当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY期刊下所有文献 > Monophosphoryl lipid A enhances nontypeable Haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization.

Monophosphoryl lipid A enhances nontypeable Haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization.

Abstract：

OBJECTIVE:Acute otitis media (AOM) is one of the most common infectious diseases in children. Nontypeable Haemophilus influenzae (NTHi) is Gram-negative bacteria that are considered major pathogens of AOM and respiratory tract infections. In this study, we used monophosphoryl lipid A (MPL), a toll-like receptor (TLR) 4 agonist, as an adjuvant to induce mucosal immune responses against NTHi to enhance bacterial clearance from the nasopharynx. METHODS:Mice were administered 10 μg outer membrane protein (OMP) from NTHi and 0, 10, or 20 μg MPL intranasally once a week for 3 weeks. Control mice were administered phosphate-buffered saline alone. After immunization, these mice were challenged with NTHi. At 6 and 12 h after bacterial challenge, the mice were killed and nasal washes and sera were collected. The numbers of NTHi- and OMP-specific antibodies were quantified by enzyme-linked immunosorbent assay. RESULTS:The MPL 10 and 20 μg group produced a significant reduction in the number of bacteria recovered from the nasopharynx at 12 h after bacterial challenge compared to the control group. OMP-specific IgA titers were also augmented in the MPL groups compared to the control and OMP groups. CONCLUSION:MPL is suitable for eliciting effective mucosal immune responses against NTHi in the nasopharynx. These results demonstrate the possibility of an adjuvant that involves stimulation of the innate immune system by TLR4 agonists such as MPL for mucosal vaccination.

journal_name

Int J Pediatr Otorhinolaryngol

journal_title

International journal of pediatric otorhinolaryngology

authors

Iwasaki T,Hirano T,Kodama S,Kadowaki Y,Moriyama M,Kawano T,Suzuki M

doi

10.1016/j.ijporl.2017.03.018

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

5-12

eissn

0165-5876

issn

1872-8464

pii

S0165-5876(17)30109-X

journal_volume

97

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY文献大全
  • Assessment of adenotonsillar size and caregiver-reported sleep symptoms among 3-6 year old children undergoing adenotonsillectomy.

    abstract：INTRODUCTION:Adenotonsillectomy remains the accepted first-line treatment for obstructive sleep apnea syndrome (OSAS) in children. Tonsillar size may be especially relevant in risk stratification as it may impact symptoms of sleep disordered breathing (SDB). This study assesses correlations among subjective tonsillar g...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2016.10.001

    authors： Balaban O,Walia H,Tumin D,Jatana KR,Raman V,Tobias JD

    更新日期：2016-12-01 00:00:00

  • Impact of pediatric obesity on the prevalence and outcome of otitis media with effusion.

    abstract：INTRODUCTION:Otitis Media with Effusion (OME) is the most common cause of hearing impairment in the pediatric population. Pediatric obesity is another major health issue with numerous reported health consequences, however, published studies about its role in OME are limited. This study aims to investigate the impact of...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2020.110005

    authors： Alaraifi AK,Alosfoor MA,Alsaab F

    更新日期：2020-06-01 00:00:00

  • 500Hz logon versus click ABR maturation.

    abstract：OBJECTIVES:To provide age-equivalent norms for a 500Hz logon evoked ABR obtained in a group of children ranging 40 weeks-4 years old and compare these 500Hz tonal norms to age-equivalent norms for click-evoked ABR. METHODS:Seventy-seven infants and children ranging from conceptional age of 40 weeks (term babies) to 4 ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2007.01.016

    authors： Külekçi S,Terlemez S,Ciprut A,Akdaş F

    更新日期：2007-05-01 00:00:00

  • The use of honey in cochlear implant associated wounds in pediatric patients.

    abstract：INTRODUCTION:The use of honey in wound care is becoming more common due to the proven benefit in all three phases of wound healing, as well as the antibacterial and antibiofilm properties. We present our experience using TheraHoney gel, a medical grade honey, for the successful treatment of cochlear implant associated ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2018.05.026

    authors： Costeloe A,Vandjelovic ND,Evans MA,Saraiya SS

    更新日期：2018-08-01 00:00:00

  • Factors associated with all-cause mortality in pediatric invasive fungal rhinosinusitis.

    abstract：INTRODUCTION:Pediatric invasive fungal rhinosinusitis (PIFR) is a potentially lethal infection seen in immunocompromised pediatric patients. Even with timely treatments, mortality ranges between 18 and 80% of the cases. OBJECTIVE:To analyze the factors associated with all-cause mortality in pediatric patients with acu...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2019.109734

    authors： Alejandro A,de la Torre González C,Edgar M,Perla V

    更新日期：2020-02-01 00:00:00

  • Unusual laryngeal cysts in the newborn.

    abstract：:In the newborn, severe airway obstruction is a rare occurrence. The possible etiologies include a broad spectrum of diseases with laryngeal cysts an unusual cause. If diagnosed and properly managed, however, the prognosis for this entity is excellent. Three cases presenting with airway obstruction secondary to unusual...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/0165-5876(96)01407-3

    authors： Forte V,Warshawski J,Thorner P,Conley S

    更新日期：1996-11-01 00:00:00

  • Laryngeal diversion in the treatment of chronic aspiration in children.

    abstract：:Chronic aspiration in children can be life-threatening, especially in patients with underlying pulmonary disorders. Numerous surgical procedures have been described to treat chronic aspiration. In patients with severe chronic aspiration, laryngeal diversion is the most effective procedure for reducing soilage of the p...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/0165-5876(89)90066-9

    authors： De Vito MA,Wetmore RF,Pransky SM

    更新日期：1989-12-01 00:00:00

  • An Usher syndrome type 1 patient diagnosed before the appearance of visual symptoms by MYO7A mutation analysis.

    abstract：:Usher syndrome type 1 (USH1) appears to have only profound non-syndromic hearing loss in childhood and retinitis pigmentosa develops in later years. This study examined the frequency of USH1 before the appearance of visual symptoms in Japanese deaf children by MYO7A mutation analysis. We report the case of 6-year-old ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2012.11.007

    authors： Yoshimura H,Iwasaki S,Kanda Y,Nakanishi H,Murata T,Iwasa Y,Nishio SY,Takumi Y,Usami S

    更新日期：2013-02-01 00:00:00

  • High homogeneity in auditory outcome of pediatric CI-patients with mutations in Gap-Junction-Protein Beta2.

    abstract：OBJECTIVES:A controversy exists in the literature regarding better auditory performance of cochlear implanted children with mutations in the Gap-Junction-Protein Beta2 (GJB2) gene. This is partially due to insufficient numbers, lack of proper statistics, etc. As this represents a very important issue for the counsellin...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2010.04.002

    authors： Reinert J,Honegger F,Gürtler N

    更新日期：2010-07-01 00:00:00

  • Cochlear implantation and vestibular function in children.

    abstract：OBJECTIVES:To analyze vestibular function Q2 (VF) after cochlear implantation (CI) in children. METHODS:Retrospective cohort study at a tertiary pediatric referral center. 43 children that had vestibular testing (VT) after unilateral cochlear implantation, from 2001 to 2010, were included. CT scan of the temporal bone...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2014.11.002

    authors： Thierry B,Blanchard M,Leboulanger N,Parodi M,Wiener-Vacher SR,Garabedian EN,Loundon N

    更新日期：2015-02-01 00:00:00

  • A sinonasal primary Ewing's sarcoma.

    abstract：:Nasal fractures are a common complaint familiar to all otolaryngologists. Sinonasal primary Ewing's sarcomas are extremely rare. The case of a 9-year-old boy is presented whose nasal fracture and subsequent lateral nasal wall hematoma revealed an underlying Ewing's sarcoma. There are several unusual features in the hi...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2003.09.011

    authors： Howarth KL,Khodaei I,Karkanevatos A,Clarke RW

    更新日期：2004-02-01 00:00:00

  • Management of epistaxis in children.

    abstract：:A randomised clinical trial of antiseptic nasal carrier cream (Naseptin) and silver nitrate cautery in the treatment of epistaxis in children was carried out. Fifty-four percent responded to cautery with silver nitrate and 50% to treatment with Naseptin antiseptic carrier cream. There were 24 patients in each group. N...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0165-5876(91)90144-z

    authors： Ruddy J,Proops DW,Pearman K,Ruddy H

    更新日期：1991-04-01 00:00:00

  • Acoustic brainstem implant in a post-meningitis deafened child-Lessons learned.

    abstract：:We report a case of a deafened child with advanced labyrinthitis ossificans resulting from meningo-encephalitis. She received a cochlear implant in the right ear, following a drill-out procedure. Post-implant hearing outcomes were satisfactory initially, but deteriorated over time as a result of partial electrode migr...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2011.11.026

    authors： Tan VY,D'Souza VD,Low WK

    更新日期：2012-02-01 00:00:00

  • Paediatric fibro-osseous lesions of the nose and paranasal sinuses.

    abstract：OBJECTIVE:The term "fibro-osseous lesion" is a generic description for a group of lesions involving the paranasal sinuses and anterior skull base. We aim to improve understanding of the clinical and pathological presentation of fibro-osseous lesions in children. METHODS AND RESULTS:We report two cases of aggressive "f...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijporl.2005.09.031

    authors： Mehta D,Clifton N,McClelland L,Jones NS

    更新日期：2006-02-01 00:00:00

  • Spontaneous resolution of recurrent tonsillitis in pediatric patients on the surgical waiting list.

    abstract：OBJECTIVE:To assess the impact of the waiting list on the spontaneous resolution of recurrent acute tonsillitis in children. METHODS:We have evaluated 623 cases placed on the waiting list for elective tonsillectomy (with or without adenoidectomy) between February 1994 and May 1999 at our institution. In each child, ag...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/s0165-5876(02)00128-3

    authors： Prim MP,de Diego JI,Larrauri M,Diaz C,Sastre N,Gavilan J

    更新日期：2002-08-01 00:00:00

  • Dichotic training in children with auditory processing disorder.

    abstract：OBJECTIVES:Several test batteries have been suggested for auditory processing disorder (APD) diagnosis. One of the important tests is dichotic listening tests. Significant ear asymmetry (usually right ear advantage) can be indicative of (APD). Two main trainings have been suggested for dichotic listening disorders: Dif...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2018.05.014

    authors： Delphi M,Zamiri Abdollahi F

    更新日期：2018-07-01 00:00:00

  • Characterization of cytokines present in pediatric otitis media with effusion: comparison of allergy positive and negative.

    abstract：:To investigate the possible relationship between allergy and otitis media with effusion (OME), we investigated the cytokine level in the middle ear effusion (MEE)s of children with persistent OME. Interleukin (IL)-2, IL-4, IL-6 and tumor necrosis factor (TNF)-alpha in the MEEs were measured by devised sensitive sandwi...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/s0165-5876(02)00185-4

    authors： Jang CH,Kim YH

    更新日期：2002-10-21 00:00:00

  • A novel mutation in the PAX3 gene causes Waardenburg syndrome type I in an Iranian family.

    abstract：OBJECTIVES:Sensorineural hearing impairment (HI) is one of the most frequent congenital defects, with a prevalence of 1 in 500 among neonates. Although there are over 400 syndromes involving HI, most cases of HI are nonsyndromic (70%), 20% of which follow autosomal dominant mode of inheritance. Waardenburg syndrome (WS...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2015.07.039

    authors： Jalilian N,Tabatabaiefar MA,Farhadi M,Bahrami T,Noori-Daloii MR

    更新日期：2015-10-01 00:00:00

  • Swallowing dynamics status post caustic ingestion in a pediatric patient: A multidisciplinary case report.

    abstract：:A case report of a 10 year old male illustrates the effect of damage to the tongue base, hypopharynx, cricopharyngeus, and esophagus on the sensory and motor components of the swallowing mechanism. The characteristics of the dysphagia were manifested clinically, radiographically, and endoscopically. A myectomy was req...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2016.04.003

    authors： Miller CK,Rutter MJ,von Allmen D,Stoops M,Putnam P,Stevens L,Willging JP

    更新日期：2016-07-01 00:00:00

  • Parents' views on the quality of life of their children 2-3 years after cochlear implantation.

    abstract：OBJECTIVE:Cochlear implants for children are known to have impact on the lives of recipients and their families in a variety of ways. To obtain a clearer picture of these benefits, we explored the quality of life of 36 Finnish children and their families 2-3 years after unilateral cochlear implantation. METHODS:The st...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2009.09.038

    authors： Huttunen K,Rimmanen S,Vikman S,Virokannas N,Sorri M,Archbold S,Lutman ME

    更新日期：2009-12-01 00:00:00

  • A re-audit of paediatric ENT services in England and Wales.

    abstract：OBJECTIVES:ENT has a high paediatric workload. National recommendations for provision of paediatric surgical services are provided by three key documents produced by the Department of Health and Royal Colleges of Surgeons and Anaesthetists. This second cycle audit assesses the current state of paediatric services in EN...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2013.10.012

    authors： Pabla L,Finn P,Blackmore KJ,Bosman DA

    更新日期：2014-01-01 00:00:00

  • Reconstruction of the pediatric airway with an open stented tracheotomy tube.

    abstract：:Reconstructive techniques for the stenotic pediatric airway have greatly enhanced the otolaryngologists ability to decannulate the tracheotomy-dependent child. Stents have played an important role in this process by both maintaining the reconstructed lumen and acting as a scaffold. However, decannulation is often not ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/0165-5876(94)90013-2

    authors： Willner A,Gereau SA,Ruben RJ

    更新日期：1994-01-01 00:00:00

  • Newborn hearing screening: an outpatient model.

    abstract：OBJECTIVE:The purpose of this study was to assess the feasibility of implementing an outpatient model of a newborn hearing screening program with a particular focus on determining how compliance with the follow-up appointment related to specific socio-economic and demographic factors associated with the mother. METHOD...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2008.09.002

    authors： Griz S,Mercês G,Menezes D,Lima ML

    更新日期：2009-01-01 00:00:00

  • The face does predict the brain--midline facial and forebrain defects uncovered during the investigation of nasal obstruction and rhinorrhea. Case report and a review of holoprosencephaly and its classifications.

    abstract：:When the embryonic forebrain (the prosencephalon) fails to sufficiently divide into the two cerebral hemispheres, holoprosencephaly (HPE) results. This disorder can result in various skull and facial defects with brain abnormalities of varying severity. These brain defects ultimately dictate the prognosis. This varies...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2005.09.020

    authors： El-Hawrani A,Sohn M,Noga M,El-Hakim H

    更新日期：2006-05-01 00:00:00

  • 'Small group' rehabilitation in adolescent cochlear implant users: aims, method and results.

    abstract：:The aim was to extend the linguistic, social and cognitive aspects of communication skills. The method was to use meaningful contexts and to attribute new significance to errors. Methods used were phonetic games (to improve speech production) and exercises (to increase reading and writing skills). The results after 18...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/s0165-5876(98)00142-6

    authors： D'Agosta L,Bosco E,Cordier A

    更新日期：1999-02-15 00:00:00

  • Evaluating the sinus and Nasal Quality of Life Survey in the pediatric cystic fibrosis patient population.

    abstract：INTRODUCTION:The Sinus and Nasal Quality of Life Survey (SN-5) is a validated quality of life (QOL) questionnaire for chronic rhinosinusitis in patients age 2-12. Its utility in the cystic fibrosis (CF) has been studied, but not yet validated. The purpose of this study is to determine the effectiveness of the SN-5 for ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2017.09.014

    authors： Xie DX,Wu J,Kelly K,Brown RF,Shannon C,Virgin FW

    更新日期：2017-11-01 00:00:00

  • Intrauterine hypoxia as a cause of hearing impairment in children.

    abstract：:Among more than 10,000 mothers giving birth during 1974-1977, there were 20 known cases of severe placental insufficiency in connection with hypertensive disease during pregnancy. Well-documented signs of intrauterine hypoxia were observed in all the cases. In 50% of the fetuses intrauterine growth retardation was fou...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/0165-5876(82)90005-2

    authors： Karjalainen S,Kärjä J,Suonio S,Yliskoski M

    更新日期：1982-08-01 00:00:00

  • A novel stent for the treatment of persistent buccopharyngeal membrane.

    abstract：:We describe a new stent design for treatment of persistent buccopharyngeal membrane. The patient is a male child diagnosed at birth with persistent buccopharyngeal membrane, managed in our institution from birth to present age of 2.5 years. We describe to problems and challenges in management for this rare anomaly by ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2006.04.009

    authors： Tan SS,Tan HK,Lim CS,Chiang WM

    更新日期：2006-09-01 00:00:00

  • Otolaryngologic surgery in children with trisomy 18 and 13.

    abstract：OBJECTIVES:Trisomy 18 and 13 are the most common autosomal trisomy disorders after Down syndrome. Given the high mortality rate (5-10% one-year survival), trisomy 18 and 13 were historically characterized as uniformly lethal and palliation was the predominant management approach. Management strategy has shifted with re...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2015.08.017

    authors： Karimnejad K,Costa DJ

    更新日期：2015-11-01 00:00:00

  • Blood transfusion in children with sickle cell disease undergoing tonsillectomy.

    abstract：INTRODUCTION:Tonsillectomy is the second most common surgery in children with sickle cell disease. These children are at an increased risk of perioperative complications due to vaso-occlusive events. Although controversial, preoperative blood transfusions are sometimes given in an effort to prevent such complications. ...

    journal_title：International journal of pediatric otorhinolaryngology

    pub_type： 杂志文章

    doi：10.1016/j.ijporl.2017.10.013

    authors： Atwood CM,Gnagi SH,Teufel RJ 2nd,Nguyen SA,White DR

    更新日期：2017-12-01 00:00:00