specific antigen (PSA) in patients with lower urinary tract symptoms and an elevated PSA level. METHODS:From June 2004 to July 2006, patients with lower urinary tract symptoms, a PSA level of >or=4 ng/mL, and a maximal flow rate o...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2009.12.083

    authors: Tubaro A,De Nunzio C,Mariani S,Trucchi A,Miano R,Vicentini C,Miano L

    更新日期:2010-08-01 00:00:00

  • Effects of vitamin C on androgen receptor mediated actions in human prostate adenocarcinoma cell line LAPC-4.

    abstract:OBJECTIVES:To examine the effects of vitamin C (VC) on androgen receptor (AR)-mediated functions in a human prostate cancer cell line, Los Angeles prostate cancer (LAPC-4). VC is an essential dietary substance in the maintenance and preservation of vital functions in humans. However, the role of VC in prostate cancer r...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(03)00136-5

    authors: Wang MH,Abreu-Delgado Y,Young CY

    更新日期:2003-07-01 00:00:00

  • Elective versus routine postoperative clinic appointments after circumcisions performed under local anesthesia.

    abstract:OBJECTIVE:To evaluate a model of elective postoperative clinic appointments after a minor urological procedure and to compare it to the traditional practice of routine appointments. METHODS:A total of 104 consecutive patients undergoing adult circumcision under local anesthesia were divided into 2 groups; group A (n =...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.12.071

    authors: Wardenburg MJ,Dobbs RW,Barnes G,Al-Qassab U,Ritenour CW,Issa MM

    更新日期:2013-06-01 00:00:00

  • Cytology of transitional cell carcinoma in situ of urinary bladder with extensive prostatic involvement.

    abstract::Cytologic differences in the urine of 6 patients with transitional cell carcinoma in situ (CIS) of the urinary bladder with and without prostatic duct involvement are described. In the former group, there was an admixture of CIS cells along with many bizarre malignant cells which increased with time and showed maligna...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(76)90203-x

    authors: Ahmed MN,Lushpihan A,Louis C,Seemayer TA,Thelmo WL,Wang NS

    更新日期:1976-05-01 00:00:00

  • Multifocal penile epithelioid hemangioendothelioma masquerading as superficial penile vein thrombosis.

    abstract::A 42-year-old man presented with a progressively painful mass of the penile shaft that clinically resembled superficial penile vein thrombosis. The patient's symptoms were refractory to conservative therapy, and surgical excision revealed multifocal penile epithelioid hemangioendothelioma. He had no evidence of metast...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2006.03.051

    authors: Gharajeh A,Siemens DR,Isotalo PA,Nascimento AG,Borth CS

    更新日期:2006-09-01 00:00:00

  • Perirenal malignant Schwannoma presenting as renal cell carcinoma.

    abstract::Clinical and radiographic evaluation of a fifty-six-year-old male with microscopic hematuria led to radical nephrectomy for renal cell carcinoma. Histologic examination by light and electronmicroscopy was most compatible with malignant schwannoma. The tumor was close to the kidney without actual renal involvement. Thi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(78)90173-5

    authors: Bair ED,Woodside JR,Williams WL,Borden TA

    更新日期:1978-05-01 00:00:00

  • Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin in men with lower urinary tract symptoms and clinical evidence of benign prostatic hyperplasia.

    abstract:OBJECTIVES:To determine the effect of discontinuation of alpha-blockade and continuation of finasteride in men with lower urinary tract symptoms and enlarged prostates receiving combination treatment and to determine whether the alpha-blocker dose influences the ability to discontinue it. METHODS:We treated 272 consec...

    journal_title:Urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0090-4295(01)01201-8

    authors: Baldwin KC,Ginsberg PC,Roehrborn CG,Harkaway RC

    更新日期:2001-08-01 00:00:00

  • Comparative Effects of Irreversible Electroporation, Radiofrequency Ablation, and Partial Nephrectomy on Renal Function Preservation in a Porcine Solitary Kidney Model.

    abstract:OBJECTIVE:To evaluate kidney function preservation or regeneration and pathological changes post-irreversible electroporation (IRE) in comparison with partial nephrectomy and radiofrequency ablation (RFA) in a solitary kidney porcine model. Tissue ablation using IRE has been reported to spare critical anatomic structur...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2016.04.035

    authors: Morgan MS,Ozayar A,Lucas E,Friedlander JI,Shakir NA,Cadeddu JA

    更新日期:2016-08-01 00:00:00

  • Cystic pelvic pathology presenting as falsely elevated post-void residual urine measured by portable ultrasound bladder scanning: report of 3 cases and review of the literature.

    abstract::Dedicated portable ultrasound devices generally offer a rapid, noninvasive, largely operator-independent means of assessing post-void residual urine (PVR) volume. In most published series, PVR measured by portable ultrasound correlates well with catheterized urine volume. We report 3 cases in which follow-up of falsel...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/s0090-4295(99)00565-8

    authors: Cooperberg MR,Chambers SK,Rutherford TJ,Foster HE Jr

    更新日期:2000-04-01 00:00:00

  • Urinary Stone Disease: Progress, Status, and Needs.

    abstract::Urinary stone disease (USD) is an important healthcare problem in the US affecting both adults and children, and costs $10 billion to the nation. Prevalence of USD has nearly doubled during the last 15 years in parallel to the obesity and type 2 diabetes epidemic. Despite the advances in the management of an acute epi...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2015.07.006

    authors: Kirkali Z,Rasooly R,Star RA,Rodgers GP

    更新日期:2015-10-01 00:00:00

  • Public awareness of testis cancer and the prevalence of testicular self-examination-changing patterns over 20 years.

    abstract:OBJECTIVES:Delay in treatment of testis cancer (TC) has a proven negative impact on disease stage, treatment outcome, and mortality. Poor public awareness of the disease and lack of testis self-examination (TSE) may account for late presentation. The aim of this study was to examine the knowledge of TC and performance ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.03.022

    authors: Casey RG,Grainger R,Butler MR,McDermott TE,Thornhill JA

    更新日期:2010-10-01 00:00:00

  • Smoking and alcohol use may be risk factors for poorer outcome in patients with clear cell renal carcinoma.

    abstract:OBJECTIVES:To correlate the clinical outcomes of 148 patients with clear cell renal carcinoma treated at a single institution with a variety of other factors. METHODS:Cases were derived from a consecutive series of nephrectomy specimens obtained from 1980 to 1994. A retrospective review of clinical records was perform...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(99)00408-2

    authors: Oh WK,Manola J,Renshaw AA,Brodkin D,Loughlin KR,Richie JP,Shapiro CL,Kantoff PW

    更新日期:2000-01-01 00:00:00

  • Chemoprevention of bladder cancer.

    abstract::Chemoprevention of cancer can be accomplished using primary, secondary, or tertiary strategies. Tertiary chemoprevention has been the predominant approach for bladder cancer and addresses the need for preventing the occurrence of second primary cancers in patients who have previously been treated for cancer. Because n...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2006.01.015

    authors: Grossman HB

    更新日期:2006-03-01 00:00:00

  • Pre- and postoperative urodynamic findings in patients after a bulbourethral composite suspension with intraoperative urodynamically controlled sling tension adjustment for postprostatectomy incontinence.

    abstract:OBJECTIVES:To compare pre- and postoperative urodynamic findings in patients with a bulbourethral composite suspension and intraoperative urodynamically controlled sling tension adjustment. METHODS AND PATIENTS:All data were prospectively collected from 10 patients (mean age 66 years) who successfully underwent bulbou...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2011.11.012

    authors: Horstmann M,Fischer I,Vollmer C,Horton K,Kurz M,Padevit C,John H

    更新日期:2012-03-01 00:00:00

  • Ureterolithotripsy in children.

    abstract:OBJECTIVES:The pediatric application of ureteroscopy was initially hindered by the size of the instruments and the fear of damaging the urethra and ureterovesical junction during endoscopic maneuvers. This review of our experience is focused on the usefulness of thin and ultrathin ureteroscopes such as the 7 F Gautier ...

    journal_title:Urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/S0090-4295(99)80358-6

    authors: Scarpa RM,De Lisa A,Porru D,Canetto A,Usai E

    更新日期:1995-12-01 00:00:00