Abstract:
:The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Kieffer N,Aires-de-Sousa M,Nordmann P,Poirel Ldoi
10.3201/eid2312.170883subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2023-2029issue
12eissn
1080-6040issn
1080-6059journal_volume
23pub_type
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