Bacteria vs. Bacteriophages: Parallel Evolution of Immune Arsenals.

Abstract:

:Bacteriophages are the most common entities on earth and represent a constant challenge to bacterial populations. To fend off bacteriophage infection, bacteria evolved immune systems to avert phage adsorption and block invader DNA entry. They developed restriction-modification systems and mechanisms to abort infection and interfere with virion assembly, as well as newly recognized clustered regularly interspaced short palindromic repeats (CRISPR). In response to bacterial immune systems, bacteriophages synchronously evolved resistance mechanisms, such as the anti-CRISPR systems to counterattack bacterial CRISPR-cas systems, in a continuing evolutionary arms race between virus and host. In turn, it is fundamental to the survival of the bacterial cell to evolve a system to combat bacteriophage immune strategies.

journal_name

Front Microbiol

authors

Shabbir MA,Hao H,Shabbir MZ,Wu Q,Sattar A,Yuan Z

doi

10.3389/fmicb.2016.01292

subject

Has Abstract

pub_date

2016-08-17 00:00:00

pages

1292

issn

1664-302X

journal_volume

7

pub_type

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