Abstract：
:Pravastatin is one of the most popular cholesterol-lowering drugs. Its industrial production represents a two-stage process including the microbial production of compactin and its further biocatalytic conversion to pravastatin. To increase a conversion rate, a higher compactin content in fermentation medium should be used; however, high compactin concentrations inhibit microbial growth. Therefore, the improvement of the compactin resistance of a producer still remains a relevant problem. A multi-step random UV mutagenesis of a Streptomyces xanthochromogenes strain RIA 1098 and the further selection of high-yield compactin-resistant mutants have resulted in a highly productive compactin-resistant strain S 33-1. After the fermentation medium improvement, the maximum bioconversion rate of this strain has reached 91 % at the daily compactin dose equal to 1 g/L and still remained high (83 %) even at the doubled dose (2 g/L). A 1-year study of the mutant strain stability has proved a stable inheritance of its characteristics that provides this strain to be very promising for the pravastatin-producing industry.
journal_name
Indian J Microbioljournal_title
Indian journal of microbiologyauthors
Dzhavakhiya VV,Voinova TM,Glagoleva EV,Petukhov DV,Ovchinnikov AI,Kartashov MI,Kuznetsov BB,Skryabin KGdoi
10.1007/s12088-015-0537-5subject
Has Abstractpub_date
2015-12-01 00:00:00pages
440-6issue
4eissn
0046-8991issn
0973-7715pii
537journal_volume
55pub_type
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