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Addition of non-invasive ventilatory support to combined aerobic and resistance training improves dyspnea and quality of life in heart failure patients: a randomized controlled trial.

Abstract：

OBJECTIVE:To test the hypothesis that combined aerobic and resistance training and non-invasive ventilatory support result in additional benefits compared with combined aerobic and resistance training alone in heart failure patients. DESIGN:A randomized, single-blind, controlled study. SETTING:Cardiac rehabilitation center. PARTICIPANTS:A total of 46 patients with New York Heart Association class II/III heart failure were randomly assigned to a 10-week program of combined aerobic and resistance training, plus non-invasive ventilatory support ( n = 23) or combined aerobic and resistance training alone ( n = 23). METHODS:Before and after intervention, results for the following were obtained: 6-minute walk test, forced vital capacity, forced expiratory volume at one second, maximal inspiratory muscle pressure, and maximal expiratory muscle pressure, with evaluation of dyspnea by the London Chest Activity of Daily Living scale, and quality of life with the Minnesota Living With Heart Failure questionnaire. RESULTS:Of the 46 included patients, 40 completed the protocol. The combined aerobic and resistance training plus non-invasive ventilatory support, as compared with combined aerobic and resistance training alone, resulted in significantly greater benefit for dyspnea (mean change: 4.8 vs. 1.3, p = 0.004), and quality of life (mean change: 19.3 vs. 6.8, p = 0.017 ). In both groups, the 6-minute walk test improved significantly (mean change: 45.7 vs. 44.1, p = 0.924), but without a statistically significant difference. CONCLUSION:Non-invasive ventilatory support combined with combined aerobic and resistance training provides additional benefits for dyspnea and quality of life in moderate heart failure patients. TRIAL REGISTRATION:ClinicalTrials.gov identifier: NCT02384798. Registered 03 April 2015.

journal_name

Clin Rehabil

journal_title

Clinical rehabilitation

authors

Bittencourt HS,Cruz CG,David BC,Rodrigues E Jr,Abade CM,Junior RA,Carvalho VO,Dos Reis FBF,Gomes Neto M

doi

10.1177/0269215517704269

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1508-1515

issue

eissn

0269-2155

issn

1477-0873

journal_volume

pub_type

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Addition of non-invasive ventilatory support to combined aerobic and resistance training improves dyspnea and quality of life in heart failure patients: a randomized controlled trial.