Abstract:
INTRODUCTION:Autologous free flaps are the criterion standard for reconstructions of complex soft tissue defects; however, they are limited by donor-site morbidities. The arteriovenous (AV) loop model enables the generation of soft tissue constructs based on acellular dermal matrices with a functional microvasculature and minimal donor site morbidity. The ideal scaffold for AV loop-based tissue engineering has not been determined. METHODS:AV loops were placed into subcutaneous isolation chambers filled with either a collagen-elastin scaffold or a collagen-glycosaminoglycan scaffold in the thighs of rats. Matrix elasticity, neoangiogenesis, cell migration, and proliferation were compared after 14 and 28 days. RESULTS:Mean vessel count and area had increased in both matrices at 28 compared with 14 days. Collagen-elastin matrices showed a higher mean vessel count and area compared with collagen-glycosaminoglycan matrices at 14 days. At 28 days, a more homogeneous vascular network and higher cell counts were observed in collagen-elastin matrices. Collagen-glycosaminoglycan matrices, however, exhibited less volume loss at day 28. CONCLUSIONS:Collagen-based scaffolds are suitable for soft tissue engineering in conjunction with the AV loop technique. These scaffolds exhibit distinct patterns of angiogenesis, cell migration, and proliferation and may in the future serve as the basis of tissue-engineered free flaps as an individualized treatment concept for critical wounds.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Schmidt VJ,Wietbrock JO,Leibig N,Gloe T,Henn D,Hernekamp JF,Harhaus L,Kneser Udoi
10.1097/SAP.0000000000001096subject
Has Abstractpub_date
2017-07-01 00:00:00pages
92-100issue
1eissn
0148-7043issn
1536-3708journal_volume
79pub_type
杂志文章abstract::A large cutaneous horn was excised from the left side of the nose and cheek of a 68-year-old woman. Reconstruction was performed with a split-thickness skin graft. Histologically the lesion represented squamous cell carcinoma. The nature of malignant degeneration in cutaneous horns is discussed. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199712000-00019
更新日期:1997-12-01 00:00:00
abstract::Biomechanical tests of torsional loading and cantilevered bending were used to study the effects of varying screw size design of five different titanium miniscrews and microscrews in a metacarpal spiral oblique fracture model. Sixty-six fresh frozen human cadaveric metacarpal bones were subjected to torsional loading ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199607000-00006
更新日期:1996-07-01 00:00:00
abstract::In the small percentage of deep wound infections complicating total hip arthroplasty and recalcitrant to conventional forms of treatment, muscle flaps with or without a cutaneous unit can offer a satisfactory solution. Seven patients (4 male, 3 female) with failed total hip arthroplasty and multimicrobial infection we...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198312000-00006
更新日期:1983-12-01 00:00:00
abstract::Double-breasted closure of the skin is achieved by deepithelialization of 1 edge of a wound and advancement of the opposite edge over this deepithelialized area. Such closure may prevent contamination or exposure of the implant in cases where immediate breast reconstruction with prosthetic material is obtained after s...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000174362.35948.65
更新日期:2005-09-01 00:00:00
abstract::As the use of rigid internal fixation of the facial skeleton has become routine in adults, many craniofacial surgeons have expanded its use to the pediatric population. The effects of miniplate and screw fixation on subsequent craniofacial growth, however, have not been examined. Using 6-week-old rabbits as an experim...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199011000-00005
更新日期:1990-11-01 00:00:00
abstract::Endoscopic facial surgery is gaining wide acceptance, as results are providing comparable if not superior to the standard, superficial musculoaponeurotic system rhytidectomy, with minimal scarring. Frontal branch facial nerve injury remains a troublesome complication. The purpose of our study was to determine if a sub...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199605000-00001
更新日期:1996-05-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare skin disorder of unknown etiology that is believed to be part of the spectrum of neutrophilic dermatoses. Although 25% to 50% of cases are idiopathic, PG is associated with systemic disease in up to 70% of patients, most notably inflammatory bowel disease, rheumatoid arthritis, and ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e318296b7ae
更新日期:2015-03-01 00:00:00
abstract::A technique for reconstruction of the bilateral cleft lip nose is described. The literature for bilateral cleft lip nasal repair and the use of autogenous cartilage grafts is reviewed. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197905000-00003
更新日期:1979-05-01 00:00:00
abstract::The trapdoor deformity has been thought to be the result of contraction of the semicircular scar of the skin surface. The hypothesis is presented that a sheet of internal scar is primarily responsible for raising the skin inside the semicircle. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199008000-00011
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Scalp melanoma is aggressive and has a proclivity for regional metastasis. We hypothesize that subperiosteal scalp melanoma resection reduces in-transit/satellite recurrence, when compared with subgaleal resection. METHODS:We identified patients with intermediate to deep, primary scalp melanoma referred to ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822592e7
更新日期:2012-08-01 00:00:00
abstract::Coronary artery bypass grafting is a common surgical procedure for myocardial revascularization. This operation usually involves the use of the left internal mammary artery to bypass the left anterior descending coronary artery. The internal mammary artery and its perforators are also an important blood supply to the ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000141597.38288.3c
更新日期:2005-01-01 00:00:00
abstract::Primary intraosseous venous malformations affecting the zygoma are rare vascular lesions, with only 35 cases reported in the surgical literature. Despite the establishment of the binary classification system, which serves to distinguish vascular tumors from malformations, inappropriate use of the term "hemangioma" to ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182605690
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:Use of the omentum for poststernotomy mediastinitis is typically viewed as a last resort. Formal debridement and muscle flap coverage is sufficient most of the time; however, there are situations when the omental flap is more appropriate. The purpose of this series is to critically evaluate the outcome in ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318054718e
更新日期:2008-02-01 00:00:00
abstract::Microcirculatory changes were monitored in 20 deep inferior epigastric artery perforator (DIEAP) flaps during unilateral breast reconstruction until the seventh postoperative day using laser Doppler perfusion imaging. Measurements were recorded according to the zonal classification by Scheflan and Dinner. The cutaneou...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/SAP.0b013e3181f3e39b
更新日期:2011-08-01 00:00:00
abstract::A study of the psychological aspects of mastectomy and reconstruction was carried out. A review of the literature revealed varied emotional responses to the mastectomy experience. An initial, limited study was designed to investigate the attitudes of two groups of women, one that chose reconstruction after mastectomy ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198407000-00008
更新日期:1984-07-01 00:00:00
abstract::Keloid disease is known to have variable clinical behavior in response to therapy and there is no clinicopathologic classification that predicts such varied behavior. The aim of this study was to study the effect of excision margins and other histopathologic characteristics on keloid prognosis.Seventy-five multiethnic...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31819b6c3a
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Dynamic Infrared Imaging (DIRI) is a noninvasive technique that precisely analyzes the infrared radiation of any object. We used this technique to locate the dominant perforator vessels in flap surgery in conjunction with conventional Doppler. METHODS:Ten patients scheduled for deep inferior epigastric arte...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181ef6da3
更新日期:2011-08-01 00:00:00
abstract::Limited access to hand surgical care in the emergency room appears to be a problem in north Florida and probably other parts of the country, as well. In this study, hand surgeons in 3 major cities were contacted to determine what on-call services they provide for hospital emergency departments in their areas. Addition...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000237636.37714.bb
更新日期:2007-02-01 00:00:00
abstract::Volume resuscitation of patients with high-voltage electrical injuries (>1000 V) is a more complex challenge than standard burn resuscitation. High voltages penetrate deep tissues. These deep injuries are not accounted for in resuscitation formulae dependent on percentage of cutaneous burn. Myonecrosis occurring from ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0000000000001374
更新日期:2018-03-01 00:00:00
abstract::We have previously demonstrated in a rat surgical incision model that charged dextran beads enhance wound repair in a charge-specific manner: positively charged beads increased wound breaking strength (WBS), whereas neutral or negatively charged beads were ineffective. The present work extends these observations into ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199606000-00008
更新日期:1996-06-01 00:00:00
abstract::A case of a closed rupture of a single slip of flexor digitorum superficialis to the little finger is described. Closed rupture injuries of the flexor digitorum profundus tendon are quite common, but closed injuries to the superficialis tendon have been rarely reported. A single slip avulsion rupture of this tendon wo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200110000-00012
更新日期:2001-10-01 00:00:00
abstract::This paper presents 4 consecutive cases using negative-pressure dressings (VAC) to bolster skin grafts in male genital reconstruction. In this series reconstruction followed 1 case of tumor ablation and 3 cases of debridement of abscesses or Fornier's gangrene. The VAC was applied circumferentially to the penis to sec...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000143606.39693.3f
更新日期:2005-02-01 00:00:00
abstract::There is a need in plastic and reconstructive surgery for a method of monitoring flaps and replants pre- and postoperatively. This study evaluates color flow Doppler done as a monitoring technique for microvascular vessels. The capability of color flow ultrasound to monitor venous and arterial insufficiency and occlus...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199303000-00001
更新日期:1993-03-01 00:00:00
abstract::Hypertrichosis is an often stigmatizing cosmetic problem not only for women but also for male-to-female transsexual patients. The hitherto described therapeutic measures include chemical epilation, razoring, camouflage, electrolysis and thermolysis, and waxing. All of these measures are transient, more or less painful...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199708000-00009
更新日期:1997-08-01 00:00:00
abstract::Prostaglandin E1 has been proven to be useful in the treatment of vascular diseases of the lower leg. Plastic surgeons have been aware of its usefulness in augmenting flap survival and have used it intraarterially or intravenously. We attempted to enhance the effect of prostaglandin E1 with heparin by local continuous...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199302000-00010
更新日期:1993-02-01 00:00:00
abstract::Terror attacks have been progressively increasing worldwide through the present era. The management of the consequences of terrorism events is under debate in almost every scientific area. The organization and advancement of health services constitute important components of the crisis management. Similar to other spe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001238
更新日期:2017-12-01 00:00:00
abstract::Postoperative cosmesis of the reconstructed breast depends on the interrelation of shape, size (volume), and symmetry. In this study, reconstructed breasts were analyzed with 3-dimensional projections generated by laser light scanning. Fifty-one cases of breast reconstruction following mastectomy (16 cases of rectus a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000200716.82945.b2
更新日期:2006-03-01 00:00:00
abstract::Many treatment modalities of ingrown toenail are reported in the literature, often associated with unacceptably high recurrence rate. The authors present their technique, which aims at reducing the convexity of the nail fold. After complete removal of the nail plate and accurate debridement of the granulomatous tissue...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000095436.08812.67
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:To study the availability and effects for application of 4 kinds of perforator flaps in repairing skin and soft tissue defects in different positions around the knee joints. METHODS:The present study included 26 cases (16 males and 10 females) with soft tissue defects with ages from 7 to 82 years who came to o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001544
更新日期:2018-10-01 00:00:00
abstract::Excessive scar contracture by wound fibroblasts can have devastating consequences, ranging from body disfigurement to joint immobility. The ability of fibroblasts isolated from lesions of hypertrophic scars, keloids, normal skin, or normal scars in contracting the provisional wound matrix (i.e., fibrin clot) was compa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199605000-00011
更新日期:1996-05-01 00:00:00