Abstract：
INTRODUCTION:The diagnostic algorithm of primary aldosteronism is burdened with uncertainties and, recently, it has been suggested that the sensitivity of the aldosterone/renin ratio used as a screening test - based on the suppression aldosterone - is low. AIM:The primary aim was to test the accuracy of aldosterone/renin ratio. METHOD:In a retrospective analysis of 309 hypertensive patients supine and ambulatory aldosterone levels were independently examined. RESULTS:Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. In 34 cases supine aldosterone was increased without elevation of the aldosterone/renin ratio. However, only 3 of them had concomitant low renin levels indicating that primary aldosteronism could not be ruled out. Abnormally increased renin was found in 69 patients, but only 59% of them had increased aldosterone level. CONCLUSION:Sensitivity of aldosterone/renin ratio is high (91%) if used only in justified cases.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Hussein T,Mezősi E,Bódis B,Nemes O,Rucz K,Bajnok Ldoi
10.1556/650.2016.30348subject
Has Abstractpub_date
2016-05-22 00:00:00pages
830-5issue
21eissn
0030-6002issn
1788-6120journal_volume
157pub_type
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