Abstract：
RATIONALE:Buprenorphine is an effective and popular treatment for opioid dependence. It remains unclear, however, when or how to transition stable buprenorphine-maintained individuals to complete abstinence. This trial investigates the feasibility of using naltrexone to facilitate buprenorphine discontinuation in stable individuals who had tolerated a taper to 2mg or less but were unable to terminate entirely due to withdrawal-related distress. METHODS:The sample consisted of 6 buprenorphine-maintained individuals in sustained full remission, and who had tolerated a taper but were unable to discontinue altogether. A rapid induction procedure was performed, which included supervised buprenorphine discontinuation, oral naltrexone titration with a starting dose of 6.25mg, and administration of long-acting injectable naltrexone. Participants were followed weekly for 5weeks after the injection, with telephone follow-up occurring at 6months. RESULTS:The rapid induction procedure was well tolerated. There was no observed or reported clinical worsening over the course of study participation. Notably, no participants experienced an increase in Subjective Opioid Withdrawal Scale (SOWS) scores after the first oral dose of NTX as compared to day 1 (24hours after last dose of buprenorphine); instead, SOWS scores decreased between days 1 and 7 (p=0.043). All participants were able to discontinue buprenorphine and to remain opioid free during the trial and at follow-up. CONCLUSIONS:This preliminary trial represented for all participants the first successful attempt at buprenorphine discontinuation. Further research is needed to better understand if naltrexone is effective at facilitating buprenorphine discontinuation, as well as the feasibility of a sequential approach (buprenorphine stabilization to naltrexone) for opioid use disorders.
journal_name
J Subst Abuse Treatjournal_title
Journal of substance abuse treatmentauthors
Dakwar E,Kleber HDdoi
10.1016/j.jsat.2015.01.004subject
Has Abstractpub_date
2015-06-01 00:00:00pages
60-3eissn
0740-5472issn
1873-6483pii
S0740-5472(15)00018-5journal_volume
53pub_type
临床试验,杂志文章abstract：:Medication-assisted treatment (MAT) with methadone or buprenorphine has been shown to be more effective at reducing the use of illicit opioids, the risk of drug-related overdose, and overall healthcare costs, on average, compared to abstinence-based addiction treatments for individuals with an opioid use disorder (OUD...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2019.05.015
更新日期：2019-09-01 00:00:00
abstract：:Following research indicating that the treatment needs of women are different from those of men, researchers and clinicians have argued that drug treatment programs for women should be designed to take their needs into account. Such programs tend to admit only women and incorporate philosophies and activities that are...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2010.12.001
更新日期：2011-06-01 00:00:00
abstract：:Alcohol exposed pregnancy (AEP) is a leading cause of preventable birth defects. While randomized controlled trials (RCTs) have shown that multi-session motivational interviewing-based interventions reduce AEP risk, a one-session intervention could facilitate broader implementation. The purposes of this study were to:...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2012.10.001
更新日期：2013-04-01 00:00:00
abstract：:This study tested a brief, Web-based personalized feedback program aimed at reducing alcohol use and alcohol-related consequences among 9th grade students (N=513). Results indicated no differences between the control group and intervention group on either frequency of drinking or alcohol-related consequences at the 6-...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2014.02.006
更新日期：2014-07-01 00:00:00
abstract：:This article investigates patterns of drinking and drinking outcomes among 753 drug-misusing clients recruited to the National Treatment Outcome Research Study (NTORS). More than one third of those who were drinking at intake reported problematic or highly problematic patterns of alcohol consumption. About one third o...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,多中心研究
doi：10.1016/s0740-5472(99)00097-5
更新日期：2000-07-01 00:00:00
abstract：:Recidivism among recovering ex-offenders is usually conceptualized as an outcome of the interplay between personal traits and treatment interventions. This focus on the individual, to the exclusion of the sociolegal context in which recovery and reintegration take place, has limited extant policy initiatives. Recidivi...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2006.05.010
更新日期：2006-12-01 00:00:00
abstract：:Drug treatment programs are a site of opportunity for the delivery of primary and secondary hepatitis C (HCV) prevention services to drug users, a population at great risk for contracting and transmitting the virus. Using data collected from a random nationwide sample (N = 439) of drug treatment programs in the United...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/s0740-5472(01)00213-6
更新日期：2002-03-01 00:00:00
abstract：:Urine drug testing has become an increasingly controversial issue in today's society. In this paper, several issues involved in urine drug testing are discussed. These include the limitations of the accuracy of urine testing, testing in schools, athletics, the military and industry, and the legalities of drug testing....
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(87)90022-5
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:To examine how significant other (SO) language in support of or against client abstinence from alcohol influences clients' in-session speech and drinking behavior over the 9 months post-Motivational Enhancement Therapy (MET). METHOD:Sequential analyses were used to examine the language of Project MATCH clien...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jsat.2016.01.008
更新日期：2016-05-01 00:00:00
abstract：:This study aims to psychometrically validate the Chilean version of the treatment outcomes profile (TOP), an instrument that can be used by treatment centers to monitor the results of drug and alcohol treatments. Specifically, this study is interested in evaluating the inter-rater reliability, concurrent validity, cha...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2015.03.002
更新日期：2015-09-01 00:00:00
abstract：:Hepatitis, HIV and tuberculosis are significant and costly public health problems that disproportionately affect individuals with substance use disorders (SUDs). Incentive-based treatment approaches (i.e., contingency management; CM) are highly effective at reducing drug use. The primary aim of this report is to revie...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jsat.2016.06.009
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Rapid HIV testing (RHT) greatly increases the proportion of clients who learn their test results. However, existing studies have not examined the adoption and implementation of RHT in programs treating persons with substance use disorders, one of the population groups at higher risk for HIV infection. MET...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2015.12.001
更新日期：2016-04-01 00:00:00
abstract：:Program graduation, even after controlling for length of stay, may predict for improved outcomes in some substance abuse treatment settings. We investigated the role of program graduation by comparing social outcomes and inpatient utilization the years before and after treatment among graduates and dropouts of a Veter...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2004.03.006
更新日期：2004-07-01 00:00:00
abstract：:Opioid treatment programs (OTPs) operate within a rigid set of clinical guidelines and regulations that specify the number of required OTP visits for supervised administration of methadone. To ensure physical distancing in light of COVID-19, the federal government loosened regulations to allow for additional flexibili...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2020.108219
更新日期：2021-03-01 00:00:00
abstract：:The research literature on the use of acupuncture as a substance abuse treatment is reviewed. In recent years numerous descriptive reports have been published concerning the efficacy of acupuncture in alleviating withdrawal symptoms with substance abusers attempting abstinence. While a limited number of experimental d...
journal_title：Journal of substance abuse treatment
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1016/0740-5472(94)90040-x
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Many studies suggest that participation in 12-step groups contributes to better recovery outcomes, but people often object to such groups and most do not sustain regular involvement. Yet, research on alternatives to 12-step groups is very sparse. The present study aimed to extend the knowledge base on mutual...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2016.10.004
更新日期：2017-02-01 00:00:00
abstract：:In his extraordinarily productive research career, G. Alan Marlatt contributed to and anticipated by decades a variety of major changes in the treatment of substance use disorders. This article briefly reviews and comments on his contributions to addiction psychology, cognitive-behavior therapy, alcohol expectancies, ...
journal_title：Journal of substance abuse treatment
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.jsat.2011.06.004
更新日期：2011-12-01 00:00:00
abstract：:This study investigates the addition of a contingency management (CM) intervention to Veterans Health Administration substance use disorders treatment on during- and post-treatment outcomes for Veterans diagnosed with alcohol dependence only (n=191) or stimulant dependence (n=139). Participants were randomly assigned ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2013.01.006
更新日期：2013-07-01 00:00:00
abstract：:The goal of this study was to compare the effects of 1, 3 and 8 mg per day doses of buprenorphine in the maintenance treatment of opium-dependent subjects in Iran over a treatment period of 12 months. Participants were randomized to three equal groups (171 subjects per group) of opium-dependent individuals who met the...
journal_title：Journal of substance abuse treatment
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0740-5472(03)00141-7
更新日期：2004-01-01 00:00:00
abstract：:This paper describes a short-term approach developed at a time of numerous drug-related incidents occurring at a large VA Hospital to help staff manage psychiatric patients abusing alcohol or drugs during hospitalization. This was accomplished through the development of a decision tree designed to improve the clinical...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(92)90063-t
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:In non-pregnant individuals being treated for opioid use disorder (OUD) with methadone, doses ≥60mg per day are associated with improved treatment retention and decreased illicit opioid use. Although methadone remains the first line treatment for OUD in pregnant women, there are no studies replicating this f...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2017.06.005
更新日期：2017-09-01 00:00:00
abstract：:Basic neuroscience research conducted over the last quarter century has provided us with much information concerning potential biobehavioral and neuromolecular mechanisms involved in the initiation and maintenance of tobacco dependence. Nicotinic-acetylcholinergic receptors (AChRs), in addition to having a primary loc...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,评审
doi：10.1016/0740-5472(93)90041-y
更新日期：1993-03-01 00:00:00
abstract：INTRODUCTION:Despite tobacco use as the largest preventable cause of premature death in the US, many healthcare providers continue to lack the knowledge and confidence in employing the Ask, Advise, Refer (AAR) model in tobacco cessation treatment delivery. This pilot study evaluated the feasibility and effectiveness of...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2019.01.024
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Women with histories of interpersonal violence (IPV) experience high levels of post-traumatic stress disorder (PTSD), problematic substance use, and repeat victimization. Previous systematic reviews considering the effectiveness of integrated trauma-specific treatments to address PTSD and substance ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2018.12.007
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:Polysubstance use disorder is prevalent in treatment-seeking patients with substance use disorder (SUD), with a higher risk of developing comorbid psychiatric symptoms, more pervasive deficits in cognitive functions, and inferior treatment results. The present study investigates if individuals with polysub...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2017.01.016
更新日期：2017-05-01 00:00:00
abstract：:Cannabis use disorder (CUD) is the most common illicit substance use disorder in the United States and is related to a range of functional impairment. CUD is associated with comorbid mental health disorders and other substance use disorders, compounding impairment from either type of disorder alone. U.S. military vete...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2019.11.003
更新日期：2020-02-01 00:00:00
abstract：:White (n = 213), African American (n = 210), and Hispanic (n = 104) Medicaid-eligible, chemically-dependent, pregnant women were interviewed during their stay in stay in publicly-funded detoxification centers in Massachusetts. Comparisons of demographic, psychosocial, and substance abuse variables revealed significant...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/s0740-5472(96)00153-5
更新日期：1997-09-01 00:00:00
abstract：:Many drug abusers have repeated exposure to treatment, yet little is known about the reasons some individuals re-enter treatment following relapse to drug use. This paper examines the predictors of treatment re-entry among cocaine abusers who relapsed to cocaine use (N = 347) within 5 years following their index treat...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,多中心研究
doi：10.1016/s0740-5472(03)00128-4
更新日期：2003-10-01 00:00:00
abstract：:The aim of this research was to measure the longitudinal effects of having children in a client's custodial care, on opioid treatment outcomes. A 3 year national, longitudinal study was implemented. Outcomes were measured using the Maudsley Addiction Profile, 404 clients (75% male) were recruited and 97% were located ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2012.04.002
更新日期：2013-01-01 00:00:00
abstract：:At the end of 2000, in Sydney, Australia, there was a dramatic reduction in heroin availability. This study examines how health agencies treating clients for drug and alcohol related issues were able to respond to the changes that took place in their clients and their treatment needs. Key informant interviews were con...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2004.10.004
更新日期：2005-01-01 00:00:00
