Abstract:
:Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is an extraordinarily successful pathogen of humankind. It has been estimated that up to one-third of the world's population is infected with M. tuberculosis, and this population is an important reservoir for disease reactivation. Resuscitation promoting factor (Rpf) is a secretory protein, which was first reported in Micrococcus luteus. There are five functionally redundant Rpf-like proteins found in M. tuberculosis. Rpf promotes the resuscitation of dormant bacilli to yield normal, viable colony forming bacteria. All Rpfs share a conserved domain of about 70 amino acids and possess a lysozyme-like activity. The structural studies of the conserved domain suggest that Rpfs could be considered as a c-type lysozyme and lytic transglycosylases. Recently a novel class of nitrophenylthiocyanates (NPT) inhibitors of the muralytic activity of Rpf were reported which opens a new approach in the study of cell-wall hydrolyzing enzymes. This review describes molecular and structural studies conducted on Rpf proteins, their role in the resuscitation of dormant bacteria, in the reactivation of latent infection and identification of low molecular weight inhibitors of resuscitation promoting factors.
journal_name
Indian J Microbioljournal_title
Indian journal of microbiologyauthors
Gupta RK,Srivastava Rdoi
10.1007/s12088-011-0202-6subject
Has Abstractpub_date
2012-06-01 00:00:00pages
114-21issue
2eissn
0046-8991issn
0973-7715pii
202journal_volume
52pub_type
杂志文章abstract::Start of the 21st century with its universal call to feed the hungry is an appropriate time to refocus attention on food security and especially the impact of biopatenting on poor communities who are the primary victims of hunger in our world. Antibacterial metabolites of lactic acid bacteria and Bacillus spp have pot...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-009-0048-3
更新日期:2009-09-01 00:00:00
abstract::Generation of biowastes is increasing rapidly and its uncontrolled, slow and persistent fermentation leads to the release of Green-house gases (GHGs) into the environment. Exploration and exploitation of microbial diversity for degrading biowastes can result in producing diverse range of bioactive molecules, which can...
journal_title:Indian journal of microbiology
pub_type: 杂志文章,评审
doi:10.1007/s12088-019-00826-w
更新日期:2019-12-01 00:00:00
abstract::Metagenome represent an unlimited resource for discovery of novel genes. Here we report, sequence analysis of a salt tolerant metagenomic clone (6B4) from a pond water metagenomic library. Clone 6B4 had an insert of 2254 bp with G+C composition of 64.06%. DNA sequence from 6B4 showed homology to DNA sequences from pro...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-010-0041-x
更新日期:2010-06-01 00:00:00
abstract::Among the cultivated mushroom, the genus Pleurotus is the second largest produced worldwide and the most produced in Brazil. The application of agricultural by-products (wastes) as substrate supplement is an effective approach to generate quality food while promoting a circular economy in agriculture. The manuscript e...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-019-00805-1
更新日期:2019-09-01 00:00:00
abstract::Staphylococcus warneri, isolated from the cervix of an adult female with unexplained infertility, was found to agglutinate human spermatozoa in vitro leading to their death. A genomic library of S. warneri was generated using pSMART-Escherichia coli vector-host system. Approximately 3500 transformants were screened an...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-018-0766-5
更新日期:2019-03-01 00:00:00
abstract::Cell biomass and metal salt concentration have great influence on morphology of biosynthesized nanoparticle. The aim of present study was to evaluate the effect of varying cell density and gold salt concentrations on synthesis of nanoparticles and its morphology, which has not been studied in bacteria till now. When c...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-016-0598-0
更新日期:2016-12-01 00:00:00
abstract::Wolbachia are maternally inherited endosymbiotic alpha-proteobacteria found in terrestrial arthropods and filarial nematodes. They are transmitted vertically through host cytoplasm and alter host biology by inducing various reproductive alterations, like feminization, parthenogenesis, male killing (MK) and cytoplasmic...
journal_title:Indian journal of microbiology
pub_type: 杂志文章,评审
doi:10.1007/s12088-014-0448-x
更新日期:2014-09-01 00:00:00
abstract::Aeromonads are inhabitants of aquatic ecosystems and are described as being involved in intestinal disturbances and other infections. The purpose of this study was to investigate the production of N-acyl-homoserine lactone (AHL) signal molecules and some virulence factors, including hemolysins, proteases, extracellula...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-013-0381-4
更新日期:2013-09-01 00:00:00
abstract::This study reports the identification of ionising radiation tolerant bacteria from a high elevation arid region of central Tibet. Nineteen isolates were isolated from soil exposed to ionising radiation at doses from 0 to 15 kGy. Isolates were phylogenetically characterised using 16S rRNA gene sequences. Most isolates ...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-016-0604-6
更新日期:2016-12-01 00:00:00
abstract::A Gram negative, yellow pigmented, rod shaped bacterium designated as RL(T) was isolated from a hot water spring (90-98 °C) located at Manikaran in Northern India. The isolate grows at 60-80 °C (optimum, 70 °C) and at pH 7.0-9.0 (optimum pH 7.2). Phylogenetic analysis of 16S rRNA gene sequences and levels of DNA-DNA r...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-015-0538-4
更新日期:2015-12-01 00:00:00
abstract::The bacterial strains resistant to pentachlorophenol (PCP) and hexavalent chromium [Cr(VI)] were isolated from treated tannery effluent of a common effluent treatment plant. Most of the physico-chemical parameters analyzed were above permissible limits. Thirty-eight and four bacterial isolates, respectively were found...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-011-0089-2
更新日期:2011-01-01 00:00:00
abstract::Potential use of Lactococcus lactis (L. lactis) as a heterologous protein expression host as well as for delivery of multiple therapeutic proteins has been investigated extensively using Nisin Inducible Controlled Expression (NICE) system. Optimum inducible expression of heterologous protein by NICE system in L. lacti...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-015-0556-2
更新日期:2016-03-01 00:00:00
abstract::Emergence of antimicrobial resistance mediated through New Delhi metallo-β-lactamases (NDMs) is a serious therapeutic challenge. Till date, 16 different NDMs have been described. In this study, we report the molecular and structural characteristics of NDM-5 isolated from an Escherichia coli isolate (KOEC3) of bovine o...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-016-0569-5
更新日期:2016-06-01 00:00:00
abstract::Peste des Petits Ruminants (PPR) is a highly contagious animal disease caused by the Peste des Petits Ruminants virus (PPRV) belonging to the genus morbillivirus and family Paramyxoviridae. The disease results in high morbidity and mortality in goats, sheep and in some small wild ruminants. The presence of large numbe...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-010-0026-9
更新日期:2010-09-01 00:00:00
abstract::Nitrogen fixing bacteria, rhizobia and phosphate solubilizing bacteria (PSB) are the commonly applied microbial inoculants in grain legumes (Pulses). It is important to apply herbicides to control weeds in order to augment yield of the crop. The herbicides may however, be incompatible with the microbial inoculants. Th...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-011-0145-y
更新日期:2011-06-01 00:00:00
abstract::This study aimed to evaluate the intrinsic antibacterial activity and antibiotic-enhancing effect of an arylamino methylene derivative (MAD) in association with fluoroquinolones. The antibacterial activity against multiresistant Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli was analyzed by determi...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-020-00910-6
更新日期:2021-03-01 00:00:00
abstract:ABSTRACT:Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic dat...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-012-0313-8
更新日期:2012-12-01 00:00:00
abstract::In recent years, investigations of microbial flora associated with fish gut have deepened our knowledge of the complex interactions occurring between microbes and host fish. The gut microbiome not only reinforces the digestive and immune systems in fish but is itself shaped by several host-associated factors. Unfortun...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-018-0760-y
更新日期:2018-12-01 00:00:00
abstract::Pectin rich wastes and waste dump yard soils were screened and eighty pectinolytic fungal isolates were obtained by enrichment culturing and ruthenium red plate assay. Eight isolates with higher zones of pectin hydrolysis were selected and tested for polygalacturonase production. One isolate identified as Aspergillus ...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-010-0054-5
更新日期:2010-09-01 00:00:00
abstract::The pharmaceutically important compound N-acetylglucosamine (NAG), is used in various therapeutic formulations, skin care products and dietary supplements. Currently, NAG is being produced by an environment-unfriendly chemical process using chitin, a polysaccharide present in abundance in the exoskeleton of crustacean...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-011-0157-7
更新日期:2011-07-01 00:00:00
abstract::Puma Yumco Lake (PYL) is an ultraoligotrophic freshwater lake that sits an altitude of 5030 m within the Qinghai-Tibet Plateau of China. The bacterial and archaeal diversity of the lake remains poorly understood, despite their potential to inform on biogeochemical cycling and environment-microbial associations in thes...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-020-00881-8
更新日期:2020-09-01 00:00:00
abstract::The present study deals with the occurrence of vesicular arbuscular mycorrhizal fungi in three cultivars of rice in Barak valley. Three cultivars of rice were Pankaj, Malati and Ranjit. The results revealed the association of VAM fungi in all the cultivars of rice. The association was maximum in Pankaj cultivar follow...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-011-0090-9
更新日期:2011-07-01 00:00:00
abstract::Bacteria possessing multiple copies of 16S rRNA (rrs) gene demonstrate high intragenomic heterogeneity. It hinders clear distinction at species level and even leads to overestimation of the bacterial diversity. Fifty completely sequenced genomes belonging to 19 species of Lactobacillus species were found to possess 4-...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-016-0605-5
更新日期:2016-09-01 00:00:00
abstract::The green synthesis of the flavor esters, n-propyl acetate, isobutyl acetate and isoamyl acetate had the advantages over the chemical synthesis. The esterase from Candida parapsilosis could transform n-propanol, isobutanol and isoamyl alcohol into n-propyl acetate, isobutyl acetate and isoamyl acetate, respectively. T...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-020-00856-9
更新日期:2020-06-01 00:00:00
abstract::The enhancement of production of asperenone (Fig. 1), an inhibitor of lipoxygenase and human platelet aggregation from Aspergillus niger CFTRI 1105, was achieved by UV and nitrous acid mutagenesis. Nitrous acid mutants exhibited increased inhibitor production when compared with UV irradiated mutants. I N 41 a first-ge...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-008-0026-1
更新日期:2008-06-01 00:00:00
abstract::Rhizobacteria belonging to Bacillus sp. were isolated from the rhizosphere of chickpea (Cicer arietinum). Ten Bacillus strains were studied for their antifungal activity, effect on seedling emergence and plant growth promotion. Two Bacillus strains CBS127 and CBS155 inhibited the growth of all the four pathogenic fung...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-007-0010-1
更新日期:2007-03-01 00:00:00
abstract::Carbon cycling in the hypersaline microbial mats from Chiprana Lake, Spain is primarily dependent on phototrophic microorganisms with the ability to fix CO2 into organics that can be further utilized by aerobic as well as anaerobic heterotrophic bacteria. Here, mat pieces were incubated in seawater amended with (14)C ...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-011-0239-6
更新日期:2012-03-01 00:00:00
abstract::As one of the most significant swine diseases, in recent years, swine influenza (SI) has had an immense impact on public health and has raised extensive public concerns in China. Swine are predisposed to both avian and human influenza virus infections, between that and/or swine influenza viruses, genetic reassortment ...
journal_title:Indian journal of microbiology
pub_type: 杂志文章,评审
doi:10.1007/s12088-013-0419-7
更新日期:2014-03-01 00:00:00
abstract::This study was attempted to develop a new exponential sum model to describe the effect of temperature on growth rate (GR) of Escherichia coli O157:H7 in broth. The growth rates of E. coli O157:H7 at different storage temperatures (4, 10, 15, 20, 25, 30, and 35°C) estimated by fitting with the modified Gompertz model w...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-011-0198-y
更新日期:2012-03-01 00:00:00
abstract::The biodiversity of epilithic cyanobacteria from one of the unexplored habitats of freshwater streams of Kakoijana reserve forest of Assam, India was estimated. This paper lists a total of 29 species representing 18 genera of 12 families and 4 orders as per recent system of classification. Morphological descriptions, ...
journal_title:Indian journal of microbiology
pub_type: 杂志文章
doi:10.1007/s12088-007-0043-5
更新日期:2007-09-01 00:00:00