Abstract：
OBJECTIVE:To determine the prevalence of thrombotic events and all-cause mortality in men older than 65 years with hypogonadism treated with testosterone therapy (TST). PATIENTS AND METHODS:We retrospectively reviewed the charts of 217 hypogonadal men >65 years. We compared men who received TST (n = 153) to hypogonadal men (n = 64) who did not receive TST. We evaluated all-cause mortality, prevalence of myocardial infarction (MI), transient ischemic attack (TIA), cerebrovascular accident (CVA or "stroke"), and deep vein thrombosis/pulmonary embolism (DVT/PE). All events were verified by contacting patients. We excluded men with previous thrombotic events, men previously on androgen deprivation therapy, and men who had used TST before age of 65 years. RESULTS:Median age and Charlson Comorbidity Index of men on TST (74y; 5.1) was similar to hypogonadal men not on TST (73y, P = .48; 5.3, P = .36). Median follow-up was 3.8 vs 3.5 years (TST vs no TST). No man on TST died, whereas 5 hypogonadal men who did not receive TST died (P = .007). There were 4 thrombotic events (1 MI, 2 CVA/TIA, and 1 PE) in men who received TST and 1 event (CVA/TIA) among men who did not receive TST (P = .8). All events (1 death, 6-month follow-up) occurred at least after 2 years of follow-up. CONCLUSION:There was increased all-cause mortality in hypogonadal men not treated with testosterone compared to men who received TST. There was no difference in prevalence of MI, TIA/CVA, or PE between patients treated with testosterone and hypogonadal men not treated with testosterone.
journal_name
Urologyjournal_title
Urologyauthors
Ramasamy R,Scovell J,Mederos M,Ren R,Jain L,Lipshultz Ldoi
10.1016/j.urology.2015.03.049subject
Has Abstractpub_date
2015-08-01 00:00:00pages
283-5issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(15)00405-7journal_volume
86pub_type
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